{"id":"https://openalex.org/W4389230469","doi":"https://doi.org/10.1182/blood-2023-181787","title":"Going Going Gonad: Assessing Iron Staining Impact on Fertility for Patients with Sickle Cell Disease","display_name":"Going Going Gonad: Assessing Iron Staining Impact on Fertility for Patients with Sickle Cell Disease","publication_year":2023,"publication_date":"2023-11-02","ids":{"openalex":"https://openalex.org/W4389230469","doi":"https://doi.org/10.1182/blood-2023-181787"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2023-181787","doi":"https://doi.org/10.1182/blood-2023-181787","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-181787","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/5343/2201214/blood-1944-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/5343/2201214/blood-1944-main.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055172436","display_name":"Mahvish Qureshi Rahim","orcid":"https://orcid.org/0000-0002-3851-1979","observed_orcids":["https://orcid.org/0000-0002-3851-1979"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahvish Q. Rahim","raw_affiliation_strings":["1Riley Hospital for Children, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Riley Hospital for Children, Indianapolis, IN","institution_ids":["https://openalex.org/I2802740592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068847859","display_name":"Derrick L. Goubeaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derrick L. Goubeaux","raw_affiliation_strings":["1Riley Hospital for Children, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Riley Hospital for Children, Indianapolis, IN","institution_ids":["https://openalex.org/I2802740592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057158615","display_name":"Seethal A. Jacob","orcid":"https://orcid.org/0000-0003-2906-6102","observed_orcids":["https://orcid.org/0000-0003-2906-6102"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seethal A Jacob","raw_affiliation_strings":["2Riley Hospital For Children, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Riley Hospital For Children, Indianapolis, IN","institution_ids":["https://openalex.org/I2802740592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036185336","display_name":"Amanda C. Zielen","orcid":"https://orcid.org/0000-0002-4291-4084","observed_orcids":["https://orcid.org/0000-0002-4291-4084"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda C. Zielen","raw_affiliation_strings":["3University of Pittsburgh School of Medicine, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Pittsburgh School of Medicine, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063861753","display_name":"Kyle E. Orwig","orcid":"https://orcid.org/0000-0002-7952-8419","observed_orcids":["https://orcid.org/0000-0002-7952-8419"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle E. Orwig","raw_affiliation_strings":["3University of Pittsburgh School of Medicine, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Pittsburgh School of Medicine, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032760756","display_name":"Jessica L. Davis","orcid":"https://orcid.org/0000-0002-2725-1518","observed_orcids":["https://orcid.org/0000-0002-2725-1518"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica L. Davis","raw_affiliation_strings":["4Riley Hosptial for Children, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Riley Hosptial for Children, Indianapolis, IN","institution_ids":["https://openalex.org/I2802740592"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091380386","display_name":"Amanda J. Saraf","orcid":"https://orcid.org/0000-0002-0167-8716","observed_orcids":["https://orcid.org/0000-0002-0167-8716"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda J Saraf","raw_affiliation_strings":["1Riley Hospital for Children, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Riley Hospital for Children, Indianapolis, IN","institution_ids":["https://openalex.org/I2802740592"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"142","issue":"Supplement 1","first_page":"5343","last_page":"5343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":1.0},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.8960000276565552},{"id":"https://openalex.org/keywords/fertility-preservation","display_name":"fertility preservation","score":0.652999997138977},{"id":"https://openalex.org/keywords/testicular-tissue-cryopreservation","display_name":"testicular tissue cryopreservation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/germ-cells","display_name":"germ cells","score":0.699999988079071},{"id":"https://openalex.org/keywords/chronic-transfusion-therapy","display_name":"chronic transfusion","score":0.753000020980835},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.777999997138977},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/gonadotoxicity","display_name":"gonadotoxicity","score":0.828000009059906},{"id":"https://openalex.org/keywords/beta-thalassemia-major","display_name":"beta-thalassemia major","score":0.7820000052452087},{"id":"https://openalex.org/keywords/fertility-counseling","display_name":"fertility counseling","score":0.5920000076293945},{"id":"https://openalex.org/keywords/prepubertal-children","display_name":"prepubertal children","score":0.6079999804496765},{"id":"https://openalex.org/keywords/iron-staining","display_name":"iron staining","score":0.414000004529953},{"id":"https://openalex.org/keywords/sperm-quality","display_name":"semen quality","score":0.5540000200271606},{"id":"https://openalex.org/keywords/target-organ-damage","display_name":"target organ damage","score":0.5590000152587891},{"id":"https://openalex.org/keywords/iron-chelation","display_name":"iron chelation","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6833779811859131},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.6447468996047974},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5130366086959839},{"id":"https://openalex.org/C2777904497","wikidata":"https://www.wikidata.org/wiki/Q5445580","display_name":"Fertility preservation","level":4,"score":0.4980144500732422},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4600510597229004},{"id":"https://openalex.org/C2779668550","wikidata":"https://www.wikidata.org/wiki/Q1642147","display_name":"Hemoglobinopathy","level":3,"score":0.4355057179927826},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3957226276397705},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37608838081359863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.331093966960907},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33063581585884094},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10562124848365784}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2023-181787","doi":"https://doi.org/10.1182/blood-2023-181787","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-181787","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/5343/2201214/blood-1944-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood-2023-181787","doi":"https://doi.org/10.1182/blood-2023-181787","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-181787","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/5343/2201214/blood-1944-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389230469.pdf","grobid_xml":"https://content.openalex.org/works/W4389230469.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149503337","https://openalex.org/W4307267297","https://openalex.org/W4311137434","https://openalex.org/W7125488199","https://openalex.org/W2770968902","https://openalex.org/W2574500472","https://openalex.org/W4224219815","https://openalex.org/W4410874276","https://openalex.org/W4415383480","https://openalex.org/W6980914945"],"abstract_inverted_index":{"Introduction:":[0],"Medical":[1,272],"advances":[2],"in":[3,39,76,83,107,147,154,593,617],"the":[4,19,45,148,173,185,201,225,268,281,295,306,346,354,359,386,412,458,609],"care":[5,22],"of":[6,21,29,124,184,187,224,249,262,270,280,290,308,348,356,462,480,493,511,517,611,623],"patients":[7,40,163,193,250,333,363,375,380,416,500,534,572],"with":[8,41,110,126,194,240,251,294,334,376,381,417,451,509,558,589],"sickle":[9],"cell":[10,64,68,600],"disease":[11,47,577],"(SCD)":[12],"and":[13,25,66,87,97,120,230,319,325,336,351,378,404,433,455,476,483,491,514,543,614],"other":[14,77],"hemoglobinopathies":[15],"have":[16,234,395,399,425,443,504,550,574],"allowed":[17],"for":[18,36,116,139,176,192,237,292,298,305,345,361,473,488],"focus":[20],"to":[23,81,199,204,208,212,219,276,322,343,394,424,465,497,503,570,583,607],"shift":[24],"incorporate":[26],"long-term":[27],"quality":[28],"life":[30],"metrics,":[31],"such":[32,58],"as":[33,49,51,59,167,172,259],"fertility.":[34],"Concerns":[35],"reproductive":[37],"health":[38],"SCD":[42,252,335,377,388],"stem":[43,67],"from":[44,52,73,332,371,415],"underlying":[46],"itself":[48],"well":[50],"medical":[53,228],"therapies":[54],"that":[55,130,227,533],"are":[56,164,178],"offered":[57],"hydroxyurea,":[60],"chronic":[61,74,188,231],"red":[62],"blood":[63,481,494,581],"transfusions,":[65,482],"transplant":[69],"(SCT).":[70],"Iron":[71,141],"deposition":[72,104,142,592],"transfusions":[75,189,232,495,582],"tissues":[78],"is":[79,92,197,245,587],"known":[80,93],"result":[82],"end":[84],"organ":[85],"damage":[86],"lifelong":[88],"consequences.":[89],"While":[90],"little":[91],"about":[94],"iron":[95,103,131,214,326,518,537,560,591],"overload":[96,132,215],"fertility,":[98],"one":[99],"study":[100,244],"noted":[101,532],"testicular":[102,217,255,506,556,595],"on":[105,137,190,216,235,447,457,471,486,519,525,540,554],"MRI":[106],"pubertal":[108],"males":[109],"transfusion-dependent":[111],"beta-thalassemia;":[112],"results":[113],"were":[114,303,328,392,422,429,456,501],"notable":[115],"lower":[117,122],"sperm":[118,125],"concentrations":[119],"a":[121,168,181,221,238,246,260,263,287,544,551,575],"percentage":[123],"normal":[127,505],"morphology,":[128],"indicating":[129],"likely":[133],"has":[134,143],"an":[135],"impact":[136,186,226,553],"fertility":[138,191,206,236,612],"patients.":[140],"not":[144,159,400,430,549],"been":[145,365,402,470],"studied":[146],"pre-pubertal":[149],"hemoglobinopathy":[150],"population.":[151],"Fertility":[152],"counseling":[153],"this":[155,312,357,586,618],"patient":[156,239,285,299,389,568,619],"population":[157],"does":[158],"often":[160],"occur":[161],"until":[162],"considering":[165],"SCT":[166,177],"curative":[169,624],"therapy":[170],"option,":[171],"conditioning":[174],"regimens":[175],"gonadotoxic.":[179],"Without":[180],"good":[182],"understanding":[183,223],"hemoglobinopathies,":[195],"it":[196,529],"difficult":[198],"determine":[200,584],"optimal":[202],"time":[203,355],"offer":[205],"preservation":[207,616],"families.":[209],"We":[210,564],"aim":[211],"assess":[213],"tissue":[218,256,291,360,370,507,596],"gain":[220],"better":[222],"management":[229],"can":[233,530],"SCD.":[241],"Methods:":[242],"Our":[243],"cross-sectional":[247],"evaluation":[248],"who":[253,573],"underwent":[254],"cryopreservation":[257],"(TTC)":[258],"part":[261,279],"multicenter":[264],"research":[265,369],"protocol":[266],"through":[267],"University":[269],"Pittsburgh":[271],"Center":[273],"(UPMC)":[274],"prior":[275,464,496],"SCT.":[277],"As":[278],"TTC":[282],"protocol,":[283],"each":[284],"provided":[286],"small":[288],"piece":[289],"research,":[293],"remaining":[296],"cryopreserved":[297],"use.":[300],"All":[301,330],"samples":[302,331,414],"evaluated":[304],"presence":[307,347,510],"germ":[309,349,396,408,426,437,512,599],"cells.":[310],"For":[311],"study,":[313],"demographics,":[314],"treatment":[315],"data,":[316],"imaging":[317],"results,":[318],"labs":[320],"pertinent":[321],"hormonal":[323],"profile":[324],"status":[327],"obtained.":[329],"thalassemia":[337,383,419],"will":[338,565,604],"undergo":[339],"additional":[340],"pathology":[341,445],"review":[342,446],"evaluate":[344],"cells":[350,409,438,513],"iron.":[352],"At":[353],"abstract,":[358],"two":[362,448],"had":[364,406,435,469,477],"analyzed.":[366],"Results:":[367],"Banked":[368],"UPMC":[372],"includes":[373],"77":[374,387],"21":[379,413],"beta":[382,418],"major.":[384],"Of":[385,411],"samples,":[390],"42":[391],"found":[393,423,502],"cells,":[397,427],"34":[398],"yet":[401,431],"analyzed":[403,432],"1":[405,434,468],"no":[407,436],"present.":[410,439],"major,":[420],"17":[421],"3":[428],"To":[440],"date,":[441],"we":[442],"obtained":[444],"patients,":[449],"both":[450],"Hb":[452],"SS":[453],"genotype":[454],"maximum":[459],"tolerated":[460],"dose":[461],"hydroxyurea":[463,472,487],"TTC.":[466,498],"Patient":[467,484],"7":[474],"years":[475,490],"13":[478],"units":[479],"2":[485],"4":[489],"6units":[492],"Both":[499],"histopathology":[508,557],"without":[515,535],"evidence":[516],"staining":[520,561],"(Table":[521],"1).":[522],"Conclusions:":[523],"Based":[524],"our":[526,567],"preliminary":[527],"data":[528],"be":[531],"significant":[536,552],"burden,":[538],"based":[539],"low":[541],"ferritin":[542],"limited":[545],"transfusion":[546],"history":[547],"may":[548],"their":[555,559,594],"being":[562],"negative.":[563],"expand":[566],"cohort":[569],"include":[571],"severe":[576],"course":[578],"requiring":[579],"more":[580],"whether":[585],"associated":[588],"increased":[590],"and/or":[597],"reduced":[598],"numbers.":[601],"This":[602],"information":[603],"allow":[605],"teams":[606],"optimize":[608],"timing":[610],"discussions":[613],"possible":[615],"population,":[620],"even":[621],"outside":[622],"treatment.":[625]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-02T00:00:00"}