{"id":"https://openalex.org/W4389220184","doi":"https://doi.org/10.1182/blood-2023-180783","title":"Myeloproliferative Neoplasms Are Associated with Increased Risk of Major Adverse Limb Events Among Patients Hospitalized for Peripheral Arterial Disease","display_name":"Myeloproliferative Neoplasms Are Associated with Increased Risk of Major Adverse Limb Events Among Patients Hospitalized for Peripheral Arterial Disease","publication_year":2023,"publication_date":"2023-11-02","ids":{"openalex":"https://openalex.org/W4389220184","doi":"https://doi.org/10.1182/blood-2023-180783"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2023-180783","doi":"https://doi.org/10.1182/blood-2023-180783","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-180783","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4570/2190503/blood-1171-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4570/2190503/blood-1171-main.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085049967","display_name":"Orly Leiva","orcid":"https://orcid.org/0000-0002-3006-6380","observed_orcids":["https://orcid.org/0000-0002-3006-6380"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orly Leiva","raw_affiliation_strings":["1NYU Grossman School of Medicine, NY, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NYU Grossman School of Medicine, NY, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009387581","display_name":"Andrew Mark Brunner","orcid":"https://orcid.org/0000-0002-2169-4115","observed_orcids":["https://orcid.org/0000-0002-2169-4115"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Brunner","raw_affiliation_strings":["2Division of Hematology/Oncology, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Hematology/Oncology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016549666","display_name":"Joan How","orcid":"https://orcid.org/0000-0002-6421-0117","observed_orcids":["https://orcid.org/0000-0002-6421-0117"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan How","raw_affiliation_strings":["3Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065595440","display_name":"Gabriela Soriano Hobbs","orcid":"https://orcid.org/0000-0002-0199-9333","observed_orcids":["https://orcid.org/0000-0002-0199-9333"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela S. Hobbs","raw_affiliation_strings":["4Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088731576","display_name":"Jeffrey S. Berger","orcid":"https://orcid.org/0000-0001-8216-4647","observed_orcids":["https://orcid.org/0000-0001-8216-4647"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S Berger","raw_affiliation_strings":["5New York University Grossman School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5New York University Grossman School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"142","issue":"Supplement 1","first_page":"4570","last_page":"4570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.32249999046325684,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":1.0},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.953000009059906},{"id":"https://openalex.org/keywords/major-adverse-limb-events","display_name":"major adverse limb events","score":0.9990000128746033},{"id":"https://openalex.org/keywords/major-amputation","display_name":"major amputation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.8299999833106995},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myelofibrosis","display_name":"myelofibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.7450000047683716},{"id":"https://openalex.org/keywords/unplanned-hospital-readmission","display_name":"unplanned hospital readmission","score":0.7429999709129333},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.4090000092983246},{"id":"https://openalex.org/keywords/lower-extremity-ulceration","display_name":"lower extremity ulceration","score":0.628000020980835},{"id":"https://openalex.org/keywords/rest-pain","display_name":"rest pain","score":0.5339999794960022},{"id":"https://openalex.org/keywords/arterial-thromboembolism","display_name":"arterial thromboembolism","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9383528232574463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6159143447875977},{"id":"https://openalex.org/C2776204877","wikidata":"https://www.wikidata.org/wiki/Q477415","display_name":"Amputation","level":2,"score":0.5453771948814392},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5216260552406311},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5046318769454956},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5041362047195435},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4933539927005768},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.490354061126709},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4730742871761322},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.44655951857566833},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4363548755645752},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4253571927547455},{"id":"https://openalex.org/C2776626339","wikidata":"https://www.wikidata.org/wiki/Q168805","display_name":"Gangrene","level":2,"score":0.4141477942466736},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.08273443579673767},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2023-180783","doi":"https://doi.org/10.1182/blood-2023-180783","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-180783","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4570/2190503/blood-1171-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood-2023-180783","doi":"https://doi.org/10.1182/blood-2023-180783","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-180783","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4570/2190503/blood-1171-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389220184.pdf","grobid_xml":"https://content.openalex.org/works/W4389220184.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408885355","https://openalex.org/W4310159081","https://openalex.org/W4380794863","https://openalex.org/W4379798020","https://openalex.org/W4400036721","https://openalex.org/W7116602137","https://openalex.org/W3108325811","https://openalex.org/W4408410478","https://openalex.org/W2556479717","https://openalex.org/W2952758203"],"abstract_inverted_index":{"Background:":[0],"Myeloproliferative":[1],"neoplasms":[2],"(MPN),":[3],"including":[4,22,34],"essential":[5],"thrombocythemia":[6],"(ET),":[7],"polycythemia":[8],"vera":[9],"(PV),":[10],"and":[11,24,55,83,95,127,182,200,241,251,273,293,346,368,436,496,523,557,563,598],"myelofibrosis":[12],"(MF),":[13],"are":[14,37,53,74,590],"at":[15,175,371],"high":[16],"risk":[17,63,355,415,509,540,554,575,595],"of":[18,40,79,88,110,116,123,134,149,208,356,416,510,541,555,576,596],"cardiovascular":[19],"(CV)":[20],"disease,":[21],"atherosclerosis":[23],"peripheral":[25],"arterial":[26,50,66,168],"disease":[27,472],"(PAD).":[28],"Major":[29],"adverse":[30,599],"limb":[31],"events":[32,52,601],"(MALE),":[33],"major":[35,153,165,369],"amputation,":[36,154],"dreaded":[38],"complications":[39,174],"PAD":[41,60,124,428],"that":[42,59,217],"portend":[43],"poor":[44],"prognosis.":[45],"Among":[46,458,544,566],"patients":[47,80,99,118,285,309,323,344,459,545,567,603],"with":[48,81,119,129,310,324,334,345,353,413,460,507,538,552,568,573,585,604],"MPN,":[49,135,348,461,569],"thrombotic":[51],"common":[54],"prior":[56],"studies":[57,589],"suggest":[58],"is":[61],"a":[62,106,120,132,147,262],"factor":[64],"for":[65,101,157,187,205,248,261,271,306,419,448,547,560],"thrombosis":[67],"in":[68,606,612],"this":[69,613],"patient":[70,221,615],"population.":[71,616],"However,":[72],"there":[73],"limited":[75],"data":[76],"on":[77,91],"outcomes":[78,171,275,611],"MPN":[82,89,209,228,311,325,350,410,549,605],"PAD.":[84,102],"Therefore,":[85],"the":[86,111],"effect":[87],"status":[90],"MALE,":[92],"in-hospital":[93,274,386],"death":[94,387],"unplanned":[96],"readmissions":[97,186],"among":[98,308,602],"hospitalized":[100,546],"Methods:":[103],"This":[104],"was":[105,143,146,234,246,265,351,411,550,571,583],"retrospective":[107],"cohort":[108],"analysis":[109],"National":[112],"Readmission":[113],"Database":[114],"(NRD)":[115],"adult":[117],"primary":[121],"diagnosis":[122],"from":[125],"2017":[126],"2018":[128],"or":[130,167,197,398],"without":[131,347],"history":[133],"as":[136],"identified":[137],"by":[138],"ICD-10":[139],"codes.":[140],"Primary":[141],"outcome":[142],"MALE":[144,272,307,357,511,556,577,597],"which":[145],"composite":[148],"index":[150,176,289,372,534,581],"hospitalization":[151,177,290,373,535,582],"death,":[152],"30-day":[155],"readmission":[156,283,418,559],"PAD,":[158,189,193,548,562],"lower":[159],"extremity":[160],"ulceration,":[161],"gangrene,":[162],"rest":[163],"pain,":[164],"amputation":[166,370],"thromboembolism.":[169],"Secondary":[170],"were":[172,210,239,257,276,291,297,312,332,341,505,536],"bleeding":[173,399,449],"(including":[178,192],"gastrointestinal,":[179],"intracranial,":[180],"post-procedure,":[181],"retroperitoneal":[183],"bleeding),":[184],"90-day":[185,282,417,558],"any-cause,":[188,561],"CV":[190,437,564,600],"reason":[191,438],"myocardial":[194],"infarction,":[195],"stroke,":[196],"heart":[198],"failure),":[199],"bleeding.":[201],"Propensity":[202],"scores":[203],"(PS)":[204],"estimating":[206],"probability":[207],"calculated":[211,247,277],"using":[212,278,299,314],"non-parsimonious":[213],"multivariable":[214],"logistic":[215,279,317],"regression":[216],"included":[218],"all":[219],"baseline":[220],"characteristics":[222],"examined.":[223],"PS":[224],"matching":[225],"(PSM)":[226],"1":[227],"case":[229],"to":[230,592,608],"5":[231],"non-MPN":[232,336],"controls":[233],"performed.":[235],"Patients":[236],"between":[237,255,343],"groups":[238,256],"compared":[240,513],"standardized":[242],"mean":[243],"difference":[244],"(SMD)":[245],"variables":[249,340],"before":[250],"after":[252],"PSM.":[253],"Imbalances":[254],"insignificant":[258],"if":[259],"SMD":[260],"given":[263],"co-variable":[264],"<":[266],"0.10.":[267],"Odds":[268],"ratio":[269],"(OR)":[270],"regression.":[280,303,318],"For":[281],"analyses,":[284],"who":[286],"died":[287],"during":[288,533,580],"excluded":[292],"hazard":[294],"ratios":[295],"(HR)":[296],"estimated":[298],"Cox":[300],"proportional":[301],"hazards":[302],"Risk":[304],"factors":[305],"assessed":[313],"backward":[315],"stepwise":[316],"Results:":[319],"After":[320,338],"PSM,":[321,339],"1702":[322],"(1338":[326],"ET,":[327],"273":[328],"PV,":[329],"91":[330],"PMF)":[331],"matched":[333],"8510":[335],"patients.":[337],"well-balanced":[342],"Table.":[349],"associated":[352,412,506,537,551,572,584],"increased":[354,414,508,553,574],"(40.3%":[358],"vs":[359,375,389,401],"27.9%,":[360],"OR":[361,377,391,403],"1.75,":[362,482],"95%":[363,379,393,405,423,431,441,452,465,475,483,491,500,518,528],"CI":[364,380,394,406,424,432,442,453,466,476,484,492,501,519,529],"1.57":[365],"-":[366,382,396,408,426,434,444,455,468,478,486,494,503,521,531],"1.95)":[367],"(34.6%":[374],"23.5%,":[376],"1.72,":[378],"1.54":[381],"1.92)":[383],"but":[384,446],"not":[385,447],"(1.8%":[388],"2.0%,":[390],"0.92,":[392],"0.63":[395],"1.36)":[397],"(17.5%":[400],"19.5%,":[402],"0.90,":[404],"0.79":[407],"1.03).":[409],"any-cause":[420],"(HR":[421,429,439,450,489],"1.21,":[422],"1.10":[425],"1.33),":[427],"1.22,":[430],"1.11":[433],"1.35),":[435],"1.32,":[440],"1.17":[443],"1.49)":[445],"1.33,":[451],"0.90":[454],"1.97),":[456],"Figure.":[457],"ET":[462,570],"(OR":[463,473,481,498,516,526],"2.08,":[464],"1.44":[467],"3.01),":[469],"end-stage":[470],"renal":[471],"1.59,":[474],"1.12":[477],"3.11),":[479],"anemia":[480],"1.39":[485],"2.21),":[487],"gangrene":[488],"1.95,":[490],"1.38":[493],"2.75),":[495],"sepsis":[497],"1.90,":[499],"1.36":[502],"2.66)":[504],"while":[512,578],"surgical":[514],"bypass":[515],"0.46,":[517],"0.31":[520],"0.68)":[522],"endovascular":[524],"revascularization":[525,579],"0.71,":[527],"0.54":[530],"0.94)":[532],"decreased":[539,586],"MALE.":[542],"Conclusions:":[543],"reasons.":[565],"risk.":[587],"Further":[588],"needed":[591],"further":[593],"elucidate":[594],"order":[607],"improve":[609],"clinical":[610],"high-risk":[614]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-02T00:00:00"}