{"id":"https://openalex.org/W4389220716","doi":"https://doi.org/10.1182/blood-2023-185157","title":"Clonal Hematopoiesis Is Associated with Severe Cytokine Release Syndrome in Patients Treated with Chimeric Antigen Receptor T-Cell (CAR-T) Therapy","display_name":"Clonal Hematopoiesis Is Associated with Severe Cytokine Release Syndrome in Patients Treated with Chimeric Antigen Receptor T-Cell (CAR-T) Therapy","publication_year":2023,"publication_date":"2023-11-02","ids":{"openalex":"https://openalex.org/W4389220716","doi":"https://doi.org/10.1182/blood-2023-185157"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2023-185157","doi":"https://doi.org/10.1182/blood-2023-185157","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-185157","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4814/2200046/blood-1415-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4814/2200046/blood-1415-main.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004885286","display_name":"Scott Ryan Goldsmith","orcid":"https://orcid.org/0000-0001-9216-2418","observed_orcids":["https://orcid.org/0000-0001-9216-2418"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott R. Goldsmith","raw_affiliation_strings":["1Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013241767","display_name":"Geoffrey Shouse","orcid":"https://orcid.org/0000-0002-7917-5713","observed_orcids":["https://orcid.org/0000-0002-7917-5713"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey P. Shouse","raw_affiliation_strings":["2Hematology/HCT, City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hematology/HCT, City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010408701","display_name":"Florence Lennie Wong","orcid":"https://orcid.org/0000-0002-4333-5017","observed_orcids":["https://orcid.org/0000-0002-4333-5017"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Lennie Wong","raw_affiliation_strings":["3City of Hope, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3City of Hope, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039069019","display_name":"Alysia Bosworth","orcid":"https://orcid.org/0000-0002-0662-5699","observed_orcids":["https://orcid.org/0000-0002-0662-5699"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alysia Bosworth","raw_affiliation_strings":["4City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093393907","display_name":"Aleksi Iujuridze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksi Iujuridze","raw_affiliation_strings":["4City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100751924","display_name":"Sitong Chen","orcid":"https://orcid.org/0000-0002-8975-7565","observed_orcids":["https://orcid.org/0000-0002-8975-7565"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sitong Chen","raw_affiliation_strings":["4City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052653853","display_name":"June\u2010Wha Rhee","orcid":"https://orcid.org/0000-0002-7044-2985","observed_orcids":["https://orcid.org/0000-0002-7044-2985"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"June-Wha Rhee","raw_affiliation_strings":["4City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063781871","display_name":"Matthew Genyeh Mei","orcid":"https://orcid.org/0000-0002-1109-6955","observed_orcids":["https://orcid.org/0000-0002-1109-6955"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew G. Mei","raw_affiliation_strings":["4City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048939308","display_name":"Murali Janakiram","orcid":"https://orcid.org/0000-0001-9323-8007","observed_orcids":["https://orcid.org/0000-0001-9323-8007"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Murali Janakiram","raw_affiliation_strings":["5Division of Myeloma, Department of Hematology, City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Division of Myeloma, Department of Hematology, City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022766377","display_name":"Myo Htut","orcid":"https://orcid.org/0000-0001-6650-5704","observed_orcids":["https://orcid.org/0000-0001-6650-5704"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myo Htut","raw_affiliation_strings":["6City of Hope Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6City of Hope Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039374832","display_name":"Stephen J. Forman","orcid":"https://orcid.org/0000-0002-2803-4152","observed_orcids":["https://orcid.org/0000-0002-2803-4152"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Forman","raw_affiliation_strings":["7Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072747994","display_name":"Raju K. Pillai","orcid":"https://orcid.org/0000-0001-8553-4252","observed_orcids":["https://orcid.org/0000-0001-8553-4252"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raju Pillai","raw_affiliation_strings":["8Department of Pathology, City of Hope National Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Department of Pathology, City of Hope National Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082326885","display_name":"Lihua Elizabeth Budde","orcid":"https://orcid.org/0000-0003-1464-5494","observed_orcids":["https://orcid.org/0000-0003-1464-5494"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Elizabeth Budde","raw_affiliation_strings":["9Department of Hematology and HCT, City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Department of Hematology and HCT, City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042736213","display_name":"Saro H. Armenian","orcid":"https://orcid.org/0000-0003-2604-8603","observed_orcids":["https://orcid.org/0000-0003-2604-8603"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saro Armenian","raw_affiliation_strings":["4City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"142","issue":"Supplement 1","first_page":"4814","last_page":"4814"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonal-hematopoiesis","display_name":"clonal hematopoiesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.9850000143051147},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cd19-car-t","display_name":"CD19 CAR-T","score":0.8799999952316284},{"id":"https://openalex.org/keywords/bcma-car-t","display_name":"BCMA CAR-T","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immune-effector-cell-associated-neurotoxicity-syndrome","display_name":"immune effector cell-associated neurotoxicity syndrome","score":0.9369999766349792},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.8629999756813049},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/neutrophil-recovery","display_name":"neutrophil recovery","score":0.734000027179718},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.6620000004768372},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6840000152587891},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9190000295639038},{"id":"https://openalex.org/keywords/car-t-toxicity","display_name":"CAR-T toxicity","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7004595994949341},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.6154698133468628},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5445454716682434},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.49686315655708313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48129621148109436},{"id":"https://openalex.org/C2780366003","wikidata":"https://www.wikidata.org/wiki/Q246147","display_name":"Cytopenia","level":3,"score":0.476136714220047},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.35543835163116455},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3431586027145386},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33365821838378906},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.299838662147522},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.26406413316726685},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2554242014884949},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.2172914445400238}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2023-185157","doi":"https://doi.org/10.1182/blood-2023-185157","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-185157","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4814/2200046/blood-1415-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood-2023-185157","doi":"https://doi.org/10.1182/blood-2023-185157","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-185157","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4814/2200046/blood-1415-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389220716.pdf","grobid_xml":"https://content.openalex.org/works/W4389220716.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405034699","https://openalex.org/W4387312034","https://openalex.org/W7162650412","https://openalex.org/W4206281921","https://openalex.org/W4390223722","https://openalex.org/W3203169950","https://openalex.org/W7162504391","https://openalex.org/W4417020311","https://openalex.org/W4417011310","https://openalex.org/W7169681669"],"abstract_inverted_index":{"Background:":[0],"Among":[1],"patients":[2,142,350,422,445,535],"receiving":[3],"CD19":[4,149],"or":[5,111,145,150,285],"B-cell":[6,329],"maturation":[7],"antigen":[8],"(BCMA)":[9],"CAR-T":[10,122,152,188,379,407,584],"therapy,":[11],"inflammation":[12],"pre-":[13],"and":[14,36,62,85,88,115,121,133,162,228,241,247,249,271,300,347,364,385,395,419,425,436,475,528,567,573,586,650,657],"post-CAR-T":[15],"infusion":[16],"is":[17],"attributed":[18],"in":[19,100,382,412,580],"the":[20,42,74,95,117,207,223,315,348,403,460,465,525,607,628,639,651,654,658],"development":[21],"of":[22,45,70,76,97,105,160,187,209,273,276,359,414,479,545,583,593,611,653],"toxicities":[23],"such":[24,58],"as":[25,59,65,67,282,390,614],"cytokine":[26],"release":[27],"syndrome":[28,34],"(CRS),":[29],"immune":[30],"effector":[31],"cell-associated":[32],"neurotoxicity":[33],"(ICANS),":[35],"prolonged":[37,128],"cytopenias.":[38],"Clonal":[39,441],"hematopoiesis":[40],"(CH),":[41],"clonal":[43,68],"expansion":[44],"hematopoietic":[46,371],"stem":[47],"cells":[48,170],"with":[49,55,107,143,175,201,488,530,536,570,589],"somatic":[50],"mutations,":[51],"has":[52],"been":[53],"associated":[54,529,588],"inflammatory":[56],"disorders":[57],"rheumatoid":[60],"arthritis":[61],"graft-versus-host":[63],"disease,":[64],"well":[66],"cytopenias":[69],"undetermined":[71],"significance.":[72],"In":[73],"setting":[75],"CAR-T,":[77,258],"others":[78],"have":[79,540],"reported":[80],"an":[81],"association":[82,224,564],"between":[83,119,225,565],"CH":[84,99,120,210,226,451,457,462,489,507,526,537,553,566,576,613],"both":[86],"ICANS":[87],"treatment-associated":[89],"myeloid":[90],"neoplasms.":[91],"Herein,":[92],"we":[93,192],"examined":[94],"prevalence":[96],"pre-CAR-T":[98,165,612],"a":[101,541,590,615],"predominantly":[102],"transplant-na\u00efve":[103],"cohort":[104,527,582],"recipients":[106,585],"non-Hodgkin":[108],"lymphoma":[109],"(NHL)":[110],"multiple":[112],"myeloma":[113],"(MM),":[114],"assessed":[116],"relationship":[118],"related":[123],"outcomes":[124],"including":[125],"CRS,":[126],"ICANS,":[127,242,426,568],"cytopenia,":[129],"progression-free":[130],"survival":[131,135],"(PFS),":[132],"overall":[134],"(OS).":[136],"Methods:":[137],"This":[138],"study":[139],"included":[140],"62":[141],"NHL":[144],"MM":[146],"who":[147,301],"underwent":[148],"BCMA":[151],"therapy":[153,269,360,376],"from":[154,181,310],"2017":[155],"to":[156,205,221,378,494,504,550],"2022":[157],"at":[158,234,251,257,447],"City":[159],"Hope":[161],"had":[163,324,333,339,343,351,367,428,446,455,481],"available":[164],"cryopreserved":[166],"peripheral":[167],"blood":[168],"mononuclear":[169],"(PBMCs).":[171],"DNA":[172,177],"was":[173,219,280,318,361,380,402,434,439,521,562,577,587],"isolated":[174],"QIAamp":[176],"Mini":[178],"Kit":[179],"(Qiagen)":[180],"PBMC":[182],"samples":[183],"(94%":[184],"collected":[185],"<30d":[186],"infusion),":[189],"on":[190],"which":[191,604],"performed":[193],"targeted":[194],"exome":[195],"sequencing":[196,203],"(108":[197],"pre-defined":[198],"gene":[199],"panel":[200],"1000x":[202],"depth)":[204],"determine":[206],"presence":[208],"(variant":[211],"allele":[212],"frequency":[213],"[VAF]":[214],"\u22652%).":[215],"Multivariable":[216],"logistic":[217],"regression":[218],"used":[220],"examine":[222],"(Yes/No)":[227],"absolute":[229],"neutrophil":[230],"count":[231],"(ANC)":[232],"recovery":[233,279,299,548],"day":[235,306],"+60":[236,307],"(Y/N),":[237,270],"maximum":[238],"grade":[239,243,283,496],"CRS":[240,424,498,595,623],"<2":[244],"vs":[245],"2+,":[246],"OS":[248,438],"PFS":[250,433,572],"1y.":[252],"Covariables":[253],"considered":[254],"were":[255,308,468,490],"age":[256,317],"baseline":[259,518],"ANC,":[260],"sex,":[261],"race,":[262],"CAR-HEMATOTOX":[263],"(Rejeski":[264],"et":[265],"al.":[266],"2021),":[267],"bridging":[268,375],"number":[272],"prior":[274,357,377],"lines":[275,358],"therapy.":[277],"ANC":[278,298,430,519,532,547],"defined":[281],"2":[284,337,341],"better":[286],"for":[287,397,517,609,617,645],"3":[288,362],"measurements":[289],"without":[290,297,506,552],"growth":[291],"factor":[292],"support":[293],">2":[294],"weeks.":[295],"Those":[296],"started":[302],"new":[303],"treatment":[304],"before":[305],"excluded":[309],"that":[311],"analysis.":[312],"Results:":[313],"Overall,":[314,416],"median":[316],"64y":[319],"(range":[320],"21y-85y);":[321],"37":[322],"(60%)":[323],"de":[325],"novo":[326],"diffuse":[327],"large":[328],"lymphoma,":[330,336,346],"17":[331],"(27%)":[332],"transformed":[334,353],"follicular":[335],"(3%)":[338,342],"MM,":[340],"mantle":[344],"cell":[345,372],"remaining":[349],"other":[352],"indolent":[354],"lymphomas.":[355],"Median":[356],"(1-12),":[363],"only":[365],"6%":[366],"previously":[368],"undergone":[369],"autologous":[370],"transplantation.":[373],"Systemic":[374],"required":[381],"27":[383],"(44%),":[384],"8":[386],"(13%)":[387],"received":[388,393],"radiation":[389],"bridging.":[391],"All":[392],"fludarabine":[394],"cyclophosphamide":[396],"lymphodepleting":[398],"chemotherapy.":[399],"Axicabtagene":[400],"ciloleucel":[401],"most":[404,466],"common":[405,467],"(76%)":[406],"product,":[408],"followed":[409],"by":[410,642],"tisagenlecleucel":[411],"16%":[413],"patients.":[415],"51":[417],"(82%)":[418],"29":[420],"(47%)":[421],"experienced":[423],"respectively.":[427],"delayed":[429,531,546],"recovery.":[431],"One-year":[432],"50%":[435],"1y":[437,571],"73%.":[440],"hematopoiesis:":[442],"15":[443],"(24%)":[444,579],"least":[448],"one":[449],"pathogenic":[450],"mutation;":[452],"4":[453],"(6.5%)":[454],"\u22652":[456,497,594],"mutations.":[458],"Of":[459],"28":[461],"mutations":[463,480],"identified,":[464],"DNMT3A":[469],"(18%),":[470],"CHEK2":[471],"(11%),":[472],"PMS2":[473],"(7%)":[474],"ASXL1":[476],"(7%);":[477],"29%":[478],"VAFs":[482],">10%.":[483],"Outcomes":[484],"after":[485,596],"CAR-T:":[486],"Patients":[487],"significantly":[491,542],"more":[492,621],"likely":[493],"develop":[495],"(60%":[499],"vs.":[500],"28%,":[501],"p=0.03)":[502],"compared":[503,549],"those":[505,551],"(odds":[508],"ratio":[509],"[OR]":[510],"3.9,":[511],"95%":[512,557],"CI":[513,558],"1.2-13.2;":[514],"p=0.027).":[515],"Accounting":[516],"(which":[520],"unexpectedly":[522],"higher":[523,591],"among":[524],"recovery,":[533],"p=0.02)":[534],"did":[538],"not":[539],"different":[543],"rate":[544],"(adjusted":[554],"OR":[555],"0.37,":[556],"0.09-1.5;":[559],"p=0.17).":[560],"There":[561],"no":[563],"nor":[569],"OS.":[574],"Conclusion:":[575],"frequent":[578],"this":[581],"risk":[592,618],"CAR-T.":[597],"Additional":[598],"validation":[599],"studies":[600],"are":[601],"currently":[602],"underway,":[603],"may":[605],"set":[606],"stage":[608],"consideration":[610],"biomarker":[616],"stratification":[619],"towards":[620],"proactive":[622],"prophylaxis":[624],"Acknowledgements:":[625],"Funding":[626],"through":[627],"CoH":[629,643],"Hematological":[630],"Malignancies":[631],"Program":[632],"Pilot":[633],"Project":[634],"Award.":[635],"The":[636],"authors":[637],"acknowledge":[638],"work":[640],"provided":[641],"Center":[644],"Informatics,":[646,649],"notably":[647],"Research":[648],"utilization":[652],"POSEIDON":[655],"platform":[656],"Honest":[659],"Broker":[660],"process.":[661]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-12-02T00:00:00"}
