{"id":"https://openalex.org/W4389329622","doi":"https://doi.org/10.1182/bloodadvances.2023011622","title":"Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML","display_name":"Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4389329622","doi":"https://doi.org/10.1182/bloodadvances.2023011622","pmid":"https://pubmed.ncbi.nlm.nih.gov/38052043","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10837477"},"language":"en","primary_location":{"id":"doi:10.1182/bloodadvances.2023011622","doi":"https://doi.org/10.1182/bloodadvances.2023011622","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2023011622","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/doi/10.1182/bloodadvances.2023011622/2175282/bloodadvances.2023011622.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ashpublications.org/bloodadvances/article-pdf/doi/10.1182/bloodadvances.2023011622/2175282/bloodadvances.2023011622.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029993254","display_name":"Joshua Alexander Fein","orcid":"https://orcid.org/0000-0001-5441-1516","observed_orcids":["https://orcid.org/0000-0001-5441-1516"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua A. Fein","raw_affiliation_strings":["1Depatment of Hematology and Medical Oncology, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY"],"raw_orcid":"https://orcid.org/0000-0001-5441-1516","affiliations":[{"raw_affiliation_string":"1Depatment of Hematology and Medical Oncology, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033851673","display_name":"Roni Shouval","orcid":"https://orcid.org/0000-0001-9827-8032","observed_orcids":["https://orcid.org/0000-0001-9827-8032"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roni Shouval","raw_affiliation_strings":["2Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":"https://orcid.org/0000-0001-9827-8032","affiliations":[{"raw_affiliation_string":"2Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059200802","display_name":"Elizabeth Krieger","orcid":"https://orcid.org/0000-0002-8728-3327","observed_orcids":["https://orcid.org/0000-0002-8728-3327"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4210166857","display_name":"Children's Hospital of Richmond at VCU","ror":"https://ror.org/05vp5x049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210166857"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Krieger","raw_affiliation_strings":["3Children\u2019s Hospital of Richmond, Virginia Commonwealth University, Richmond, VA"],"raw_orcid":"https://orcid.org/0000-0002-8728-3327","affiliations":[{"raw_affiliation_string":"3Children\u2019s Hospital of Richmond, Virginia Commonwealth University, Richmond, VA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4210166857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064818358","display_name":"Stephen R. Spellman","orcid":"https://orcid.org/0000-0002-7271-8252","observed_orcids":["https://orcid.org/0000-0002-7271-8252"]},"institutions":[{"id":"https://openalex.org/I1318116459","display_name":"National Marrow Donor Program","ror":"https://ror.org/016cke005","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1318116459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R. Spellman","raw_affiliation_strings":["4Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, MN","institution_ids":["https://openalex.org/I1318116459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453497","display_name":"Tao Wang","orcid":"https://orcid.org/0000-0002-2596-6843","observed_orcids":["https://orcid.org/0000-0002-2596-6843"]},"institutions":[{"id":"https://openalex.org/I1318116459","display_name":"National Marrow Donor Program","ror":"https://ror.org/016cke005","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1318116459"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tao Wang","raw_affiliation_strings":["4Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, MN","5Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":"https://orcid.org/0000-0002-2596-6843","affiliations":[{"raw_affiliation_string":"4Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, MN","institution_ids":["https://openalex.org/I1318116459"]},{"raw_affiliation_string":"5Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080827913","display_name":"Henning Baldauf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henning Baldauf","raw_affiliation_strings":["6Clinical Trials Unit, DKMS Bone Marrow Registry, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Clinical Trials Unit, DKMS Bone Marrow Registry, T\u00fcbingen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027599215","display_name":"Katharina Fleischhauer","orcid":"https://orcid.org/0000-0002-5827-8000","observed_orcids":["https://orcid.org/0000-0002-5827-8000"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Fleischhauer","raw_affiliation_strings":["7Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5827-8000","affiliations":[{"raw_affiliation_string":"7Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001646221","display_name":"Nicolaus Martin Kr\u00f6ger","orcid":"https://orcid.org/0000-0001-5103-9966","observed_orcids":["https://orcid.org/0000-0001-5103-9966"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicolaus Kr\u00f6ger","raw_affiliation_strings":["8Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5103-9966","affiliations":[{"raw_affiliation_string":"8Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112746586","display_name":"Mary Horowitz","orcid":"https://orcid.org/0000-0002-9502-785X","observed_orcids":["https://orcid.org/0000-0002-9502-785X"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Horowitz","raw_affiliation_strings":["5Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036285459","display_name":"Martin J. Maiers","orcid":"https://orcid.org/0000-0002-0198-2064","observed_orcids":["https://orcid.org/0000-0002-0198-2064"]},"institutions":[{"id":"https://openalex.org/I1318116459","display_name":"National Marrow Donor Program","ror":"https://ror.org/016cke005","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1318116459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Maiers","raw_affiliation_strings":["4Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, MN"],"raw_orcid":"https://orcid.org/0000-0002-0198-2064","affiliations":[{"raw_affiliation_string":"4Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, MN","institution_ids":["https://openalex.org/I1318116459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027151969","display_name":"Jeffrey S. Miller","orcid":"https://orcid.org/0000-0002-0339-4944","observed_orcids":["https://orcid.org/0000-0002-0339-4944"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S Miller","raw_affiliation_strings":["9Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020996390","display_name":"Mohamad Mohty","orcid":"https://orcid.org/0000-0002-7264-808X","observed_orcids":["https://orcid.org/0000-0002-7264-808X","https://orcid.org/0000-0001-8536-7781"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mohamad Mohty","raw_affiliation_strings":["10Department of Hematology, Saint Antoine Hospital, Sorbonne University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Department of Hematology, Saint Antoine Hospital, Sorbonne University, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058925624","display_name":"Arnon Nagler","orcid":"https://orcid.org/0000-0002-0763-1265","observed_orcids":["https://orcid.org/0000-0002-0763-1265","https://orcid.org/0000-0002-6126-884X"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Arnon Nagler","raw_affiliation_strings":["11Division of Hematoloy, Chaim Sheba Medical Center, Tel HaShomer, Israel"],"raw_orcid":"https://orcid.org/0000-0002-0763-1265","affiliations":[{"raw_affiliation_string":"11Division of Hematoloy, Chaim Sheba Medical Center, Tel HaShomer, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070132319","display_name":"Daniel Jordan Weisdorf","orcid":"https://orcid.org/0000-0001-8078-8579","observed_orcids":["https://orcid.org/0000-0001-8078-8579"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Weisdorf","raw_affiliation_strings":["9Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN"],"raw_orcid":"https://orcid.org/0000-0001-8078-8579","affiliations":[{"raw_affiliation_string":"9Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061606756","display_name":"Karl\u2010Johan Malmberg","orcid":"https://orcid.org/0000-0002-8718-9373","observed_orcids":["https://orcid.org/0000-0002-8718-9373"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Karl-Johan Malmberg","raw_affiliation_strings":["12Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0002-8718-9373","affiliations":[{"raw_affiliation_string":"12Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085875329","display_name":"Amir Ahmed Toor","orcid":"https://orcid.org/0000-0001-5317-8433","observed_orcids":["https://orcid.org/0000-0001-5317-8433"]},"institutions":[{"id":"https://openalex.org/I4210094360","display_name":"Lehigh Valley Health Network","ror":"https://ror.org/00sf92s91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210094360"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amir A. Toor","raw_affiliation_strings":["13Topper Cancer Institute, Lehigh Valley Health Network, Allentown, PA"],"raw_orcid":"https://orcid.org/0000-0001-5317-8433","affiliations":[{"raw_affiliation_string":"13Topper Cancer Institute, Lehigh Valley Health Network, Allentown, PA","institution_ids":["https://openalex.org/I4210094360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004741011","display_name":"Johannes Schetelig","orcid":"https://orcid.org/0000-0002-2780-2981","observed_orcids":["https://orcid.org/0000-0002-2780-2981"]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Schetelig","raw_affiliation_strings":["14Medizinische Klinik I, University Hospital TU Dresden, Dresden, Germany","6Clinical Trials Unit, DKMS Bone Marrow Registry, T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2780-2981","affiliations":[{"raw_affiliation_string":"14Medizinische Klinik I, University Hospital TU Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"6Clinical Trials Unit, DKMS Bone Marrow Registry, T\u00fcbingen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061484901","display_name":"Rizwan Romee","orcid":"https://orcid.org/0000-0001-9077-4736","observed_orcids":["https://orcid.org/0000-0001-9077-4736"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rizwan Romee","raw_affiliation_strings":["15Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA","Dana Farber / Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":"https://orcid.org/0000-0001-9077-4736","affiliations":[{"raw_affiliation_string":"15Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana Farber / Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029390145","display_name":"John Koreth","orcid":"https://orcid.org/0000-0002-7428-1330","observed_orcids":["https://orcid.org/0000-0002-7428-1330"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Koreth","raw_affiliation_strings":["15Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5061484901"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.9815,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73027898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"8","issue":"3","first_page":"581","last_page":"590"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.19059999287128448,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/kir-hla-interaction","display_name":"HLA-KIR interaction","score":0.800000011920929},{"id":"https://openalex.org/keywords/nk-cell-receptors","display_name":"NK cell receptors","score":0.6830000281333923},{"id":"https://openalex.org/keywords/hla-matched-unrelated-donor","display_name":"HLA-matched unrelated donor","score":0.753000020980835},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/graft-versus-leukemia-effect","display_name":"graft-versus-leukemia effect","score":0.9769999980926514},{"id":"https://openalex.org/keywords/risk-of-relapse","display_name":"relapse risk","score":0.8069999814033508},{"id":"https://openalex.org/keywords/unrelated-donor-selection","display_name":"unrelated donor selection","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.7558785080909729},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7524935007095337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6240044832229614},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5929552912712097},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5908575654029846},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.573782205581665},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.54953932762146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5170431733131409},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4994344711303711},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.456605464220047},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45522627234458923},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4412144720554352},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4267657399177551},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37790539860725403},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34774842858314514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1888592541217804},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.17274266481399536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10824939608573914},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07079216837882996}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054340","descriptor_name":"Receptors, KIR","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061349","descriptor_name":"Unrelated Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/bloodadvances.2023011622","doi":"https://doi.org/10.1182/bloodadvances.2023011622","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2023011622","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/doi/10.1182/bloodadvances.2023011622/2175282/bloodadvances.2023011622.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10837477","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10837477","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10837477/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Adv","raw_type":"Text"},{"id":"pmid:38052043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38052043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/bloodadvances.2023011622","doi":"https://doi.org/10.1182/bloodadvances.2023011622","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2023011622","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/doi/10.1182/bloodadvances.2023011622/2175282/bloodadvances.2023011622.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G7844266926","display_name":"Immune Modulation After Allogeneic HCT","funder_award_id":"P01CA229092","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000907011","display_name":"NK cells, their receptors and cancer therapy","funder_award_id":"P01CA111412","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389329622.pdf","grobid_xml":"https://content.openalex.org/works/W4389329622.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W88513585","https://openalex.org/W1672775443","https://openalex.org/W1964968270","https://openalex.org/W1969950463","https://openalex.org/W1974308995","https://openalex.org/W2007509667","https://openalex.org/W2019796011","https://openalex.org/W2019958642","https://openalex.org/W2039808932","https://openalex.org/W2045884561","https://openalex.org/W2048245039","https://openalex.org/W2051885016","https://openalex.org/W2075049419","https://openalex.org/W2077044862","https://openalex.org/W2094852305","https://openalex.org/W2098501185","https://openalex.org/W2108395794","https://openalex.org/W2121158936","https://openalex.org/W2137419821","https://openalex.org/W2147068163","https://openalex.org/W2158804326","https://openalex.org/W2594275567","https://openalex.org/W2615393228","https://openalex.org/W2784989383","https://openalex.org/W2888069257","https://openalex.org/W2982488323","https://openalex.org/W2999721358","https://openalex.org/W3008199892","https://openalex.org/W3014650375","https://openalex.org/W3082142739","https://openalex.org/W3122354936","https://openalex.org/W3131348164","https://openalex.org/W3154051626","https://openalex.org/W3166064790","https://openalex.org/W3181218975","https://openalex.org/W4310944692","https://openalex.org/W4381487086","https://openalex.org/W7074089550"],"related_works":["https://openalex.org/W3214082586","https://openalex.org/W3181218975","https://openalex.org/W2979537593","https://openalex.org/W3154051626","https://openalex.org/W1199917093","https://openalex.org/W3041017926","https://openalex.org/W7100742565","https://openalex.org/W3033683217","https://openalex.org/W2166422464","https://openalex.org/W3096222358"],"abstract_inverted_index":{"ABSTRACT:":[0],"In":[1],"acute":[2],"myeloid":[3],"leukemia":[4],"(AML),":[5],"donor":[6,47,141],"natural":[7],"killer":[8,10],"cell":[9,27],"immunoglobulin-like":[11],"receptors":[12],"(KIR)":[13],"and":[14,40,63,95,147,161,180,190],"recipient":[15],"HLA":[16],"interactions":[17,59,243],"may":[18],"contribute":[19],"to":[20,89],"the":[21,44,90,101,212,232],"graft-versus-leukemia":[22],"effect":[23],"of":[24,31,56,227,240,248],"allogeneic":[25],"hematopoietic":[26],"transplantation":[28,234],"(HCT).":[29],"Analyses":[30],"individual":[32,57],"KIR/HLA":[33],"interactions,":[34],"however,":[35],"have":[36],"yielded":[37],"conflicting":[38],"findings,":[39],"their":[41],"importance":[42],"in":[43,85,144,158,163,204,222,268],"HLA-matched":[45],"unrelated":[46],"(MUD)":[48],"setting":[49],"remains":[50],"controversial.":[51],"We":[52,137],"systematically":[53],"studied":[54],"outcomes":[55,62],"donor-KIR/recipient-HLA":[58],"for":[60,69,92,150,265],"HCT":[61,81],"empirically":[64],"evaluated":[65],"prevalent":[66,140,249],"KIR":[67,142,250],"genotypes":[68,143,251],"clinical":[70],"benefit.":[71],"Adult":[72],"patients":[73,210],"with":[74,82,106,122,152,168,200,208,211],"AML":[75,229],"(n":[76],"=":[77,119,178,187,198],"2025)":[78],"who":[79],"received":[80],"MUD":[83,266],"grafts":[84],"complete":[86],"remission":[87],"reported":[88],"Center":[91],"International":[93],"Blood":[94],"Marrow":[96],"Transplantation":[97],"were":[98,166],"evaluated.":[99],"Only":[100],"donor-2DL2+/recipient-HLA-C1+":[102],"pair":[103],"was":[104,128],"associated":[105,167],"reduced":[107],"relapse":[108,153,170,202],"(hazard":[109],"ratio":[110],"[HR],":[111],"0.79;":[112],"95%":[113,174,183,194],"confidence":[114],"interval":[115],"[CI],":[116],"0.67-0.93;":[117],"P":[118,177,186,197],".006)":[120],"compared":[121,207],"donor-2DL2-/recipient-HLA-C1+":[123],"pair.":[124],"However,":[125,215],"no":[126],"association":[127,151],"found":[129],"when":[130],"comparing":[131],"HLA-C":[132],"groups":[133],"among":[134],"KIR-2DL2+-graft":[135],"recipients.":[136],"identified":[138],"9":[139],"our":[145],"cohort":[146],"screened":[148],"them":[149],"risk.":[154],"Genotype":[155],"5":[156],"(G5)":[157],"all":[159],"recipients":[160,165],"G3":[162],"Bw4+":[164],"decreased":[169],"risk":[171,203],"(HR,":[172],"0.52;":[173],"CI,":[175,184,195],"0.35-0.78;":[176],".002;":[179],"HR,":[181],"0.32;":[182],"0.14-0.72;":[185],".006;":[188],"respectively)":[189],"G2":[191],"(HR":[192],"1.63,":[193],"1.15-2.29;":[196],".005)":[199],"increased":[201],"C1-homozygous":[205],"recipients,":[206],"other":[209],"same":[213],"ligand.":[214],"we":[216],"could":[217],"not":[218,260],"validate":[219],"these":[220,257,262],"findings":[221],"an":[223,245],"external":[224],"data":[225,258],"set":[226],"796":[228],"transplants":[230],"from":[231],"German":[233],"registry.":[235],"Neither":[236],"a":[237],"systematic":[238],"evaluation":[239],"known":[241],"HLA-KIR":[242],"nor":[244],"empiric":[246],"assessment":[247],"demonstrated":[252],"clinically":[253],"actionable":[254],"associations;":[255],"therefore,":[256],"do":[259],"support":[261],"KIR-driven":[263],"strategies":[264],"selection":[267],"AML.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-06T00:00:00"}
