{"id":"https://openalex.org/W4389241663","doi":"https://doi.org/10.1158/1535-7163.targ-23-c049","title":"Abstract C049: Copenhagen Prospective Personalized Oncology (CoPPO) \u2013 The utility of using genomic profiling for tailored therapy in a Phase 1 setting","display_name":"Abstract C049: Copenhagen Prospective Personalized Oncology (CoPPO) \u2013 The utility of using genomic profiling for tailored therapy in a Phase 1 setting","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4389241663","doi":"https://doi.org/10.1158/1535-7163.targ-23-c049"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-23-c049","doi":"https://doi.org/10.1158/1535-7163.targ-23-c049","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.targ-23-c049","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030700880","display_name":"La\u00efla Belcaid","orcid":"https://orcid.org/0000-0001-8062-1533","observed_orcids":["https://orcid.org/0000-0001-8062-1533"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Laila Belcaid","raw_affiliation_strings":["1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109686774","display_name":"Martin Hoejgaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Martin Hoejgaard","raw_affiliation_strings":["1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073724601","display_name":"Ida Viller Tuxen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ida Tuxen","raw_affiliation_strings":["1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060631720","display_name":"Iben Spanggaard","orcid":"https://orcid.org/0000-0001-5925-2630","observed_orcids":["https://orcid.org/0000-0001-5925-2630"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Iben Spanggaard","raw_affiliation_strings":["1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077199450","display_name":"Ulrik Lassen","orcid":"https://orcid.org/0000-0002-3865-4574","observed_orcids":["https://orcid.org/0000-0002-3865-4574"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ulrik Lassen","raw_affiliation_strings":["1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004907539","display_name":"Finn Cilius Nielsen","orcid":"https://orcid.org/0000-0002-9829-1031","observed_orcids":["https://orcid.org/0000-0002-9829-1031"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Finn Cilius Nielsen","raw_affiliation_strings":["2Center for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Center for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017762827","display_name":"Christina Westmose Yde","orcid":"https://orcid.org/0000-0001-9578-9136","observed_orcids":["https://orcid.org/0000-0001-9578-9136"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christina Westmose Yde","raw_affiliation_strings":["2Center for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Center for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040078542","display_name":"Kristoffer Staal Rohrberg","orcid":"https://orcid.org/0000-0002-5448-9003","observed_orcids":["https://orcid.org/0000-0002-5448-9003"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kristoffer Rohrberg","raw_affiliation_strings":["1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology, Rigshospitalet, Copenhagen, Denmark,","institution_ids":["https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802709434"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"12_Supplement","first_page":"C049","last_page":"C049"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comprehensive-genomic-profiling","display_name":"comprehensive genomic profiling","score":0.8830000162124634},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6549999713897705},{"id":"https://openalex.org/keywords/advanced-solid-tumors","display_name":"advanced solid tumors","score":0.7350000143051147},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.7829999923706055},{"id":"https://openalex.org/keywords/actionable-therapeutic-targets","display_name":"actionable targets","score":0.8420000076293945},{"id":"https://openalex.org/keywords/dna-repair-pathways","display_name":"DNA repair pathways","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.8690000176429749},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.6970000267028809},{"id":"https://openalex.org/keywords/multidisciplinary-tumor-board","display_name":"multidisciplinary tumor board","score":0.6769999861717224},{"id":"https://openalex.org/keywords/treatment-refractory-cancer","display_name":"treatment-refractory cancer","score":0.4819999933242798},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.652999997138977},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7820000052452087},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.31200000643730164},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.722735583782196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5662509202957153},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5593941807746887},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.552912712097168},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5346360206604004},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.48499247431755066},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.4770214557647705},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4642546772956848},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.464252769947052},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.42607229948043823},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.42038509249687195},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2695768177509308},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24940919876098633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12386929988861084}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-23-c049","doi":"https://doi.org/10.1158/1535-7163.targ-23-c049","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.targ-23-c049","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3082935376","https://openalex.org/W3193951088","https://openalex.org/W4322484660","https://openalex.org/W2899657781","https://openalex.org/W4386960999","https://openalex.org/W2770866531","https://openalex.org/W4388011470","https://openalex.org/W4230423494","https://openalex.org/W4298001029","https://openalex.org/W3176719936"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"In":[2,96,281],"recent":[3],"years,":[4],"targeted":[5,267,279,284,346],"therapy":[6,354,395],"based":[7],"on":[8,410],"the":[9,17,27,41,144,242,293,359,405],"molecular":[10],"characterization":[11],"of":[12,29,46,156,170,241,278,349,389,404],"tumors":[13,39],"has":[14],"been":[15],"among":[16],"most":[18,179,227],"remarkable":[19],"advances":[20],"in":[21,33,83,211,222,396],"cancer":[22,67,161,185,189,195,202],"medicine.":[23,134],"Here,":[24],"we":[25],"report":[26,121],"impact":[28],"comprehensive":[30],"genomic":[31,120,145,333,391],"profiling":[32,334,392],"patients":[34],"(pts)":[35],"with":[36,65,140,159,260,266,273,352],"advanced":[37,66,160],"solid":[38],"at":[40,358],"Phase":[42,71,398],"1":[43,399],"unit,":[44],"Department":[45],"Oncology,":[47],"Rigshospitalet,":[48],"Denmark.":[49],"Materials":[50],"and":[51,93,124,151,162,178,200,250,321,341,413],"Methods:":[52],"A":[53],"prospective,":[54],"single-center,":[55],"single-arm":[56],"open":[57],"label":[58],"study":[59,330],"(NCT02290522)":[60],"was":[61,85,102,122,172,220],"conducted,":[62],"enrolling":[63],"pts":[64,137,158,171,213,224,258,270,344,350],"referred":[68],"to":[69,132,143,235,310,337,342,345],"a":[70,127,154,397],"I":[72],"Unit.":[73],"Fresh":[74],"tumor":[75,100,107,111,129,181,251,322],"tissue":[76,101,108],"18G":[77],"core":[78],"needle":[79],"or":[80,90,109],"equivalent":[81],"preserved":[82],"RNAlater":[84],"obtained":[86,210],"for":[87,393],"whole":[88],"genome":[89],"exome":[91],"sequencing":[92],"RNA":[94],"sequencing.":[95],"cases":[97],"where":[98],"fresh":[99],"unavailable,":[103],"archived":[104],"formalin-fixed":[105],"paraffin-embedded":[106],"circulating":[110],"DNA":[112,243,294],"extracted":[113],"from":[114],"plasma":[115],"were":[116,138,166,209,231,264,271,287],"obtained.":[117],"Each":[118],"individual":[119],"reviewed":[123],"discussed":[125],"by":[126],"multidisciplinary":[128],"board":[130],"dedicated":[131],"precision":[133],"When":[135],"possible,":[136],"treated":[139,265,272,351],"regimen":[141],"matched":[142,234,309,353],"profile.":[146],"Results:":[147],"Between":[148],"April":[149],"2013":[150],"December":[152],"2022,":[153],"total":[155,282],"2151":[157],"exhausted":[163],"treatment":[164,285],"options":[165],"enrolled.":[167],"Median":[168],"age":[169],"62":[173],"years":[174],"(range:":[175],"17-":[176],"87)":[177],"common":[180,228],"types":[182],"included":[183],"colorectal":[184],"(N=465,":[186],"22%),":[187],"breast":[188],"(N=290,":[190],"13%),":[191,314],"non-small":[192],"cell":[193],"lung":[194],"(N":[196,203],"=":[197,204],"251,":[198],"12%)":[199,320],"prostate":[201],"174,":[205],"8%).":[206,255],"Genomic":[207],"profiles":[208,233,308],"1870":[212],"(87%).":[214],"At":[215],"least":[216],"one":[217,276],"actionable":[218,229,262,339],"target":[219,263],"identified":[221],"1067":[223],"(57%).":[225],"The":[226,289,387],"targets":[230,340],"expression":[232,307],"monoclonal":[236,311],"antibodies":[237,312],"(N=559,":[238],"52%),":[239],"alteration":[240],"damage":[244,295],"repair":[245,296],"response":[246,297],"pathway":[247,298,317],"(N=407,":[248],"38%)":[249],"mutational":[252,323],"burden-high":[253,324],"(N=84,":[254],"Overall,":[256],"261":[257],"(24%)":[259],"an":[261],"therapy.":[268,280],"11":[269],"more":[274],"than":[275],"line":[277],"276":[283],"regimens":[286],"initiated.":[288],"treatments":[290],"predominantly":[291],"targeted;":[292],"(N=54,":[299],"20%),":[300],"BRAF":[301],"V600E":[302],"mutation":[303],"(N=":[304],"47,":[305],"17%),":[306],"(N=35,":[313],"ERBB2":[315],"family":[316],"alterations":[318],"(N=34,":[319,325],"12%).":[326],"Conclusion:":[327],"This":[328],"large-scale":[329],"demonstrates":[331],"that":[332],"is":[335],"efficient":[336],"identify":[338],"match":[343],"therapies.":[347],"Outcomes":[348],"will":[355],"be":[356],"presented":[357],"meeting.":[360],"Citation":[361],"Format:":[362],"Laila":[363],"Belcaid,":[364],"Martin":[365],"Hoejgaard,":[366],"Ida":[367],"Tuxen,":[368],"Iben":[369],"Spanggaard,":[370],"Ulrik":[371],"Lassen,":[372],"Finn":[373],"Cilius":[374],"Nielsen,":[375],"Christina":[376],"Westmose":[377],"Yde,":[378],"Kristoffer":[379],"Rohrberg.":[380],"Copenhagen":[381],"Prospective":[382],"Personalized":[383],"Oncology":[384],"(CoPPO)":[385],"\u2013":[386],"utility":[388],"using":[390],"tailored":[394],"setting":[400],"[abstract].":[401],"In:":[402],"Proceedings":[403],"AACR-NCI-EORTC":[406],"Virtual":[407],"International":[408],"Conference":[409],"Molecular":[411],"Targets":[412],"Cancer":[414,425],"Therapeutics;":[415],"2023":[416],"Oct":[417],"11-15;":[418],"Boston,":[419],"MA.":[420],"Philadelphia":[421],"(PA):":[422],"AACR;":[423],"Mol":[424],"Ther":[426],"2023;22(12":[427],"Suppl):Abstract":[428],"nr":[429],"C049.":[430]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
