{"id":"https://openalex.org/W4389234752","doi":"https://doi.org/10.1182/blood-2023-190948","title":"Avatrombopag Is Effective in First-Line Treatment of Severe Aplastic Anemia: Early Outcomes of a Prospective Study","display_name":"Avatrombopag Is Effective in First-Line Treatment of Severe Aplastic Anemia: Early Outcomes of a Prospective Study","publication_year":2023,"publication_date":"2023-11-02","ids":{"openalex":"https://openalex.org/W4389234752","doi":"https://doi.org/10.1182/blood-2023-190948"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2023-190948","doi":"https://doi.org/10.1182/blood-2023-190948","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-190948","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4087/2194912/blood-688-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4087/2194912/blood-688-main.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100625557","display_name":"Xin Zhao","orcid":"https://orcid.org/0000-0002-5621-0459","observed_orcids":["https://orcid.org/0000-0002-5621-0459"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Zhao","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100370614","display_name":"Jianping Li","orcid":"https://orcid.org/0000-0002-5392-0471","observed_orcids":["https://orcid.org/0000-0002-5392-0471"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianping Li","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103019963","display_name":"Huihui Fan","orcid":"https://orcid.org/0000-0002-7356-6190","observed_orcids":["https://orcid.org/0000-0002-7356-6190"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huihui Fan","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110949623","display_name":"Liping Jing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Jing","raw_affiliation_strings":["2Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425554","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-3617-2627","observed_orcids":["https://orcid.org/0000-0002-3617-2627","https://orcid.org/0000-0003-2756-2620","https://orcid.org/0009-0001-8129-4308"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101543940","display_name":"Kang Zhou","orcid":"https://orcid.org/0000-0002-7237-2247","observed_orcids":["https://orcid.org/0000-0002-7237-2247"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kang Zhou","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009364448","display_name":"Wenrui Yang","orcid":"https://orcid.org/0000-0001-9650-3937","observed_orcids":["https://orcid.org/0000-0001-9650-3937"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenrui Yang","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Li","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yang Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100328600","display_name":"Lei Ye","orcid":"https://orcid.org/0000-0002-6216-3265","observed_orcids":["https://orcid.org/0000-0002-6216-3265"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Ye","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063604601","display_name":"Guangxin Peng","orcid":"https://orcid.org/0000-0002-8087-5442","observed_orcids":["https://orcid.org/0000-0002-8087-5442"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangxin Peng","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109592012","display_name":"Youzhen Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youzhen Xiong","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054739067","display_name":"Jun Shi","orcid":"https://orcid.org/0000-0002-8531-0483","observed_orcids":["https://orcid.org/0000-0002-8531-0483"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Shi","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056433537","display_name":"Fengkui Zhang","orcid":"https://orcid.org/0000-0002-2797-1339","observed_orcids":["https://orcid.org/0000-0002-2797-1339"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengkui Zhang","raw_affiliation_strings":["1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"142","issue":"Supplement 1","first_page":"4087","last_page":"4087"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.10360000282526016,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.08179999887943268,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/avatrombopag","display_name":"avatrombopag","score":0.9610000252723694},{"id":"https://openalex.org/keywords/severe-aplastic-anemia","display_name":"severe aplastic anemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/very-severe-aplastic-anemia","display_name":"very severe aplastic anemia","score":0.8539999723434448},{"id":"https://openalex.org/keywords/thrombopoietin-receptor-agonists","display_name":"thrombopoietin receptor agonists","score":0.8849999904632568},{"id":"https://openalex.org/keywords/antithymocyte-globulin","display_name":"antithymocyte globulin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.824999988079071},{"id":"https://openalex.org/keywords/complete-hematologic-response","display_name":"complete hematologic response","score":0.9610000252723694},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bone-marrow-failure","display_name":"bone marrow failure","score":0.6880000233650208},{"id":"https://openalex.org/keywords/t-cell-mediated-autoimmunity","display_name":"T cell-mediated autoimmunity","score":0.824999988079071},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6389999985694885},{"id":"https://openalex.org/keywords/eltrombopag","display_name":"eltrombopag","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8521844148635864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6475577354431152},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6315958499908447},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.5732955932617188},{"id":"https://openalex.org/C2780588981","wikidata":"https://www.wikidata.org/wiki/Q411588","display_name":"Eltrombopag","level":4,"score":0.5591367483139038},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5128881931304932},{"id":"https://openalex.org/C2780525284","wikidata":"https://www.wikidata.org/wiki/Q7882181","display_name":"Bone marrow failure","level":4,"score":0.4798395335674286},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.4778722822666168},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.473296582698822},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.41235336661338806},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.3261905312538147},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2635311186313629},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.22698050737380981},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.19560173153877258},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.1417982280254364},{"id":"https://openalex.org/C2993327898","wikidata":"https://www.wikidata.org/wiki/Q638729","display_name":"Immune thrombocytopenia","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2023-190948","doi":"https://doi.org/10.1182/blood-2023-190948","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-190948","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4087/2194912/blood-688-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood-2023-190948","doi":"https://doi.org/10.1182/blood-2023-190948","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-190948","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4087/2194912/blood-688-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4389234752.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310096217","https://openalex.org/W4404027399","https://openalex.org/W4405044448","https://openalex.org/W4310104748","https://openalex.org/W4391004756","https://openalex.org/W2753643104","https://openalex.org/W3095393609","https://openalex.org/W4405044353","https://openalex.org/W4389222105","https://openalex.org/W2987747988"],"abstract_inverted_index":{"Acquired":[0],"severe":[1,176],"aplastic":[2,177],"anemia":[3,178],"(SAA)":[4],"is":[5,28,43,100,104],"a":[6,59,141,250],"life-threatening":[7],"bone":[8],"marrow":[9],"failure":[10],"disease":[11],"and":[12,22,39,71,87,119,129,134,147,173,188,192,218,246,265,289,302,323,342],"its":[13,98],"pathogenesis":[14],"involves":[15],"T":[16],"cell-mediated":[17],"autoimmunity.":[18],"Antithymocyte":[19],"globulin":[20],"(ATG)":[21],"cyclosporine":[23,191],"based":[24],"immunosuppressive":[25],"therapy":[26],"(IST)":[27],"effective":[29],"for":[30,34,149,213,222,230,347],"patients":[31,53,61,92,116,160,172,214,223,258,267,276,348],"not":[32],"eligible":[33],"hematopoietic":[35],"stem":[36],"cell":[37],"transplant,":[38],"the":[40,82,163,201,260,329],"response":[41,47,84,279,295,341,345],"rate":[42,86,89,128,131,296,304,346],"60-70%.":[44],"Complete":[45],"hematological":[46],"(CR)":[48],"predicts":[49],"better":[50],"survival":[51],"of":[52,90,145,204,209,240,253,262,270,321,331],"received":[54,117,189],"IST":[55,120,148,334],"treatment,":[56],"but":[57,97],"only":[58],"few":[60],"achieve":[62],"CR":[63,88,127,303],"within":[64,185],"6":[65,74,135,186,271,298],"months":[66,70,187,264,282,299],"(5%":[67],"at":[68,73,132,200,207,238,249,280,297,315],"3":[69,133,263,281,316],"12-17%":[72],"months).":[75],"Thrombopoietin":[76],"receptor":[77],"agonist":[78],"(TPO-RA)":[79],"eltrombopag":[80],"improves":[81],"overall":[83,294],"(OR)":[85],"SAA":[91,115,152,171],"when":[93],"combined":[94],"with":[95,318,349],"IST,":[96],"hepatotoxicity":[99],"still":[101],"worrying.":[102],"Avatrombopag":[103,197],"another":[105],"small-molecule":[106],"TPO-RA":[107],"without":[108],"hepatic":[109],"toxicity.":[110],"We":[111],"previously":[112],"found":[113],"that":[114],"avatrombopag":[118,146,193,332],"as":[121,183,194,335],"first-line":[122,195,336],"treatment":[123,337],"showed":[124,338],"both":[125],"higher":[126,343],"OR":[130],"months.":[136,272],"To":[137],"validate":[138],"our":[139],"findings,":[140],"prospective,":[142],"single-arm":[143],"study":[144,164],"newly":[150],"diagnosed":[151,182],"was":[153,198,228,235,300,305],"carried":[154],"out":[155],"(NCT05720234).":[156],"There":[157,242,273],"were":[158,181,243,274],"25":[159],"enrolled":[161],"in":[162],"by":[165],"June":[166],"31,":[167],"2023,":[168],"including":[169,284],"21":[170],"4":[174],"very":[175],"patients.":[179],"Patients":[180],"AA":[184],"ATG,":[190],"treatment.":[196],"administered":[199],"first":[202],"day":[203,212,221],"ATG":[205,227],"initiation":[206],"dose":[208,239],"60mg":[210],"per":[211,220],"weight":[215,224],"\u2265":[216],"50kg":[217],"40mg":[219],"<":[225],"50kg.":[226],"given":[229,236],"5":[231,285],"consecutive":[232],"days.":[233],"Cyclosporine":[234],"orally":[237],"3.5-5mg/kg.d.":[241],"15":[244,275],"males":[245],"10":[247,266,290],"males,":[248],"median":[251],"age":[252],"37":[254],"years":[255],"old.":[256],"Eighteen":[257],"achieved":[259,268,277],"end-point":[261,269],"hematologic":[278,340],"(83.3%),":[283],"complete":[286,344],"responders":[287],"(27.8%)":[288],"partial":[291],"responders.":[292],"The":[293],"80%,":[301],"60%.":[306],"One":[307],"patient":[308],"evolved":[309],"to":[310,333],"hemolytic":[311],"paroxysmal":[312],"nocturnal":[313],"hemoglobinuria":[314],"months,":[317],"normal":[319],"count":[320],"platelet":[322],"white":[324],"blood":[325],"cell.":[326],"In":[327],"conclusion,":[328],"addition":[330],"earlier":[339],"SAA.":[350]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-12-02T00:00:00"}
