{"id":"https://openalex.org/W4389359751","doi":"https://doi.org/10.1016/j.biopha.2023.115977","title":"New insights into the role of VKORC1 polymorphisms for optimal warfarin dose selection in Caribbean Hispanic patients through an external validation of a population PK/PD model","display_name":"New insights into the role of VKORC1 polymorphisms for optimal warfarin dose selection in Caribbean Hispanic patients through an external validation of a population PK/PD model","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4389359751","doi":"https://doi.org/10.1016/j.biopha.2023.115977","pmid":"https://pubmed.ncbi.nlm.nih.gov/38056237","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10853672"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2023.115977","doi":"https://doi.org/10.1016/j.biopha.2023.115977","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2023.115977","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0753332223017754-ga1_lrg.jpg","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0753332223017754-ga1_lrg.jpg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078729859","display_name":"Karine Rodr\u00edguez-Fern\u00e1ndez","orcid":"https://orcid.org/0009-0008-2065-7188","observed_orcids":["https://orcid.org/0009-0008-2065-7188"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Karine Rodr\u00edguez-Fern\u00e1ndez","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056254135","display_name":"Gledys Reynaldo Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Gledys Reynaldo-Fern\u00e1ndez","raw_affiliation_strings":["Institute of Pharmacy and Foods, University of Havana, Havana 11300, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacy and Foods, University of Havana, Havana 11300, Cuba","institution_ids":["https://openalex.org/I2656126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037771934","display_name":"Stephanie Reyes-Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Stephanie Reyes-Gonz\u00e1lez","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021250252","display_name":"Camila de las Barreras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Camila de las Barreras","raw_affiliation_strings":["Institute of Pharmacy and Foods, University of Havana, Havana 11300, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacy and Foods, University of Havana, Havana 11300, Cuba","institution_ids":["https://openalex.org/I2656126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082604779","display_name":"Leyanis Rodr\u00edguez\u2010Vera","orcid":"https://orcid.org/0000-0003-1688-7008","observed_orcids":["https://orcid.org/0000-0003-1688-7008"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leyanis Rodr\u00edguez-Vera","raw_affiliation_strings":["Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021173615","display_name":"Cornelis P. Vlaar","orcid":"https://orcid.org/0000-0001-5145-8300","observed_orcids":["https://orcid.org/0000-0001-5145-8300"]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Cornelis Vlaar","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001225766","display_name":"Jean\u2010Christophe M. Monbaliu","orcid":"https://orcid.org/0000-0001-6916-8846","observed_orcids":["https://orcid.org/0000-0001-6916-8846"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Christophe M. Monbaliu","raw_affiliation_strings":["Center for Integrated Technology and Organic Synthesis, MolSys Research Unit, University of Li\u00e8ge, B-4000 Li\u00e8ge (Sart Tilman), Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrated Technology and Organic Synthesis, MolSys Research Unit, University of Li\u00e8ge, B-4000 Li\u00e8ge (Sart Tilman), Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045730408","display_name":"Torsten Stelzer","orcid":"https://orcid.org/0000-0003-3881-0183","observed_orcids":["https://orcid.org/0000-0003-3881-0183"]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]},{"id":"https://openalex.org/I1662191","display_name":"University of Puerto Rico at R\u00edo Piedras","ror":"https://ror.org/0453v4r20","country_code":"PR","type":"education","lineage":["https://openalex.org/I1662191","https://openalex.org/I200399037"]},{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Torsten Stelzer","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA; Crystallization Design Institute, Molecular Sciences Research Center, University of Puerto Rico, San Juan 00926, PR, USA","Crystallization Design Institute, Molecular Sciences Research Center, University of Puerto Rico, San Juan 00926, PR, USA","Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA; Crystallization Design Institute, Molecular Sciences Research Center, University of Puerto Rico, San Juan 00926, PR, USA","institution_ids":["https://openalex.org/I158818660"]},{"raw_affiliation_string":"Crystallization Design Institute, Molecular Sciences Research Center, University of Puerto Rico, San Juan 00926, PR, USA","institution_ids":["https://openalex.org/I1662191","https://openalex.org/I200399037"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003831723","display_name":"Jorge Duconge-Soler","orcid":"https://orcid.org/0000-0002-5955-3449","observed_orcids":["https://orcid.org/0000-0002-5955-3449"]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]},{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":true,"raw_author_name":"Jorge Duconge","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA. Electronic address: jorge.duconge@upr.edu","Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA. Electronic address: jorge.duconge@upr.edu","institution_ids":["https://openalex.org/I158818660","https://openalex.org/I200399037"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan 00936, PR, USA","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069976655","display_name":"Victor Mangas Sanjuan","orcid":"https://orcid.org/0000-0002-3388-5023","observed_orcids":["https://orcid.org/0000-0002-3388-5023"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Victor Mangas-Sanjuan","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain; Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain","Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain; Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986","https://openalex.org/I60053951"]},{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5003831723"],"corresponding_institution_ids":["https://openalex.org/I158818660","https://openalex.org/I200399037"],"apc_list":{"value":3050,"currency":"USD","value_usd":3050},"apc_paid":{"value":3050,"currency":"USD","value_usd":3050},"fwci":0.601,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.56086809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"170","issue":null,"first_page":"115977","last_page":"115977"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/vkorc1-polymorphism","display_name":"VKORC1 polymorphism","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cyp2c9-genotype","display_name":"CYP2C9 genotype","score":0.9490000009536743},{"id":"https://openalex.org/keywords/population-pharmacokinetic-pharmacodynamic-model","display_name":"population pharmacokinetic/pharmacodynamic model","score":0.800000011920929},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.800000011920929},{"id":"https://openalex.org/keywords/international-normalized-ratio","display_name":"international normalized ratio","score":0.8029999732971191},{"id":"https://openalex.org/keywords/personalized-anticoagulation","display_name":"personalized anticoagulation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/underrepresented-groups","display_name":"underrepresented groups","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2776318485","wikidata":"https://www.wikidata.org/wiki/Q18045930","display_name":"VKORC1","level":5,"score":0.9568803906440735},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.8934582471847534},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8450589776039124},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.7945085763931274},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6867431402206421},{"id":"https://openalex.org/C2776239304","wikidata":"https://www.wikidata.org/wiki/Q6954915","display_name":"NONMEM","level":3,"score":0.672132670879364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6623924374580383},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.645079493522644},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47740593552589417},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.46540409326553345},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.4574425220489502},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.4440954923629761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39211905002593994},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.33307409286499023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19123074412345886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07545992732048035},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000094859","descriptor_name":"Caribbean People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006630","descriptor_name":"Hispanic or Latino","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064417","descriptor_name":"Vitamin K Epoxide Reductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D065729","descriptor_name":"Cytochrome P-450 CYP2C9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.biopha.2023.115977","doi":"https://doi.org/10.1016/j.biopha.2023.115977","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2023.115977","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0753332223017754-ga1_lrg.jpg","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:38056237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38056237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10853672","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10853672","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10853672/pdf/nihms-1960651.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biomed Pharmacother","raw_type":"Text"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/317347","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/317347","pdf_url":"https://orbi.uliege.be/bitstream/2268/317347/1/_Duconge%20et%20al_2024.pdf","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicine and Pharmacotherapy, 170, 115977 (2024)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:riunet.upv.es:10251/203670","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10251/203670","pdf_url":"https://riunet.upv.es/bitstream/10251/203670/1/Rodriguez-FernandezReynaldo-FernandezReyes-Gonzalez%20-%20New%20insights%20into%20the%20role%20ofi%20VKORC1i%20poly....pdf","source":{"id":"https://openalex.org/S4306400639","display_name":"RiuNet (Universitat Polit\u00e8cnica de Val\u00e8ncia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60053951","host_organization_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I60053951"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:roderic.uv.es:10550/91915","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10550/91915","pdf_url":"https://roderic.uv.es/bitstreams/10535502-0946-4642-a77c-35ba3ff54e00/download","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rodr\u00edguez-Fern\u00e1ndez, Karine Mangas Sanjuan, Victor 2023 New insights into the role of VKORC1 polymorphisms for optimal warfarin dose selection in Caribbean Hispanic patients through an external validation of a population PK/PD model Biomedicine &amp; Pharmacotherapy 170","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2023.115977","doi":"https://doi.org/10.1016/j.biopha.2023.115977","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2023.115977","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0753332223017754-ga1_lrg.jpg","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1495376708","display_name":null,"funder_award_id":"80NSSC19M0148","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G9000882464","display_name":"Merging artificial intelligence (AI) and pharmacometrics to elucidate gene-drug interactions linked to clopidogrel responsiveness in genetically heterogeneous patients","funder_award_id":"R16GM149372","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320322037","display_name":"Nuclear Safety and Security Commission","ror":"https://ror.org/05qk3ge34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338283","display_name":"Office of Experimental Program to Stimulate Competitive Research","ror":"https://ror.org/04k9mqs78"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389359751.pdf","grobid_xml":"https://content.openalex.org/works/W4389359751.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1499157913","https://openalex.org/W1515782956","https://openalex.org/W1920947146","https://openalex.org/W1977244553","https://openalex.org/W1999521622","https://openalex.org/W2006640042","https://openalex.org/W2042553471","https://openalex.org/W2058734479","https://openalex.org/W2064817897","https://openalex.org/W2068291372","https://openalex.org/W2068476516","https://openalex.org/W2071697045","https://openalex.org/W2102553995","https://openalex.org/W2103655515","https://openalex.org/W2119810234","https://openalex.org/W2125650394","https://openalex.org/W2126321110","https://openalex.org/W2152057496","https://openalex.org/W2157839219","https://openalex.org/W2526157531","https://openalex.org/W2588108371","https://openalex.org/W2601238907","https://openalex.org/W2612983761","https://openalex.org/W2772649872","https://openalex.org/W3081128082","https://openalex.org/W3081521734","https://openalex.org/W4226104943","https://openalex.org/W4323037015"],"related_works":["https://openalex.org/W2417199667","https://openalex.org/W2152057496","https://openalex.org/W2127164331","https://openalex.org/W2079472374","https://openalex.org/W7037159946","https://openalex.org/W2068291372","https://openalex.org/W1947958445","https://openalex.org/W2158071144","https://openalex.org/W2003696901","https://openalex.org/W1502383101"],"abstract_inverted_index":{"Warfarin,":[0],"an":[1],"oral":[2],"anticoagulant,":[3],"has":[4],"been":[5],"used":[6,82],"for":[7,47,101,122,137,168,244],"decades":[8],"to":[9,39,58,83,117,154,171,210,224],"prevent":[10],"thromboembolic":[11],"events.":[12],"The":[13,92,157],"complex":[14],"interplay":[15],"between":[16],"CYP2C9":[17,74,181],"and":[18,24,57,73,75,140,146,182,191,228,235,247],"VKORC1":[19,76,142,183],"genotypes":[20,77,170,184],"on":[21,52,64,127],"warfarin":[22,51,163,213],"PK":[23],"PD":[25,99],"properties":[26],"is":[27],"not":[28],"fully":[29],"understood":[30],"in":[31,68,89,150,215,219,251],"special":[32],"sub-groups":[33],"of":[34,50,95,108,165,180,206],"patients.":[35,71],"This":[36,201],"study":[37],"aimed":[38],"externally":[40],"validate":[41],"a":[42,85,96],"population":[43,86,152,207],"pharmacokinetic/pharmacodynamic":[44],"(PK/PD)":[45],"model":[46,88,100],"the":[48,65,109,204,242],"effect":[49],"international":[53],"normalized":[54],"ratio":[55],"(INR)":[56],"evaluate":[59],"optimal":[60,119],"dosing":[61,120,159,214],"strategies":[62,121],"based":[63],"selected":[66],"covariates":[67],"Caribbean":[69],"Hispanic":[70],"INR,":[72],"from":[78],"138":[79],"patients":[80],"were":[81,115],"develop":[84],"PK/PD":[87,208],"NONMEM":[90],".":[91],"structural":[93],"definition":[94],"previously":[97],"published":[98],"INR":[102,130,174],"was":[103,112],"implemented.":[104],"A":[105],"numerical":[106],"evaluation":[107],"parameter-covariate":[110],"relationship":[111],"performed.":[113],"Simulations":[114],"conducted":[116],"determine":[118],"each":[123],"genotype":[124],"combinations,":[125],"focusing":[126],"achieving":[128],"therapeutic":[129],"levels.":[131],"Findings":[132],"revealed":[133],"elevated":[134],"IC":[135],"50":[136],"G/G,":[138],"G/A,":[139],"A/A":[141],"haplotypes":[143],"(11.76,":[144],"10.49,":[145],"9.22":[147],"mg/L,":[148],"respectively),":[149],"this":[151,238],"compared":[153],"previous":[155],"reports.":[156],"model-guided":[158],"analysis":[160],"recommended":[161],"daily":[162],"doses":[164],"3\u20135":[166],"mg":[167,199],"most":[169],"maintain":[172],"desired":[173],"levels,":[175],"although":[176],"subjects":[177],"with":[178],"combination":[179],"*":[185,188,192],"2/*":[186,189,193],"2-,":[187],"3-":[190],"5-A/A":[194],"would":[195],"require":[196],"only":[197],"1":[198],"daily.":[200],"research":[202],"underscores":[203],"potential":[205],"modeling":[209],"inform":[211],"personalized":[212],"populations":[216],"typically":[217],"underrepresented":[218],"clinical":[220,236],"studies,":[221],"potentially":[222],"leading":[223],"improved":[225],"treatment":[226],"outcomes":[227],"patient":[229,253],"safety.":[230],"By":[231],"integrating":[232],"genetic":[233],"factors":[234],"data,":[237],"approach":[239],"could":[240],"pave":[241],"way":[243],"more":[245],"effective":[246],"tailored":[248],"anticoagulation":[249],"therapy":[250],"diverse":[252],"groups.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-12-06T00:00:00"}
