{"id":"https://openalex.org/W4389334002","doi":"https://doi.org/10.1111/jgs.18702","title":"Fall risk and cardiovascular outcomes of first\u2010line antihypertensive medications in nursing home residents","display_name":"Fall risk and cardiovascular outcomes of first\u2010line antihypertensive medications in nursing home residents","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4389334002","doi":"https://doi.org/10.1111/jgs.18702","pmid":"https://pubmed.ncbi.nlm.nih.gov/38051600","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10947930"},"language":"en","primary_location":{"id":"doi:10.1111/jgs.18702","doi":"https://doi.org/10.1111/jgs.18702","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jgs.18702","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jgs.18702","source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jgs.18702","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103101213","display_name":"Sarah D. Berry","orcid":"https://orcid.org/0000-0002-3793-4187","observed_orcids":["https://orcid.org/0000-0002-3793-4187"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah D. Berry","raw_affiliation_strings":["Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA","Hebrew Senior Life, Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Roslindale, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Hebrew Senior Life, Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Roslindale, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046389212","display_name":"Kaleen N. Hayes","orcid":"https://orcid.org/0000-0002-1122-0071","observed_orcids":["https://orcid.org/0000-0002-1122-0071"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaleen Hayes","raw_affiliation_strings":["Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA"],"raw_orcid":"https://orcid.org/0000-0002-1122-0071","affiliations":[{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100657011","display_name":"Yoojin Lee","orcid":"https://orcid.org/0000-0003-2475-5857","observed_orcids":["https://orcid.org/0000-0003-2475-5857"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoojin Lee","raw_affiliation_strings":["Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100763110","display_name":"Yuan Zhang","orcid":"https://orcid.org/0000-0003-3049-9482","observed_orcids":["https://orcid.org/0000-0003-3049-9482"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Zhang","raw_affiliation_strings":["Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023135047","display_name":"Dae Hyun Kim","orcid":"https://orcid.org/0000-0001-7290-6838","observed_orcids":["https://orcid.org/0000-0001-7290-6838","https://orcid.org/0000-0003-4315-9145"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dae H. Kim","raw_affiliation_strings":["Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA","Hebrew Senior Life, Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Roslindale, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0001-7290-6838","affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Hebrew Senior Life, Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Roslindale, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075169530","display_name":"Darae Ko","orcid":"https://orcid.org/0000-0002-1174-7535","observed_orcids":["https://orcid.org/0000-0002-1174-7535"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darae Ko","raw_affiliation_strings":["Hebrew Senior Life, Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Roslindale, Massachusetts, USA","Section of Cardiovascular Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebrew Senior Life, Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Roslindale, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123879"]},{"raw_affiliation_string":"Section of Cardiovascular Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011048149","display_name":"Douglas P. Kiel","orcid":"https://orcid.org/0000-0001-8474-0310","observed_orcids":["https://orcid.org/0000-0001-8474-0310"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas P. Kiel","raw_affiliation_strings":["Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA","Hebrew Senior Life, Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Roslindale, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Hebrew Senior Life, Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Roslindale, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010769904","display_name":"Lori A. Daiello","orcid":"https://orcid.org/0000-0003-3159-8597","observed_orcids":["https://orcid.org/0000-0003-3159-8597"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori Daielo","raw_affiliation_strings":["Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329638","display_name":"Tingting Zhang","orcid":"https://orcid.org/0000-0002-7447-8504","observed_orcids":["https://orcid.org/0000-0002-7447-8504"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingting Zhang","raw_affiliation_strings":["Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026584861","display_name":"Andrew R. Zullo","orcid":"https://orcid.org/0000-0003-1673-4570","observed_orcids":["https://orcid.org/0000-0003-1673-4570"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew R. Zullo","raw_affiliation_strings":["Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA","Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA"],"raw_orcid":"https://orcid.org/0000-0003-1673-4570","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health  Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5103101213"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210123879"],"apc_list":{"value":4530,"currency":"USD","value_usd":4530},"apc_paid":null,"fwci":0.4432,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.60511698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"72","issue":"3","first_page":"682","last_page":"692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.5800999999046326,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.5800999999046326,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.32499998807907104,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11376","display_name":"Geriatric Care and Nursing Homes","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fall-risk","display_name":"fall risk","score":0.7509999871253967},{"id":"https://openalex.org/keywords/nursing-home-residents","display_name":"nursing home residents","score":0.949999988079071},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system-inhibitors","display_name":"renin-angiotensin-aldosterone system inhibitors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thiazide-diuretics","display_name":"thiazide diuretics","score":1.0},{"id":"https://openalex.org/keywords/fall-injuries","display_name":"fall-related injuries","score":0.75},{"id":"https://openalex.org/keywords/hip-fracture","display_name":"hip fracture","score":0.921999990940094},{"id":"https://openalex.org/keywords/major-adverse-cardiac-events","display_name":"major adverse cardiac events","score":0.925000011920929},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5849999785423279},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cardiovascular-outcomes","display_name":"cardiovascular outcomes","score":0.546999990940094},{"id":"https://openalex.org/keywords/medicare-beneficiaries","display_name":"Medicare beneficiaries","score":0.3059999942779541},{"id":"https://openalex.org/keywords/limited-life-expectancy","display_name":"limited life expectancy","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9427050352096558},{"id":"https://openalex.org/C2779646130","wikidata":"https://www.wikidata.org/wiki/Q411347","display_name":"Amlodipine","level":3,"score":0.7172881364822388},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6983282566070557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5153300166130066},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4876915216445923},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.48651641607284546},{"id":"https://openalex.org/C2780437262","wikidata":"https://www.wikidata.org/wiki/Q665843","display_name":"Thiazide","level":3,"score":0.4844810664653778},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.461629182100296},{"id":"https://openalex.org/C2780739214","wikidata":"https://www.wikidata.org/wiki/Q6723023","display_name":"Mace","level":4,"score":0.4124599099159241},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.385280042886734},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.34845805168151855},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.21496164798736572},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.17332687973976135},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1654658317565918}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006278","descriptor_name":"Medicare","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009735","descriptor_name":"Nursing Homes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D049971","descriptor_name":"Thiazides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/jgs.18702","doi":"https://doi.org/10.1111/jgs.18702","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jgs.18702","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jgs.18702","source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},{"id":"pmid:38051600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38051600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10947930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10947930","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10947930/pdf/nihms-1946378.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Geriatr Soc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/jgs.18702","doi":"https://doi.org/10.1111/jgs.18702","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jgs.18702","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jgs.18702","source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G269004622","display_name":"Safe Cardiometabolic Drug Prescribing to Prevent Injury in Nursing Home Residents","funder_award_id":"RF1AG061221","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4686765747","display_name":"A Clinical Prediction Tool to Guide Treatment of Osteoporosis in the Nursing Home","funder_award_id":"R01AG045441","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6666935566","display_name":null,"funder_award_id":"1RF1AG045441","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000865940","display_name":"Risk-Guided Atrial Fibrillation Surveillance in Ischemic Stroke","funder_award_id":"K23HL151903","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389334002.pdf","grobid_xml":"https://content.openalex.org/works/W4389334002.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1543112878","https://openalex.org/W1588563799","https://openalex.org/W1971918017","https://openalex.org/W1983311436","https://openalex.org/W2087018232","https://openalex.org/W2088027173","https://openalex.org/W2134394834","https://openalex.org/W2146050890","https://openalex.org/W2152933085","https://openalex.org/W2166089332","https://openalex.org/W2475261460","https://openalex.org/W2509173468","https://openalex.org/W2549805816","https://openalex.org/W2562329777","https://openalex.org/W2765979443","https://openalex.org/W2768267412","https://openalex.org/W2770837559","https://openalex.org/W2790467552","https://openalex.org/W2791636814","https://openalex.org/W2810429480","https://openalex.org/W2896156603","https://openalex.org/W2921012991","https://openalex.org/W2944271381","https://openalex.org/W2952502123","https://openalex.org/W2976142407","https://openalex.org/W2981993384","https://openalex.org/W3127907964","https://openalex.org/W3162502115","https://openalex.org/W3199122051","https://openalex.org/W4210347219","https://openalex.org/W4236540794","https://openalex.org/W4295151945","https://openalex.org/W4311448277","https://openalex.org/W4364352257"],"related_works":["https://openalex.org/W1997101859","https://openalex.org/W2976142407","https://openalex.org/W2810429480","https://openalex.org/W4250652441","https://openalex.org/W2363773630","https://openalex.org/W2921270983","https://openalex.org/W2152933085","https://openalex.org/W2888892822","https://openalex.org/W2099699400","https://openalex.org/W3013272618"],"abstract_inverted_index":{"BACKGROUND:":[0],"Little":[1],"evidence":[2],"exists":[3],"about":[4],"the":[5,31,111,117,289],"comparative":[6],"effects":[7],"of":[8,33,60,113,119,143,186,238,278,288],"first-line":[9,42,71,290],"antihypertensive":[10,43,72,114,153,291],"medications":[11,73],"(i.e.,":[12,86],"renin-angiotensin-aldosterone":[13],"converting":[14],"enzyme":[15],"inhibitors":[16],"(RAASi),":[17],"amlodipine,":[18,145,159],"or":[19,123,146],"thiazide":[20],"diuretics)":[21],"in":[22,46,50,66,260],"older":[23],"adults":[24,47,270],"with":[25,83,271],"limited":[26,272],"life":[27,273],"expectancy.":[28],"We":[29],"compared":[30],"rates":[32,237,277],"injurious":[34,194,212,279],"falls":[35,213,280],"and":[36,81,95,177,200,226,281],"short-term":[37,282],"cardiovascular":[38,283],"events":[39,99,284],"between":[40,137,242],"different":[41],"medication":[44],"classes":[45],"receiving":[48,64],"care":[49,65],"nursing":[51],"homes":[52],"(NH).":[53],"METHODS:":[54],"This":[55],"was":[56,169,219,231],"a":[57,183],"retrospective":[58],"cohort":[59,150],"Medicare":[61],"fee-for-service":[62],"beneficiaries":[63],"NHs.":[67],"Patients":[68,107],"newly":[69],"dispensed":[70],"were":[74,102,108,132,140,175,179,240,248,257,265],"identified":[75,103],"using":[76,104],"Part":[77],"D":[78],"claims":[79],"(2015-2018)":[80],"linked":[82],"clinical":[84],"assessments":[85],"Minimum":[87],"Data":[88],"Set).":[89],"Fall-related":[90],"injuries":[91],"(FRI),":[92],"hip":[93],"fractures,":[94],"major":[96],"adverse":[97],"cardiac":[98],"(MACE)":[100],"outcomes":[101,136],"hospitalization":[105],"claims.":[106],"followed":[109],"from":[110],"date":[112],"dispensing":[115],"until":[116],"occurrence":[118],"outcomes,":[120],"death,":[121],"disenrollment,":[122],"6-month":[124],"follow-up.":[125],"Inverse-probability-of-treatment-weighted":[126],"(IPTW)":[127],"cause-specific":[128],"hazards":[129],"regression":[130],"models":[131],"used":[133],"to":[134],"compare":[135],"patients":[138,190,202],"who":[139],"new":[141],"users":[142,154],"RAASi,":[144],"thiazides.":[147],"RESULTS:":[148],"Our":[149],"included":[151],"16,504":[152],"(RAASi,":[155],"n":[156,160,164],"=":[157,161,165],"9574;":[158],"5049;":[162],"thiazide,":[163],"1881).":[166],"Mean":[167],"age":[168],"83.5":[170],"years":[171],"(\u00b1":[172],"8.2),":[173],"70.6%":[174],"female,":[176],"17.2%":[178],"non-white":[180],"race.":[181],"During":[182],"mean":[184],"follow-up":[185],"5.3":[187],"months,":[188],"326":[189],"(2.0%)":[191],"experienced":[192,198],"an":[193],"fall,":[195],"1590":[196],"(9.6%)":[197],"MACE,":[199],"2123":[201],"(12.9%)":[203],"died.":[204],"The":[205,236],"intention-to-treat":[206],"IPTW":[207],"hazard":[208],"ratio":[209],"(HR)":[210],"for":[211,214,227],"amlodipine":[215],"(vs":[216,229],"RAASi)":[217,230],"use":[218],"0.85":[220],"(95%":[221,233],"confidence":[222],"interval":[223],"(CI)":[224],"0.66-1.08)":[225],"thiazides":[228],"1.22":[232],"CI":[234],"0.88-1.66).":[235],"MACE":[239],"similar":[241,276],"those":[243],"taking":[244],"anti-hypertensive":[245],"medications.":[246,292],"Thiazides":[247],"discontinued":[249],"more":[250],"often":[251],"than":[252],"other":[253],"classes;":[254],"however,":[255],"inferences":[256],"largely":[258],"unchanged":[259],"as-treated":[261],"analyses.":[262],"Subgroup":[263],"analyses":[264],"generally":[266],"consistent.":[267],"CONCLUSIONS:":[268],"Older":[269],"expectancy":[274],"experience":[275],"after":[285],"initiating":[286],"any":[287]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-06T00:00:00"}