{"id":"https://openalex.org/W4389219010","doi":"https://doi.org/10.1182/blood-2023-190898","title":"Investigating Racially Induced Metabolic and Genomic Signatures Mediating Inferior Survival in African Americans with Acute Myelogenous Leukemia","display_name":"Investigating Racially Induced Metabolic and Genomic Signatures Mediating Inferior Survival in African Americans with Acute Myelogenous Leukemia","publication_year":2023,"publication_date":"2023-11-02","ids":{"openalex":"https://openalex.org/W4389219010","doi":"https://doi.org/10.1182/blood-2023-190898"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2023-190898","doi":"https://doi.org/10.1182/blood-2023-190898","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-190898","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4320/2197586/blood-921-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4320/2197586/blood-921-main.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058210300","display_name":"Lacey Scott Williams","orcid":"https://orcid.org/0009-0007-9032-5253","observed_orcids":["https://orcid.org/0009-0007-9032-5253"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lacey Scott Williams","raw_affiliation_strings":["1Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Alexandria, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Alexandria, VA","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036179975","display_name":"Alexis K. Williams","orcid":"https://orcid.org/0000-0003-4132-8806","observed_orcids":["https://orcid.org/0000-0003-4132-8806"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis K Williams","raw_affiliation_strings":["2NYU, New York CIty, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NYU, New York CIty, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072425794","display_name":"Sarah Elizabeth Mudra","orcid":"https://orcid.org/0009-0005-8904-1267","observed_orcids":["https://orcid.org/0009-0005-8904-1267"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Elizabeth Mudra","raw_affiliation_strings":["3Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081615407","display_name":"Paul E. Sackstein","orcid":"https://orcid.org/0000-0003-3786-6126","observed_orcids":["https://orcid.org/0000-0003-3786-6126"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Sackstein","raw_affiliation_strings":["3Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075816369","display_name":"Garrett Diltz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett Diltz","raw_affiliation_strings":["4Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Boston, MA","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081286799","display_name":"Rachel Zemel","orcid":"https://orcid.org/0000-0002-3942-7285","observed_orcids":["https://orcid.org/0000-0002-3942-7285"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Zemel","raw_affiliation_strings":["3Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090817673","display_name":"Purnima Sravanti Teegavarapu","orcid":"https://orcid.org/0000-0002-5804-153X","observed_orcids":["https://orcid.org/0000-0002-5804-153X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Purnima Sravanti Teegavarapu","raw_affiliation_strings":["5Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110886100","display_name":"Martha Pritchett Mims","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha P. Mims","raw_affiliation_strings":["6Section of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Section of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031554507","display_name":"Kimberley Doucette","orcid":"https://orcid.org/0000-0003-1165-2250","observed_orcids":["https://orcid.org/0000-0003-1165-2250"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberley Doucette","raw_affiliation_strings":["3Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011726172","display_name":"Catherine Lai","orcid":"https://orcid.org/0000-0001-8861-0281","observed_orcids":["https://orcid.org/0000-0001-8861-0281"]},"institutions":[{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Lai","raw_affiliation_strings":["7Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059002977","display_name":"Gustavo Rivero","orcid":"https://orcid.org/0000-0002-2866-9203","observed_orcids":["https://orcid.org/0000-0002-2866-9203"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo A. Rivero","raw_affiliation_strings":["3Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I2802534011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"142","issue":"Supplement 1","first_page":"4320","last_page":"4320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.878000020980835},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.7459999918937683},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6389999985694885},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6740000247955322},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7670000195503235},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/dna-methylation-signature","display_name":"DNA methylation signature","score":0.41499999165534973},{"id":"https://openalex.org/keywords/nucleotide-modification","display_name":"nucleotide modification","score":0.5139999985694885},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.5410000085830688},{"id":"https://openalex.org/keywords/metabolic-signatures","display_name":"metabolic signatures","score":0.335999995470047},{"id":"https://openalex.org/keywords/cardiometabolic-complications","display_name":"cardiometabolic complications","score":0.5929999947547913},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5899999737739563},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.4690000116825104},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7123726606369019},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6273322701454163},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.530254065990448},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.49781012535095215}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2023-190898","doi":"https://doi.org/10.1182/blood-2023-190898","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-190898","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4320/2197586/blood-921-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood-2023-190898","doi":"https://doi.org/10.1182/blood-2023-190898","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1182/blood-2023-190898","pdf_url":"https://ashpublications.org/blood/article-pdf/142/Supplement 1/4320/2197586/blood-921-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389219010.pdf","grobid_xml":"https://content.openalex.org/works/W4389219010.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404330104","https://openalex.org/W4310105114","https://openalex.org/W1904222554","https://openalex.org/W2241087165","https://openalex.org/W2953469880","https://openalex.org/W3141588811","https://openalex.org/W2114188307","https://openalex.org/W4256197027","https://openalex.org/W3095381141","https://openalex.org/W7162510715"],"abstract_inverted_index":{"Background:":[0],"African":[1,507],"American":[2,508],"(AA)":[3],"patients":[4,12,124,185,211,215,273,279,293,330,342,351,356,417,442,458],"experience":[5],"worse":[6,62,275,312,361,391],"survival":[7,31,64],"outcomes":[8,122,313,439],"compared":[9],"to":[10,47,94,145,247,320,474,488,498],"other":[11,133,402],"with":[13,35,120,125,216,266,294,331,354,357,380,390,396,418,437],"acute":[14,126],"myelogenous":[15],"leukemia":[16,128],"(AML),":[17],"independent":[18],"of":[19,73,85,182,308,324,410,422,448,469],"socioeconomic":[20],"and":[21,42,69,79,101,155,166,171,191,198,208,225,232,238,269,328,333,385,407,434,463,483,494,567],"molecular":[22],"factors.":[23],"1":[24],"Indeed,":[25],"our":[26,344,349],"group":[27],"previously":[28],"demonstrated":[29,459],"inferior":[30,438],"in":[32,88,112,132,136,236,343,415,432,578],"AA":[33,67,74,89,113,268,272,292,315,327,341,350,355,416,441,454,457],"associated":[34],"the":[36,96,137,322],"proxy":[37],"for":[38,45,66,123,250,314,348,375,393,401,440,461],"(1)":[39],"genomic":[40],"instability":[41],"(2)":[43],"suggestion":[44],"inability":[46],"achieve":[48],"protein":[49],"damaging":[50],"threshold":[51],"among":[52,326],"concurrent":[53],"mutations.":[54],"2":[55],"In":[56,115],"study":[57],"expansion,":[58],"we":[59,105,318],"have":[60],"confirmed":[61],"overall":[63],"(OS)":[65],"patients,":[68,75,90,265,316],"detected":[70],"rapid":[71],"attrition":[72],"soon":[76],"after":[77],"diagnosis":[78],"therapy":[80],"initiation.":[81],"Given":[82],"high":[83,334,381,419],"incidence":[84],"cardiometabolic":[86],"complications":[87],"this":[91],"prompted":[92],"us":[93],"investigate":[95],"link":[97],"between":[98],"deranged":[99],"metabolism":[100],"clinical":[102,199,423],"outcomes.":[103],"Additionally":[104],"explored":[106],"nucleotide":[107,168,465],"modifications":[108],"that":[109,149,452],"influence":[110],"leukemogenesis":[111],"patients.":[114,377,455],"previous":[116],"data,":[117,218],"obesity":[118,142,325],"correlated":[119,436],"poor":[121],"promyelocytic":[127],"(APL),":[129],"but":[130,399],"not":[131,290,373,400],"AML,":[134],"including":[135,196],"CALGB":[138],"cohort.":[139],"3-5":[140],"Interestingly,":[141],"is":[143],"linked":[144,473],"1)":[146],"FTO/IRX3":[147,496],"pathways":[148,497],"block":[150],"hematopoietic":[151],"stem":[152],"cell":[153],"differentiation,":[154],"2)":[156],"oxidative":[157,411,470,492],"stress,":[158,471,493],"which":[159,371],"may":[160,484],"induce":[161,499],"DNA":[162],"damage":[163],"favoring":[164],"C>A":[165,406,462],"G>T":[167,408,464],"changes":[169,405],"6,7":[170],"aberrant":[172],"bone":[173],"marrow":[174],"microenvironment":[175],"8.":[176,572],"Methods:":[177],"We":[178],"conducted":[179],"retrospective":[180],"analysis":[181],"272":[183,263],"AML":[184,264,336,451],"from":[186],"Baylor":[187],"TX,":[188],"Georgetown":[189],"DC,":[190,195],"Washington":[192],"Hospital":[193],"Center":[194],"demographic":[197],"variables":[200,240],"(age,":[201],"sex,":[202],"race,":[203],"BMI,":[204],"comorbidities,":[205],"smoking,":[206],"treatments,":[207],"outcomes).":[209],"APL":[210],"were":[212,221,289,413],"excluded.":[213],"For":[214,506],"NGS":[217],"mutation":[219],"frequencies":[220],"annotated":[222],"by":[223,227,511],"ethnicity":[224],"prioritized":[226],"ELN":[228,297,302],"2022":[229,298,303],"classification.":[230],"Chi-square":[231],"t-test":[233],"evaluated":[234],"differences":[235],"categorical":[237],"continuous":[239],"respectively.":[241],"Logistic":[242],"binary":[243],"regression":[244],"was":[245,256,352,372],"used":[246],"detect":[248],"predictors":[249],"racial":[251],"induced":[252],"survival.":[253],"SAS":[254],"software":[255],"used.":[257],"Results:":[258],"Our":[259],"expanded":[260],"cohort":[261],"has":[262],"43":[267],"229":[270],"non-AA.":[271],"showed":[274],"OS":[276,362,392],"than":[277],"non-AA":[278,329,376],"(Fig":[280,363],"1;":[281,364],"149":[282],"days":[283,366],"vs":[284,367,426],"605":[285],"days,":[286,369],"p=0.01).":[287],"There":[288],"any":[291],"favorable":[295,339],"risk":[296,304,335,340],"disease":[299],"status.":[300],"Neither":[301],"groups":[305],"nor":[306],"presence":[307],"MDS-like":[309],"mutations":[310],"differentiated":[311],"so":[317],"opted":[319],"examine":[321],"effect":[323],"intermediate":[332],"(given":[337],"no":[338],"cohort).":[345],"Mean":[346],"BMI":[347,420,433],"28,":[353],"BMI>28":[358,512],"showing":[359],"significantly":[360],"67":[365],"198":[368],"p=0.001),":[370],"present":[374,485],"Metabolic":[378,430],"derangement":[379,431],"total":[382],"cholesterol":[383,397],"(p=0.02)":[384],"LDL":[386],"(p=0.04)":[387],"also":[388,472],"segregated":[389],"AAs":[394],"(n=8":[395],"data),":[398],"races.":[403],"Nucleotide":[404],"characteristic":[409],"stress":[412],"overrepresented":[414],"suggestive":[421],"trend":[424],"(33%":[425],"11%,":[427],"p=0.06).":[428],"Conclusion:":[429],"lipids":[435],"only,":[443],"supporting":[444],"a":[445,467],"unique":[446],"pathobiology":[447],"highly":[449],"aggressive":[450],"afflicts":[453],"Only":[456],"preference":[460],"changes,":[466],"hallmark":[468],"obesity.":[475],"These":[476],"negative":[477],"impacts":[478],"support":[479],"further":[480],"mechanistic":[481],"studies,":[482],"therapeutic":[486],"strategies":[487],"improve":[489],"metabolism,":[490],"reduce":[491],"suppress":[495],"myeloid":[500],"differentiation.":[501],"Figure":[502],"1:":[503],"Inferior":[504],"Survival":[505],"Patients":[509],"Differentiated":[510],"References:":[513],"1.":[514],"Bhatnagar":[515],"B,":[516],"et":[517,525,532,539,548,556,575],"al.":[518,526,533,540,549,557,576],"Cancer":[519],"Discov.":[520],"2021":[521,535,562],"2.":[522],"Williams":[523],"AK,":[524],"Blood.":[527],"2022;140(Supp_":[528],"3.":[529],"Kashanian":[530],"SM,":[531],"EJHaem.":[534],"4.":[536],"Castillo":[537,546],"JJ,":[538,547],"Am":[541],"J":[542,559],"Hematol.":[543],"2016":[544],"5.":[545],"Leuk":[550],"Res.":[551],"2012":[552],"6.":[553],"Usman":[554],"M,":[555],"Int":[558],"Obes":[560],"(Lond).":[561],"7.":[563],"Poetsch":[564],"AR.":[565],"Comp":[566],"Struct":[568],"Biotech":[569],"J.":[570],"2020":[571],"Cheng":[573],"F,":[574],"Trends":[577],"Cancer.":[579],"2023":[580]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2023-12-02T00:00:00"}
