{"id":"https://openalex.org/W4389178486","doi":"https://doi.org/10.7554/elife.91854.1","title":"WASP facilitates tumor mechanosensitivity in T lymphocytes","display_name":"WASP facilitates tumor mechanosensitivity in T lymphocytes","publication_year":2023,"publication_date":"2023-11-30","ids":{"openalex":"https://openalex.org/W4389178486","doi":"https://doi.org/10.7554/elife.91854.1"},"language":"en","primary_location":{"id":"doi:10.7554/elife.91854.1","doi":"https://doi.org/10.7554/elife.91854.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.91854.1","pdf_url":"https://github.com/elifesciences/enhanced-preprints-data/raw/master/data/91854/v1/91854-v1.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://github.com/elifesciences/enhanced-preprints-data/raw/master/data/91854/v1/91854-v1.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061135980","display_name":"Srishti Mandal","orcid":"https://orcid.org/0009-0001-3037-4607","observed_orcids":["https://orcid.org/0009-0001-3037-4607"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Srishti Mandal","raw_affiliation_strings":["Indian Institute of Science","Indian Institute of Science, Bengaluru, India"],"raw_orcid":"https://orcid.org/0009-0001-3037-4607","affiliations":[{"raw_affiliation_string":"Indian Institute of Science","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000197567","display_name":"Mariane B. Melo","orcid":"https://orcid.org/0000-0002-0409-2454","observed_orcids":["https://orcid.org/0000-0002-0409-2454"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariane Melo","raw_affiliation_strings":["Koch Institute of Integrative Cancer Research, MIT","Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039823903","display_name":"Pavlo I. Gordiichuk","orcid":"https://orcid.org/0000-0002-8275-1910","observed_orcids":["https://orcid.org/0000-0002-8275-1910"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavlo Gordiichuk","raw_affiliation_strings":["Department of Biological Engineering, MIT","Department of Biological Engineering, MIT, Cambridge, USA"],"raw_orcid":"https://orcid.org/0000-0002-8275-1910","affiliations":[{"raw_affiliation_string":"Department of Biological Engineering, MIT","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biological Engineering, MIT, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089673638","display_name":"Sayanti Acharya","orcid":"https://orcid.org/0009-0009-3128-4687","observed_orcids":["https://orcid.org/0009-0009-3128-4687"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sayanti Acharya","raw_affiliation_strings":["Indian Institute of Science","Indian Institute of Science, Bengaluru, India"],"raw_orcid":"https://orcid.org/0009-0009-3128-4687","affiliations":[{"raw_affiliation_string":"Indian Institute of Science","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046611398","display_name":"Yeh\u2010Chuin Poh","orcid":"https://orcid.org/0000-0003-3510-6369","observed_orcids":["https://orcid.org/0000-0003-3510-6369"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yeh-Chuin Poh","raw_affiliation_strings":["Koch Institute of Integrative Cancer Research, MIT","Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA"],"raw_orcid":"https://orcid.org/0000-0003-3510-6369","affiliations":[{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Na Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Na Li","raw_affiliation_strings":["Koch Institute of Integrative Cancer Research, MIT","Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043814029","display_name":"Aereas Aung","orcid":"https://orcid.org/0000-0003-2429-5547","observed_orcids":["https://orcid.org/0000-0003-2429-5547"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aereas Aung","raw_affiliation_strings":["Koch Institute of Integrative Cancer Research, MIT","Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA"],"raw_orcid":"https://orcid.org/0000-0003-2429-5547","affiliations":[{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086914628","display_name":"Eric L. Dane","orcid":"https://orcid.org/0000-0002-4022-7264","observed_orcids":["https://orcid.org/0000-0002-4022-7264"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L. Dane","raw_affiliation_strings":["Koch Institute of Integrative Cancer Research, MIT","Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087926553","display_name":"Darrell J. Irvine","orcid":"https://orcid.org/0000-0002-8637-1405","observed_orcids":["https://orcid.org/0000-0002-8637-1405"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darrell J. Irvine","raw_affiliation_strings":["Department of Biological Engineering, MIT","Howard Hughes Medical Institute","Koch Institute of Integrative Cancer Research, MIT","Department of Biological Engineering, MIT, Cambridge, USA; Howard Hughes Medical Institute, Ashburn, Virginia, USA; Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Engineering, MIT","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biological Engineering, MIT, Cambridge, USA; Howard Hughes Medical Institute, Ashburn, Virginia, USA; Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035163409","display_name":"Sudha Kumari","orcid":"https://orcid.org/0000-0001-7082-2825","observed_orcids":["https://orcid.org/0000-0001-7082-2825","https://orcid.org/0009-0003-9063-5818"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Sudha Kumari","raw_affiliation_strings":["Indian Institute of Science","Koch Institute of Integrative Cancer Research, MIT","Indian Institute of Science, Bengaluru, India; Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA"],"raw_orcid":"https://orcid.org/0000-0001-7082-2825","affiliations":[{"raw_affiliation_string":"Indian Institute of Science","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Koch Institute of Integrative Cancer Research, MIT","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Indian Institute of Science, Bengaluru, India; Koch Institute of Integrative Cancer Research, MIT, Cambridge, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wiskott-aldrich-syndrome-protein","display_name":"Wiskott-Aldrich syndrome protein","score":0.953000009059906},{"id":"https://openalex.org/keywords/wasps","display_name":"wasps","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9039999842643738},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mechanosensing","display_name":"mechanosensing","score":0.8069999814033508},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8610000014305115},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.45500001311302185},{"id":"https://openalex.org/keywords/immunosurveillance","display_name":"immune surveillance","score":0.6830000281333923},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.8909320831298828},{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.8059740662574768},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6862363815307617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.685247004032135},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5947121381759644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5648142695426941},{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.5052137970924377},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.4925104081630707},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4822538495063782},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.43996939063072205},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43539342284202576},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.41203194856643677},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35019850730895996},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30780649185180664},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1558457612991333},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.10668569803237915},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06963291764259338},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.91854.1","doi":"https://doi.org/10.7554/elife.91854.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.91854.1","pdf_url":"https://github.com/elifesciences/enhanced-preprints-data/raw/master/data/91854/v1/91854-v1.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.91854.1","doi":"https://doi.org/10.7554/elife.91854.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.91854.1","pdf_url":"https://github.com/elifesciences/enhanced-preprints-data/raw/master/data/91854/v1/91854-v1.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2360436881","display_name":null,"funder_award_id":"P30-CA14051","funder_id":"https://openalex.org/F4320316943","funder_display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology"},{"id":"https://openalex.org/G4774430914","display_name":null,"funder_award_id":"CA14051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891960","display_name":"Cancer Center Support (Core) Grant","funder_award_id":"P30CA014051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310071","display_name":"Indian Institute of Science","ror":"https://ror.org/04dese585"},{"id":"https://openalex.org/F4320316943","display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology","ror":"https://ror.org/01xd6q208"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389178486.pdf","grobid_xml":"https://content.openalex.org/works/W4389178486.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1587510658","https://openalex.org/W1877879829","https://openalex.org/W1900620157","https://openalex.org/W1945972342","https://openalex.org/W1966474647","https://openalex.org/W1967359088","https://openalex.org/W1974374103","https://openalex.org/W1975132186","https://openalex.org/W1980754944","https://openalex.org/W1993369787","https://openalex.org/W1996152000","https://openalex.org/W2006073003","https://openalex.org/W2011584482","https://openalex.org/W2037117428","https://openalex.org/W2052186210","https://openalex.org/W2065681262","https://openalex.org/W2070638961","https://openalex.org/W2085036470","https://openalex.org/W2085559627","https://openalex.org/W2085815361","https://openalex.org/W2096234619","https://openalex.org/W2097841259","https://openalex.org/W2106829507","https://openalex.org/W2116413963","https://openalex.org/W2123590972","https://openalex.org/W2130159724","https://openalex.org/W2133240422","https://openalex.org/W2138204597","https://openalex.org/W2150338395","https://openalex.org/W2152645204","https://openalex.org/W2158175056","https://openalex.org/W2158421588","https://openalex.org/W2179097247","https://openalex.org/W2280722998","https://openalex.org/W2347077379","https://openalex.org/W2417253274","https://openalex.org/W2468082290","https://openalex.org/W2514175262","https://openalex.org/W2560099569","https://openalex.org/W2613271410","https://openalex.org/W2622883680","https://openalex.org/W2731449818","https://openalex.org/W2739884871","https://openalex.org/W2760071615","https://openalex.org/W2784975031","https://openalex.org/W2791670200","https://openalex.org/W2802077859","https://openalex.org/W2810745017","https://openalex.org/W2884166686","https://openalex.org/W2886509367","https://openalex.org/W2897545405","https://openalex.org/W2958230540","https://openalex.org/W2995443875","https://openalex.org/W2997357579","https://openalex.org/W3029655541","https://openalex.org/W3102167701","https://openalex.org/W3168627799","https://openalex.org/W4220656329","https://openalex.org/W4223964264","https://openalex.org/W4311503204","https://openalex.org/W4322745526","https://openalex.org/W4360611437","https://openalex.org/W4372279040"],"related_works":["https://openalex.org/W4391657457","https://openalex.org/W2055578595","https://openalex.org/W1982128760","https://openalex.org/W2062011663","https://openalex.org/W2033042234","https://openalex.org/W2114756397","https://openalex.org/W2980195787","https://openalex.org/W2092420351","https://openalex.org/W2332409697","https://openalex.org/W2049553378"],"abstract_inverted_index":{"Abstract":[0],"Cytotoxic":[1],"T":[2,29,57],"lymphocytes":[3],"(CTLs)":[4],"carry":[5],"out":[6],"immunosurveillance":[7],"by":[8,27,97],"scanning":[9],"target":[10,49,109,155],"cells":[11,50,73],"of":[12,19,24,48,71,85,101,108,119,150],"diverse":[13,154],"physical":[14],"properties":[15,100],"for":[16,36],"the":[17,22,28,33,45,61,68,83,86,98,125,148],"presence":[18],"antigens.":[20],"While":[21],"recognition":[23],"cognate":[25],"antigen":[26,134],"cell":[30,58,110],"receptor":[31],"is":[32,95],"primary":[34],"signal":[35],"CTL":[37,137],"activation,":[38],"it":[39],"has":[40],"become":[41],"increasingly":[42],"clear":[43],"that":[44,66,78,142],"mechanical":[46,69,99,151],"stiffness":[47],"plays":[51],"an":[52],"important":[53],"role":[54],"in":[55,124],"antigen-triggered":[56],"responses.":[59],"However,":[60],"molecular":[62,131],"machinery":[63],"within":[64],"CTLs":[65],"transduces":[67],"information":[70,152],"tumor":[72],"remains":[74],"unclear.":[75],"We":[76],"find":[77],"CTL\u2019s":[79],"mechanosensitive":[80,117],"ability":[81],"requires":[82],"activity":[84],"actin-organizing":[87],"protein":[88],"Wiskott-Aldrich":[89],"Syndrome":[90],"Protein":[91],"(WASP).":[92],"WASP":[93,114],"activation":[94,118],"modulated":[96],"antigen-presenting":[102],"contexts":[103],"across":[104],"a":[105,130],"wide":[106],"range":[107],"stiffnesses":[111],"and":[112,136,140],"activated":[113],"then":[115],"mediates":[116],"early":[120],"TCR":[121],"signaling":[122],"markers":[123],"CTL.":[126],"Our":[127],"results":[128],"provide":[129],"link":[132],"between":[133],"mechanosensing":[135],"immune":[138],"response":[139],"suggest":[141],"CTL-intrinsic":[143],"cytoskeletal":[144],"organizing":[145],"principles":[146],"enable":[147],"processing":[149],"from":[153],"cells.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2023-12-01T00:00:00"}