{"id":"https://openalex.org/W4389426643","doi":"https://doi.org/10.1093/ofid/ofad616","title":"A Systematic Literature Review to Identify Diagnostic Gaps in Managing Immunocompromised Patients With Cancer and Suspected Infection","display_name":"A Systematic Literature Review to Identify Diagnostic Gaps in Managing Immunocompromised Patients With Cancer and Suspected Infection","publication_year":2023,"publication_date":"2023-12-07","ids":{"openalex":"https://openalex.org/W4389426643","doi":"https://doi.org/10.1093/ofid/ofad616","pmid":"https://pubmed.ncbi.nlm.nih.gov/38221981","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10787371"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofad616","doi":"https://doi.org/10.1093/ofid/ofad616","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad616","pdf_url":"https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad616/54092634/ofad616.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad616/54092634/ofad616.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000958441","display_name":"Joshua Aiden Hill","orcid":"https://orcid.org/0000-0002-7665-7100","observed_orcids":["https://orcid.org/0000-0002-7665-7100","https://orcid.org/0000-0002-3617-6142"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua A Hill","raw_affiliation_strings":["Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington , Seattle, Washington , USA","Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center , Seattle, Washington , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington , Seattle, Washington , USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center , Seattle, Washington , USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036500682","display_name":"Sarah Y. Park","orcid":"https://orcid.org/0000-0002-5997-2723","observed_orcids":["https://orcid.org/0000-0002-5997-2723"]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Y Park","raw_affiliation_strings":["Medical Affairs, Karius, Inc , Redwood City, California , USA"],"raw_orcid":"https://orcid.org/0000-0002-5997-2723","affiliations":[{"raw_affiliation_string":"Medical Affairs, Karius, Inc , Redwood City, California , USA","institution_ids":["https://openalex.org/I4405267391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060515267","display_name":"Kiran Gajurel","orcid":"https://orcid.org/0000-0001-7141-8322","observed_orcids":["https://orcid.org/0000-0001-7141-8322","https://orcid.org/0000-0002-2185-1600"]},"institutions":[{"id":"https://openalex.org/I2802101240","display_name":"Carolinas Medical Center","ror":"https://ror.org/0483mr804","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334069289","https://openalex.org/I2802101240"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiran Gajurel","raw_affiliation_strings":["Division of Infectious Diseases, Carolinas Medical Center, Atrium Health, Charlotte, North Carolina , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Carolinas Medical Center, Atrium Health, Charlotte, North Carolina , USA","institution_ids":["https://openalex.org/I2802101240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110239267","display_name":"Randy A. Taplitz","orcid":"https://orcid.org/0000-0002-6279-7567","observed_orcids":["https://orcid.org/0000-0002-6279-7567"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randy Taplitz","raw_affiliation_strings":["Department of Medicine, City of Hope National Medical Center , Duarte, California , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, City of Hope National Medical Center , Duarte, California , USA","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000958441"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"],"apc_list":{"value":3676,"currency":"USD","value_usd":3676},"apc_paid":{"value":3676,"currency":"USD","value_usd":3676},"fwci":0.3454,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.40714622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"ofad616","last_page":"ofad616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-associated-infections","display_name":"cancer-associated infections","score":0.6589999794960022},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.9890000224113464},{"id":"https://openalex.org/keywords/diagnostic-gap","display_name":"diagnostic gap","score":0.6930000185966492},{"id":"https://openalex.org/keywords/acute-infection-diagnosis","display_name":"acute infection diagnosis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cultural-diagnosis","display_name":"culture diagnosis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8560421466827393},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.667833685874939},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.5209082961082458},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4751819670200348},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4659584164619446},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.41806361079216003},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.18449744582176208},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1593589186668396},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/ofid/ofad616","doi":"https://doi.org/10.1093/ofid/ofad616","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad616","pdf_url":"https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad616/54092634/ofad616.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10787371","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10787371","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10787371/pdf/ofad616.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"},{"id":"pmid:38221981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38221981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open forum infectious diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofad616","doi":"https://doi.org/10.1093/ofid/ofad616","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad616","pdf_url":"https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad616/54092634/ofad616.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389426643.pdf","grobid_xml":"https://content.openalex.org/works/W4389426643.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W25847692","https://openalex.org/W1522598141","https://openalex.org/W1826344816","https://openalex.org/W1974143296","https://openalex.org/W1975547754","https://openalex.org/W2006181009","https://openalex.org/W2010629948","https://openalex.org/W2040290875","https://openalex.org/W2059048036","https://openalex.org/W2073876491","https://openalex.org/W2078472716","https://openalex.org/W2089857225","https://openalex.org/W2110605108","https://openalex.org/W2113208081","https://openalex.org/W2116960637","https://openalex.org/W2119842397","https://openalex.org/W2121481719","https://openalex.org/W2123306665","https://openalex.org/W2124709079","https://openalex.org/W2134244284","https://openalex.org/W2201419078","https://openalex.org/W2203222190","https://openalex.org/W2253542151","https://openalex.org/W2290503699","https://openalex.org/W2315172512","https://openalex.org/W2337937901","https://openalex.org/W2419106232","https://openalex.org/W2520127373","https://openalex.org/W2532158931","https://openalex.org/W2551196944","https://openalex.org/W2586233372","https://openalex.org/W2606361633","https://openalex.org/W2661445781","https://openalex.org/W2740967304","https://openalex.org/W2765500523","https://openalex.org/W2782325677","https://openalex.org/W2783828954","https://openalex.org/W2793561101","https://openalex.org/W2888958616","https://openalex.org/W2912885719","https://openalex.org/W2917204397","https://openalex.org/W2964546655","https://openalex.org/W2973408389","https://openalex.org/W2974274912","https://openalex.org/W2985817260","https://openalex.org/W2986834938","https://openalex.org/W2992250822","https://openalex.org/W2992497948","https://openalex.org/W2993521675","https://openalex.org/W3000477794","https://openalex.org/W3004697887","https://openalex.org/W3017059345","https://openalex.org/W3021323231","https://openalex.org/W3030124710","https://openalex.org/W3035617019","https://openalex.org/W3042253385","https://openalex.org/W3045799552","https://openalex.org/W3046833084","https://openalex.org/W3048374657","https://openalex.org/W3080274032","https://openalex.org/W3080280840","https://openalex.org/W3081521239","https://openalex.org/W3084709515","https://openalex.org/W3087199694","https://openalex.org/W3097629286","https://openalex.org/W3131877627","https://openalex.org/W3133965994","https://openalex.org/W3134291767","https://openalex.org/W3135697997","https://openalex.org/W3136614732","https://openalex.org/W3152205174","https://openalex.org/W3154652039","https://openalex.org/W3156645577","https://openalex.org/W3183575368","https://openalex.org/W3191480438","https://openalex.org/W3193329895","https://openalex.org/W3194329906","https://openalex.org/W3202224572","https://openalex.org/W3207271601","https://openalex.org/W3209611130","https://openalex.org/W3213327045","https://openalex.org/W4200237499","https://openalex.org/W4223452175","https://openalex.org/W4235844351","https://openalex.org/W4281921659","https://openalex.org/W4288826405","https://openalex.org/W4315754600","https://openalex.org/W4383187555","https://openalex.org/W4387472467","https://openalex.org/W6677371223"],"related_works":["https://openalex.org/W2008316386","https://openalex.org/W2031672612","https://openalex.org/W2419106232","https://openalex.org/W2808134212","https://openalex.org/W7132855283","https://openalex.org/W4406213173","https://openalex.org/W2050823955","https://openalex.org/W2328279645","https://openalex.org/W2049647323","https://openalex.org/W1985139269"],"abstract_inverted_index":{"Patients":[0],"with":[1,47,81],"cancer":[2,48],"are":[3,27,122],"increasingly":[4],"vulnerable":[5],"to":[6,24,35,112,124,138],"infections,":[7],"which":[8],"may":[9,110],"be":[10],"more":[11],"severe":[12],"than":[13],"in":[14,19,40,44,69],"the":[15,37,92,113],"general":[16],"population.":[17],"Improvements":[18],"rapid":[20],"and":[21,49,61,72,76,78,129,131],"timely":[22],"diagnosis":[23],"optimize":[25],"management":[26],"needed.":[28],"We":[29],"conducted":[30],"a":[31],"systematic":[32],"literature":[33,104],"review":[34],"determine":[36],"unmet":[38],"need":[39],"diagnosing":[41],"acute":[42],"infections":[43],"immunocompromised":[45],"patients":[46],"identified":[50],"50":[51],"eligible":[52],"studies":[53,97,118],"from":[54],"5188":[55],"records":[56],"between":[57],"1":[58],"January":[59],"2012":[60],"23":[62],"June":[63],"2022.":[64],"There":[65],"was":[66],"considerable":[67],"heterogeneity":[68],"study":[70],"designs":[71],"parameters,":[73],"laboratory":[74],"methods":[75],"definitions,":[77],"assessed":[79],"outcomes,":[80],"limited":[82],"evaluation":[83],"of":[84,134],"diagnostic":[85,94,114,136],"impact":[86],"on":[87],"clinical":[88,117,130],"outcomes.":[89,141],"Culture":[90],"remains":[91],"primary":[93],"strategy.":[95],"Fewer":[96],"employing":[98],"molecular":[99,108],"technologies":[100],"exist,":[101],"but":[102],"emerging":[103,135],"suggests":[105],"that":[106],"pathogen-agnostic":[107],"tests":[109],"add":[111],"armamentarium.":[115],"Well-designed":[116],"using":[119],"standardized":[120],"methodologies":[121],"needed":[123],"better":[125],"evaluate":[126],"performance":[127],"characteristics":[128],"economic":[132],"impacts":[133],"techniques":[137],"improve":[139],"patient":[140]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-08T00:00:00"}