{"id":"https://openalex.org/W4389220183","doi":"https://doi.org/10.1182/blood-2023-182559","title":"Safety, Efficacy and T-Cell Predictive Biomarkers in a Phase I Trial of Copanlisib+Nivolumab in Patients with Richter's Transformation (RT) or Transformed Non-Hodgkin Lymphoma (tNHL)","display_name":"Safety, Efficacy and T-Cell Predictive Biomarkers in a Phase I Trial of Copanlisib+Nivolumab in Patients with Richter's Transformation (RT) or Transformed Non-Hodgkin Lymphoma (tNHL)","publication_year":2023,"publication_date":"2023-11-02","ids":{"openalex":"https://openalex.org/W4389220183","doi":"https://doi.org/10.1182/blood-2023-182559"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2023-182559","doi":"https://doi.org/10.1182/blood-2023-182559","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2023-182559","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013241767","display_name":"Geoffrey Shouse","orcid":"https://orcid.org/0000-0002-7917-5713","observed_orcids":["https://orcid.org/0000-0002-7917-5713"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey P. Shouse","raw_affiliation_strings":["1Hematology/HCT, City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology/HCT, City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004358801","display_name":"Leslie L. Popplewell","orcid":"https://orcid.org/0000-0002-8418-2811","observed_orcids":["https://orcid.org/0000-0002-8418-2811"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie L. Popplewell","raw_affiliation_strings":["2Department of Hematology and HCT, City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Hematology and HCT, City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082301359","display_name":"Alex Muir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Muir","raw_affiliation_strings":["3City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005565037","display_name":"Tanya Siddiqi","orcid":"https://orcid.org/0000-0001-5292-8298","observed_orcids":["https://orcid.org/0000-0001-5292-8298"]},"institutions":[{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanya Siddiqi","raw_affiliation_strings":["4City of Hope, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4City of Hope, Irvine, CA","institution_ids":["https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030788778","display_name":"Alex Francisco Herrera","orcid":"https://orcid.org/0000-0002-9665-7415","observed_orcids":["https://orcid.org/0000-0002-9665-7415"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex F. Herrera","raw_affiliation_strings":["5City of Hope, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5City of Hope, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103039650","display_name":"Olga V. Danilova","orcid":"https://orcid.org/0000-0001-9557-9032","observed_orcids":["https://orcid.org/0000-0001-9557-9032"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Danilova","raw_affiliation_strings":["5City of Hope, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5City of Hope, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036031227","display_name":"Sandrine Puverel","orcid":"https://orcid.org/0000-0002-8667-5193","observed_orcids":["https://orcid.org/0000-0002-8667-5193"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandrine Puverel","raw_affiliation_strings":["3City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100356381","display_name":"Lili Wang","orcid":"https://orcid.org/0000-0001-9347-3939","observed_orcids":["https://orcid.org/0000-0001-9347-3939","https://orcid.org/0009-0000-3638-274X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lili Wang","raw_affiliation_strings":["6Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069318162","display_name":"Adam S. Kittai","orcid":"https://orcid.org/0000-0002-4891-6144","observed_orcids":["https://orcid.org/0000-0002-4891-6144"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam S Kittai","raw_affiliation_strings":["7Division of Hematology, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Division of Hematology, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432064","display_name":"Lu Chen","orcid":"https://orcid.org/0000-0001-9708-341X","observed_orcids":["https://orcid.org/0000-0001-9708-341X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Chen","raw_affiliation_strings":["8Department of Computational and Quantitative Medicine, City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Department of Computational and Quantitative Medicine, City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063755644","display_name":"Matthew Steven Davids","orcid":"https://orcid.org/0000-0003-4529-2003","observed_orcids":["https://orcid.org/0000-0003-4529-2003"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew S Davids","raw_affiliation_strings":["9Department of Medical Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Department of Medical Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067633124","display_name":"Alexey Valeryevich Danilov","orcid":"https://orcid.org/0000-0003-4461-0970","observed_orcids":["https://orcid.org/0000-0003-4461-0970"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexey Danilov","raw_affiliation_strings":["10Department of Hematology and HCT, City of Hope National Medical Center, La Canada Flintridge, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Department of Hematology and HCT, City of Hope National Medical Center, La Canada Flintridge, CA","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"142","issue":"Supplement 1","first_page":"1730","last_page":"1730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.18019999563694,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copanlisib","display_name":"copanlisib","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":1.0},{"id":"https://openalex.org/keywords/richter-transformation","display_name":"Richter transformation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.7749999761581421},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.949999988079071},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9319999814033508},{"id":"https://openalex.org/keywords/t-cell-function","display_name":"T cell function","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.5149999856948853},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.3959999978542328},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.578000009059906},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.7570000290870667},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.796999990940094},{"id":"https://openalex.org/keywords/single-cell-proteomics","display_name":"single-cell proteomics","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8378909826278687},{"id":"https://openalex.org/C2777058707","wikidata":"https://www.wikidata.org/wiki/Q123251","display_name":"Follicular lymphoma","level":3,"score":0.6263219118118286},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.6164707541465759},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6144838929176331},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.51924729347229},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.5132379531860352},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4995899200439453},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4829375147819519},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.4619256854057312},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.41217291355133057},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36324313282966614},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3248475193977356},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.265308678150177},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.17534852027893066},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2023-182559","doi":"https://doi.org/10.1182/blood-2023-182559","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2023-182559","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.75,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2914827752","https://openalex.org/W2791043965","https://openalex.org/W2904705343","https://openalex.org/W3042573404","https://openalex.org/W2671701005","https://openalex.org/W3157524275","https://openalex.org/W2955654676","https://openalex.org/W2947335179","https://openalex.org/W2592092676","https://openalex.org/W2045413621"],"abstract_inverted_index":{"Background.":[0],"Despite":[1],"advances":[2],"in":[3,38,59,71,86,90,107,303,315,405,421,581,590,611,619,676,695,699,715,724,728,740,748,761],"targeted":[4],"and":[5,14,40,66,98,103,181,183,192,207,286,288,309,313,323,329,398,453,482,517,530,552,561,576,587,614,649,655,690,704,711,735,750],"cellular":[6],"therapy,":[7,499],"outcomes":[8],"among":[9],"patients":[10],"(pts)":[11],"with":[12,88,92,121,162,508,520,543,555,697,701,717,718,758],"RT":[13,94,122,322,544,603,628,661,703],"tNHL":[15,96,326],"remain":[16,471],"dismal.":[17],"Copanlisib":[18],"(COPA)":[19],"is":[20,41,51,118,201,240,764],"a":[21,52,80,149,155,195,351,434,463,503,588],"selective,":[22],"small":[23],"molecule,":[24],"PI3Kinhibitor":[25],"which":[26,55,384],"preferentially":[27],"targets":[28],"the":[29,146,243,249,290,390,425,442,488,641,693,733,741,745],"p110\u03b1\u03b4":[30],"isoforms":[31],".":[32],"COPA":[33,85,168,428,682],"has":[34,56,68,130],"shown":[35],"clinical":[36],"efficacy":[37,255],"NHL":[39],"an":[42,511,546,579],"approved":[43],"therapy":[44,358,477],"for":[45],"follicular":[46],"lymphoma":[47,73],"(FL).":[48],"Nivolumab":[49],"(NIVO)":[50],"PD-1":[53,67],"antagonist":[54],"demonstrated":[57,69,578,607],"activity":[58],"NHL.":[60],"Furthermore,":[61],"combined":[62],"targeting":[63],"of":[64,79,84,139,145,158,167,194,215,248,269,292,353,357,383,427,437,465,498,513,533,548,568,600,609,616,640,647,652,666,738,744],"PI3K":[65],"synergy":[70],"pre-clinical":[72],"models.":[74],"Here":[75],"we":[76],"report":[77],"results":[78],"phase":[81,114,142],"1":[82,206,285,330,646],"study":[83,117,147,238,296],"combination":[87,696,707],"NIVO":[89,198,698],"pts":[91,120,281,299,320,362,375,386,408,423,458,475,491,501,572,604,700,716],"R/R":[93,702],"or":[95,123,132,231],"(NCT03884998)":[97],"correlate":[99],"response":[100,504,534,618,643,755,760],"to":[101,135,212,241,300,394,429,479,485,597],"treatment":[102,648,759],"T":[104,369,584,620,729],"cell":[105,270,585,730],"functionality":[106,263],"RT.":[108,762],"Methods.":[109],"This":[110,622,706],"ongoing":[111],"multicenter,":[112],"open-label,":[113],"I,":[115],"investigator-sponsored":[116],"enrolling":[119],"tNHL,":[124],"age":[125,336],"\u226518":[126],"years,":[127],"whose":[128],"disease":[129,397,481],"relapsed":[131],"was":[133,337,624,708],"refractory":[134],"\u22651":[136],"prior":[137,355],"line":[138],"therapy.":[140,216],"The":[141,236,295],"I":[143],"portion":[144],"follows":[148],"standard":[150],"3+3":[151],"design,":[152],"followed":[153],"by":[154,256,265,605],"dose":[156,165,246,304,316,372],"expansion":[157,317],"16":[159],"evaluable":[160,407],"pts,":[161],"two":[163],"planned":[164],"levels":[166],"administered":[169],"IV":[170,203,685],"(dose":[171],"level":[172],"[DL]1":[173],"-":[174,185],"45":[175,431,683],"mg":[176,187,200,381,414,684],"on":[177,188,204,277,472,686],"days":[178,189,205,230,687],"1,":[179,190,688],"8":[180,191,361,374,689],"15":[182,193,691],"DL2":[184,412],"60":[186],"28-day":[196],"cycle).":[197],"240":[199],"given":[202],"15.":[208],"Pts":[209,348,507,542],"receive":[210],"up":[211],"24":[213],"cycles":[214,284,467],"Dose":[217],"limiting":[218],"toxicities":[219],"(DLT)":[220],"were":[221,376,399,403,451,674,756],"defined":[222],"as":[223,272,274,692],"grade":[224,232],"\u22654":[225],"hematologic":[226],"lasting":[227],">":[228],"7":[229],"\u22653":[233],"non-hematologic":[234],"toxicities.":[235],"primary":[237],"objective":[239],"evaluate":[242],"maximum":[244],"tolerated":[245],"(MTD)":[247],"combination;":[250],"secondary":[251],"objectives":[252,260],"are":[253],"preliminary":[254],"Lugano":[257],"criteria.":[258],"Exploratory":[259],"include":[261],"T-cell":[262,753],"assessed":[264],"flow":[266,574],"cytometry":[267,575],"analysis":[268],"subsets":[271,731],"well":[273],"scRNA-Seq":[275,577,606],"performed":[276],"biospecimens":[278],"banked":[279],"from":[280,571,636,660],"pre-treatment,":[282],"after":[283,462,595,644,669],"5,":[287],"at":[289,307,311,378,409,494],"end":[291],"treatment.":[293,473],"Results.":[294],"enrolled":[297],"25":[298],"date,":[301],"11":[302,324],"finding":[305],"(8":[306],"DL1":[308,379],"3":[310,466,627],"DL2)":[312],"14":[314,438],"cohorts.":[318],"Fourteen":[319],"had":[321,325,343,349,367,510,545,712],"(10":[327],"tFL":[328,509],"transformed":[331],"lymphoplasmacytic":[332],"lymphoma).":[333],"Median":[334],"(med)":[335],"65":[338],"years":[339],"(32-77),":[340],"88%":[341],"(22/25)":[342],"ECOG":[344],"performance":[345],"status":[346],"0-1.":[347],"received":[350],"med":[352,464],"4":[354,518],"lines":[356],"(range,":[359],"1-10);":[360],"(2":[363,515,550],"RT,":[364],"6":[365,406,483],"tNHL)":[366],"CAR":[368],"cells.":[370,621],"During":[371],"finding,":[373],"treated":[377],"(45":[380],"COPA),":[382,415],"2":[385,422,470,553,601],"did":[387],"not":[388,563,625],"complete":[389],"DLT":[391],"period":[392],"due":[393,478,484],"rapidly":[395],"progressive":[396,480],"replaced.":[400],"No":[401],"DLTs":[402,417],"observed":[404,626,721],"DL1.":[410],"At":[411],"(60":[413],"three":[416],"(neutropenia,":[418],"thrombocytopenia)":[419],"occurred":[420],"determining":[424],"MTD":[426],"be":[430],"mg.":[432],"After":[433],"median":[435,521,531],"follow-up":[436],"months":[439,527,537,558],"(range":[440,468],"1.8-20.6),":[441],"most":[443],"common":[444],"treatment-related":[445],"adverse":[446],"events":[447],"(AEs,":[448],"any":[449],"grade)":[450],"diarrhea":[452],"anemia":[454],"(Table":[455],"1).":[456,541],"Twenty-three":[457],"went":[459],"off":[460],"protocol":[461],"1-20);":[469],"Sixteen":[474],"discontinued":[476],"AEs.":[486],"Among":[487],"23":[489],"efficacy-evaluable":[490],"who":[492],"completed":[493],"least":[495],"one":[496],"cycle":[497,645],"10":[500],"achieved":[502],"(ORR":[505],"43%).":[506],"ORR":[512,547],"60%":[514],"CR":[516,551],"PR)":[519,554],"progression":[522],"free":[523],"survival":[524],"(mPFS)":[525],"4.8":[526],"(95%CI:":[528,538,559,565],"0.4-16.8)":[529],"duration":[532],"(mDOR)":[535],"10.2":[536],"2.0-13.6)":[539],"(Figure":[540],"33%":[549],"mPFS":[556],"2.0":[557],"0.7-4.9)":[560],"mDOR":[562],"reached":[564],"3.0-NA).":[566],"Analysis":[567,599],"paired":[569],"samples":[570],"using":[573],"increase":[580],"circulating":[582],"CD8+":[583,633],"population":[586],"decrease":[589],"exhaustion":[591],"markers":[592],"(PD1,":[593],"CTLA-4)":[594],"exposure":[596],"COPA/NIVO.":[598],"responding":[602],"downregulation":[608],"MYC":[610,739],"tumor":[612],"cells":[613],"upregulation":[615],"IFN":[617,642,754],"pattern":[623],"non-responders":[629],"(NRs).":[630],"By":[631],"contrast,":[632],"effector":[634],"T-cells":[635],"NRs":[637],"exhibited":[638],"downmodulation":[639],"concurrent":[650],"activation":[651,743],"p53-regulated":[653],"genes":[654],"apoptotic":[656,746],"genes.":[657],"Tregs":[658,749],"sourced":[659],"responders":[662,734],"showed":[663],"enhanced":[664,751],"expression":[665,726],"apoptosis":[667],"pathways":[668,673],"treatment,":[670],"while":[671],"these":[672],"downregulated":[675],"NR":[677],"Tregs.":[678],"Discussion.":[679],"We":[680,720],"identified":[681],"MTD/RP2D":[694],"tFL.":[705,719],"generally":[709],"well-tolerated":[710],"activity,":[713],"particularly":[714],"key":[722],"differences":[723],"gene":[725],"patterns":[727],"between":[732],"NRs.":[736],"Downregulation":[737],"tumor,":[742],"program":[747],"CD8":[752],"associated":[757],"Accrual":[763],"ongoing.":[765]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2025-10-10T00:00:00"}
