{"id":"https://openalex.org/W4389239557","doi":"https://doi.org/10.1158/2326-6066.c.6960360.v1","title":"Data from Tumor-Reactive CD8+ T Cells Enter a TCF1+PD-1\u2212 Dysfunctional State","display_name":"Data from Tumor-Reactive CD8+ T Cells Enter a TCF1+PD-1\u2212 Dysfunctional State","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4389239557","doi":"https://doi.org/10.1158/2326-6066.c.6960360.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.c.6960360.v1","doi":"https://doi.org/10.1158/2326-6066.c.6960360.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6960360.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2326-6066.c.6960360.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010582214","display_name":"Jessica J. Roetman","orcid":"https://orcid.org/0009-0005-7783-8308","observed_orcids":["https://orcid.org/0009-0005-7783-8308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica J. Roetman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-7783-8308","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079240549","display_name":"Megan M. Erwin","orcid":"https://orcid.org/0000-0002-7014-0856","observed_orcids":["https://orcid.org/0000-0002-7014-0856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megan M. Erwin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7014-0856","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032744758","display_name":"Michael W. Rudloff","orcid":"https://orcid.org/0000-0002-2950-1218","observed_orcids":["https://orcid.org/0000-0002-2950-1218"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael W. Rudloff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2950-1218","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014080829","display_name":"Natalie R. Favret","orcid":"https://orcid.org/0000-0002-4458-7785","observed_orcids":["https://orcid.org/0000-0002-4458-7785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalie R. Favret","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4458-7785","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047603238","display_name":"Carlos R. Detr\u00e9s Rom\u00e1n","orcid":"https://orcid.org/0009-0008-1223-4177","observed_orcids":["https://orcid.org/0009-0008-1223-4177"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos R. Detr\u00e9s Rom\u00e1n","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-1223-4177","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039403168","display_name":"Minna K.I. Apostolova","orcid":"https://orcid.org/0000-0003-3382-7082","observed_orcids":["https://orcid.org/0000-0003-3382-7082"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minna K.I. Apostolova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3382-7082","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018903605","display_name":"Kristen A. Murray","orcid":"https://orcid.org/0009-0002-7772-3277","observed_orcids":["https://orcid.org/0009-0002-7772-3277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristen A. Murray","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-7772-3277","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057288571","display_name":"Ting\u2010Fang Lee","orcid":"https://orcid.org/0000-0003-2693-9510","observed_orcids":["https://orcid.org/0000-0003-2693-9510","https://orcid.org/0000-0003-4939-7136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting-Fang Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2693-9510","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091411449","display_name":"Youngmin A. Lee","orcid":"https://orcid.org/0000-0002-6567-7755","observed_orcids":["https://orcid.org/0000-0002-6567-7755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youngmin A. Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6567-7755","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049229364","display_name":"Mary Philip","orcid":"https://orcid.org/0000-0001-7496-2630","observed_orcids":["https://orcid.org/0000-0001-7496-2630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Philip","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7496-2630","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.1006999984383583,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-specific-cd8-t-cells","display_name":"tumor-specific CD8+ T cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tumor-specific-antigens","display_name":"tumor-specific antigens","score":0.859000027179718},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.781000018119812},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.6669999957084656},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.7229999899864197},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.9750000238418579},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.671999990940094},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tox","display_name":"TOX","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cd39","display_name":"CD39","score":0.9580000042915344},{"id":"https://openalex.org/keywords/effector-function-loss","display_name":"effector function loss","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6408683061599731},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5407258868217468},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5235744714736938},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5179680585861206},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4845842123031616},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.4840828478336334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4653049111366272},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.441845178604126},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.41386762261390686},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4131966531276703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3396323025226593},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28838157653808594},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22416985034942627},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.18863683938980103},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14579042792320251},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14210301637649536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0967286229133606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6066.c.6960360.v1","doi":"https://doi.org/10.1158/2326-6066.c.6960360.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6960360.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.c.6960360.v1","doi":"https://doi.org/10.1158/2326-6066.c.6960360.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6960360.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387665466","https://openalex.org/W4389239586","https://openalex.org/W4389242372","https://openalex.org/W4389239583","https://openalex.org/W2514996992","https://openalex.org/W4389242005","https://openalex.org/W4389239528","https://openalex.org/W3096220156","https://openalex.org/W4389242016","https://openalex.org/W4404175169"],"abstract_inverted_index":{"Abstract":[0],"T":[1,84,90,198],"cells":[2,85,92,199],"recognize":[3],"several":[4],"types":[5],"of":[6,148,214],"antigens":[7,41,98],"in":[8,94,109,166,168,180,207],"tumors,":[9],"including":[10],"aberrantly":[11],"expressed,":[12],"nonmutated":[13],"proteins,":[14,34],"which":[15,35,110],"are":[16,36],"therefore":[17],"shared":[18],"with":[19],"normal":[20],"tissue":[21],"and":[22,28,60,87,115,128,141,151,158],"referred":[23,37],"to":[24,38,57,79,96,174,182,201],"as":[25,39,45,119],"self/shared-antigens":[26],"(SSA),":[27],"mutated":[29],"proteins":[30],"or":[31,178,186],"oncogenic":[32],"viral":[33],"tumor-specific":[40,82],"(TSA).":[42],"Immunotherapies":[43],"such":[44],"immune":[46],"checkpoint":[47],"blockade":[48],"(ICB)":[49],"can":[50,112],"activate":[51],"T-cell":[52,194,220],"responses":[53],"against":[54,62],"TSA,":[55],"leading":[56],"tumor":[58,215],"control,":[59],"also":[61],"SSA,":[63],"causing":[64],"immune-related":[65],"adverse":[66],"events":[67],"(irAE).":[68],"To":[69],"improve":[70],"anti-TSA":[71],"immunity":[72],"while":[73,136],"limiting":[74],"anti-SSA":[75],"autoreactivity,":[76],"we":[77,102,111],"need":[78],"understand":[80],"how":[81],"CD8+":[83,89],"(TST)":[86],"SSA-specific":[88],"(SST)":[91],"differentiate":[93],"response":[95,181],"cognate":[97],"during":[99],"tumorigenesis.":[100],"Therefore,":[101],"developed":[103],"a":[104,143,169,192,203],"genetic":[105],"cancer":[106],"mouse":[107],"model":[108],"track":[113],"TST":[114,127,137],"SST":[116,129,153,164],"differentiation":[117],"longitudinally":[118],"liver":[120,161],"cancers":[121],"develop.":[122],"We":[123],"found":[124],"that":[125,211],"both":[126],"lost":[130],"effector":[131,176,208],"function":[132],"over":[133],"time,":[134],"but":[135],"persisted":[138,165],"long":[139],"term":[140],"had":[142],"dysfunctional/exhausted":[144],"phenotype":[145],"(including":[146],"expression":[147],"PD1,":[149],"CD39,":[150],"TOX),":[152],"exited":[154],"cell":[155],"cycle":[156],"prematurely":[157],"disappeared":[159],"from":[160],"lesions.":[162],"However,":[163],"spleens":[167],"dysfunctional":[170,193],"TCF1+PD-1\u2013":[171,204],"state:":[172],"unable":[173],"produce":[175],"cytokines":[177],"proliferate":[179],"ICB":[183],"targeting":[184],"PD-1":[185],"PD-L1.":[187],"Thus,":[188],"our":[189],"studies":[190],"identify":[191],"state":[195,205],"occupied":[196],"by":[197],"reactive":[200],"SSA:":[202],"lacking":[206],"function,":[209],"demonstrating":[210],"the":[212],"type/specificity":[213],"antigen":[216],"may":[217],"determine":[218],"tumor-reactive":[219],"differentiation.":[221]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-12-02T00:00:00"}