{"id":"https://openalex.org/W4389399731","doi":"https://doi.org/10.1007/s11334-023-00537-y","title":"Nuclei-Net: a multi-stage fusion model for nuclei segmentation in microscopy images","display_name":"Nuclei-Net: a multi-stage fusion model for nuclei segmentation in microscopy images","publication_year":2023,"publication_date":"2023-12-06","ids":{"openalex":"https://openalex.org/W4389399731","doi":"https://doi.org/10.1007/s11334-023-00537-y"},"language":"en","primary_location":{"id":"doi:10.1007/s11334-023-00537-y","doi":"https://doi.org/10.1007/s11334-023-00537-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11334-023-00537-y","pdf_url":null,"source":{"id":"https://openalex.org/S151239915","display_name":"Innovations in Systems and Software Engineering","issn_l":"1614-5046","issn":["1614-5046","1614-5054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovations in Systems and Software Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3077385/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060052879","display_name":"Kaushiki Roy","orcid":"https://orcid.org/0000-0003-1510-6433","observed_orcids":["https://orcid.org/0000-0003-1510-6433"]},"institutions":[{"id":"https://openalex.org/I1296725772","display_name":"University of Engineering & Management","ror":"https://ror.org/02decng19","country_code":"IN","type":"education","lineage":["https://openalex.org/I1296725772"]},{"id":"https://openalex.org/I170979836","display_name":"Jadavpur University","ror":"https://ror.org/02af4h012","country_code":"IN","type":"education","lineage":["https://openalex.org/I170979836"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Kaushiki Roy","raw_affiliation_strings":["Computer Science and Engineering Department (AIML), Computer Science and Business Systems (CSBS), Institute of Engineering and Management, Kolkata, West-Bengal, 700091, India","Computer Science and Engineering Department, Jadavpur University, Kolkata, West-Bengal, 700032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science and Engineering Department (AIML), Computer Science and Business Systems (CSBS), Institute of Engineering and Management, Kolkata, West-Bengal, 700091, India","institution_ids":["https://openalex.org/I1296725772"]},{"raw_affiliation_string":"Computer Science and Engineering Department, Jadavpur University, Kolkata, West-Bengal, 700032, India","institution_ids":["https://openalex.org/I170979836"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Subhadeep Saha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170979836","display_name":"Jadavpur University","ror":"https://ror.org/02af4h012","country_code":"IN","type":"education","lineage":["https://openalex.org/I170979836"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhadeep Saha","raw_affiliation_strings":["Computer Science and Engineering Department, Jadavpur University, Kolkata, West-Bengal, 700032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science and Engineering Department, Jadavpur University, Kolkata, West-Bengal, 700032, India","institution_ids":["https://openalex.org/I170979836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040547240","display_name":"Debapriya Banik","orcid":"https://orcid.org/0000-0001-5031-1374","observed_orcids":["https://orcid.org/0000-0001-5031-1374"]},"institutions":[{"id":"https://openalex.org/I170979836","display_name":"Jadavpur University","ror":"https://ror.org/02af4h012","country_code":"IN","type":"education","lineage":["https://openalex.org/I170979836"]},{"id":"https://openalex.org/I173462786","display_name":"ICFAI University, Tripura","ror":"https://ror.org/01c06s784","country_code":"IN","type":"education","lineage":["https://openalex.org/I173462786"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Debapriya Banik","raw_affiliation_strings":["Computer Science and Engineering Department, ICFAI University, Tripura, Agartala, Tripura, 799210, India","Computer Science and Engineering Department, Jadavpur University, Kolkata, West-Bengal, 700032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science and Engineering Department, ICFAI University, Tripura, Agartala, Tripura, 799210, India","institution_ids":["https://openalex.org/I173462786"]},{"raw_affiliation_string":"Computer Science and Engineering Department, Jadavpur University, Kolkata, West-Bengal, 700032, India","institution_ids":["https://openalex.org/I170979836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075849780","display_name":"Debotosh Bhattacharjee","orcid":"https://orcid.org/0000-0002-1163-6413","observed_orcids":["https://orcid.org/0000-0002-1163-6413","https://orcid.org/0000-0001-7225-7778"]},"institutions":[{"id":"https://openalex.org/I170979836","display_name":"Jadavpur University","ror":"https://ror.org/02af4h012","country_code":"IN","type":"education","lineage":["https://openalex.org/I170979836"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Debotosh Bhattacharjee","raw_affiliation_strings":["Computer Science and Engineering Department, Jadavpur University, Kolkata, West-Bengal, 700032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science and Engineering Department, Jadavpur University, Kolkata, West-Bengal, 700032, India","institution_ids":["https://openalex.org/I170979836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060052879"],"corresponding_institution_ids":["https://openalex.org/I1296725772","https://openalex.org/I170979836"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":null,"fwci":0.5446,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.5557696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"21","issue":"3","first_page":"855","last_page":"862"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclei-segmentation","display_name":"nuclei segmentation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/microscopy-images","display_name":"microscopic images","score":0.921999990940094},{"id":"https://openalex.org/keywords/mask-r-cnn","display_name":"Mask R-CNN","score":0.9649999737739563},{"id":"https://openalex.org/keywords/marker-controlled-watershed-segmentation","display_name":"marker-controlled watershed segmentation","score":0.921999990940094},{"id":"https://openalex.org/keywords/cell-segmentation","display_name":"cell segmentation","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7978395223617554},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7485158443450928},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.6473925113677979},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5876930952072144},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5721782445907593},{"id":"https://openalex.org/C141353440","wikidata":"https://www.wikidata.org/wiki/Q182221","display_name":"Fuse (electrical)","level":2,"score":0.5574957132339478},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.509046733379364},{"id":"https://openalex.org/C14166107","wikidata":"https://www.wikidata.org/wiki/Q253829","display_name":"Net (polyhedron)","level":2,"score":0.5038544535636902},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.46290573477745056},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.44359079003334045},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4322810471057892},{"id":"https://openalex.org/C125308379","wikidata":"https://www.wikidata.org/wiki/Q363057","display_name":"Market segmentation","level":2,"score":0.41631758213043213},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3970026969909668},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2994347810745239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19448372721672058},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1504136323928833},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0815349817276001},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s11334-023-00537-y","doi":"https://doi.org/10.1007/s11334-023-00537-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11334-023-00537-y","pdf_url":null,"source":{"id":"https://openalex.org/S151239915","display_name":"Innovations in Systems and Software Engineering","issn_l":"1614-5046","issn":["1614-5046","1614-5054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovations in Systems and Software Engineering","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-3077385/v1","doi":"https://doi.org/10.21203/rs.3.rs-3077385/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3077385/v1","pdf_url":"https://www.researchsquare.com/article/rs-3077385/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3077385/v1","doi":"https://doi.org/10.21203/rs.3.rs-3077385/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3077385/v1","pdf_url":"https://www.researchsquare.com/article/rs-3077385/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389399731.pdf","grobid_xml":"https://content.openalex.org/works/W4389399731.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W173931755","https://openalex.org/W1995030392","https://openalex.org/W2128920415","https://openalex.org/W2186289225","https://openalex.org/W2806070179","https://openalex.org/W2905338897","https://openalex.org/W2911188335","https://openalex.org/W2963150697","https://openalex.org/W2963875806","https://openalex.org/W2980998394","https://openalex.org/W2981994674","https://openalex.org/W2998825217","https://openalex.org/W2999770235","https://openalex.org/W3012478585","https://openalex.org/W3015600294","https://openalex.org/W3082182183","https://openalex.org/W3096947210","https://openalex.org/W3196890347","https://openalex.org/W3214596602","https://openalex.org/W4220911046","https://openalex.org/W4236400424","https://openalex.org/W4377235489","https://openalex.org/W6819060087"],"related_works":["https://openalex.org/W3084995528","https://openalex.org/W2826827454","https://openalex.org/W3210886217","https://openalex.org/W4388144782","https://openalex.org/W4311061640","https://openalex.org/W2949851741","https://openalex.org/W6967010625","https://openalex.org/W3174998459","https://openalex.org/W3202961885","https://openalex.org/W4391342736"],"abstract_inverted_index":{"Abstract":[0],"In":[1,24],"this":[2],"study,":[3],"we":[4,28,74,126],"proposed":[5,18,90,141,162],"Nuclei-Net:":[6],"A":[7],"multi-stage":[8],"fusion":[9],"model":[10,19,35,163],"for":[11,40,86,95,107],"segmenting":[12],"nuclei":[13,65,79,85,118],"in":[14,21,68,98],"microscopy":[15],"images.":[16],"Our":[17,140,161],"works":[20],"two":[22,132],"stages.":[23],"the":[25,41,45,53,69,76,108,128,131,136],"first":[26],"stage,":[27],"incorporated":[29],"a":[30,91,99,165],"deep":[31],"learning":[32],"(DL)":[33],"based":[34],"namely":[36],"Mask":[37,123],"Region-Based-CNN":[38],"(Mask-RCNN)":[39],"coarse":[42],"segmentation":[43,138],"of":[44,56,72,167,170,173,177],"nuclei.":[46],"However,":[47],"it":[48],"can":[49],"be":[50],"observed":[51],"that":[52],"predicted":[54],"mask":[55],"Mask-RCNN":[57],"is":[58,143],"unable":[59],"to":[60,134],"segment":[61],"some":[62,157],"complex":[63,77],"overlapping":[64,78,84,117],"boundaries.":[66],"So,":[67],"second":[70],"stage":[71],"Nuclei-Net,":[73],"detect":[75],"and":[80,145,154,175],"pass":[81],"only":[82],"those":[83,116],"fine":[87,114],"segmentation.":[88],"We":[89],"marker":[92],"generation":[93],"method":[94],"each":[96],"nucleus":[97],"clump.":[100],"These":[101],"markers":[102],"serve":[103],"as":[104],"seed":[105],"points":[106],"marker-controlled":[109],"watershed":[110],"algorithm.":[111],"This":[112],"algorithm":[113],"segments":[115],"which":[119],"were":[120],"failed":[121],"by":[122],"R-CNN.":[124],"Finally,":[125],"fuse":[127],"results":[129],"from":[130],"stages":[133],"develop":[135],"final":[137],"map.":[139],"Nuclei-Net":[142],"trained":[144],"tested":[146],"on":[147],"Kaggle":[148],"2018":[149],"Data":[150],"Science":[151],"Bowl":[152],"dataset":[153],"compared":[155],"with":[156],"standard":[158],"DL":[159],"models.":[160],"achieved":[164],"DSC":[166],"83.3%,":[168],"AJI":[169],"70.03%,":[171],"Pre":[172],"89.80%,":[174],"Rec":[176],"87.20%":[178],"respectively":[179]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-12-07T00:00:00"}