{"id":"https://openalex.org/W4389344764","doi":"https://doi.org/10.1177/09636897231215233","title":"Isolation, Expansion, and Endoscopic Delivery of Autologous Enteric Neuronal Stem Cells in Swine","display_name":"Isolation, Expansion, and Endoscopic Delivery of Autologous Enteric Neuronal Stem Cells in Swine","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4389344764","doi":"https://doi.org/10.1177/09636897231215233","pmid":"https://pubmed.ncbi.nlm.nih.gov/38049927","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10697035"},"language":"en","primary_location":{"id":"doi:10.1177/09636897231215233","doi":"https://doi.org/10.1177/09636897231215233","is_oa":true,"landing_page_url":"https://doi.org/10.1177/09636897231215233","pdf_url":null,"source":{"id":"https://openalex.org/S165333527","display_name":"Cell Transplantation","issn_l":"0963-6897","issn":["0963-6897","1555-3892"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/09636897231215233","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091865934","display_name":"Ryo Hotta","orcid":"https://orcid.org/0000-0001-9890-8241","observed_orcids":["https://orcid.org/0000-0001-9890-8241"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryo Hotta","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9890-8241","affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024394546","display_name":"Weikang Pan","orcid":"https://orcid.org/0000-0003-1400-7222","observed_orcids":["https://orcid.org/0000-0003-1400-7222"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weikang Pan","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051149813","display_name":"Sukhada M. Bhave","orcid":"https://orcid.org/0000-0002-5508-2571","observed_orcids":["https://orcid.org/0000-0002-5508-2571"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sukhada Bhave","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071006771","display_name":"N\u00e1ndor Nagy","orcid":"https://orcid.org/0000-0002-6223-5214","observed_orcids":["https://orcid.org/0000-0002-6223-5214"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Nandor Nagy","raw_affiliation_strings":["Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024681677","display_name":"Rhian G Stavely","orcid":"https://orcid.org/0000-0002-5099-3704","observed_orcids":["https://orcid.org/0000-0002-5099-3704"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rhian Stavely","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066306510","display_name":"Takahiro Ohkura","orcid":"https://orcid.org/0000-0002-4168-167X","observed_orcids":["https://orcid.org/0000-0002-4168-167X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takahiro Ohkura","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034166738","display_name":"Kumar Krishnan","orcid":"https://orcid.org/0000-0002-9962-8732","observed_orcids":["https://orcid.org/0000-0002-9962-8732"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kumar Krishnan","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014169253","display_name":"Geoffrey de Couto","orcid":"https://orcid.org/0000-0002-1158-0560","observed_orcids":["https://orcid.org/0000-0002-1158-0560"]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Geoffrey de Couto","raw_affiliation_strings":["Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Richard Myers","raw_affiliation_strings":["Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057259429","display_name":"Luis Rodr\u0131\u0301guez-Borlado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Luis Rodriguez-Borlado","raw_affiliation_strings":["Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025418303","display_name":"Alan J. Burns","orcid":"https://orcid.org/0000-0002-1725-1071","observed_orcids":["https://orcid.org/0000-0002-1725-1071"]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","JP","US"],"is_corresponding":false,"raw_author_name":"Alan J. Burns","raw_affiliation_strings":["Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA","Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"raw_affiliation_string":"Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027979899","display_name":"Allan M. Goldstein","orcid":"https://orcid.org/0000-0003-2106-847X","observed_orcids":["https://orcid.org/0000-0003-2106-847X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan M. Goldstein","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5027979899"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":2.4006,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.8945565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"32","issue":null,"first_page":"9636897231215233","last_page":"9636897231215233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.1445000022649765,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0989999994635582,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enteric-nervous-system","display_name":"enteric nervous system","score":0.9190000295639038},{"id":"https://openalex.org/keywords/autologous-cell-transplantation","display_name":"autologous cell transplantation","score":0.824999988079071},{"id":"https://openalex.org/keywords/neurospheres","display_name":"neurospheres","score":0.7250000238418579},{"id":"https://openalex.org/keywords/low-oxygen-culture","display_name":"low oxygen culture","score":0.8130000233650208},{"id":"https://openalex.org/keywords/glial-differentiation","display_name":"glial differentiation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cell-isolation-and-expansion","display_name":"cell isolation and expansion","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.8038167953491211},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7928584218025208},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6821669340133667},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.6067858934402466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.544455349445343},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.5100393891334534},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4410571753978729},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43791717290878296},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4336029291152954},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.4320240914821625},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38725733757019043},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.38200703263282776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3435057997703552},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2630932331085205},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2552359700202942},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24874907732009888},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017615","descriptor_name":"Enteric Nervous System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1177/09636897231215233","doi":"https://doi.org/10.1177/09636897231215233","is_oa":true,"landing_page_url":"https://doi.org/10.1177/09636897231215233","pdf_url":null,"source":{"id":"https://openalex.org/S165333527","display_name":"Cell Transplantation","issn_l":"0963-6897","issn":["0963-6897","1555-3892"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Transplantation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10697035","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10697035","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10697035/pdf/10.1177_09636897231215233.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Transplant","raw_type":"Text"},{"id":"pmid:38049927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38049927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell transplantation","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3jq5g2bg","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3jq5g2bg","pdf_url":"https://escholarship.org/content/qt3jq5g2bg/qt3jq5g2bg.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2be94383c769473181d73fdc2d28dfb1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2be94383c769473181d73fdc2d28dfb1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Transplantation, Vol 32 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/09636897231215233","doi":"https://doi.org/10.1177/09636897231215233","is_oa":true,"landing_page_url":"https://doi.org/10.1177/09636897231215233","pdf_url":null,"source":{"id":"https://openalex.org/S165333527","display_name":"Cell Transplantation","issn_l":"0963-6897","issn":["0963-6897","1555-3892"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F1462049487","display_name":"Takeda Development Center Americas","ror":null},{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1497542682","https://openalex.org/W1849652248","https://openalex.org/W1888386056","https://openalex.org/W1976989940","https://openalex.org/W1977148261","https://openalex.org/W1994068179","https://openalex.org/W2010998840","https://openalex.org/W2013606469","https://openalex.org/W2019240380","https://openalex.org/W2023718751","https://openalex.org/W2029487190","https://openalex.org/W2033261352","https://openalex.org/W2033798970","https://openalex.org/W2042750894","https://openalex.org/W2048835849","https://openalex.org/W2062395814","https://openalex.org/W2068755072","https://openalex.org/W2073108014","https://openalex.org/W2073186828","https://openalex.org/W2089368087","https://openalex.org/W2100942332","https://openalex.org/W2116965927","https://openalex.org/W2117556516","https://openalex.org/W2120131466","https://openalex.org/W2123142347","https://openalex.org/W2134186925","https://openalex.org/W2150770577","https://openalex.org/W2157902911","https://openalex.org/W2159305532","https://openalex.org/W2168329818","https://openalex.org/W2204168958","https://openalex.org/W2216654280","https://openalex.org/W2252541578","https://openalex.org/W2264853099","https://openalex.org/W2274531174","https://openalex.org/W2290001148","https://openalex.org/W2316205686","https://openalex.org/W2334193991","https://openalex.org/W2529790295","https://openalex.org/W2550899530","https://openalex.org/W2568033066","https://openalex.org/W2570218720","https://openalex.org/W2572852851","https://openalex.org/W2727727649","https://openalex.org/W2893675669","https://openalex.org/W2911795105","https://openalex.org/W2916661695","https://openalex.org/W2981950096","https://openalex.org/W3008913904","https://openalex.org/W3035825274","https://openalex.org/W3087783362","https://openalex.org/W3157095589","https://openalex.org/W3190810627","https://openalex.org/W3196876928","https://openalex.org/W4211042350","https://openalex.org/W4214568105","https://openalex.org/W4307968322","https://openalex.org/W4317904514","https://openalex.org/W4322767169"],"related_works":["https://openalex.org/W2030495590","https://openalex.org/W4393011262","https://openalex.org/W2320275480","https://openalex.org/W4303940458","https://openalex.org/W4403912528","https://openalex.org/W2252541578","https://openalex.org/W2204168958","https://openalex.org/W2024544528","https://openalex.org/W3032180914","https://openalex.org/W2946115044"],"abstract_inverted_index":{"The":[0],"enteric":[1],"nervous":[2],"system":[3],"(ENS)":[4],"is":[5],"an":[6,89],"extensive":[7],"network":[8],"of":[9,16,29,51,78,92,137,227,236],"neurons":[10],"and":[11,49,88,118,205,224,240,246],"glia":[12],"within":[13,218],"the":[14,17,30,47,64,79,83,100,106,177,193,200,234],"wall":[15],"gastrointestinal":[18],"(GI)":[19],"tract":[20],"that":[21,153],"regulates":[22],"many":[23],"essential":[24],"GI":[25],"functions.":[26],"Consequently,":[27],"disorders":[28],"ENS":[31,80],"due":[32],"to":[33,42,61,75,109,125,191,215,253],"developmental":[34],"defects,":[35],"inflammation,":[36],"infection,":[37],"or":[38,85],"age-associated":[39],"neurodegeneration":[40],"lead":[41],"serious":[43],"neurointestinal":[44,258],"diseases.":[45,259],"Despite":[46],"prevalence":[48],"severity":[50],"these":[52],"diseases,":[53],"effective":[54],"treatments":[55],"are":[56],"lacking":[57],"as":[58,151],"they":[59,182],"fail":[60],"directly":[62],"address":[63,110],"underlying":[65],"pathology.":[66],"Neuronal":[67],"stem":[68,93,132,146,163],"cell":[69,114,238],"therapy":[70,256],"represents":[71],"a":[72,121,135,243],"promising":[73],"approach":[74],"treating":[76],"diseases":[77],"by":[81,98,167],"replacing":[82],"absent":[84],"injured":[86],"neurons,":[87],"autologous":[90,237],"source":[91],"cells":[94,133,147,164],"would":[95],"be":[96],"optimal":[97],"obviating":[99],"need":[101],"for":[102,257],"immunosuppression.":[103],"We":[104,128],"utilized":[105,190],"swine":[107,179],"model":[108],"key":[111],"questions":[112],"concerning":[113],"isolation,":[115],"delivery,":[116],"engraftment,":[117],"fate":[119],"in":[120,156],"large":[122],"animal":[123],"relevant":[124],"human":[126],"therapy.":[127],"successfully":[129],"isolated":[130],"neural":[131],"from":[134,141,180],"segment":[136],"small":[138],"intestine":[139],"resected":[140],"1-month-old":[142],"swine.":[143],"Enteric":[144,161],"neuronal":[145,162],"(ENSCs)":[148],"were":[149,165,213],"expanded":[150],"neurospheres":[152,196],"grew":[154],"optimally":[155],"low-oxygen":[157],"(5%)":[158],"culture":[159],"conditions.":[160],"labeled":[166],"lentiviral":[168],"green":[169],"fluorescent":[170],"protein":[171],"(GFP)":[172],"transduction,":[173],"then":[174,189],"transplanted":[175],"into":[176,199],"same":[178],"which":[181],"had":[183],"been":[184],"harvested.":[185],"Endoscopic":[186],"ultrasound":[187],"was":[188],"deliver":[192],"ENSCs":[194,212],"(10,000-30,000":[195],"per":[197],"animal)":[198],"rectal":[201,219],"wall.":[202],"At":[203],"10":[204],"28":[206],"days":[207],"following":[208],"injection,":[209],"autologously":[210],"derived":[211],"found":[214],"have":[216],"engrafted":[217],"wall,":[220],"with":[221],"neuroglial":[222],"differentiation":[223],"no":[225],"evidence":[226],"ectopic":[228],"spreading.":[229],"These":[230],"findings":[231],"strongly":[232],"support":[233],"feasibility":[235],"isolation":[239],"delivery":[241],"using":[242],"clinically":[244],"useful":[245],"minimally":[247],"invasive":[248],"technique,":[249],"bringing":[250],"us":[251],"closer":[252],"first-in-human":[254],"ENSC":[255]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-06T00:00:00"}