{"id":"https://openalex.org/W4389447388","doi":"https://doi.org/10.1212/wnl.94.15_supplement.2012","title":"A Phase II, Single Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and the Therapeutic Effectiveness of Rapid Acting Insulin in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer\u2019s Disease (2012)","display_name":"A Phase II, Single Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and the Therapeutic Effectiveness of Rapid Acting Insulin in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer\u2019s Disease (2012)","publication_year":2020,"publication_date":"2020-04-14","ids":{"openalex":"https://openalex.org/W4389447388","doi":"https://doi.org/10.1212/wnl.94.15_supplement.2012"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.94.15_supplement.2012","doi":"https://doi.org/10.1212/wnl.94.15_supplement.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.94.15_supplement.2012","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076343334","display_name":"Michael Henry Rosenbloom","orcid":"https://orcid.org/0000-0002-2768-9501","observed_orcids":["https://orcid.org/0000-0002-2768-9501"]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Rosenbloom","raw_affiliation_strings":["HealthPartners Center for Memory and Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Center for Memory and Aging","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054717422","display_name":"Terry R. Barclay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry Barclay","raw_affiliation_strings":["HealthPartners Center for Memory and Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Center for Memory and Aging","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019701779","display_name":"Lauren O. Erickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Erickson","raw_affiliation_strings":["HealthPartners Center for Memory and Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Center for Memory and Aging","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020587040","display_name":"Maria Pyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Pyle","raw_affiliation_strings":["HealthPartners Center for Memory and Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Center for Memory and Aging","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007760146","display_name":"Lyndsay M. Hage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lyndsay Hage","raw_affiliation_strings":["HealthPartners Center for Memory and Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Center for Memory and Aging","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emily Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Green","raw_affiliation_strings":["HealthPartners Center for Memory and Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Center for Memory and Aging","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038266828","display_name":"Aleta L. Svitak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleta Svitak","raw_affiliation_strings":["HealthPartners Center for Memory and Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Center for Memory and Aging","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071493455","display_name":"Bhavani Kashyap","orcid":"https://orcid.org/0000-0003-4823-9638","observed_orcids":["https://orcid.org/0000-0003-4823-9638"]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavani Kashyap","raw_affiliation_strings":["HealthPartners Center for Memory and Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Center for Memory and Aging","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046805860","display_name":"William H. Frey","orcid":"https://orcid.org/0000-0002-6373-0794","observed_orcids":["https://orcid.org/0000-0002-6373-0794"]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Frey","raw_affiliation_strings":["HealthPartners Center for Memory and Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Center for Memory and Aging","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021352245","display_name":"Leah R. Hanson","orcid":"https://orcid.org/0000-0002-2847-7949","observed_orcids":["https://orcid.org/0000-0002-2847-7949"]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah Hanson","raw_affiliation_strings":["HealthPartners Center for Memory and Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Center for Memory and Aging","institution_ids":["https://openalex.org/I52792670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52792670"],"apc_list":null,"apc_paid":null,"fwci":0.1782,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55487489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"94","issue":"15_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.31450000405311584,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapid-acting-insulin","display_name":"rapid-acting insulin","score":0.800000011920929},{"id":"https://openalex.org/keywords/intranasal-insulin","display_name":"intranasal insulin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/amnestic-mild-cognitive-impairment","display_name":"amnestic mild cognitive impairment","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mild-alzheimer-s-disease","display_name":"mild Alzheimer's disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/global-cognition","display_name":"global cognition","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.8029999732971191},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.756049394607544},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.687000572681427},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.6706758737564087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6567863821983337},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.49023038148880005},{"id":"https://openalex.org/C3018954396","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Single blind","level":3,"score":0.4516070783138275},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.41973596811294556},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3974418044090271},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.30826833844184875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2984234690666199},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.11453172564506531},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.94.15_supplement.2012","doi":"https://doi.org/10.1212/wnl.94.15_supplement.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.94.15_supplement.2012","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3113339329","https://openalex.org/W3137380811","https://openalex.org/W2048808278","https://openalex.org/W2153284686","https://openalex.org/W1971690256","https://openalex.org/W7164131109","https://openalex.org/W1980193858","https://openalex.org/W7116795844","https://openalex.org/W3035782677","https://openalex.org/W2062220936"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"measure":[2],"the":[3,81,95,159,267],"effect":[4],"of":[5,83,161,182,213,258,276],"rapid":[6],"acting":[7],"(RA)":[8,54],"intranasal":[9],"(IN)":[10],"insulin":[11,29,300],"on":[12,261,315],"global":[13,107],"cognition":[14],"and":[15,22,42,109,116,130,135,141,151,188,236,244,246,280],"function":[16],"in":[17,46,61,88,147,200,302],"mild":[18,23],"cognitive":[19,63],"impairment":[20],"(MCI)":[21],"Alzheimer\u2019s":[24],"disease":[25,36],"(AD).":[26],"Background:":[27],"IN":[28,84,92,177,240,259],"is":[30],"a":[31,286,291,316],"potential":[32],"treatment":[33,156,232],"for":[34,222,312],"neurodegenerative":[35],"shown":[37],"to":[38,66,79,195,269,296,340,346,352,358,364,370,376,382,388],"reduce":[39],"amyloid":[40],"plaques":[41],"improve":[43],"verbal":[44],"memory":[45],"memory-impaired":[47],"adults.":[48],"Investigations":[49],"have":[50],"suggested":[51],"that":[52],"rapid-acting":[53],"insulins":[55],"such":[56],"as":[57],"glulisine":[58,85,178,241,260],"may":[59],"result":[60],"superior":[62],"benefits":[64],"compared":[65,194],"regular":[67],"insulin.":[68],"Design/Methods:":[69],"A":[70],"single":[71],"center,":[72],"randomized,":[73],"double-blind,":[74],"placebo-controlled":[75],"study":[76,281],"was":[77,166,198,242,272],"performed":[78],"test":[80],"efficacy":[82,301],"versus":[86],"placebo":[87],"N=35":[89],"MCI/AD":[90,288],"subjects.":[91],"administration":[93],"utilized":[94],"Impel":[96],"NeuroPharma":[97],"I109":[98],"Precision":[99],"Olfactory":[100],"Delivery":[101],"(POD\u00ae)":[102],"device.":[103],"The":[104],"ADAS-Cog13,":[105],"CDR":[106,225],"score,":[108],"FAQ":[110,227],"were":[111,137,209,229,254],"measured":[112],"at":[113,234],"baseline,":[114],"3":[115,235],"6":[117,237],"months.":[118,238],"Secondary":[119],"outcome":[120],"measures":[121],"included":[122],"digit":[123],"span":[124],"forward/backwards,":[125],"Trailmaking":[126],"part":[127],"A/B,":[128],"COWAT,":[129],"WMS":[131],"logical":[132],"memory.":[133],"Depression":[134],"suicidality":[136],"assessed":[138],"using":[139],"GDS":[140],"C-SSRS.":[142],"Results:":[143],"No":[144,219],"significant":[145,220],"differences":[146],"education,":[148],"ApoE4":[149],"status,":[150],"MOCA":[152],"score":[153],"existed":[154],"between":[155,168,231],"groups.":[157],"Overall,":[158],"number":[160,275],"adverse":[162],"events":[163],"per":[164],"person":[165],"similar":[167],"groups":[169,233],"(2.32":[170],"vs.":[171],"2.24,":[172],"p=0.824);":[173],"although":[174],"subjects":[175,277],"receiving":[176,203],"had":[179],"higher":[180],"rates":[181],"nasal":[183],"irritation":[184],"(25.0%":[185],"vs":[186,192],"13.9%)":[187],"respiratory":[189],"symptoms":[190],"(15.9%":[191],"8.3%)":[193],"placebo.":[196],"Glucose<70":[197],"observed":[199],"one":[201],"subject":[202],"RA":[204,299],"insulin,":[205],"but":[206,266],"otherwise,":[207],"there":[208],"no":[210,255],"other":[211,322],"cases":[212],"hypoglycemia,":[214],"including":[215],"three":[216],"NIDDM":[217],"patients.":[218],"difference":[221],"ADAS-Cog":[223],"13,":[224],"or":[226,264,321],"scores":[228],"found":[230],"Conclusions:":[239],"safe":[243],"well-tolerated":[245],"did":[247],"not":[248],"consistently":[249],"impact":[250],"peripheral":[251],"glucose.":[252],"There":[253],"enhancing":[256],"effects":[257],"cognition,":[262],"function,":[263],"mood,":[265],"ability":[268],"detect":[270],"significances":[271],"limited":[273],"by":[274],"successfully":[278],"enrolled":[279],"duration.":[282],"Additional":[283],"investigations":[284],"following":[285],"larger":[287],"cohort":[289],"over":[290],"longer":[292],"duration":[293],"are":[294],"necessary":[295],"better":[297],"evaluate":[298],"this":[303],"population.":[304],"Disclosure:":[305],"Dr.":[306,327,336,342,348,354,360,366,372,378,384],"Rosenbloom":[307,328],"has":[308,329,338,344,350,356,362,368,374,380,386],"received":[309,330],"personal":[310],"compensation":[311],"consulting,":[313],"serving":[314],"scientific":[317],"advisory":[318],"board,":[319],"speaking,":[320],"activities":[323],"with":[324],"Paul":[325],"Weiss.":[326],"research":[331],"support":[332],"from":[333],"Merck":[334],"Foundation.":[335],"Barclay":[337],"nothing":[339,345,351,357,363,369,375,381,387],"disclose.":[341,347,353,359,365,371,377,383,389],"Erickson":[343],"Pyle":[349],"Hage":[355],"Green":[361],"Svitak":[367],"Kashyap":[373],"Frey":[379],"Hanson":[385]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-08T00:00:00"}