{"id":"https://openalex.org/W4389399271","doi":"https://doi.org/10.7759/cureus.50042","title":"A Race Against Time: Early-Onset Differentiation Syndrome Following All-Trans-Retinoic-Acid (ATRA) Therapy in Acute Promyelocytic Leukemia (AML-M3)","display_name":"A Race Against Time: Early-Onset Differentiation Syndrome Following All-Trans-Retinoic-Acid (ATRA) Therapy in Acute Promyelocytic Leukemia (AML-M3)","publication_year":2023,"publication_date":"2023-12-06","ids":{"openalex":"https://openalex.org/W4389399271","doi":"https://doi.org/10.7759/cureus.50042","pmid":"https://pubmed.ncbi.nlm.nih.gov/38186512","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10768710"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.50042","doi":"https://doi.org/10.7759/cureus.50042","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7759/cureus.50042","pdf_url":"https://www.cureus.com/articles/207571-a-race-against-time-early-onset-differentiation-syndrome-following-all-trans-retinoic-acid-atra-therapy-in-acute-promyelocytic-leukemia-aml-m3.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/207571-a-race-against-time-early-onset-differentiation-syndrome-following-all-trans-retinoic-acid-atra-therapy-in-acute-promyelocytic-leukemia-aml-m3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100586157","display_name":"Kamran Ahmad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137562272","display_name":"Ayub Medical College","ror":"https://ror.org/03aypnd11","country_code":"PK","type":"education","lineage":["https://openalex.org/I137562272"]},{"id":"https://openalex.org/I2801036794","display_name":"Hayatabad Medical Complex","ror":"https://ror.org/03vpd6e34","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2801036794"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Kamran Ahmad","raw_affiliation_strings":["Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Endocrinology,",". Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK",". Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Pharmacology, Peshawar Medical College, Peshawar, PAK","Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Endocrinology,","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK","institution_ids":["https://openalex.org/I137562272"]},{"raw_affiliation_string":". Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Pharmacology, Peshawar Medical College, Peshawar, PAK","institution_ids":[]},{"raw_affiliation_string":"Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113004434","display_name":"Mahnosh Saleh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137562272","display_name":"Ayub Medical College","ror":"https://ror.org/03aypnd11","country_code":"PK","type":"education","lineage":["https://openalex.org/I137562272"]},{"id":"https://openalex.org/I2801036794","display_name":"Hayatabad Medical Complex","ror":"https://ror.org/03vpd6e34","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2801036794"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mahnosh Saleh","raw_affiliation_strings":["Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK",". Endocrinology,",". Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Pharmacology, Peshawar Medical College, Peshawar, PAK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK","institution_ids":["https://openalex.org/I137562272"]},{"raw_affiliation_string":". Endocrinology,","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Pharmacology, Peshawar Medical College, Peshawar, PAK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100647846","display_name":"Yasir Ali","orcid":"https://orcid.org/0009-0000-5591-975X","observed_orcids":["https://orcid.org/0009-0000-5591-975X"]},"institutions":[{"id":"https://openalex.org/I2801036794","display_name":"Hayatabad Medical Complex","ror":"https://ror.org/03vpd6e34","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2801036794"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Yasir Ali","raw_affiliation_strings":["Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Pharmacology, Peshawar Medical College, Peshawar, PAK","Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Pharmacology, Peshawar Medical College, Peshawar, PAK","institution_ids":[]},{"raw_affiliation_string":"Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amna Yaseen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137562272","display_name":"Ayub Medical College","ror":"https://ror.org/03aypnd11","country_code":"PK","type":"education","lineage":["https://openalex.org/I137562272"]},{"id":"https://openalex.org/I2801036794","display_name":"Hayatabad Medical Complex","ror":"https://ror.org/03vpd6e34","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2801036794"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Amna Yaseen","raw_affiliation_strings":["Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Endocrinology,",". Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK",". Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Pharmacology, Peshawar Medical College, Peshawar, PAK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Endocrinology,","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK","institution_ids":["https://openalex.org/I137562272"]},{"raw_affiliation_string":". Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Pharmacology, Peshawar Medical College, Peshawar, PAK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078311621","display_name":"Muhammad Ali","orcid":"https://orcid.org/0000-0002-5805-6213","observed_orcids":["https://orcid.org/0000-0002-5805-6213"]},"institutions":[{"id":"https://openalex.org/I137562272","display_name":"Ayub Medical College","ror":"https://ror.org/03aypnd11","country_code":"PK","type":"education","lineage":["https://openalex.org/I137562272"]},{"id":"https://openalex.org/I2801036794","display_name":"Hayatabad Medical Complex","ror":"https://ror.org/03vpd6e34","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2801036794"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Ali","raw_affiliation_strings":["Endocrinology, Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK",". Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology, Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK","institution_ids":["https://openalex.org/I137562272"]},{"raw_affiliation_string":". Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":"Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103050234","display_name":"Musa Kakakhel","orcid":"https://orcid.org/0009-0003-9545-7774","observed_orcids":["https://orcid.org/0009-0003-9545-7774"]},"institutions":[{"id":"https://openalex.org/I137562272","display_name":"Ayub Medical College","ror":"https://ror.org/03aypnd11","country_code":"PK","type":"education","lineage":["https://openalex.org/I137562272"]},{"id":"https://openalex.org/I2801036794","display_name":"Hayatabad Medical Complex","ror":"https://ror.org/03vpd6e34","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2801036794"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Musa Kakakhel","raw_affiliation_strings":["Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Endocrinology,",". Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK",". Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Pharmacology, Peshawar Medical College, Peshawar, PAK","Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Endocrinology,","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK","institution_ids":["https://openalex.org/I137562272"]},{"raw_affiliation_string":". Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Pharmacology, Peshawar Medical College, Peshawar, PAK","institution_ids":[]},{"raw_affiliation_string":"Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027931456","display_name":"Muhammad Azeem Hayat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137562272","display_name":"Ayub Medical College","ror":"https://ror.org/03aypnd11","country_code":"PK","type":"education","lineage":["https://openalex.org/I137562272"]},{"id":"https://openalex.org/I2801036794","display_name":"Hayatabad Medical Complex","ror":"https://ror.org/03vpd6e34","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2801036794"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Azeem Hayat","raw_affiliation_strings":["Pharmacology, Peshawar Medical College, Peshawar, PAK",". Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK",". Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK",". Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, Peshawar Medical College, Peshawar, PAK","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK","institution_ids":["https://openalex.org/I137562272"]},{"raw_affiliation_string":". Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":". Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]},{"raw_affiliation_string":"Diabetes and Metabolism, Hayatabad Medical Complex Peshawar, Peshawar, PAK","institution_ids":["https://openalex.org/I2801036794"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103050234"],"corresponding_institution_ids":["https://openalex.org/I137562272","https://openalex.org/I2801036794"],"apc_list":null,"apc_paid":null,"fwci":0.1485,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.30973821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"12","first_page":"e50042","last_page":"e50042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/differentiation-syndrome","display_name":"differentiation syndrome","score":0.9309999942779541},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.7760000228881836},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9490000009536743},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.6019999980926514},{"id":"https://openalex.org/keywords/hypoxemic-respiratory-failure","display_name":"hypoxemic respiratory failure","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hypoxemia","display_name":"hypoxemia","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9460494518280029},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.8503756523132324},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.6117238402366638},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.44933056831359863},{"id":"https://openalex.org/C2779982571","wikidata":"https://www.wikidata.org/wiki/Q25098780","display_name":"Differentiation therapy","level":5,"score":0.4401451647281647},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.4179905354976654},{"id":"https://openalex.org/C2779382419","wikidata":"https://www.wikidata.org/wiki/Q1757427","display_name":"Pancytopenia","level":3,"score":0.41025251150131226},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39329081773757935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3772856593132019},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3714008629322052},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.3690943121910095},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.50042","doi":"https://doi.org/10.7759/cureus.50042","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7759/cureus.50042","pdf_url":"https://www.cureus.com/articles/207571-a-race-against-time-early-onset-differentiation-syndrome-following-all-trans-retinoic-acid-atra-therapy-in-acute-promyelocytic-leukemia-aml-m3.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10768710","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10768710","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10768710/pdf/cureus-0015-00000050042.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:38186512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38186512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.50042","doi":"https://doi.org/10.7759/cureus.50042","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7759/cureus.50042","pdf_url":"https://www.cureus.com/articles/207571-a-race-against-time-early-onset-differentiation-syndrome-following-all-trans-retinoic-acid-atra-therapy-in-acute-promyelocytic-leukemia-aml-m3.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389399271.pdf","grobid_xml":"https://content.openalex.org/works/W4389399271.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W570370693","https://openalex.org/W1982745688","https://openalex.org/W2034259042","https://openalex.org/W2968563688","https://openalex.org/W3010783628","https://openalex.org/W4296941689"],"related_works":["https://openalex.org/W3111183286","https://openalex.org/W4387247942","https://openalex.org/W2534609259","https://openalex.org/W4388452973","https://openalex.org/W2603345871","https://openalex.org/W4394725925","https://openalex.org/W2972871216","https://openalex.org/W2129363017","https://openalex.org/W2095640498","https://openalex.org/W570370693"],"abstract_inverted_index":{"This":[0,111],"study":[1],"reports":[2],"a":[3,8,17],"case":[4,112],"of":[5,11,28,60,98,116,124,132],"differentiation":[6,61,103,133],"syndrome,":[7],"rare":[9],"complication":[10],"ATRA":[12,29,63,109,117],"(all-trans-retinoic-acid)":[13],"therapy,":[14],"observed":[15],"in":[16,105,128],"20-year-old":[18],"male":[19],"with":[20,36,120],"acute":[21],"promyelocytic":[22],"leukemia":[23],"(APML).":[24],"Following":[25],"the":[26,33,58,69,96,114,121,129],"initiation":[27],"therapy":[30,64],"for":[31],"APML,":[32],"patient":[34],"presented":[35],"fever,":[37],"bleeding":[38],"gums,":[39],"bloody":[40],"stool,":[41],"and":[42,54,68,86,100,126],"mouth":[43],"ulcers.":[44],"After":[45,88],"36":[46],"hours,":[47],"he":[48],"developed":[49],"respiratory":[50,74],"distress,":[51],"hypotension,":[52],"tachycardia,":[53],"hypoxemia,":[55],"leading":[56],"to":[57],"diagnosis":[59],"syndrome.":[62,134],"was":[65,93],"promptly":[66,101],"discontinued,":[67],"patient,":[70],"exhibiting":[71],"type":[72],"1":[73],"failure,":[75],"necessitated":[76],"intubation.":[77],"The":[78],"management":[79,131],"included":[80],"hydroxyurea,":[81,127],"dexamethasone,":[82],"vasopressors,":[83],"intravenous":[84],"fluids,":[85],"furosemide.":[87],"seven":[89],"days,":[90],"significant":[91],"improvement":[92],"observed,":[94],"underscoring":[95],"importance":[97],"recognizing":[99],"addressing":[102],"syndrome":[104],"APML":[106],"patients":[107],"undergoing":[108],"therapy.":[110],"emphasizes":[113],"necessity":[115],"discontinuation,":[118],"coupled":[119],"judicious":[122],"use":[123],"steroids":[125],"effective":[130]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-12-07T00:00:00"}
