{"id":"https://openalex.org/W4389338016","doi":"https://doi.org/10.1038/s41420-023-01719-0","title":"RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1\u03b1-induced metabolic reprogramming in hepatocellular carcinoma","display_name":"RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1\u03b1-induced metabolic reprogramming in hepatocellular carcinoma","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4389338016","doi":"https://doi.org/10.1038/s41420-023-01719-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/38052785","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10697958"},"language":"en","primary_location":{"id":"doi:10.1038/s41420-023-01719-0","doi":"https://doi.org/10.1038/s41420-023-01719-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41420-023-01719-0","pdf_url":"https://www.nature.com/articles/s41420-023-01719-0.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41420-023-01719-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042912637","display_name":"Qingqing Yang","orcid":"https://orcid.org/0000-0002-9950-8984","observed_orcids":["https://orcid.org/0000-0002-9950-8984","https://orcid.org/0009-0005-9670-0662","https://orcid.org/0009-0008-3074-7515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingqing Yang","raw_affiliation_strings":["Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiangrui Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119554","display_name":"Yancheng First People's Hospital","ror":"https://ror.org/02rbkz523","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119554"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangrui Meng","raw_affiliation_strings":["Yancheng Medical Research Center of Nanjing University Medical School, Yancheng First Hospital, Affiliated Hospital of Nanjing University Medical School, The First People's Hospital of Yancheng, 224006, Yancheng, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yancheng Medical Research Center of Nanjing University Medical School, Yancheng First Hospital, Affiliated Hospital of Nanjing University Medical School, The First People's Hospital of Yancheng, 224006, Yancheng, Jiangsu, China","institution_ids":["https://openalex.org/I4210119554","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jin Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Chen","raw_affiliation_strings":["Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113063071","display_name":"Xiangsu Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiangsu Li","raw_affiliation_strings":["Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100612176","display_name":"Yang Huang","orcid":"https://orcid.org/0000-0001-7177-5020","observed_orcids":["https://orcid.org/0000-0001-7177-5020","https://orcid.org/0009-0000-3527-2936"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Huang","raw_affiliation_strings":["Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108883207","display_name":"Xueyi Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueyi Xiao","raw_affiliation_strings":["Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103040078","display_name":"Rongqing Li","orcid":"https://orcid.org/0009-0003-6202-9407","observed_orcids":["https://orcid.org/0009-0003-6202-9407","https://orcid.org/0000-0003-1501-6171"]},"institutions":[{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rongqing Li","raw_affiliation_strings":["Department of Medical Genetics and Prenatal Diagnosis, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 225399, Taizhou, Jiangsu, China. lee15722557261@163.com","Department of Medical Genetics and Prenatal Diagnosis, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 225399, Taizhou, Jiangsu, China"],"raw_orcid":"https://orcid.org/0009-0003-6202-9407","affiliations":[{"raw_affiliation_string":"Department of Medical Genetics and Prenatal Diagnosis, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 225399, Taizhou, Jiangsu, China. lee15722557261@163.com","institution_ids":["https://openalex.org/I4210122818","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Medical Genetics and Prenatal Diagnosis, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 225399, Taizhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210122818","https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100757917","display_name":"Xudong Wu","orcid":"https://orcid.org/0000-0002-2881-954X","observed_orcids":["https://orcid.org/0000-0002-2881-954X"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xudong Wu","raw_affiliation_strings":["Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China. hnjsycwxd@163.com","Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-2881-954X","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China. hnjsycwxd@163.com","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Department of Gastroenterology, The Yancheng Clinical College of Xuzhou Medical University, 224006, Yancheng, Jiangsu, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100757917","https://openalex.org/A5103040078"],"corresponding_institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210122818","https://openalex.org/I83519826"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":2.8363,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.92948268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"440","last_page":"440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9259999990463257},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.9789999723434448},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ribosomal-proteins","display_name":"ribosomal proteins","score":0.6729999780654907},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7369999885559082},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.6816174983978271},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6714444756507874},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6476784944534302},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6407039165496826},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6074346303939819},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5414599776268005},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5360707640647888},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5262928605079651},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5056397914886475},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5026423931121826},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.4386081397533417},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41868138313293457},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3646635413169861},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30654269456863403},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2516498565673828},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17542767524719238},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.11634886264801025},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05956465005874634},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41420-023-01719-0","doi":"https://doi.org/10.1038/s41420-023-01719-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41420-023-01719-0","pdf_url":"https://www.nature.com/articles/s41420-023-01719-0.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10697958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10697958","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10697958/pdf/41420_2023_Article_1719.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discov","raw_type":"Text"},{"id":"pmid:38052785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38052785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death discovery","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6cca427651004d7aa0f8de416020b2d3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6cca427651004d7aa0f8de416020b2d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41420-023-01719-0","doi":"https://doi.org/10.1038/s41420-023-01719-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41420-023-01719-0","pdf_url":"https://www.nature.com/articles/s41420-023-01719-0.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4247087044","display_name":null,"funder_award_id":"BK20200265","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G4257225966","display_name":null,"funder_award_id":"ZDB2020033","funder_id":"https://openalex.org/F4320334975","funder_display_name":"Key Medical Subjects of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320317802","display_name":"Jiangsu Commission of Health","ror":null},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334975","display_name":"Key Medical Subjects of Jiangsu Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389338016.pdf","grobid_xml":"https://content.openalex.org/works/W4389338016.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1706227909","https://openalex.org/W1985458442","https://openalex.org/W2011906599","https://openalex.org/W2022101765","https://openalex.org/W2049591326","https://openalex.org/W2062515127","https://openalex.org/W2071361463","https://openalex.org/W2072451938","https://openalex.org/W2074824347","https://openalex.org/W2079999658","https://openalex.org/W2085153086","https://openalex.org/W2103461167","https://openalex.org/W2115894077","https://openalex.org/W2127934565","https://openalex.org/W2130503287","https://openalex.org/W2234115940","https://openalex.org/W2295486337","https://openalex.org/W2395626624","https://openalex.org/W2403473377","https://openalex.org/W2415939518","https://openalex.org/W2790705019","https://openalex.org/W2803752613","https://openalex.org/W2954966589","https://openalex.org/W2994673696","https://openalex.org/W3004434748","https://openalex.org/W3021610682","https://openalex.org/W3080758841","https://openalex.org/W3083157135","https://openalex.org/W3097121612","https://openalex.org/W3133656293","https://openalex.org/W3172823398","https://openalex.org/W3174177463","https://openalex.org/W3204325474","https://openalex.org/W4200369270","https://openalex.org/W4205227392","https://openalex.org/W4205930233","https://openalex.org/W4220817929","https://openalex.org/W4225146220","https://openalex.org/W4245115391","https://openalex.org/W4285492624","https://openalex.org/W4290742145","https://openalex.org/W4291824965","https://openalex.org/W4294379421","https://openalex.org/W4297540742","https://openalex.org/W4304114153","https://openalex.org/W4308891835","https://openalex.org/W4362607663","https://openalex.org/W4367042839"],"related_works":["https://openalex.org/W3163323323","https://openalex.org/W4391918025","https://openalex.org/W4403225437","https://openalex.org/W4411575879","https://openalex.org/W7167483009","https://openalex.org/W4221116798","https://openalex.org/W4389789500","https://openalex.org/W4293749450","https://openalex.org/W4405280207","https://openalex.org/W4387061257"],"abstract_inverted_index":{"Metabolic":[0],"reprogramming":[1,19],"is":[2,11,26,66],"a":[3,55,82,166,207],"major":[4],"feature":[5],"of":[6,13,42,58,88,114,129,146,176,181],"cancer,":[7],"and":[8,31,72,91,120,132,172],"aerobic":[9,118,170],"glycolysis":[10,119,171,198],"one":[12],"the":[14,40,50,86,100,112,127,133,144,149,174,182,188,193],"most":[15],"widely":[16],"studied":[17],"metabolic":[18,167],"processes.":[20],"Acidic":[21],"ribosome":[22],"protein":[23,195],"P2":[24],"(RPLP2)":[25],"associated":[27],"with":[28,69],"both":[29],"tumorigenesis":[30],"endoplasmic":[32],"reticulum":[33],"stress.":[34],"However,":[35],"limited":[36],"knowledge":[37],"exists":[38],"regarding":[39],"role":[41,110],"RPLP2":[43,59,64,80,123,164,196],"in":[44,60,111],"hepatocellular":[45],"carcinoma":[46],"(HCC)":[47],"progression.":[48,202],"In":[49,158],"present":[51],"study,":[52],"we":[53],"observed":[54],"significant":[56],"upregulation":[57],"HCC":[61,96,130,177,201,212],"tissues.":[62],"Moreover,":[63],"expression":[65,87],"closely":[67],"correlated":[68],"patient":[70],"prognosis":[71],"survival.":[73],"The":[74],"subsequent":[75],"experimental":[76],"validation":[77],"demonstrated":[78],"that":[79,163],"exerted":[81],"regulatory":[83],"effect":[84],"on":[85,126],"glycolytic":[89],"enzymes":[90],"lactate":[92],"production,":[93],"thereby":[94],"facilitating":[95],"cell":[97,121],"proliferation.":[98],"Mechanistically,":[99],"PI3K/AKT":[101,135],"signalling":[102],"pathway":[103,136],"was":[104],"found":[105],"to":[106,153,199],"play":[107],"an":[108],"important":[109],"regulation":[113],"hypoxia-inducible":[115],"factor-1\u03b1":[116],"(HIF-1\u03b1)-mediated":[117],"growth.":[122],"activates":[124],"TLR4":[125],"surface":[128],"cells":[131],"downstream":[134],"through":[137,178],"autocrine":[138],"signalling.":[139],"This":[140],"activation":[141,180],"then":[142],"facilitates":[143,173],"entry":[145],"HIF-1\u03b1":[147],"into":[148],"nucleus,":[150],"enabling":[151],"it":[152],"fulfil":[154],"its":[155],"transcriptional":[156],"function.":[157],"conclusion,":[159],"our":[160],"findings":[161,204],"suggested":[162],"induces":[165],"shift":[168],"towards":[169],"progression":[175],"TLR4-dependent":[179],"PI3K/AKT/HIF-1\u03b1":[183],"pathway.":[184],"Our":[185],"study":[186],"revealed":[187],"novel":[189],"mechanism":[190],"by":[191],"which":[192],"ribosomal":[194],"regulates":[197],"promote":[200],"These":[203],"may":[205],"offer":[206],"potential":[208],"therapeutic":[209],"target":[210],"for":[211],"treatment.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-06T00:00:00"}