{"id":"https://openalex.org/W4389374468","doi":"https://doi.org/10.1212/wnl.98.18_supplement.2806","title":"Resting-State Connectivity Between the Insula and Prefrontal Cortex Is Sensitive to Acute Injury and Symptom Persistence After Sport-Related Concussion (P11-8.005)","display_name":"Resting-State Connectivity Between the Insula and Prefrontal Cortex Is Sensitive to Acute Injury and Symptom Persistence After Sport-Related Concussion (P11-8.005)","publication_year":2022,"publication_date":"2022-05-03","ids":{"openalex":"https://openalex.org/W4389374468","doi":"https://doi.org/10.1212/wnl.98.18_supplement.2806"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.98.18_supplement.2806","doi":"https://doi.org/10.1212/wnl.98.18_supplement.2806","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.98.18_supplement.2806","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004562427","display_name":"Christopher Andrew Sheridan","orcid":"https://orcid.org/0000-0002-9410-274X","observed_orcids":["https://orcid.org/0000-0002-9410-274X"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Sheridan","raw_affiliation_strings":["Radiology, Wake Forest School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, Wake Forest School of Medicine","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000180621","display_name":"Kevin C. Bickart","orcid":"https://orcid.org/0000-0002-8389-8922","observed_orcids":["https://orcid.org/0000-0002-8389-8922"]},"institutions":[{"id":"https://openalex.org/I4210164563","display_name":"Neurology, Inc","ror":"https://ror.org/05ne0gd95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210164563"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Bickart","raw_affiliation_strings":["Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology","institution_ids":["https://openalex.org/I4210164563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011606501","display_name":"Corey M. Thibeault","orcid":"https://orcid.org/0000-0002-3916-901X","observed_orcids":["https://orcid.org/0000-0002-3916-901X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Corey Thibeault","raw_affiliation_strings":["NovaSignal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovaSignal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051289030","display_name":"Christopher C. Giza","orcid":"https://orcid.org/0000-0002-5721-2667","observed_orcids":["https://orcid.org/0000-0002-5721-2667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Giza","raw_affiliation_strings":["Pediatrics and Neurosurgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics and Neurosurgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000092822","display_name":"Christopher T. Whitlow","orcid":"https://orcid.org/0000-0003-2392-8293","observed_orcids":["https://orcid.org/0000-0003-2392-8293"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Whitlow","raw_affiliation_strings":["Radiology, Wake Forest School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, Wake Forest School of Medicine","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert Hamilton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Hamilton","raw_affiliation_strings":["NovaSignal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovaSignal","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007798624","display_name":"Meeryo C. Choe","orcid":"https://orcid.org/0000-0001-8142-9471","observed_orcids":["https://orcid.org/0000-0001-8142-9471"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meeryo Choe","raw_affiliation_strings":["Pediatrics, Div. of Neurology, UCLA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Div. of Neurology, UCLA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1425,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47667528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"98","issue":"18_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sports-related-concussion","display_name":"sports-related concussion","score":0.9980000257492065},{"id":"https://openalex.org/keywords/resting-state-functional-connectivity","display_name":"resting-state functional connectivity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/insular-cortex","display_name":"insula","score":0.9929999709129333},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":1.0},{"id":"https://openalex.org/keywords/post-concussion-symptoms","display_name":"post-concussion symptoms","score":0.7919999957084656},{"id":"https://openalex.org/keywords/symptom-persistence","display_name":"symptom persistence","score":0.9309999942779541},{"id":"https://openalex.org/keywords/acute-brain-injury","display_name":"acute brain injury","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C104996578","wikidata":"https://www.wikidata.org/wiki/Q827617","display_name":"Insula","level":2,"score":0.8848578929901123},{"id":"https://openalex.org/C2778426673","wikidata":"https://www.wikidata.org/wiki/Q326921","display_name":"Concussion","level":4,"score":0.8287810683250427},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.7917331457138062},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.6204798817634583},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47579988837242126},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4499925673007965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36485224962234497},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.33205676078796387},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.18632295727729797},{"id":"https://openalex.org/C190385971","wikidata":"https://www.wikidata.org/wiki/Q373494","display_name":"Injury prevention","level":3,"score":0.14758601784706116},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.09266683459281921},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.0864725112915039},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.06646332144737244},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.98.18_supplement.2806","doi":"https://doi.org/10.1212/wnl.98.18_supplement.2806","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.98.18_supplement.2806","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2793001425","https://openalex.org/W2900497911","https://openalex.org/W7117296261","https://openalex.org/W3105802339","https://openalex.org/W2968068770","https://openalex.org/W2259362834","https://openalex.org/W2888206153","https://openalex.org/W1495727135","https://openalex.org/W2945337105","https://openalex.org/W4401573982"],"abstract_inverted_index":{"Objective:":[0],"We":[1,39,56,68],"investigated":[2],"the":[3,11,51,59,114,243,287,297,351,376,401,548],"relationship":[4],"between":[5,10,50,172,181,191,205,228,248,273],"symptoms":[6,24],"and":[7,13,22,29,54,90,97,139,189,210,219,233,242,253,264,267,275],"rsfMRI":[8,75],"connectivity":[9,72,143,204,227,247],"insula":[12,60,108,209,232,252,274,289,299],"PFC":[14,276],"in":[15,85,350,375,400,547],"sport-related":[16],"concussion":[17],"(SRC).":[18],"Background:":[19],"Autonomic,":[20],"affective,":[21],"nociceptive":[23],"are":[25],"common":[26],"after":[27,80,282],"SRC":[28,81,168,200,223],"have":[30],"well-established":[31],"relationships":[32],"with":[33,48,148,217,239,261,286,296],"central":[34],"autonomic":[35],"network":[36],"(CAN)":[37],"structures.":[38],"previously":[40],"found":[41],"that":[42,58],"symptom":[43,151],"persistence":[44],"was":[45,132,214,236,258],"positively":[46,237],"correlated":[47,147,216,238,260],"hyperconnectivity":[49,171,180,272,285],"medial":[52],"amygdala":[53],"vmPFC/sgACC.":[55],"hypothesized":[57],"might":[61],"also":[62],"display":[63],"similar":[64],"symptom-relevant":[65],"hyperconnectivity.":[66],"Design/Methods:":[67],"computed":[69],"whole-brain":[70],"seed-to-voxel":[71],"from":[73,113,341,427,439,450,464,485,522,532,570],"BOLD":[74],"acquisitions":[76],"at":[77,161,178,187,197,202,225],"3":[78],"timepoints":[79],"(T1=1\u20134days,":[82],"T2=10\u201314days,":[83],"T3=2\u20133months)":[84],"collegiate":[86],"athletes":[87],"(N=31,":[88],"female=14)":[89],"for":[91,324,355,366,380,391,405,411,476,504,552,558],"two":[92],"groups":[93],"of":[94,174,183,193,329,353,378,403,432,443,453,457,509,550,563],"healthy":[95],"age-":[96],"gender-matched":[98],"controls":[99],"(insport,":[100],"N=36,":[101],"female=17;":[102],"non-contact":[103],"sport":[104],"N=37,":[105],"female=15).":[106],"Twelve":[107],"seed":[109],"regions":[110],"were":[111,146],"selected":[112],"Brainnetome":[115],"264":[116],"Atlas":[117],"(voxel":[118],"threshold":[119,124],"uncorrected":[120],"p<0.001,":[121],"two-sided;":[122],"cluster":[123],"FDR-corrected":[125],"p<0.001).":[126],"ANOVA":[127],"followed":[128],"by":[129],"Tukey\u2019s":[130],"HSD":[131],"used":[133],"to":[134,166,310,316,489,496,538],"assess":[135],"differences":[136],"across":[137],"group":[138],"time.":[140],"Subject-level":[141],"insula-PFC":[142,176,185,195],"values":[144],"(Fisher\u2019sZ)":[145],"SCAT-3":[149],"graded":[150],"checklist":[152],"(GSC)":[153],"or":[154,280,337,361,386,423,518,535],"Brief":[155],"Symptom":[156],"Inventory":[157],"18":[158],"(BSI-18)":[159],"scores":[160],"each":[162],"timepoint.":[163],"Results:":[164],"Compared":[165],"controls,":[167],"subjects":[169,201,224],"displayed":[170],"8":[173,192],"13":[175,184,194],"pairs":[177,186,196],"T1,":[179,203],"2":[182],"T2,":[188],"hypoconnectivity":[190,295],"T3.":[198],"Among":[199,222],"right":[206,234,249,298],"dorsal":[207],"dysgranular":[208],"left":[211,229,254,288],"frontal":[212,256],"pole":[213,257],"negatively":[215,259],"GSC":[218,240,244],"BSI-18":[220,262,265],"severity.":[221],"T3,":[226],"ventral":[230,250],"dysgranular/granular":[231,251],"mPFC/dlPFC":[235],"severity":[241,263],"cognitive":[245,293],"subscale;":[246],"lateral":[255],"depression":[266],"anxiety":[268],"subscales.":[269],"Conclusions:":[270],"Acute":[271],"may":[277,290,300],"be":[278],"protective":[279],"compensatory":[281],"SRC.":[283],"Chronic":[284],"signal":[291,301],"persistent":[292,302],"symptoms;":[294],"affective":[303],"symptoms.":[304],"Disclosure:":[305],"Mr.":[306],"Sheridan":[307],"has":[308,314,320,334,346,371,396,420,435,446,460,481,494,500,515,527,543,566],"nothing":[309,315,495],"disclose.":[311,317,497],"Dr.":[312,318,332,344,369,394,418,433,444,458,479,492,498,513,525,541,564],"Bickart":[313],"Thibeault":[319,333],"received":[321,335,347,372,397,421,436,447,461,482,501,516,528,544,567],"personal":[322,348,373,398,502,545],"compensation":[323,349,374,399,503,546],"serving":[325,356,381,406,505,553],"as":[326,407,506,554],"an":[327,338,408,424,507,519,555],"employee":[328,508],"NovaSignal":[330,342,510,523,571],"Corp.":[331,524],"stock":[336,422,517],"ownership":[339,425,520],"interest":[340,426,521],"Inc.":[343],"Giza":[345,370,395,419,434,445,459,480],"range":[352,377,402,549],"$5,000-$9,999":[354,379,551],"on":[357,382],"a":[358,383,486,533],"Scientific":[359,384],"Advisory":[360,385],"Data":[362,387],"Safety":[363,388],"Monitoring":[364,389],"board":[365,390],"Highmark":[367,428],"Interactive.":[368,429],"Novartis":[392],"Pharmaceutical.":[393],"$500-$4,999":[404],"Expert":[409,556],"Witness":[410,557],"Lewitt,":[412],"Hackman,":[413],"Shapiro,":[414],"Marshall":[415],"&":[416],"Harlan.":[417],"The":[430,441,455,561],"institution":[431,442,456,562],"research":[437,448,462,568],"support":[438,449,463,569],"NCAA.":[440],"US":[451],"Department":[452],"Defense.":[454],"UCLA:":[465],"Brain":[466,477],"Injury":[467],"Research":[468],"Center,":[469],"Steve":[470],"Tisch":[471],"BrainSPORT":[472],"Program,":[473],"Easton":[474],"Clinic":[475],"Health.":[478],"publishing":[483],"royalties":[484],"publication":[487],"relating":[488,537],"health":[490,539],"care.":[491,540],"Whitlow":[493],"Hamilton":[499,514,526],"Corp":[511],".":[512],"intellectual":[529],"property":[530],"interests":[531],"discovery":[534],"technology":[536],"Choe":[542,565],"Legal":[559],"Cases.":[560],"(previously":[572],"Neural":[573],"Analytics).":[574]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-12-07T00:00:00"}
