{"id":"https://openalex.org/W4389477350","doi":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2023048197","title":"Non-Invasive Delivery of Insulin for Breaching Hindrances against Diabetes","display_name":"Non-Invasive Delivery of Insulin for Breaching Hindrances against Diabetes","publication_year":2023,"publication_date":"2023-12-08","ids":{"openalex":"https://openalex.org/W4389477350","doi":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2023048197","pmid":"https://pubmed.ncbi.nlm.nih.gov/38608132"},"language":"en","primary_location":{"id":"doi:10.1615/critrevtherdrugcarriersyst.2023048197","doi":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2023048197","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2023048197","pdf_url":null,"source":{"id":"https://openalex.org/S22829174","display_name":"Critical Reviews in Therapeutic Drug Carrier Systems","issn_l":"0743-4863","issn":["0743-4863","2162-660X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews\u2122 in Therapeutic Drug Carrier Systems","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052774924","display_name":"Manoj Kumar Sarangi","orcid":"https://orcid.org/0000-0003-4539-5213","observed_orcids":["https://orcid.org/0000-0003-4539-5213"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Manoj Sarangi","raw_affiliation_strings":["Amity University, Lucknow Campus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amity University, Lucknow Campus","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085002696","display_name":"Sasmita Kumari Padhi","orcid":"https://orcid.org/0009-0009-7989-1021","observed_orcids":["https://orcid.org/0009-0009-7989-1021"]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sasmita Padhi","raw_affiliation_strings":["Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Malhaur Railway Station Road, Gomti Nagar, Lucknow, Uttar Pradesh, Pin-201313, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Malhaur Railway Station Road, Gomti Nagar, Lucknow, Uttar Pradesh, Pin-201313, India","institution_ids":["https://openalex.org/I191972202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004740492","display_name":"Goutam Rath","orcid":"https://orcid.org/0000-0001-6921-7513","observed_orcids":["https://orcid.org/0000-0001-6921-7513"]},"institutions":[{"id":"https://openalex.org/I193073490","display_name":"Siksha O Anusandhan University","ror":"https://ror.org/056ep7w45","country_code":"IN","type":"education","lineage":["https://openalex.org/I193073490"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Goutam Rath","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar-751030, Odisha, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar-751030, Odisha, India","institution_ids":["https://openalex.org/I193073490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052774924"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.212,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.17267081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"41","issue":"5","first_page":"1","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.2865999937057495,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.06310000270605087,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-delivery","display_name":"insulin delivery","score":0.8790000081062317},{"id":"https://openalex.org/keywords/non-invasive-drug-delivery","display_name":"non-invasive drug delivery","score":0.8309999704360962},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8600000143051147},{"id":"https://openalex.org/keywords/oral-insulin","display_name":"oral insulin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/inhaled-insulin","display_name":"inhaled insulin","score":0.7950000166893005},{"id":"https://openalex.org/keywords/intranasal-insulin","display_name":"intranasal insulin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7310000061988831},{"id":"https://openalex.org/keywords/insulin-bioavailability","display_name":"insulin bioavailability","score":0.7450000047683716},{"id":"https://openalex.org/keywords/insulin-absorption","display_name":"insulin absorption","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7403663396835327},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6927406191825867},{"id":"https://openalex.org/C2994527087","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin delivery","level":4,"score":0.6616058945655823},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.5807607769966125},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.5624644756317139},{"id":"https://openalex.org/C195735259","wikidata":"https://www.wikidata.org/wiki/Q16963239","display_name":"Buccal administration","level":2,"score":0.5312811136245728},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.49386054277420044},{"id":"https://openalex.org/C2776093070","wikidata":"https://www.wikidata.org/wiki/Q621636","display_name":"Route of administration","level":2,"score":0.41959917545318604},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4141806662082672},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3958742916584015},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32426905632019043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13642141222953796},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.12318733334541321},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09624230861663818},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.08820122480392456},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000285","descriptor_name":"Administration, Rectal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061386","descriptor_name":"Insulin, Regular, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1615/critrevtherdrugcarriersyst.2023048197","doi":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2023048197","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2023048197","pdf_url":null,"source":{"id":"https://openalex.org/S22829174","display_name":"Critical Reviews in Therapeutic Drug Carrier Systems","issn_l":"0743-4863","issn":["0743-4863","2162-660X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews\u2122 in Therapeutic Drug Carrier Systems","raw_type":"journal-article"},{"id":"pmid:38608132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38608132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in therapeutic drug carrier systems","raw_type":"Review"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":360,"referenced_works":["https://openalex.org/W39672263","https://openalex.org/W88550752","https://openalex.org/W140541985","https://openalex.org/W251599530","https://openalex.org/W1275656638","https://openalex.org/W1507741472","https://openalex.org/W1511175494","https://openalex.org/W1545369727","https://openalex.org/W1586224712","https://openalex.org/W1756039870","https://openalex.org/W1807009022","https://openalex.org/W1912810339","https://openalex.org/W1915780530","https://openalex.org/W1924967540","https://openalex.org/W1939160085","https://openalex.org/W1965935677","https://openalex.org/W1966218182","https://openalex.org/W1967239261","https://openalex.org/W1967287759","https://openalex.org/W1967299150","https://openalex.org/W1968797408","https://openalex.org/W1968918493","https://openalex.org/W1969654631","https://openalex.org/W1969865667","https://openalex.org/W1973792081","https://openalex.org/W1974371653","https://openalex.org/W1975970944","https://openalex.org/W1977341641","https://openalex.org/W1977533639","https://openalex.org/W1977555380","https://openalex.org/W1979394695","https://openalex.org/W1980359748","https://openalex.org/W1980439325","https://openalex.org/W1980887070","https://openalex.org/W1981549554","https://openalex.org/W1982201600","https://openalex.org/W1982204426","https://openalex.org/W1983078634","https://openalex.org/W1985405412","https://openalex.org/W1986073861","https://openalex.org/W1987087659","https://openalex.org/W1988218731","https://openalex.org/W1988644249","https://openalex.org/W1989318720","https://openalex.org/W1990240479","https://openalex.org/W1990932004","https://openalex.org/W1991952748","https://openalex.org/W1993512164","https://openalex.org/W1994232452","https://openalex.org/W1995261371","https://openalex.org/W1997061160","https://openalex.org/W1998794754","https://openalex.org/W1999649954","https://openalex.org/W1999803295","https://openalex.org/W2000997628","https://openalex.org/W2001525797","https://openalex.org/W2002684795","https://openalex.org/W2003859016","https://openalex.org/W2004798263","https://openalex.org/W2008124244","https://openalex.org/W2009289323","https://openalex.org/W2010783504","https://openalex.org/W2011201653","https://openalex.org/W2011308189","https://openalex.org/W2011693526","https://openalex.org/W2011772503","https://openalex.org/W2015100872","https://openalex.org/W2015366463","https://openalex.org/W2016299303","https://openalex.org/W2018761941","https://openalex.org/W2019408568","https://openalex.org/W2020120276","https://openalex.org/W2020196793","https://openalex.org/W2020457329","https://openalex.org/W2021092323","https://openalex.org/W2022242219","https://openalex.org/W2024665739","https://openalex.org/W2026099689","https://openalex.org/W2026598982","https://openalex.org/W2026936063","https://openalex.org/W2027854981","https://openalex.org/W2029485903","https://openalex.org/W2030112081","https://openalex.org/W2030674598","https://openalex.org/W2030774865","https://openalex.org/W2030841219","https://openalex.org/W2032195777","https://openalex.org/W2033415451","https://openalex.org/W2034175025","https://openalex.org/W2034795452","https://openalex.org/W2036493052","https://openalex.org/W2037105467","https://openalex.org/W2037425544","https://openalex.org/W2037529176","https://openalex.org/W2038977649","https://openalex.org/W2039165347","https://openalex.org/W2041610836","https://openalex.org/W2043937990","https://openalex.org/W2044738873","https://openalex.org/W2046788321","https://openalex.org/W2047270160","https://openalex.org/W2047405069","https://openalex.org/W2049975169","https://openalex.org/W2051935236","https://openalex.org/W2053643483","https://openalex.org/W2053898244","https://openalex.org/W2054560823","https://openalex.org/W2054641547","https://openalex.org/W2054749836","https://openalex.org/W2056607944","https://openalex.org/W2056894933","https://openalex.org/W2057015639","https://openalex.org/W2060449729","https://openalex.org/W2061958341","https://openalex.org/W2062474373","https://openalex.org/W2063647961","https://openalex.org/W2064924580","https://openalex.org/W2065892321","https://openalex.org/W2066957786","https://openalex.org/W2067778485","https://openalex.org/W2068023049","https://openalex.org/W2068301308","https://openalex.org/W2069516100","https://openalex.org/W2070184746","https://openalex.org/W2070658050","https://openalex.org/W2072467614","https://openalex.org/W2077401984","https://openalex.org/W2077474285","https://openalex.org/W2078988420","https://openalex.org/W2080430067","https://openalex.org/W2080768357","https://openalex.org/W2082504721","https://openalex.org/W2083843602","https://openalex.org/W2084277996","https://openalex.org/W2085092891","https://openalex.org/W2085387111","https://openalex.org/W2086328714","https://openalex.org/W2087032263","https://openalex.org/W2087612635","https://openalex.org/W2088627782","https://openalex.org/W2089350447","https://openalex.org/W2090000969","https://openalex.org/W2091668300","https://openalex.org/W2091800220","https://openalex.org/W2092046345","https://openalex.org/W2093934309","https://openalex.org/W2093987440","https://openalex.org/W2095844870","https://openalex.org/W2098562002","https://openalex.org/W2099671153","https://openalex.org/W2101021968","https://openalex.org/W2103011143","https://openalex.org/W2103521522","https://openalex.org/W2105968451","https://openalex.org/W2107432007","https://openalex.org/W2108602557","https://openalex.org/W2109984296","https://openalex.org/W2110954157","https://openalex.org/W2114762161","https://openalex.org/W2116577859","https://openalex.org/W2117279110","https://openalex.org/W2117285020","https://openalex.org/W2124473241","https://openalex.org/W2126906532","https://openalex.org/W2130441153","https://openalex.org/W2132748744","https://openalex.org/W2132894292","https://openalex.org/W2133396078","https://openalex.org/W2133449485","https://openalex.org/W2138281910","https://openalex.org/W2140161618","https://openalex.org/W2141095211","https://openalex.org/W2142414345","https://openalex.org/W2142887300","https://openalex.org/W2146794940","https://openalex.org/W2148648362","https://openalex.org/W2148661843","https://openalex.org/W2150032401","https://openalex.org/W2150193157","https://openalex.org/W2153320168","https://openalex.org/W2154310398","https://openalex.org/W2154367497","https://openalex.org/W2155440188","https://openalex.org/W2158671989","https://openalex.org/W2159505559","https://openalex.org/W2159584298","https://openalex.org/W2159649364","https://openalex.org/W2161014072","https://openalex.org/W2161105252","https://openalex.org/W2162139246","https://openalex.org/W2163278160","https://openalex.org/W2168843846","https://openalex.org/W2172312226","https://openalex.org/W2173131003","https://openalex.org/W2180614941","https://openalex.org/W2187215187","https://openalex.org/W2187976253","https://openalex.org/W2246598239","https://openalex.org/W2281837728","https://openalex.org/W2284082872","https://openalex.org/W2298343040","https://openalex.org/W2303440816","https://openalex.org/W2314367108","https://openalex.org/W2316031239","https://openalex.org/W2322706961","https://openalex.org/W2324048625","https://openalex.org/W2339086236","https://openalex.org/W2345393207","https://openalex.org/W2357798170","https://openalex.org/W2372848131","https://openalex.org/W2397408890","https://openalex.org/W2402319960","https://openalex.org/W2441017351","https://openalex.org/W2467628837","https://openalex.org/W2467655264","https://openalex.org/W2487054047","https://openalex.org/W2497317277","https://openalex.org/W2505099964","https://openalex.org/W2507216667","https://openalex.org/W2517604419","https://openalex.org/W2527042635","https://openalex.org/W2539812081","https://openalex.org/W2541710294","https://openalex.org/W2554789097","https://openalex.org/W2557638772","https://openalex.org/W2558631261","https://openalex.org/W2564886939","https://openalex.org/W2569734753","https://openalex.org/W2570509715","https://openalex.org/W2570855767","https://openalex.org/W2574151119","https://openalex.org/W2583535720","https://openalex.org/W2587898145","https://openalex.org/W2588858456","https://openalex.org/W2588902435","https://openalex.org/W2591577217","https://openalex.org/W2597825251","https://openalex.org/W2604111100","https://openalex.org/W2604897276","https://openalex.org/W2605088214","https://openalex.org/W2613540483","https://openalex.org/W2615117811","https://openalex.org/W2623556215","https://openalex.org/W2624101773","https://openalex.org/W2711879312","https://openalex.org/W2735404102","https://openalex.org/W2752952060","https://openalex.org/W2753692261","https://openalex.org/W2753976580","https://openalex.org/W2760821910","https://openalex.org/W2761951506","https://openalex.org/W2762607875","https://openalex.org/W2767739802","https://openalex.org/W2768502235","https://openalex.org/W2768814852","https://openalex.org/W2775215939","https://openalex.org/W2778351249","https://openalex.org/W2782982816","https://openalex.org/W2789498616","https://openalex.org/W2789839590","https://openalex.org/W2790192752","https://openalex.org/W2791027065","https://openalex.org/W2797059900","https://openalex.org/W2799813315","https://openalex.org/W2803288171","https://openalex.org/W2808183621","https://openalex.org/W2808431275","https://openalex.org/W2808474537","https://openalex.org/W2808747546","https://openalex.org/W2809102603","https://openalex.org/W2809596873","https://openalex.org/W2810846480","https://openalex.org/W2884315462","https://openalex.org/W2886105578","https://openalex.org/W2890126851","https://openalex.org/W2890385930","https://openalex.org/W2891457650","https://openalex.org/W2893169720","https://openalex.org/W2900475493","https://openalex.org/W2900490394","https://openalex.org/W2900887638","https://openalex.org/W2902575307","https://openalex.org/W2903220880","https://openalex.org/W2903909531","https://openalex.org/W2905490638","https://openalex.org/W2909762453","https://openalex.org/W2909963249","https://openalex.org/W2910866765","https://openalex.org/W2913419232","https://openalex.org/W2913709462","https://openalex.org/W2914130091","https://openalex.org/W2914208290","https://openalex.org/W2915827885","https://openalex.org/W2919059684","https://openalex.org/W2932991390","https://openalex.org/W2942937212","https://openalex.org/W2952538924","https://openalex.org/W2968255272","https://openalex.org/W2969516318","https://openalex.org/W2972610603","https://openalex.org/W2972648870","https://openalex.org/W2972869264","https://openalex.org/W2978037498","https://openalex.org/W2979925678","https://openalex.org/W2983120443","https://openalex.org/W2988193748","https://openalex.org/W2990060381","https://openalex.org/W2991105408","https://openalex.org/W2994771479","https://openalex.org/W2994807408","https://openalex.org/W2995605526","https://openalex.org/W2998069424","https://openalex.org/W3000999664","https://openalex.org/W3005350736","https://openalex.org/W3007521785","https://openalex.org/W3009803743","https://openalex.org/W3010330442","https://openalex.org/W3011038379","https://openalex.org/W3022660602","https://openalex.org/W3023514077","https://openalex.org/W3025788478","https://openalex.org/W3025864905","https://openalex.org/W3033611127","https://openalex.org/W3034425677","https://openalex.org/W3038381272","https://openalex.org/W3040859487","https://openalex.org/W3045764311","https://openalex.org/W3046113295","https://openalex.org/W3046438908","https://openalex.org/W3080589879","https://openalex.org/W3083987393","https://openalex.org/W3084346878","https://openalex.org/W3093655228","https://openalex.org/W3107820398","https://openalex.org/W3115856194","https://openalex.org/W3117186677","https://openalex.org/W3120083719","https://openalex.org/W3124155924","https://openalex.org/W3135796132","https://openalex.org/W3139366746","https://openalex.org/W3143926833","https://openalex.org/W3151853927","https://openalex.org/W3163727976","https://openalex.org/W3183085193","https://openalex.org/W3199685641","https://openalex.org/W3200923526","https://openalex.org/W3216501087","https://openalex.org/W4210805092","https://openalex.org/W4212966463","https://openalex.org/W4213296643","https://openalex.org/W4223540989","https://openalex.org/W4281731184","https://openalex.org/W4283813679","https://openalex.org/W4290759900","https://openalex.org/W4294190112","https://openalex.org/W4309065798","https://openalex.org/W4309343742","https://openalex.org/W4324144447","https://openalex.org/W4361007059","https://openalex.org/W6686504550"],"related_works":["https://openalex.org/W4223540989","https://openalex.org/W1980439325","https://openalex.org/W2043937990","https://openalex.org/W2117285020","https://openalex.org/W4386722974","https://openalex.org/W7166194819","https://openalex.org/W4415279123","https://openalex.org/W2354215449","https://openalex.org/W2281837728","https://openalex.org/W3160517505"],"abstract_inverted_index":{"Insulin":[0],"is":[1],"recognized":[2],"as":[3,49,51],"a":[4,108],"crucial":[5],"weapon":[6],"in":[7,99,171],"managing":[8],"diabetes.":[9],"Subcutaneous":[10],"(s.c.)":[11],"injections":[12],"are":[13,102,144,153,183],"the":[14,36,78,100,105,139,146,169,176,185],"traditional":[15],"approach":[16],"for":[17,38,44,104,137],"insulin":[18,43,67,117,189],"administration,":[19],"which":[20],"usually":[21],"have":[22,32,132],"many":[23,71,156],"limitations.":[24],"Numerous":[25],"alternative":[26],"(non-invasive)":[27],"slants":[28],"through":[29],"different":[30],"routes":[31],"been":[33],"explored":[34],"by":[35,69,82],"researchers":[37],"making":[39],"needle-free":[40],"delivery":[41,68,106],"of":[42,61,65,72,91,107,116,130,155,163,178,180,187],"attaining":[45],"its":[46],"augmented":[47],"absorption":[48],"well":[50],"bioavailability.":[52],"The":[53,150],"current":[54],"review":[55],"delineating":[56],"numerous":[57],"pros":[58],"and":[59,112,126,161],"cons":[60],"several":[62],"novel":[63],"approaches":[64,97],"non-invasive":[66],"overcoming":[70],"their":[73,134],"hurdles.":[74],"Primary":[75],"information":[76],"on":[77],"topic":[79],"was":[80],"gathered":[81],"searching":[83],"scholarly":[84],"articles":[85],"from":[86,93],"PubMed":[87],"added":[88],"with":[89],"extraction":[90],"data":[92],"auxiliary":[94],"manuscripts.":[95],"Many":[96],"(discussed":[98],"article)":[101],"meant":[103],"safe,":[109],"effective,":[110],"stable,":[111],"patient":[113],"friendly":[114],"administration":[115],"via":[118],"buccal,":[119],"oral,":[120],"inhalational,":[121],"transdermal,":[122],"intranasal,":[123],"ocular,":[124],"vaginal":[125],"rectal":[127],"routes.":[128],"Few":[129],"them":[131,164],"proven":[133],"clinical":[135],"efficacy":[136],"maintaining":[138],"glycemic":[140],"levels,":[141],"whereas":[142],"others":[143],"under":[145,184],"investigational":[147],"pipe":[148],"line.":[149],"developed":[151],"products":[152],"comprising":[154],"advanced":[157],"micro/nano":[158],"composite":[159],"technologies":[160],"few":[162],"might":[165],"be":[166],"entering":[167],"into":[168],"market":[170],"near":[172],"future,":[173],"thereby":[174],"garnishing":[175],"hopes":[177],"millions":[179],"diabetics":[181],"who":[182],"network":[186],"s.c.":[188],"injections.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-09T00:00:00"}