{"id":"https://openalex.org/W4389374657","doi":"https://doi.org/10.1212/wnl.98.18_supplement.3734","title":"Safety and Efficacy of Siponimod in Patients with Active Secondary Progressive Multiple Sclerosis Identifying as Hispanic from the Phase 3 EXPAND Study (P8-4.007)","display_name":"Safety and Efficacy of Siponimod in Patients with Active Secondary Progressive Multiple Sclerosis Identifying as Hispanic from the Phase 3 EXPAND Study (P8-4.007)","publication_year":2022,"publication_date":"2022-05-03","ids":{"openalex":"https://openalex.org/W4389374657","doi":"https://doi.org/10.1212/wnl.98.18_supplement.3734"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.98.18_supplement.3734","doi":"https://doi.org/10.1212/wnl.98.18_supplement.3734","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.98.18_supplement.3734","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067317369","display_name":"STANLEY L. COHAN","orcid":"https://orcid.org/0000-0002-9568-346X","observed_orcids":["https://orcid.org/0000-0002-9568-346X"]},"institutions":[{"id":"https://openalex.org/I94396219","display_name":"Providence Health & Services","ror":"https://ror.org/00n4k4n97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley Cohan","raw_affiliation_strings":["Providence Brain and Spine Institute, and Providence Multiple Sclerosis Center, Providence Health & Services"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Providence Brain and Spine Institute, and Providence Multiple Sclerosis Center, Providence Health & Services","institution_ids":["https://openalex.org/I94396219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035194673","display_name":"Le H. Hua","orcid":"https://orcid.org/0000-0002-0535-3978","observed_orcids":["https://orcid.org/0000-0002-0535-3978"]},"institutions":[{"id":"https://openalex.org/I2800445466","display_name":"Lou Ruvo Brain Institute","ror":"https://ror.org/03wqknk68","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800445466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Le Hua","raw_affiliation_strings":["Lou Ruvo Center for Brain Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lou Ruvo Center for Brain Health","institution_ids":["https://openalex.org/I2800445466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077310868","display_name":"Amit Bar\u2010Or","orcid":"https://orcid.org/0000-0001-7179-0335","observed_orcids":["https://orcid.org/0000-0001-7179-0335","https://orcid.org/0000-0003-2931-1585"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Bar-Or","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025501697","display_name":"FRED D. LUBLIN","orcid":"https://orcid.org/0000-0001-5722-0475","observed_orcids":["https://orcid.org/0000-0001-5722-0475"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred Lublin","raw_affiliation_strings":["Icahn School of Medicine At Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine At Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101721800","display_name":"Xiangyi Meng","orcid":"https://orcid.org/0000-0002-2034-4551","observed_orcids":["https://orcid.org/0000-0002-2034-4551"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Xiangyi Meng","raw_affiliation_strings":["Novartis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076130466","display_name":"Gina Mavrikis Cox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gina Cox","raw_affiliation_strings":["Novartis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012376027","display_name":"Patricia Katherine Coyle","orcid":"https://orcid.org/0000-0002-3801-6177","observed_orcids":["https://orcid.org/0000-0002-3801-6177"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Coyle","raw_affiliation_strings":["SUNY At Stony Brook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY At Stony Brook","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029734617","display_name":"Robert James Fox","orcid":"https://orcid.org/0000-0002-4263-3717","observed_orcids":["https://orcid.org/0000-0002-4263-3717"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Fox","raw_affiliation_strings":["Cleveland Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"98","issue":"18_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/siponimod","display_name":"siponimod","score":1.0},{"id":"https://openalex.org/keywords/secondary-progressive-multiple-sclerosis","display_name":"secondary progressive multiple sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/hispanic-patients","display_name":"Hispanic patients","score":0.9509999752044678},{"id":"https://openalex.org/keywords/expand-trial","display_name":"EXPAND trial","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6230000257492065},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.902999997138977},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7260000109672546},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.625},{"id":"https://openalex.org/keywords/underrepresentation-in-clinical-trials","display_name":"underrepresentation in clinical trials","score":0.6880000233650208},{"id":"https://openalex.org/keywords/relapse-rate","display_name":"relapse rate","score":0.414000004529953},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7433301210403442},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5791689157485962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4903299808502197},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.40207889676094055},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3579067587852478},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13075631856918335}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.98.18_supplement.3734","doi":"https://doi.org/10.1212/wnl.98.18_supplement.3734","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.98.18_supplement.3734","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4281916721","https://openalex.org/W3191053673","https://openalex.org/W4389446002","https://openalex.org/W4377208533","https://openalex.org/W4389375161","https://openalex.org/W2999381801","https://openalex.org/W4281650051","https://openalex.org/W2790816436","https://openalex.org/W3019627920","https://openalex.org/W2777830529"],"abstract_inverted_index":{"Objective:":[0],"Assess":[1],"the":[2,69,118,172,267,286,289,296,312,330,348,366,385,406,425,445,464,484,505,523,541,559,578,598,617,635,653,677,701,726,750,771,801,820,838,856,875,893,911,930,948,973,997,1021,1046,1115,1133,1151,1169,1187,1205,1223,1248,1272,1296,1320,1344,1368,1392,1416,1440,1459,1471,1486,1550,1576,1594,1612,1630,1648,1666,1684,1702,1799,1818,1836,1854,1872,1891,1909,1927,1945,1963,1981,2000,2024,2048,2072],"efficacy/safety":[3],"profile":[4],"of":[5,12,107,127,165,231,285,298,314,332,350,368,387,408,427,447,466,486,507,525,543,561,580,600,619,637,655,679,703,728,752,773,785,803,822,840,858,877,895,913,932,950,975,999,1023,1048,1065,1076,1087,1098,1117,1135,1153,1171,1189,1207,1225,1250,1274,1298,1322,1346,1370,1394,1418,1442,1461,1470,1473,1488,1512,1523,1534,1552,1578,1596,1614,1632,1650,1668,1686,1704,1716,1727,1738,1750,1761,1772,1783,1801,1820,1838,1856,1874,1893,1911,1929,1947,1965,1983,2002,2026,2050,2074,2091,2101],"siponimod":[6,215,243],"2mg":[7],"daily":[8],"in":[9,37,49,53,68,101,117,171,253,256,272,288,301,311,329,347,365,384,405,424,444,463,483,504,522,540,558,577,597,616,634,652,676,700,725,749,770,800,819,837,855,874,892,910,929,947,972,996,1020,1045,1114,1132,1150,1168,1186,1204,1222,1247,1271,1295,1319,1343,1367,1391,1415,1439,1458,1485,1549,1575,1593,1611,1629,1647,1665,1683,1701,1798,1817,1835,1853,1871,1890,1908,1926,1944,1962,1980,1999,2023,2047,2071],"a":[10,217,249,319,337,355,373,392,413,432,452,471,491,512,530,548,566,585,605,624,642,660,684,708,733,757,778,808,827,845,863,882,900,918,937,955,980,1004,1028,1053,1122,1140,1158,1176,1194,1212,1230,1255,1279,1303,1327,1351,1375,1399,1423,1447,1557,1583,1601,1619,1637,1655,1673,1691,1709,1806,1825,1843,1861,1879,1898,1916,1934,1952,1970,1988,2007,2031,2055,2079,2110],"subgroup":[11],"patients":[13,38,46,108,116,166,258],"with":[14,39,109,259,266,1559],"active":[15,40,131,260,269],"SPMS":[16,41,61,132,261,270],"from":[17,42,212,279,792,1072,1083,1094,1105,1508,1519,1530,1541,1723,1734,1745,1757,1768,1779,1790,2098,2109],"EXPAND":[18,120],"who":[19],"identified":[20,124],"as":[21,64,125,263,318,336,354,372,391,511,529,547,565,584,604,623,641,807,826,844,862,881,899,917,936,1121,1139,1157,1175,1193,1211,1465,1492,1556,1582,1600,1618,1636,1654,1672,1690,1805,1824,1842,1860,1878,1897,1915,1933,1951,1969,1987],"Hispanic.":[22],"Background:":[23],"Siponimod":[24,179],"significantly":[25],"reduced":[26,180],"3-month":[27,181],"and":[28,34,83,93,99,105,163,193,235,244],"6-month":[29,94,194],"CDP":[30,95,182,195,254],"risk":[31,183,196,255],"by":[32,184,197],"31%":[33],"37%,":[35],"respectively,":[36],"EXPAND.":[43,273],"Minority":[44],"group":[45],"are":[47],"underrepresented":[48],"clinical":[50,302],"trials,":[51],"resulting":[52],"limited":[54],"data":[55],"to":[56,88,91,177,238,1567,2113],"inform":[57],"decision-making.":[58],"Design/Methods:":[59],"Active":[60],"was":[62,140,152,160,248],"defined":[63],"having":[65],"\u22651":[66,75,168],"relapse":[67,170],"2":[70,174],"years":[71,175],"before":[72],"Baseline":[73,213],"and/or":[74],"T1":[76],"Gd+":[77],"lesion":[78],"at":[79],"Baseline.":[80,178],"Proportional":[81],"hazard":[82],"ANCOVA":[84],"models":[85],"were":[86,111,144,240],"applied":[87],"analyze":[89],"time":[90],"3-":[92],"(as":[96],"per":[97],"EDSS)":[98],"change":[100],"SDMT,":[102],"respectively.":[103],"Number":[104],"percentage":[106],"AEs":[110,236],"reported.":[112],"Results:":[113],"Of":[114],"1651":[115],"overall":[119,268],"population,":[121],"106":[122],"(6.4%)":[123],"Hispanic,":[126,264],"which":[128],"40":[129],"had":[130,167],"(siponimod":[133],"[n=31],":[134],"placebo":[135,221],"[n=9]).":[136],"Mean":[137],"(SD)":[138,147,157],"age":[139],"47.4":[141],"(7.6),":[142],"65.0%":[143],"female,":[145],"mean":[146,156,207],"duration":[148],"since":[149],"MS":[150,169],"onset":[151],"15.3":[153],"(6.4)":[154],"years,":[155],"baseline":[158],"EDSS":[159],"5.4":[161],"(1.1),":[162],"77.5%":[164],"last":[173],"prior":[176],"42%":[185],"(HR":[186],"[95%":[187],"CI]:":[188],"0.58":[189],"[0.17,":[190],"1.92];":[191],"p=0.37)":[192],"67%":[198],"(0.33":[199],"[0.07,":[200],"1.53],":[201],"p=0.16)":[202],"vs":[203,216],"placebo.":[204,245],"At":[205],"Month-12,":[206],"SDMT":[208],"score":[209],"changed":[210],"minimally":[211],"for":[214,220,242,316,321,334,339,352,357,370,375,389,394,410,416,429,435,449,455,468,474,488,494,509,514,527,532,545,550,563,568,582,587,602,607,621,626,639,644,657,668,681,692,705,716,730,741,754,760,775,781,805,810,824,829,842,847,860,865,879,884,897,902,915,920,934,939,952,963,977,988,1001,1012,1025,1036,1050,1061,1119,1124,1137,1142,1155,1160,1173,1178,1191,1196,1209,1214,1227,1238,1252,1263,1276,1287,1300,1311,1324,1335,1348,1359,1372,1383,1396,1407,1420,1431,1444,1450,1463,1475,1490,1496,1554,1580,1585,1598,1603,1616,1621,1634,1639,1652,1657,1670,1675,1688,1693,1706,1712,1803,1808,1822,1827,1840,1845,1858,1863,1876,1881,1895,1900,1913,1918,1931,1936,1949,1954,1967,1972,1985,1990,2004,2015,2028,2039,2052,2063,2076,2087],"4.7-point":[218],"worsening":[219],"(difference":[222],"between":[223],"treatment":[224],"groups,":[225],"4.9":[226],"(SE":[227],"2.6,":[228],"p=0.07)).":[229],"Rates":[230],"any":[232],"AEs,":[233],"SAEs,":[234],"leading":[237],"discontinuation":[239],"similar":[241],"Conclusions:":[246],"There":[247],"numeric":[250],"relative":[251],"reduction":[252],"siponimod-treated":[257],"identifying":[262],"consistent":[265],"cohort":[271],"Small":[274],"sample":[275],"size":[276],"prevents":[277],"us":[278],"drawing":[280],"conclusions":[281],"on":[282,412,431,451,470,490,659,683,707,732,756,777,954,979,1003,1027,1052,1229,1254,1278,1302,1326,1350,1374,1398,1422,1446,1708,2006,2030,2054,2078],"statistical":[283],"significance":[284],"results":[287],"Hispanic":[290],"subgroup.":[291],"This":[292],"brings":[293],"into":[294],"focus":[295],"challenges":[297],"minority":[299],"under-representation":[300],"trials.":[303],"Disclosure:":[304],"Dr.":[305,323,341,359,378,399,418,438,457,477,498,516,534,552,571,591,610,628,646,670,694,719,743,764,786,794,813,831,849,868,886,904,923,941,966,990,1014,1039,1066,1077,1088,1099,1108,1126,1144,1162,1180,1198,1216,1241,1265,1289,1313,1337,1361,1385,1409,1433,1452,1479,1499,1513,1524,1535,1543,1563,1569,1587,1605,1623,1641,1659,1677,1695,1717,1728,1739,1751,1762,1773,1784,1792,1811,1829,1847,1865,1884,1902,1920,1938,1956,1974,1993,2017,2041,2065,2092,2103],"Cohan":[306,324,342,360,379,400,419,439,458,478],"has":[307,325,343,361,380,401,420,440,459,479,500,518,536,554,573,593,612,630,648,672,696,721,745,766,788,796,815,833,851,870,888,906,925,943,968,992,1016,1041,1068,1079,1090,1101,1110,1128,1146,1164,1182,1200,1218,1243,1267,1291,1315,1339,1363,1387,1411,1435,1454,1481,1501,1515,1526,1537,1545,1565,1571,1589,1607,1625,1643,1661,1679,1697,1719,1730,1741,1753,1764,1775,1786,1794,1813,1831,1849,1867,1886,1904,1922,1940,1958,1976,1995,2019,2043,2067,2094,2105],"received":[308,326,344,362,381,402,421,441,460,480,501,519,537,555,574,594,613,631,649,673,697,722,746,767,789,797,816,834,852,871,889,907,926,944,969,993,1017,1042,1069,1080,1091,1102,1111,1129,1147,1165,1183,1201,1219,1244,1268,1292,1316,1340,1364,1388,1412,1436,1455,1482,1502,1516,1527,1538,1546,1572,1590,1608,1626,1644,1662,1680,1698,1720,1731,1742,1754,1765,1776,1787,1795,1814,1832,1850,1868,1887,1905,1923,1941,1959,1977,1996,2020,2044,2068,2095,2106],"personal":[309,327,345,363,382,403,422,442,461,481,502,520,538,556,575,595,614,632,650,674,698,723,747,768,798,817,835,853,872,890,908,927,945,970,994,1018,1043,1112,1130,1148,1166,1184,1202,1220,1245,1269,1293,1317,1341,1365,1389,1413,1437,1456,1483,1547,1573,1591,1609,1627,1645,1663,1681,1699,1796,1815,1833,1851,1869,1888,1906,1924,1942,1960,1978,1997,2021,2045,2069],"compensation":[310,328,346,364,383,404,423,443,462,482,503,521,539,557,576,596,615,633,651,675,699,724,748,769,799,818,836,854,873,891,909,928,946,971,995,1019,1044,1113,1131,1149,1167,1185,1203,1221,1246,1270,1294,1318,1342,1366,1390,1414,1438,1457,1484,1548,1574,1592,1610,1628,1646,1664,1682,1700,1797,1816,1834,1852,1870,1889,1907,1925,1943,1961,1979,1998,2022,2046,2070],"range":[313,331,349,367,386,407,426,446,465,485,506,524,542,560,579,599,618,636,654,678,702,727,751,772,802,821,839,857,876,894,912,931,949,974,998,1022,1047,1116,1134,1152,1170,1188,1206,1224,1249,1273,1297,1321,1345,1369,1393,1417,1441,1460,1487,1551,1577,1595,1613,1631,1649,1667,1685,1703,1800,1819,1837,1855,1873,1892,1910,1928,1946,1964,1982,2001,2025,2049,2073],"$500-$4,999":[315,333,369,388,487,526,581,601,620,638,680,704,729,753,804,823,841,859,878,896,914,933,951,976,1000,1024,1049,1154,1208,1299,1371,1462,1579,1651,1802,1984],"serving":[317,335,353,371,390,411,430,450,469,489,510,528,546,564,583,603,622,640,658,682,706,731,755,776,806,825,843,861,880,898,916,935,953,978,1002,1026,1051,1120,1138,1156,1174,1192,1210,1228,1253,1277,1301,1325,1349,1373,1397,1421,1445,1464,1491,1555,1581,1599,1617,1635,1653,1671,1689,1707,1804,1823,1841,1859,1877,1896,1914,1932,1950,1968,1986,2005,2029,2053,2077],"Consultant":[320,338,356,374,393,513,531,549,567,586,606,625,643,809,828,846,864,883,901,919,938,1123,1141,1159,1177,1195,1213,1558,1584,1602,1620,1638,1656,1674,1692,1807,1826,1844,1862,1880,1899,1917,1935,1953,1971,1989],"Biogen.":[322,417,669,793,885,1084,1161,1604,1713,1846,2016],"AbbVie.":[340],"$5,000-$9,999":[351,428,448,467,508,544,562,656,774,1136,1190,1419,1443,1597,1705,1821,1839,1857,1875,1894,1930,1948,1966,2003,2027,2051,2075],"Novartis.":[358,456,551,693,830,1013,1073,1408,1676,1791,1937,2064],"Roche":[376,475,811],"Genentech.":[377,476,533,742,812,1901],"Bristol":[395,495,588,761],"Myers":[396,496,589,762],"Squibb":[397],"(Celgene).":[398],"$10,000-$49,999":[409,1118,1172,1275,1323,1347,1395,1615,1669,1687,1912],"Speakers":[414,433,453,472,492,758,779,1448,1710],"Bureau":[415,434,454,473,493,759,780,1449,1711],"sanofi":[436],"genzyme.":[437],"Squibb.":[497,590,763],"Hua":[499,517,535,553,572,592,611,629,647,671,695,720,744,765,787],"Genzyme.":[515,782],"EMD":[569,717,1882],"Serono.":[570,718,922,1038,1107,1694,1883],"Veila":[608],"Bio.":[609,1240],"Horizon.":[627],"Greenwich.":[645],"Scientific":[661,685,709,734,956,981,1005,1029,1054,1231,1256,1280,1304,1328,1352,1376,1400,1424,2008,2032,2056,2080],"Advisory":[662,686,710,735,957,982,1006,1030,1055,1232,1257,1281,1305,1329,1353,1377,1401,1425,2009,2033,2057,2081],"or":[663,687,711,736,958,983,1007,1031,1056,1233,1258,1282,1306,1330,1354,1378,1402,1426,1468,1504,2010,2034,2058,2082],"Data":[664,688,712,737,959,984,1008,1032,1057,1234,1259,1283,1307,1331,1355,1379,1403,1427,2011,2035,2059,2083],"Safety":[665,689,713,738,960,985,1009,1033,1058,1235,1260,1284,1308,1332,1356,1380,1404,1428,2012,2036,2060,2084],"Monitoring":[666,690,714,739,961,986,1010,1034,1059,1236,1261,1285,1309,1333,1357,1381,1405,1429,2013,2037,2061,2085],"board":[667,691,715,740,962,987,1011,1035,1060,1237,1262,1286,1310,1334,1358,1382,1406,1430,2014,2038,2062,2086],"The":[783,1063,1074,1085,1096,1476,1510,1521,1532,1560,1714,1725,1736,1748,1759,1770,1781,2089],"institution":[784,1064,1075,1086,1097,1511,1522,1533,1715,1726,1737,1749,1760,1771,1782,2090],"research":[790,1070,1081,1092,1103,1517,1528,1539,1721,1732,1743,1755,1766,1777,1788,2096],"support":[791,1071,1082,1093,1104,1518,1529,1540,1722,1733,1744,1756,1767,1778,1789,2097],"Bar-Or":[795,814,832,850,869,887,905,924,942,967,991,1015,1040,1067,1078,1089,1100],"Janssen/Actelion.":[848],"Atara":[866,964],"Biotherapeutics.":[867,965],"BMS.":[903],"Merk/EMD":[921],"Sanofi-Genzyme.":[940],"Roche/Genentech.":[989,1095,1125],"Merck/EMD":[1037,1106],"Sanofi/Genzyme.":[1062],"Lublin":[1109,1127,1145,1163,1181,1199,1217,1242,1266,1290,1314,1338,1362,1386,1410,1434,1453,1480,1500,1514,1525,1536,1544],"Orion.":[1143],"Mapi.":[1179],"Brainstrom.":[1197],"Apitope.":[1215],"$50,000-$99,999":[1226,1251,1633],"Medimmune/Viela":[1239],"Receptos/Celgene/BMS.":[1264],"Teva.":[1288,1973],"Actelion.":[1312,1724],"GW.":[1336],"MedDay.":[1360,1769],"Jazz.":[1384],"Immunic.":[1432,1919,2040],"Sanofi.":[1451,1955],"an":[1466,1493,1505],"officer":[1467],"member":[1469],"Board":[1472],"Directors":[1474],"population":[1477],"Council.":[1478,1562],"$100,000-$499,999":[1489],"Expert":[1494],"Witness":[1495],"Multiple":[1497],"entities.":[1498],"stock":[1503],"ownership":[1506],"interest":[1507],"Avotres.":[1509],"Brainstorm.":[1520],"biogen.":[1531],"NIH.":[1542],"$0-$499":[1553],"Population":[1561],"Meng":[1564],"nothing":[1566],"disclose.":[1568],"Coyle":[1570,1588,1606,1624,1642,1660,1678,1696,1718,1729,1740,1752,1763,1774,1785],"Accordant.":[1586],"Genentech/Roche.":[1622,1758],"Genzyme/Sanofi.":[1640],"Janssen.":[1658,1828,2088],"Alkermes.":[1735],"Corrona":[1746],"LLD.":[1747],"NINDS.":[1780],"Fox":[1793,1812,1830,1848,1866,1885,1903,1921,1939,1957,1975,1994,2018,2042,2066,2093,2104],"AB":[1809],"Science.":[1810],"Celgene.":[1864],"TG":[1991],"Therapeutics.":[1992],"National":[2099],"Institutes":[2100],"Health.":[2102],"publishing":[2107],"royalties":[2108],"publication":[2111],"relating":[2112],"health":[2114],"care.":[2115]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-12-07T00:00:00"}