{"id":"https://openalex.org/W4389239882","doi":"https://doi.org/10.1158/1535-7163.targ-23-lb_b06","title":"Abstract LB_B06: Single cell transcriptomics guided identification of antigen combinations for the design of logic-gated CAR therapies","display_name":"Abstract LB_B06: Single cell transcriptomics guided identification of antigen combinations for the design of logic-gated CAR therapies","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4389239882","doi":"https://doi.org/10.1158/1535-7163.targ-23-lb_b06"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-23-lb_b06","doi":"https://doi.org/10.1158/1535-7163.targ-23-lb_b06","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.targ-23-lb_b06","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030786757","display_name":"Sanna Madan","orcid":"https://orcid.org/0000-0001-8865-5789","observed_orcids":["https://orcid.org/0000-0001-8865-5789"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanna Madan","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069858313","display_name":"Tiangen Chang","orcid":"https://orcid.org/0000-0003-1485-1992","observed_orcids":["https://orcid.org/0000-0003-1485-1992"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiangen Chang","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415584","display_name":"Binbin Wang","orcid":"https://orcid.org/0000-0003-2885-6428","observed_orcids":["https://orcid.org/0000-0003-2885-6428"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Binbin Wang","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000317216","display_name":"Alejandro A. Sch\u00e4ffer","orcid":"https://orcid.org/0000-0002-2147-8033","observed_orcids":["https://orcid.org/0000-0002-2147-8033"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro A. Sch\u00e4ffer","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063492133","display_name":"Eytan Ruppin","orcid":"https://orcid.org/0000-0002-7862-3940","observed_orcids":["https://orcid.org/0000-0002-7862-3940"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eytan Ruppin","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"12_Supplement","first_page":"LB_B06","last_page":"LB_B06"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.8859999775886536},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"genetic algorithm","score":0.9229999780654907},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tumor-antigen-heterogeneity","display_name":"tumor antigen heterogeneity","score":0.6740000247955322},{"id":"https://openalex.org/keywords/on-target-off-tumor-toxicity","display_name":"on-target off-tumor toxicity","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-cell-discrimination","display_name":"tumor cell discrimination","score":0.6539999842643738},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7389837503433228},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6345576643943787},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.6077604293823242},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5560045838356018},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4796460270881653},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47875896096229553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44979241490364075},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.445582777261734},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4302104711532593},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4000972807407379},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39308011531829834},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32188138365745544},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.28837162256240845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2735154628753662},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.184147447347641},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16720536351203918},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11510556936264038}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-23-lb_b06","doi":"https://doi.org/10.1158/1535-7163.targ-23-lb_b06","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.targ-23-lb_b06","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393983074","https://openalex.org/W4408326265","https://openalex.org/W4409629088","https://openalex.org/W4408723262","https://openalex.org/W4416087837","https://openalex.org/W4415444430","https://openalex.org/W4321079297","https://openalex.org/W4321748624","https://openalex.org/W3212900065","https://openalex.org/W3084569243"],"abstract_inverted_index":{"Abstract":[0],"Chimeric":[1],"antigen":[2,24,163],"receptor":[3],"(CAR)":[4],"T-cell":[5],"therapy":[6],"has":[7],"demonstrated":[8],"significant":[9],"efficacy":[10],"in":[11,18,30,108],"treating":[12,19],"hematological":[13],"cancers":[14],"but":[15],"faces":[16],"challenges":[17],"solid":[20],"tumors":[21],"due":[22],"to":[23,44,60,74,89],"heterogeneity":[25],"and":[26,67,79,139,184],"off-tumor,":[27],"on-target":[28],"expression":[29],"normal":[31],"tissues.":[32],"To":[33],"combat":[34],"these":[35,142],"challenges,":[36],"we":[37],"developed":[38],"a":[39],"novel":[40],"genetic":[41],"algorithm":[42,52,94],"approach":[43,121],"analyze":[45],"patient":[46,116],"tumor":[47,110],"single-cell":[48],"transcriptomics":[49,159],"data.":[50],"This":[51],"identifies":[53],"combinations":[54,75,97,164],"of":[55,76,98,126,141,162,168,175],"cell":[56,158],"surface":[57],"antigens":[58,100,107],"specific":[59],"cancer":[61,91],"cells":[62,111,114],"by":[63],"incorporating":[64],"\"AND,\"":[65],"\"OR,\"":[66],"\"NOT\"":[68],"logic.":[69],"Our":[70],"method":[71],"is":[72],"generalizable":[73],"any":[77],"size":[78],"demonstrates":[80],"rapid":[81],"convergence":[82],"across":[83,115],"different":[84],"parameter":[85],"choices.":[86],"When":[87],"applied":[88],"breast":[90],"datasets,":[92],"our":[93,120],"identified":[95],"optimal":[96],"triplet":[99],"that":[101],"outperformed":[102],"clinically":[103],"tested":[104],"single":[105],"target":[106,133],"discriminating":[109],"from":[112],"non-tumor":[113],"samples.":[117],"In":[118],"sum,":[119],"may":[122],"guide":[123],"the":[124,137,166,176],"design":[125,167],"logic-gated":[127,169],"CAR":[128,170],"therapies":[129,171],"aimed":[130],"at":[131],"multiple":[132],"antigens,":[134],"thereby":[135],"increasing":[136],"safety":[138],"selectivity":[140],"therapies.":[143],"Citation":[144],"Format:":[145],"Sanna":[146],"Madan,":[147],"Tiangen":[148],"Chang,":[149],"Binbin":[150],"Wang,":[151],"Alejandro":[152],"A.":[153],"Sch\u00e4ffer,":[154],"Eytan":[155],"Ruppin.":[156],"Single":[157],"guided":[160],"identification":[161],"for":[165],"[abstract].":[172],"In:":[173],"Proceedings":[174],"AACR-NCI-EORTC":[177],"Virtual":[178],"International":[179],"Conference":[180],"on":[181],"Molecular":[182],"Targets":[183],"Cancer":[185,196],"Therapeutics;":[186],"2023":[187],"Oct":[188],"11-15;":[189],"Boston,":[190],"MA.":[191],"Philadelphia":[192],"(PA):":[193],"AACR;":[194],"Mol":[195],"Ther":[197],"2023;22(12":[198],"Suppl):Abstract":[199],"nr":[200],"LB_B06.":[201]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2023-12-02T00:00:00"}