{"id":"https://openalex.org/W4389328640","doi":"https://doi.org/10.1016/j.nano.2023.102728","title":"Membrane cholesterol enrichment and folic acid functionalization lead to increased accumulation of erythrocyte-derived optical nano-constructs within the ovarian intraperitoneal tumor implants in mice","display_name":"Membrane cholesterol enrichment and folic acid functionalization lead to increased accumulation of erythrocyte-derived optical nano-constructs within the ovarian intraperitoneal tumor implants in mice","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4389328640","doi":"https://doi.org/10.1016/j.nano.2023.102728","pmid":"https://pubmed.ncbi.nlm.nih.gov/38061449"},"language":"en","primary_location":{"id":"doi:10.1016/j.nano.2023.102728","doi":"https://doi.org/10.1016/j.nano.2023.102728","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nano.2023.102728","pdf_url":null,"source":{"id":"https://openalex.org/S80729884","display_name":"Nanomedicine Nanotechnology Biology and Medicine","issn_l":"1549-9634","issn":["1549-9634","1549-9642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanomedicine: Nanotechnology, Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.nano.2023.102728","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103079682","display_name":"Chi-Hua Lee","orcid":"https://orcid.org/0000-0002-6786-7659","observed_orcids":["https://orcid.org/0000-0002-6786-7659"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi-Hua Lee","raw_affiliation_strings":["Department of Biochemistry, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090137453","display_name":"Jenny T. Mac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny Mac","raw_affiliation_strings":["Department of Biochemistry, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070202286","display_name":"Taylor Hanley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor Hanley","raw_affiliation_strings":["Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111091179","display_name":"Shamima Zaman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shamima Zaman","raw_affiliation_strings":["Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032776915","display_name":"Raviraj Vankayala","orcid":"https://orcid.org/0000-0002-4661-066X","observed_orcids":["https://orcid.org/0000-0002-4661-066X"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raviraj Vankayala","raw_affiliation_strings":["Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072261948","display_name":"Bahman Anvari","orcid":"https://orcid.org/0000-0002-2511-5854","observed_orcids":["https://orcid.org/0000-0002-2511-5854"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bahman Anvari","raw_affiliation_strings":["Department of Biochemistry, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA; Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA. Electronic address: anvarib@ucr.edu","Department of Biochemistry, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA","Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA; Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA. Electronic address: anvarib@ucr.edu","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Department of Biochemistry, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072261948"],"corresponding_institution_ids":["https://openalex.org/I103635307"],"apc_list":{"value":3140,"currency":"USD","value_usd":3140},"apc_paid":null,"fwci":0.2363,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40987399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"56","issue":null,"first_page":"102728","last_page":"102728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8500000238418579},{"id":"https://openalex.org/keywords/indocyanine-green","display_name":"indocyanine green","score":0.7860000133514404},{"id":"https://openalex.org/keywords/folic-acid-functionalization","display_name":"folic acid functionalization","score":0.9290000200271606},{"id":"https://openalex.org/keywords/folate-receptor-alpha","display_name":"folate receptor alpha","score":0.8429999947547913},{"id":"https://openalex.org/keywords/near-infrared-fluorescence-imaging","display_name":"near-infrared fluorescence imaging","score":0.875},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.5070000290870667},{"id":"https://openalex.org/keywords/cytoreductive-surgery","display_name":"cytoreductive surgery","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.6974374651908875},{"id":"https://openalex.org/C2780306303","wikidata":"https://www.wikidata.org/wiki/Q24784504","display_name":"Folate receptor","level":4,"score":0.684635579586029},{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.6777114868164062},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5929564237594604},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5672447085380554},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.5429229140281677},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5052474141120911},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4981992244720459},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.49546778202056885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46679243445396423},{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.4153635799884796},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.4149821996688843},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36142727732658386},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34042954444885254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31489700078964233},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25426170229911804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2493494153022766},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.23847758769989014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21108010411262512},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1973695158958435},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007208","descriptor_name":"Indocyanine Green","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.nano.2023.102728","doi":"https://doi.org/10.1016/j.nano.2023.102728","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nano.2023.102728","pdf_url":null,"source":{"id":"https://openalex.org/S80729884","display_name":"Nanomedicine Nanotechnology Biology and Medicine","issn_l":"1549-9634","issn":["1549-9634","1549-9642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanomedicine: Nanotechnology, Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:38061449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38061449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine : nanotechnology, biology, and medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.nano.2023.102728","doi":"https://doi.org/10.1016/j.nano.2023.102728","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nano.2023.102728","pdf_url":null,"source":{"id":"https://openalex.org/S80729884","display_name":"Nanomedicine Nanotechnology Biology and Medicine","issn_l":"1549-9634","issn":["1549-9634","1549-9642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanomedicine: Nanotechnology, Biology and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2555754267","display_name":"EAGER: Dual magnetic resonance and optical modalities for image-guided early detection, staging, and resection of ovarian tumors","funder_award_id":"1940965","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W31526245","https://openalex.org/W175635469","https://openalex.org/W1020015644","https://openalex.org/W1570518064","https://openalex.org/W1985241728","https://openalex.org/W1985712964","https://openalex.org/W1986826787","https://openalex.org/W1987286203","https://openalex.org/W1994645123","https://openalex.org/W1996463727","https://openalex.org/W2024546396","https://openalex.org/W2032760352","https://openalex.org/W2039949492","https://openalex.org/W2049490668","https://openalex.org/W2055838678","https://openalex.org/W2091007499","https://openalex.org/W2099521317","https://openalex.org/W2106062954","https://openalex.org/W2113719877","https://openalex.org/W2122359067","https://openalex.org/W2129028425","https://openalex.org/W2134628193","https://openalex.org/W2233414233","https://openalex.org/W2290569047","https://openalex.org/W2305251701","https://openalex.org/W2421919823","https://openalex.org/W2541390219","https://openalex.org/W2575180130","https://openalex.org/W2782420369","https://openalex.org/W2883955846","https://openalex.org/W2888518190","https://openalex.org/W2896039917","https://openalex.org/W2912471195","https://openalex.org/W2920960497","https://openalex.org/W2955255901","https://openalex.org/W2993138039","https://openalex.org/W2996124270","https://openalex.org/W3010931789","https://openalex.org/W3165389856","https://openalex.org/W3178957657","https://openalex.org/W3209417051","https://openalex.org/W4205619537","https://openalex.org/W4240398962","https://openalex.org/W4294892020","https://openalex.org/W4295011690","https://openalex.org/W4310928465","https://openalex.org/W4315754639","https://openalex.org/W4318394988","https://openalex.org/W4320488991","https://openalex.org/W4320880590","https://openalex.org/W4366084692","https://openalex.org/W4379283496","https://openalex.org/W6626604940"],"related_works":["https://openalex.org/W3133621706","https://openalex.org/W3165389856","https://openalex.org/W1997410326","https://openalex.org/W3047221718","https://openalex.org/W2421919823","https://openalex.org/W7160844369","https://openalex.org/W2326456232","https://openalex.org/W4383599752","https://openalex.org/W1189867518","https://openalex.org/W2598168782"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-06T00:00:00"}