{"id":"https://openalex.org/W4389453063","doi":"https://doi.org/10.1111/hae.14905","title":"Iron overload causes macrophages to produce a pro\u2010inflammatory phenotype in the synovium of hemophiliac arthritis via the acetyl\u2010p53 pathway","display_name":"Iron overload causes macrophages to produce a pro\u2010inflammatory phenotype in the synovium of hemophiliac arthritis via the acetyl\u2010p53 pathway","publication_year":2023,"publication_date":"2023-12-06","ids":{"openalex":"https://openalex.org/W4389453063","doi":"https://doi.org/10.1111/hae.14905","pmid":"https://pubmed.ncbi.nlm.nih.gov/38058260"},"language":"en","primary_location":{"id":"doi:10.1111/hae.14905","doi":"https://doi.org/10.1111/hae.14905","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.14905","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.14905?download=true","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.14905?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002203088","display_name":"Nanyu Pang","orcid":"https://orcid.org/0009-0006-4874-5265","observed_orcids":["https://orcid.org/0009-0006-4874-5265"]},"institutions":[{"id":"https://openalex.org/I4210149412","display_name":"Second Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/047aw1y82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nanyu Pang","raw_affiliation_strings":["Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China"],"raw_orcid":"https://orcid.org/0009-0006-4874-5265","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China","institution_ids":["https://openalex.org/I4210149412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010045676","display_name":"Mingyang Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149412","display_name":"Second Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/047aw1y82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyang Ding","raw_affiliation_strings":["Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China","institution_ids":["https://openalex.org/I4210149412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101426574","display_name":"Yang Hu","orcid":"https://orcid.org/0000-0001-5900-7432","observed_orcids":["https://orcid.org/0000-0001-5900-7432"]},"institutions":[{"id":"https://openalex.org/I4210149412","display_name":"Second Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/047aw1y82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hu Yang","raw_affiliation_strings":["Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China","institution_ids":["https://openalex.org/I4210149412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032906184","display_name":"Qigang Zhong","orcid":"https://orcid.org/0000-0001-8333-6914","observed_orcids":["https://orcid.org/0000-0001-8333-6914"]},"institutions":[{"id":"https://openalex.org/I4210165165","display_name":"Anshan Hospital","ror":"https://ror.org/05p2t9n36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210165165"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qigang Zhong","raw_affiliation_strings":["Department of Orthopaedic Surgery, Ma Anshan People's Hospital, Ma Anshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Ma Anshan People's Hospital, Ma Anshan, China","institution_ids":["https://openalex.org/I4210165165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087251905","display_name":"Liujie Zheng","orcid":"https://orcid.org/0000-0002-9223-8782","observed_orcids":["https://orcid.org/0000-0002-9223-8782"]},"institutions":[{"id":"https://openalex.org/I4210093544","display_name":"Wuhan Puai Hospital","ror":"https://ror.org/00qavst65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liujie Zheng","raw_affiliation_strings":["Department of Orthopaedic Surgery, The Fourth Hospital of Wuhan, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0002-9223-8782","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The Fourth Hospital of Wuhan, Wuhan, China","institution_ids":["https://openalex.org/I4210093544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058143167","display_name":"Dasheng Luo","orcid":"https://orcid.org/0000-0003-0486-2428","observed_orcids":["https://orcid.org/0000-0003-0486-2428"]},"institutions":[{"id":"https://openalex.org/I4210149412","display_name":"Second Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/047aw1y82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dasheng Luo","raw_affiliation_strings":["Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China","institution_ids":["https://openalex.org/I4210149412"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031618106","display_name":"Yunfeng Yao","orcid":"https://orcid.org/0000-0001-7118-2524","observed_orcids":["https://orcid.org/0000-0001-7118-2524"]},"institutions":[{"id":"https://openalex.org/I4210149412","display_name":"Second Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/047aw1y82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149412"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunfeng Yao","raw_affiliation_strings":["Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China"],"raw_orcid":"https://orcid.org/0000-0001-7118-2524","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China","institution_ids":["https://openalex.org/I4210149412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031618106"],"corresponding_institution_ids":["https://openalex.org/I4210149412"],"apc_list":{"value":4530,"currency":"USD","value_usd":4530},"apc_paid":null,"fwci":3.0821,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.92331478,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"30","issue":"1","first_page":"195","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12800","display_name":"Musculoskeletal synovial abnormalities and treatments","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.9599999785423279},{"id":"https://openalex.org/keywords/synovium","display_name":"synovium","score":0.7649999856948853},{"id":"https://openalex.org/keywords/m1-macrophage-polarization","display_name":"M1 macrophage polarization","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8330000042915344},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.7229999899864197},{"id":"https://openalex.org/keywords/ferric-ammonium-citrate","display_name":"ferric ammonium citrate","score":0.7649999856948853},{"id":"https://openalex.org/keywords/thp-1-macrophages","display_name":"THP-1 macrophages","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C2779244835","wikidata":"https://www.wikidata.org/wiki/Q538432","display_name":"Synovitis","level":3,"score":0.8341331481933594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7377526760101318},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6698929071426392},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.551701545715332},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5295506119728088},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.46160688996315},{"id":"https://openalex.org/C2777652487","wikidata":"https://www.wikidata.org/wiki/Q575064","display_name":"Synovial membrane","level":3,"score":0.456184059381485},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.4561026692390442},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.42792823910713196},{"id":"https://openalex.org/C2775858924","wikidata":"https://www.wikidata.org/wiki/Q18034009","display_name":"CD163","level":4,"score":0.41452500224113464},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3978838324546814},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3545921742916107},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3413957357406616},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1635272204875946},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1299755573272705},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013585","descriptor_name":"Synovitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/hae.14905","doi":"https://doi.org/10.1111/hae.14905","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.14905","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.14905?download=true","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},{"id":"pmid:38058260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38058260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia : the official journal of the World Federation of Hemophilia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/hae.14905","doi":"https://doi.org/10.1111/hae.14905","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.14905","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.14905?download=true","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321603","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389453063.pdf","grobid_xml":"https://content.openalex.org/works/W4389453063.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1498892853","https://openalex.org/W1551404437","https://openalex.org/W1876057856","https://openalex.org/W1974873853","https://openalex.org/W2001545291","https://openalex.org/W2025853481","https://openalex.org/W2041365657","https://openalex.org/W2056594657","https://openalex.org/W2058889918","https://openalex.org/W2066352130","https://openalex.org/W2085865967","https://openalex.org/W2092287343","https://openalex.org/W2093230923","https://openalex.org/W2095397737","https://openalex.org/W2096008021","https://openalex.org/W2139181115","https://openalex.org/W2149751495","https://openalex.org/W2162352227","https://openalex.org/W2168114765","https://openalex.org/W2171798103","https://openalex.org/W2320744331","https://openalex.org/W2553640388","https://openalex.org/W2586474705","https://openalex.org/W2805945157","https://openalex.org/W2882633359","https://openalex.org/W2911189556","https://openalex.org/W2921824125","https://openalex.org/W3015839297","https://openalex.org/W3034814111","https://openalex.org/W3035609764","https://openalex.org/W3073655768","https://openalex.org/W3197056531","https://openalex.org/W4205962955","https://openalex.org/W4310384231"],"related_works":["https://openalex.org/W4392744444","https://openalex.org/W2162352227","https://openalex.org/W2041365657","https://openalex.org/W2056594657","https://openalex.org/W7161110668","https://openalex.org/W2400276001","https://openalex.org/W2169182592","https://openalex.org/W2882633359","https://openalex.org/W4318832663","https://openalex.org/W4416917875"],"abstract_inverted_index":{"AIM:":[0],"Haemophiliac":[1],"arthritis":[2,256],"(HA)":[3],"is":[4,247,266],"caused":[5],"by":[6,37,130],"spontaneous":[7],"intra-articular":[8,12],"hemorrhage":[9],"and":[10,25,69,85,98,114,138,177,235],"repeated":[11],"hematomas,":[13],"leading":[14,227],"to":[15,152,228],"iron":[16,39,95,125,156,200,213,221,245],"overload,":[17],"which,":[18],"in":[19,30,41,77,123,144,158,184,196,198,209,241,251,254,269,276],"turn,":[20],"induces":[21,43],"M1":[22,47,145,172,233,277,287],"macrophage":[23,103,146,173,229,264],"polarisation":[24,45,147,230],"inflammatory":[26,237],"cytokine":[27,238],"secretion,":[28,239],"resulting":[29,240],"synovitis.":[31,58,242],"Here,":[32],"we":[33],"explored":[34],"the":[35,44,54,63,78,94,139,155,159,185,197,204,232,285],"mechanism":[36],"which":[38],"overload":[40,126,201,222,246],"HA":[42,57,72,164,270,279],"of":[46,56,66,111,141,161,171,188,206,263,292],"macrophages,":[48],"providing":[49],"a":[50,260,273],"new":[51],"approach":[52],"for":[53],"treatment":[55],"METHODS:":[59],"The":[60,109,168],"synovium":[61,160],"from":[62],"knee":[64],"joints":[65],"normal":[67],"amputees":[68],"patients":[70,162,189,218],"with":[71,134,163,190,219,249],"was":[73,91,105,128,148,165],"collected.":[74],"Pathological":[75],"changes":[76,250],"synovial":[79,186,224,280],"tissues":[80,187],"were":[81,117,180,194],"analysed":[82],"using":[83,93,107,119],"hematoxylin":[84],"eosin":[86],"staining.":[87],"Iron":[88],"tissue":[89],"deposition":[90],"evaluated":[92],"assay":[96],"kit":[97],"Prussia":[99],"Blue":[100],"staining,":[101],"while":[102],"phenotype":[104,234],"determined":[106],"immunofluorescence.":[108],"levels":[110,170,291],"pro-inflammatory":[112,175,286,293],"cytokines":[113],"p53":[115,143,207,225],"acetylation":[116,208,253],"determine":[118],"western":[120],"blotting.":[121],"An":[122],"vitro":[124,199,210],"model":[127],"established":[129],"inducing":[131],"THP-1":[132],"macrophages":[133,281],"ferric":[135],"ammonium":[136],"citrate,":[137],"involvement":[140],"acetylated":[142,178],"investigated.":[149],"RESULTS:":[150],"Compared":[151],"control":[153],"samples,":[154],"content":[157],"significantly":[166,182],"increased.":[167],"protein":[169],"markers,":[174],"cytokines,":[176],"p53,":[179,259],"also":[181],"elevated":[183,290],"HA.":[191],"Similar":[192],"results":[193],"observed":[195],"model.":[202],"Furthermore,":[203],"inhibition":[205],"reversed":[211],"these":[212],"overload-induced":[214],"effects.":[215],"CONCLUSION:":[216],"In":[217],"HA,":[220],"induced":[223],"acetylation,":[226],"toward":[231],"increased":[236],"HIGHLIGHTS:":[243],"Synovial":[244],"associated":[248],"P53":[252],"hemophiliac":[255],"(HA).":[257],"Acetylated":[258],"known":[261],"regulator":[262],"polarization,":[265],"highly":[267],"expressed":[268],"synovium,":[271],"suggesting":[272],"potential":[274],"role":[275],"polarization.":[278],"predominantly":[282],"polarize":[283],"into":[284],"phenotype,":[288],"secreting":[289],"cytokines.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-08T00:00:00"}