{"id":"https://openalex.org/W4389296372","doi":"https://doi.org/10.1186/s13054-023-04759-1","title":"Iron as an emerging therapeutic target in critically ill patients","display_name":"Iron as an emerging therapeutic target in critically ill patients","publication_year":2023,"publication_date":"2023-12-04","ids":{"openalex":"https://openalex.org/W4389296372","doi":"https://doi.org/10.1186/s13054-023-04759-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/38049866","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10694984"},"language":"en","primary_location":{"id":"doi:10.1186/s13054-023-04759-1","doi":"https://doi.org/10.1186/s13054-023-04759-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-023-04759-1","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-023-04759-1","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-023-04759-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049455964","display_name":"Coralie Grange","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133140","display_name":"Institut Lumi\u00e8re Mati\u00e8re","ror":"https://ror.org/0323bey33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210098836","https://openalex.org/I4210133140","https://openalex.org/I4405259976","https://openalex.org/I4405263940","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Coralie Grange","raw_affiliation_strings":["Institut Lumi\u00e8re-Mati\u00e8re, UMR 5306, Universit\u00e9 Claude Bernard Lyon1-CNRS, Villeurbanne Cedex, France","MexBrain, 13 Avenue Albert Einstein, Villeurbanne, France","MexBrain (13 avenue Albert Einstein\r\n69100 Villeurbanne - France)","iLM - FENNEC - iLM - Formation, \u00e9laboration de nanomat\u00e9riaux et cristaux (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Lumi\u00e8re-Mati\u00e8re, UMR 5306, Universit\u00e9 Claude Bernard Lyon1-CNRS, Villeurbanne Cedex, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210133140"]},{"raw_affiliation_string":"MexBrain, 13 Avenue Albert Einstein, Villeurbanne, France","institution_ids":[]},{"raw_affiliation_string":"MexBrain (13 avenue Albert Einstein\r\n69100 Villeurbanne - France)","institution_ids":[]},{"raw_affiliation_string":"iLM - FENNEC - iLM - Formation, \u00e9laboration de nanomat\u00e9riaux et cristaux (France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043706856","display_name":"Fran\u00e7ois Lux","orcid":"https://orcid.org/0000-0003-1568-0240","observed_orcids":["https://orcid.org/0000-0003-1568-0240"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I185839726","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266","country_code":"FR","type":"education","lineage":["https://openalex.org/I185839726"]},{"id":"https://openalex.org/I4210133140","display_name":"Institut Lumi\u00e8re Mati\u00e8re","ror":"https://ror.org/0323bey33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210098836","https://openalex.org/I4210133140","https://openalex.org/I4405259976","https://openalex.org/I4405263940","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fran\u00e7ois Lux","raw_affiliation_strings":["Institut Lumi\u00e8re-Mati\u00e8re, UMR 5306, Universit\u00e9 Claude Bernard Lyon1-CNRS, Villeurbanne Cedex, France. francois.lux@univ-lyon1.fr","Institut Universitaire de France (IUF), 75231, Paris, France. francois.lux@univ-lyon1.fr","IUF - Institut universitaire de France (Maison des Universit\u00e9s 103 Boulevard Saint-Michel 75005 Paris - France)","iLM - FENNEC - iLM - Formation, \u00e9laboration de nanomat\u00e9riaux et cristaux (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Lumi\u00e8re-Mati\u00e8re, UMR 5306, Universit\u00e9 Claude Bernard Lyon1-CNRS, Villeurbanne Cedex, France. francois.lux@univ-lyon1.fr","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210133140"]},{"raw_affiliation_string":"Institut Universitaire de France (IUF), 75231, Paris, France. francois.lux@univ-lyon1.fr","institution_ids":["https://openalex.org/I185839726"]},{"raw_affiliation_string":"IUF - Institut universitaire de France (Maison des Universit\u00e9s 103 Boulevard Saint-Michel 75005 Paris - France)","institution_ids":["https://openalex.org/I185839726"]},{"raw_affiliation_string":"iLM - FENNEC - iLM - Formation, \u00e9laboration de nanomat\u00e9riaux et cristaux (France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067249545","display_name":"Thomas Brichart","orcid":"https://orcid.org/0000-0002-6534-4731","observed_orcids":["https://orcid.org/0000-0002-6534-4731"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Brichart","raw_affiliation_strings":["MexBrain, 13 Avenue Albert Einstein, Villeurbanne, France","MexBrain (13 avenue Albert Einstein\r\n69100 Villeurbanne - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MexBrain, 13 Avenue Albert Einstein, Villeurbanne, France","institution_ids":[]},{"raw_affiliation_string":"MexBrain (13 avenue Albert Einstein\r\n69100 Villeurbanne - France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070639075","display_name":"Laurent David","orcid":"https://orcid.org/0000-0003-3632-8537","observed_orcids":["https://orcid.org/0000-0003-3632-8537"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210115277","display_name":"Ingenierie des Materiaux polymeres","ror":"https://ror.org/02160my55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210115277","https://openalex.org/I4210128300","https://openalex.org/I4405259976","https://openalex.org/I48430043"]},{"id":"https://openalex.org/I4405259976","display_name":"Universit\u00e9 Jean Monnet","ror":"https://ror.org/030bahv93","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264","https://openalex.org/I4405259976"]},{"id":"https://openalex.org/I86767153","display_name":"Universit\u00e9 Jean Monnet","ror":"https://ror.org/04yznqr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264","https://openalex.org/I4405259976","https://openalex.org/I86767153"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent David","raw_affiliation_strings":["Institut National des Sciences Appliqu\u00e9es, CNRS UMR 5223, Ing\u00e9nierie des Mat\u00e9riaux Polym\u00e8res, Univ Claude Bernard Lyon 1, Universit\u00e9 Jean Monnet, 15 bd Latarjet, 69622, Villeurbanne, France","IMP - Ing\u00e9nierie des Mat\u00e9riaux Polym\u00e8res (17, Av. Jean Capelle 69621 Villeurbanne Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National des Sciences Appliqu\u00e9es, CNRS UMR 5223, Ing\u00e9nierie des Mat\u00e9riaux Polym\u00e8res, Univ Claude Bernard Lyon 1, Universit\u00e9 Jean Monnet, 15 bd Latarjet, 69622, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210115277","https://openalex.org/I4405259976","https://openalex.org/I86767153"]},{"raw_affiliation_string":"IMP - Ing\u00e9nierie des Mat\u00e9riaux Polym\u00e8res (17, Av. Jean Capelle 69621 Villeurbanne Cedex - France)","institution_ids":["https://openalex.org/I4210115277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076193954","display_name":"A. Couturier","orcid":"https://orcid.org/0009-0001-7181-8585","observed_orcids":["https://orcid.org/0009-0001-7181-8585","https://orcid.org/0000-0002-3752-8533"]},"institutions":[{"id":"https://openalex.org/I1285426703","display_name":"H\u00f4pital am\u00e9ricain de paris","ror":"https://ror.org/04wttst55","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1285426703"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aymeric Couturier","raw_affiliation_strings":["MexBrain, 13 Avenue Albert Einstein, Villeurbanne, France","Nephrology, American Hospital of Paris, Paris, France","H\u00f4pital Am\u00e9ricain de Paris (63, Bd Victor Hugo 92200 Neuilly-sur-Seine - France)","MexBrain (13 avenue Albert Einstein\r\n69100 Villeurbanne - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MexBrain, 13 Avenue Albert Einstein, Villeurbanne, France","institution_ids":[]},{"raw_affiliation_string":"Nephrology, American Hospital of Paris, Paris, France","institution_ids":["https://openalex.org/I1285426703"]},{"raw_affiliation_string":"H\u00f4pital Am\u00e9ricain de Paris (63, Bd Victor Hugo 92200 Neuilly-sur-Seine - France)","institution_ids":["https://openalex.org/I1285426703"]},{"raw_affiliation_string":"MexBrain (13 avenue Albert Einstein\r\n69100 Villeurbanne - France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020460043","display_name":"David E. Leaf","orcid":"https://orcid.org/0000-0001-7875-090X","observed_orcids":["https://orcid.org/0000-0001-7875-090X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Leaf","raw_affiliation_strings":["Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA","Brigham and Women\u2019s Hospital [Boston, MA] (75 Francis Street, Boston MA 02115 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Brigham and Women\u2019s Hospital [Boston, MA] (75 Francis Street, Boston MA 02115 - United States)","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014519093","display_name":"Bernard Allaouchiche","orcid":"https://orcid.org/0000-0003-0988-1716","observed_orcids":["https://orcid.org/0000-0003-0988-1716"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210104684","display_name":"VetAgro Sup","ror":"https://ror.org/01c7wz417","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210104684"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Allaouchiche","raw_affiliation_strings":["University of Lyon, University Lyon I Claude Bernard, APCSe VetAgro Sup UP, 2021. A10, Marcy L'\u00c9toile, France","APCS\u00e9 - Agressions Pulmonaires et Circulatoires dans le Sepsis - UR (Universit\u00e9 de Lyon, VetAgro Sup, Agressions pulmonaires et circulatoires dans le sepsis, APCS\u00e9, 69280, Marcy l\u2019Etoile, France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lyon, University Lyon I Claude Bernard, APCSe VetAgro Sup UP, 2021. A10, Marcy L'\u00c9toile, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4210104684"]},{"raw_affiliation_string":"APCS\u00e9 - Agressions Pulmonaires et Circulatoires dans le Sepsis - UR (Universit\u00e9 de Lyon, VetAgro Sup, Agressions pulmonaires et circulatoires dans le sepsis, APCS\u00e9, 69280, Marcy l\u2019Etoile, France - France)","institution_ids":["https://openalex.org/I203339264","https://openalex.org/I4210104684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105990096","display_name":"Olivier Tillement","orcid":"https://orcid.org/0000-0001-7166-6537","observed_orcids":["https://orcid.org/0000-0001-7166-6537"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210133140","display_name":"Institut Lumi\u00e8re Mati\u00e8re","ror":"https://ror.org/0323bey33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210098836","https://openalex.org/I4210133140","https://openalex.org/I4405259976","https://openalex.org/I4405263940","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Tillement","raw_affiliation_strings":["Institut Lumi\u00e8re-Mati\u00e8re, UMR 5306, Universit\u00e9 Claude Bernard Lyon1-CNRS, Villeurbanne Cedex, France","iLM - FENNEC - iLM - Formation, \u00e9laboration de nanomat\u00e9riaux et cristaux (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Lumi\u00e8re-Mati\u00e8re, UMR 5306, Universit\u00e9 Claude Bernard Lyon1-CNRS, Villeurbanne Cedex, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210133140"]},{"raw_affiliation_string":"iLM - FENNEC - iLM - Formation, \u00e9laboration de nanomat\u00e9riaux et cristaux (France)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5043706856"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I185839726","https://openalex.org/I4210133140"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":1.2582,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.77874659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"27","issue":"1","first_page":"475","last_page":"475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-transferrin-bound-iron","display_name":"non-transferrin-bound iron","score":0.9390000104904175},{"id":"https://openalex.org/keywords/catalytic-iron","display_name":"catalytic iron","score":0.9909999966621399},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.6520000100135803},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.9100000262260437},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.6909999847412109},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8029999732971191},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9959999918937683},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pathogen-growth","display_name":"pathogen growth","score":0.7269999980926514},{"id":"https://openalex.org/keywords/iron-dysregulation","display_name":"iron dysregulation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.6909999847412109},{"id":"https://openalex.org/keywords/chelation-therapy","display_name":"chelation therapy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/renal-replacement-therapy","display_name":"renal replacement therapy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8309733867645264},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7294777631759644},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.5533018708229065},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5130583047866821},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.48146381974220276},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.4769816994667053},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.4473263621330261},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.440822571516037},{"id":"https://openalex.org/C2777218474","wikidata":"https://www.wikidata.org/wiki/Q1069061","display_name":"Chelation therapy","level":3,"score":0.43373504281044006},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36926978826522827},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29417359828948975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15487676858901978},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14226436614990234},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0902220606803894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08150070905685425}],"mesh":[{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13054-023-04759-1","doi":"https://doi.org/10.1186/s13054-023-04759-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-023-04759-1","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-023-04759-1","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10694984","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10694984","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10694984/pdf/13054_2023_Article_4759.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"},{"id":"pmid:38049866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38049866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04390052v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04390052","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care, 2023, 27 (1), pp.475. ⟨10.1186/s13054-023-04759-1⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s13054-023-04759-1","doi":"https://doi.org/10.1186/s13054-023-04759-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-023-04759-1","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-023-04759-1","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389296372.pdf","grobid_xml":"https://content.openalex.org/works/W4389296372.grobid-xml"},"referenced_works_count":131,"referenced_works":["https://openalex.org/W1245788081","https://openalex.org/W1570067866","https://openalex.org/W1672889289","https://openalex.org/W1725148922","https://openalex.org/W1844080681","https://openalex.org/W1909945636","https://openalex.org/W1967017135","https://openalex.org/W1967932437","https://openalex.org/W1968565666","https://openalex.org/W1979107365","https://openalex.org/W1985344826","https://openalex.org/W1992291863","https://openalex.org/W1997183854","https://openalex.org/W1998636169","https://openalex.org/W2002188125","https://openalex.org/W2007157083","https://openalex.org/W2010431026","https://openalex.org/W2011297686","https://openalex.org/W2012136328","https://openalex.org/W2013094638","https://openalex.org/W2024428199","https://openalex.org/W2025068702","https://openalex.org/W2026254409","https://openalex.org/W2030743629","https://openalex.org/W2043233697","https://openalex.org/W2044678473","https://openalex.org/W2046118093","https://openalex.org/W2047570111","https://openalex.org/W2048120922","https://openalex.org/W2051186502","https://openalex.org/W2057431246","https://openalex.org/W2058493175","https://openalex.org/W2059778114","https://openalex.org/W2071957948","https://openalex.org/W2072298587","https://openalex.org/W2073083848","https://openalex.org/W2073087806","https://openalex.org/W2073843577","https://openalex.org/W2078601157","https://openalex.org/W2079837262","https://openalex.org/W2082948734","https://openalex.org/W2086567353","https://openalex.org/W2087639565","https://openalex.org/W2089049808","https://openalex.org/W2094683614","https://openalex.org/W2103551786","https://openalex.org/W2117061420","https://openalex.org/W2124451906","https://openalex.org/W2132785271","https://openalex.org/W2146081758","https://openalex.org/W2149687213","https://openalex.org/W2156390223","https://openalex.org/W2168866606","https://openalex.org/W2190900500","https://openalex.org/W2213332728","https://openalex.org/W2253997241","https://openalex.org/W2324521520","https://openalex.org/W2330559186","https://openalex.org/W2341907426","https://openalex.org/W2345124960","https://openalex.org/W2405183840","https://openalex.org/W2415064366","https://openalex.org/W2430092136","https://openalex.org/W2509733395","https://openalex.org/W2512505680","https://openalex.org/W2521663372","https://openalex.org/W2531541703","https://openalex.org/W2563186820","https://openalex.org/W2583964565","https://openalex.org/W2592811288","https://openalex.org/W2611092877","https://openalex.org/W2613624993","https://openalex.org/W2621689399","https://openalex.org/W2704386052","https://openalex.org/W2767127256","https://openalex.org/W2790659043","https://openalex.org/W2793944650","https://openalex.org/W2810192557","https://openalex.org/W2883366512","https://openalex.org/W2883965892","https://openalex.org/W2888749427","https://openalex.org/W2892710900","https://openalex.org/W2894202568","https://openalex.org/W2903234309","https://openalex.org/W2911814182","https://openalex.org/W2912140935","https://openalex.org/W2915000266","https://openalex.org/W2924341243","https://openalex.org/W2937074474","https://openalex.org/W2969617477","https://openalex.org/W2971040102","https://openalex.org/W2973305257","https://openalex.org/W2977065915","https://openalex.org/W2981384529","https://openalex.org/W2990641423","https://openalex.org/W2999262601","https://openalex.org/W3011989646","https://openalex.org/W3016576290","https://openalex.org/W3027028445","https://openalex.org/W3034768431","https://openalex.org/W3037431152","https://openalex.org/W3045038276","https://openalex.org/W3045395785","https://openalex.org/W3090782506","https://openalex.org/W3092589524","https://openalex.org/W3093014708","https://openalex.org/W3094155532","https://openalex.org/W3110927546","https://openalex.org/W3119741766","https://openalex.org/W3120108880","https://openalex.org/W3124674952","https://openalex.org/W3163205669","https://openalex.org/W3171474857","https://openalex.org/W3184295893","https://openalex.org/W3188804152","https://openalex.org/W3201681435","https://openalex.org/W3213259336","https://openalex.org/W4211157472","https://openalex.org/W4213442676","https://openalex.org/W4223442068","https://openalex.org/W4223908131","https://openalex.org/W4224304951","https://openalex.org/W4225939148","https://openalex.org/W4229006585","https://openalex.org/W4246391876","https://openalex.org/W4285728634","https://openalex.org/W4289884481","https://openalex.org/W4308249260","https://openalex.org/W4315650236","https://openalex.org/W4376643882","https://openalex.org/W4387647282"],"related_works":["https://openalex.org/W7160152247","https://openalex.org/W3112821000","https://openalex.org/W4243211588","https://openalex.org/W177610023","https://openalex.org/W4401093781","https://openalex.org/W3025976671","https://openalex.org/W2916079475","https://openalex.org/W2009929945","https://openalex.org/W2056426465","https://openalex.org/W4250521882"],"abstract_inverted_index":{"The":[0,151],"multiple":[1],"roles":[2],"of":[3,33,46,58,64,76,83,100,118,132,139,179,191],"iron":[4,17,36,59,93,127,183],"in":[5,16,43,50,73,120,143,164,182],"the":[6,30,44,65,74,81,98,114,137,165,177,189],"body":[7],"have":[8],"been":[9],"known":[10,39],"for":[11],"decades,":[12],"particularly":[13],"its":[14,155],"involvement":[15],"overload":[18],"diseases":[19],"such":[20],"as":[21,40,136],"hemochromatosis.":[22],"More":[23],"recently,":[24],"compelling":[25],"evidence":[26,153],"has":[27],"emerged":[28],"regarding":[29],"critical":[31],"role":[32],"non-transferrin":[34],"bound":[35],"(NTBI),":[37],"also":[38],"catalytic":[41,92],"iron,":[42,67],"care":[45,52],"critically":[47],"ill":[48],"patients":[49],"intensive":[51],"units":[53],"(ICUs).":[54],"These":[55],"trace":[56],"amounts":[57],"constitute":[60],"a":[61,140],"small":[62],"percentage":[63],"serum":[66],"yet":[68],"they":[69],"are":[70,148],"heavily":[71],"implicated":[72],"exacerbation":[75],"diseases,":[77],"primarily":[78],"by":[79],"catalyzing":[80],"formation":[82],"reactive":[84],"oxygen":[85],"species,":[86],"which":[87,123],"promote":[88],"oxidative":[89],"stress.":[90],"Additionally,":[91],"activates":[94],"macrophages":[95],"and":[96,112,188],"facilitates":[97],"growth":[99],"pathogens.":[101],"This":[102],"review":[103],"aims":[104],"to":[105,125],"shed":[106],"light":[107],"on":[108,158],"this":[109],"underappreciated":[110],"phenomenon":[111],"explore":[113],"various":[115],"common":[116],"sources":[117],"NTBI":[119],"ICU":[121,145,167],"patients,":[122],"lead":[124],"transient":[126],"dysregulation":[128],"during":[129],"acute":[130],"phases":[131],"disease.":[133],"Iron":[134],"serves":[135],"linchpin":[138],"vicious":[141],"cycle":[142],"many":[144],"pathologies":[146],"that":[147],"often":[149],"multifactorial.":[150],"clinical":[152],"showing":[154],"detrimental":[156],"impact":[157],"patient":[159],"outcomes":[160],"will":[161,173],"be":[162,174],"outlined":[163],"major":[166],"pathologies.":[168],"Finally,":[169],"different":[170],"therapeutic":[171],"strategies":[172],"reviewed,":[175],"including":[176],"targeting":[178],"proteins":[180],"involved":[181],"metabolism,":[184],"conventional":[185],"chelation":[186,196],"therapy,":[187],"combination":[190],"renal":[192],"replacement":[193],"therapy":[194],"with":[195],"therapy.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-05T00:00:00"}