{"id":"https://openalex.org/W4389498121","doi":"https://doi.org/10.1016/j.envpol.2023.123092","title":"Non-regulated haloaromatic water disinfection byproducts act as endocrine and lipid disrupters in human placental cells","display_name":"Non-regulated haloaromatic water disinfection byproducts act as endocrine and lipid disrupters in human placental cells","publication_year":2023,"publication_date":"2023-12-08","ids":{"openalex":"https://openalex.org/W4389498121","doi":"https://doi.org/10.1016/j.envpol.2023.123092","pmid":"https://pubmed.ncbi.nlm.nih.gov/38072025"},"language":"en","primary_location":{"id":"doi:10.1016/j.envpol.2023.123092","doi":"https://doi.org/10.1016/j.envpol.2023.123092","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envpol.2023.123092","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0269749123020948-ga1_lrg.jpg","source":{"id":"https://openalex.org/S201530359","display_name":"Environmental Pollution","issn_l":"0269-7491","issn":["0269-7491","1873-6424"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Pollution","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0269749123020948-ga1_lrg.jpg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049219262","display_name":"Elisabet P\u00e9rez\u2010Albaladejo","orcid":"https://orcid.org/0000-0002-1319-9552","observed_orcids":["https://orcid.org/0000-0002-1319-9552"]},"institutions":[{"id":"https://openalex.org/I4210143256","display_name":"Institute of Environmental Assessment and Water Research","ror":"https://ror.org/056yktd04","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210143256"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elisabet P\u00e9rez-Albaladejo","raw_affiliation_strings":["Environmental Chemistry Department, IDAEA -CSIC-, C/ Jordi Girona, 18-26, 08034, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1319-9552","affiliations":[{"raw_affiliation_string":"Environmental Chemistry Department, IDAEA -CSIC-, C/ Jordi Girona, 18-26, 08034, Barcelona, Spain","institution_ids":["https://openalex.org/I4210143256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101785223","display_name":"Marta Casado","orcid":"https://orcid.org/0000-0001-9255-0138","observed_orcids":["https://orcid.org/0000-0001-9255-0138"]},"institutions":[{"id":"https://openalex.org/I4210143256","display_name":"Institute of Environmental Assessment and Water Research","ror":"https://ror.org/056yktd04","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210143256"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Casado","raw_affiliation_strings":["Environmental Chemistry Department, IDAEA -CSIC-, C/ Jordi Girona, 18-26, 08034, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Chemistry Department, IDAEA -CSIC-, C/ Jordi Girona, 18-26, 08034, Barcelona, Spain","institution_ids":["https://openalex.org/I4210143256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082489677","display_name":"Cristina Postigo","orcid":"https://orcid.org/0000-0002-7344-7044","observed_orcids":["https://orcid.org/0000-0002-7344-7044"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Postigo","raw_affiliation_strings":["Technologies for Water Management and Treatment Research Group, Department of Civil Engineering, University of Granada, Avda Severo Ochoa s/n, Campus de Fuentenueva, Granada, 18071, Spain; Institute for Water Research (IdA), University of Granada, Ram\u00f3n y Cajal 4, 18071, Granada, Spain","Institute for Water Research (IdA), University of Granada, Ram\u00f3n y Cajal 4, 18071, Granada, Spain","Technologies for Water Management and Treatment Research Group, Department of Civil Engineering, University of Granada, Campus de Fuentenueva s/n, Granada, 18071, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7344-7044","affiliations":[{"raw_affiliation_string":"Technologies for Water Management and Treatment Research Group, Department of Civil Engineering, University of Granada, Avda Severo Ochoa s/n, Campus de Fuentenueva, Granada, 18071, Spain; Institute for Water Research (IdA), University of Granada, Ram\u00f3n y Cajal 4, 18071, Granada, Spain","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"Institute for Water Research (IdA), University of Granada, Ram\u00f3n y Cajal 4, 18071, Granada, Spain","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"Technologies for Water Management and Treatment Research Group, Department of Civil Engineering, University of Granada, Campus de Fuentenueva s/n, Granada, 18071, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046250915","display_name":"Cinta Porte","orcid":"https://orcid.org/0000-0002-3940-6409","observed_orcids":["https://orcid.org/0000-0002-3940-6409"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210143256","display_name":"Institute of Environmental Assessment and Water Research","ror":"https://ror.org/056yktd04","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210143256"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Cinta Porte","raw_affiliation_strings":["Environmental Chemistry Department, IDAEA -CSIC-, C/ Jordi Girona, 18-26, 08034, Barcelona, Spain. Electronic address: cpvqam@cid.csic.es","Environmental Chemistry Department, IDAEA -CSIC-, C/ Jordi Girona, 18-26, 08034, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3940-6409","affiliations":[{"raw_affiliation_string":"Environmental Chemistry Department, IDAEA -CSIC-, C/ Jordi Girona, 18-26, 08034, Barcelona, Spain. Electronic address: cpvqam@cid.csic.es","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210143256"]},{"raw_affiliation_string":"Environmental Chemistry Department, IDAEA -CSIC-, C/ Jordi Girona, 18-26, 08034, Barcelona, Spain","institution_ids":["https://openalex.org/I4210143256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046250915"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210143256"],"apc_list":{"value":3770,"currency":"USD","value_usd":3770},"apc_paid":{"value":3770,"currency":"USD","value_usd":3770},"fwci":1.8977,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.84004852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"342","issue":null,"first_page":"123092","last_page":"123092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drinking-water-disinfection","display_name":"drinking water disinfection","score":0.9129999876022339},{"id":"https://openalex.org/keywords/halobenzoquinones","display_name":"halobenzoquinones","score":0.9110000133514404},{"id":"https://openalex.org/keywords/2-6-dichloro-1-4-benzoquinone","display_name":"2,6-dichloro-1,4-benzoquinone","score":0.925000011920929},{"id":"https://openalex.org/keywords/endocrine-disruption","display_name":"endocrine disruption","score":0.7480000257492065},{"id":"https://openalex.org/keywords/estrogen-biosynthesis","display_name":"estrogen synthesis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7590000033378601},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9829999804496765},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.6959999799728394},{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.9390000104904175},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.6330000162124634},{"id":"https://openalex.org/keywords/jeg-3-cells","display_name":"JEG-3 cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cyp19a1","display_name":"CYP19A1","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hsd17b1","display_name":"HSD17B1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6039999723434448},{"id":"https://openalex.org/keywords/2-4-6-trichlorophenol","display_name":"2,4,6-trichlorophenol","score":0.843999981880188},{"id":"https://openalex.org/keywords/2-4-6-tribromophenol","display_name":"2,4,6-tribromophenol","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7785542607307434},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6620470285415649},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.485506534576416},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.4580818712711334},{"id":"https://openalex.org/C2780862370","wikidata":"https://www.wikidata.org/wiki/Q1138899","display_name":"Endocrine disruptor","level":4,"score":0.42321962118148804},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.36975035071372986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2906004786491394},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.25327184796333313},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1600528359413147},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06718477606773376}],"mesh":[{"descriptor_ui":"D004202","descriptor_name":"Disinfectants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004202","descriptor_name":"Disinfectants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004203","descriptor_name":"Disinfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018508","descriptor_name":"Water Purification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060766","descriptor_name":"Drinking Water","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.envpol.2023.123092","doi":"https://doi.org/10.1016/j.envpol.2023.123092","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envpol.2023.123092","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0269749123020948-ga1_lrg.jpg","source":{"id":"https://openalex.org/S201530359","display_name":"Environmental Pollution","issn_l":"0269-7491","issn":["0269-7491","1873-6424"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Pollution","raw_type":"journal-article"},{"id":"pmid:38072025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38072025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental pollution (Barking, Essex : 1987)","raw_type":"Journal Article"},{"id":"pmh:oai:digibug.ugr.es:10481/90536","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10481/90536","pdf_url":"https://digibug.ugr.es/bitstream/10481/90536/1/1-s2.0-S0269749123020948-main.pdf","source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.csic.es:10261/341797","doi":null,"is_oa":true,"landing_page_url":"https://api.elsevier.com/content/abstract/scopus_id/85179885702","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1016/j.envpol.2023.123092","doi":"https://doi.org/10.1016/j.envpol.2023.123092","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envpol.2023.123092","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0269749123020948-ga1_lrg.jpg","source":{"id":"https://openalex.org/S201530359","display_name":"Environmental Pollution","issn_l":"0269-7491","issn":["0269-7491","1873-6424"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Pollution","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Clean water and sanitation","score":0.6618000268936157,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G121809054","display_name":null,"funder_award_id":"MCIN/AEI/10","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G1525255349","display_name":null,"funder_award_id":"CEX2018-000794-S","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G2021903752","display_name":null,"funder_award_id":"CEX2018-000794-S","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G2309174360","display_name":null,"funder_award_id":"10.13039","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G2660406951","display_name":null,"funder_award_id":"/ AEI/10","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G3480869486","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G3975674108","display_name":null,"funder_award_id":"RYC2020-028901-I","funder_id":"https://openalex.org/F4320323583","funder_display_name":"Fundaci\u00f3n General CSIC"},{"id":"https://openalex.org/G4996865202","display_name":null,"funder_award_id":"CEX2018-0 0 0794-S","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G5080475149","display_name":null,"funder_award_id":"10.13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G5118252151","display_name":null,"funder_award_id":"PID2021-122592NB-I00","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G624877701","display_name":null,"funder_award_id":"MCIN/AEI/ 10.13039/501100011033","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G7084143925","display_name":null,"funder_award_id":"AEI/10","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G897484643","display_name":null,"funder_award_id":"MCIN /AEI /10.13039","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320323583","display_name":"Fundaci\u00f3n General CSIC","ror":"https://ror.org/03byqb733"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389498121.pdf","grobid_xml":"https://content.openalex.org/works/W4389498121.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1969888404","https://openalex.org/W1972756092","https://openalex.org/W1973578930","https://openalex.org/W1981206423","https://openalex.org/W2024264346","https://openalex.org/W2037804387","https://openalex.org/W2044318948","https://openalex.org/W2055816951","https://openalex.org/W2070048028","https://openalex.org/W2088285066","https://openalex.org/W2090038789","https://openalex.org/W2095358649","https://openalex.org/W2107277218","https://openalex.org/W2167801130","https://openalex.org/W2252583923","https://openalex.org/W2313054799","https://openalex.org/W2334195826","https://openalex.org/W2476400701","https://openalex.org/W2533216396","https://openalex.org/W2589572040","https://openalex.org/W2604951002","https://openalex.org/W2767346094","https://openalex.org/W2794179708","https://openalex.org/W2803306832","https://openalex.org/W2888576105","https://openalex.org/W2892665961","https://openalex.org/W2898948619","https://openalex.org/W2905534447","https://openalex.org/W2942055468","https://openalex.org/W2952271545","https://openalex.org/W2988657905","https://openalex.org/W3000429575","https://openalex.org/W3005308306","https://openalex.org/W3033364254","https://openalex.org/W3039471068","https://openalex.org/W3086219246","https://openalex.org/W3128187441","https://openalex.org/W3138260977","https://openalex.org/W3144115272","https://openalex.org/W3159995035","https://openalex.org/W3166894392","https://openalex.org/W3184180027","https://openalex.org/W3194491314","https://openalex.org/W4224062070","https://openalex.org/W4311769030","https://openalex.org/W4353055831"],"related_works":["https://openalex.org/W3073818547","https://openalex.org/W4353055831","https://openalex.org/W4223910654","https://openalex.org/W2988657905","https://openalex.org/W4311769030","https://openalex.org/W1560099890","https://openalex.org/W6991488166","https://openalex.org/W3124470246","https://openalex.org/W2300482845","https://openalex.org/W7196933537"],"abstract_inverted_index":{"The":[0,116],"disinfection":[1,8],"of":[2,7,80,84,93,108,141,161,163,171,181],"drinking":[3],"water":[4,152],"generates":[5],"hundreds":[6],"byproducts":[9],"(DBPs),":[10],"including":[11],"haloaromatic":[12,15,60,164],"DBPs.":[13],"These":[14],"DBPs":[16,61,118],"are":[17,28],"suspected":[18],"to":[19,39,105],"be":[20],"more":[21],"toxic":[22,169],"than":[23,147],"haloaliphatic":[24],"ones,":[25],"and":[26,37,49,65,89,135,166,187],"they":[27],"currently":[29],"not":[30],"regulated.":[31],"This":[32,155],"work":[33],"investigates":[34],"their":[35,50],"toxicity":[36],"ability":[38],"interfere":[40],"with":[41],"estrogen":[42,97],"synthesis":[43,98],"in":[44,53,96,151],"human":[45,54],"placenta":[46,182],"JEG-3":[47],"cells,":[48],"genotoxic":[51],"potential":[52,170,192],"alveolar":[55],"A549":[56],"cells.":[57],"Among":[58],"the":[59,70,78,91,139,158,168,179],"studied,":[62],"halobenzoquinones":[63],"(2,6-dichloro-":[64],"2,6-dibromo-1,4-benzoquinone":[66],"(DCBQ,":[67],"DBBQ))":[68],"showed":[69,120],"highest":[71],"cytotoxicity":[72,125],"(EC50:":[73],"18\u201326":[74],"\u03bcg/mL).":[75,154],"They":[76],"induced":[77,138],"generation":[79],"very":[81],"high":[82],"levels":[83],"reactive":[85],"oxygen":[86],"species":[87,111],"(ROS)":[88],"up-regulated":[90],"expression":[92,180],"genes":[94,186],"involved":[95],"(cyp19a1,":[99],"hsd17b1).":[100],"Increased":[101],"ROS":[102],"was":[103],"linked":[104],"significant":[106,124,176],"depletion":[107],"polyunsaturated":[109],"lipid":[110],"from":[112],"inner":[113],"cell":[114],"membranes.":[115],"other":[117],"tested":[119],"low":[121],"or":[122],"no":[123],"(EC50":[126],"\u2265":[127],"100":[128],"\u03bcg/mL),":[129],"while":[130],"2,4,6-trichloro-,":[131],"2,4,6-tribromo-phenol":[132],"(TCP,":[133],"TBP)":[134],"3,5-dibromo-4-hydroxybenzaldehyde":[136],"(DCHB)":[137],"formation":[140],"micronuclei":[142],"at":[143],"concentrations":[144],"much":[145],"higher":[146],"those":[148],"typically":[149],"found":[150],"(100":[153],"study":[156],"reveals":[157],"different":[159],"modes":[160],"action":[162],"DBPs,":[165],"highlights":[167],"halobenzoquinones,":[172],"which":[173],"had":[174],"a":[175],"impact":[177],"on":[178],"steroid":[183],"metabolism":[184],"related":[185],"induce":[188],"oxidative":[189],"stress,":[190],"implying":[191],"adverse":[193],"health":[194],"effects.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-12-09T00:00:00"}