{"id":"https://openalex.org/W4389100739","doi":"https://doi.org/10.1016/j.xjidi.2023.100251","title":"ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201","display_name":"ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201","publication_year":2023,"publication_date":"2023-11-28","ids":{"openalex":"https://openalex.org/W4389100739","doi":"https://doi.org/10.1016/j.xjidi.2023.100251","pmid":"https://pubmed.ncbi.nlm.nih.gov/38299059","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10825549"},"language":"en","primary_location":{"id":"doi:10.1016/j.xjidi.2023.100251","doi":"https://doi.org/10.1016/j.xjidi.2023.100251","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjidi.2023.100251","pdf_url":null,"source":{"id":"https://openalex.org/S4210189051","display_name":"JID Innovations","issn_l":"2667-0267","issn":["2667-0267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JID Innovations","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xjidi.2023.100251","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047461250","display_name":"Paul S. Changelian","orcid":"https://orcid.org/0000-0002-2957-6412","observed_orcids":["https://orcid.org/0000-0002-2957-6412"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul Changelian","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-2957-6412","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101635677","display_name":"Canxin Xu","orcid":"https://orcid.org/0000-0002-5153-2424","observed_orcids":["https://orcid.org/0000-0002-5153-2424"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Canxin Xu","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-5153-2424","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008807927","display_name":"Steve Mnich","orcid":"https://orcid.org/0000-0002-8153-5968","observed_orcids":["https://orcid.org/0000-0002-8153-5968"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Mnich","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-8153-5968","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067784373","display_name":"Heidi Rath Hope","orcid":"https://orcid.org/0000-0003-3731-0320","observed_orcids":["https://orcid.org/0000-0003-3731-0320"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi Hope","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0003-3731-0320","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090103262","display_name":"Kourtney L. Kostecki","orcid":"https://orcid.org/0000-0003-2289-5194","observed_orcids":["https://orcid.org/0000-0003-2289-5194"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kourtney Kostecki","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA"],"raw_orcid":"https://orcid.org/0000-0003-2289-5194","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]},{"raw_affiliation_string":"Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jeff Hirsch","orcid":"https://orcid.org/0000-0002-1954-234X","observed_orcids":["https://orcid.org/0000-0002-1954-234X"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Hirsch","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-1954-234X","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007598647","display_name":"Chin-Yi Loh","orcid":"https://orcid.org/0000-0002-4009-4094","observed_orcids":["https://orcid.org/0000-0002-4009-4094"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]},{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Chin-Yi Loh","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","Miguel Hern\u00e1ndez University of Elche, Alicante, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4009-4094","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]},{"raw_affiliation_string":"Miguel Hern\u00e1ndez University of Elche, Alicante, Spain","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101522328","display_name":"David R. Anderson","orcid":"https://orcid.org/0000-0001-8692-2556","observed_orcids":["https://orcid.org/0000-0001-8692-2556"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Anderson","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-8692-2556","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036741368","display_name":"James R. Blinn","orcid":"https://orcid.org/0000-0001-7210-9011","observed_orcids":["https://orcid.org/0000-0001-7210-9011"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Blinn","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-7210-9011","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009434142","display_name":"Susan L. Hockerman","orcid":"https://orcid.org/0000-0002-9169-4954","observed_orcids":["https://orcid.org/0000-0002-9169-4954"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Hockerman","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-9169-4954","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Evan Dick","orcid":"https://orcid.org/0000-0002-4562-3477","observed_orcids":["https://orcid.org/0000-0002-4562-3477"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Dick","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","Research and Development, Context Therapeutics, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-4562-3477","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]},{"raw_affiliation_string":"Research and Development, Context Therapeutics, Philadelphia, Pennsylvania, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Walter Smith","orcid":"https://orcid.org/0000-0001-7834-6675","observed_orcids":["https://orcid.org/0000-0001-7834-6675"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter Smith","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-7834-6675","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059569112","display_name":"Joseph B. Monahan","orcid":"https://orcid.org/0000-0002-5433-4001","observed_orcids":["https://orcid.org/0000-0002-5433-4001"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Monahan","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-5433-4001","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050999393","display_name":"Tooraj Joseph Raoof","orcid":"https://orcid.org/0000-0001-8634-4303","observed_orcids":["https://orcid.org/0000-0001-8634-4303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tooraj Raoof","raw_affiliation_strings":["Raoof MD Dermatology, Encino, California, USA"],"raw_orcid":"https://orcid.org/0000-0001-8634-4303","affiliations":[{"raw_affiliation_string":"Raoof MD Dermatology, Encino, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078964682","display_name":"Seth B. Forman","orcid":"https://orcid.org/0000-0001-5800-1856","observed_orcids":["https://orcid.org/0000-0001-5800-1856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seth Forman","raw_affiliation_strings":["CenExel FCR, Tampa, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0001-5800-1856","affiliations":[{"raw_affiliation_string":"CenExel FCR, Tampa, Florida, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049281279","display_name":"David Burt","orcid":"https://orcid.org/0000-0001-8525-3258","observed_orcids":["https://orcid.org/0000-0001-8525-3258"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Burt","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-8525-3258","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014613255","display_name":"Brad Barnes","orcid":"https://orcid.org/0000-0002-7180-807X","observed_orcids":["https://orcid.org/0000-0002-7180-807X"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad Barnes","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-7180-807X","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Gordon","orcid":"https://orcid.org/0000-0002-9593-1590","observed_orcids":["https://orcid.org/0000-0002-9593-1590"]},"institutions":[{"id":"https://openalex.org/I1330063522","display_name":"Johnson & Johnson (United States)","ror":"https://ror.org/03qd7mz70","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522"]},{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Gordon","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","Clinical Development, Immunology, Johnson & Johnson, West Chester, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-9593-1590","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]},{"raw_affiliation_string":"Clinical Development, Immunology, Johnson & Johnson, West Chester, Pennsylvania, USA","institution_ids":["https://openalex.org/I1330063522"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Neal Walker","orcid":"https://orcid.org/0000-0002-4733-6789","observed_orcids":["https://orcid.org/0000-0002-4733-6789"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal Walker","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-4733-6789","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093363603","display_name":"John Sudzina","orcid":"https://orcid.org/0000-0002-4800-8904","observed_orcids":["https://orcid.org/0000-0002-4800-8904"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Sudzina","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-4800-8904","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029577432","display_name":"Stephen B. Tucker","orcid":"https://orcid.org/0000-0002-8026-9266","observed_orcids":["https://orcid.org/0000-0002-8026-9266"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Tucker","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-8026-9266","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046256045","display_name":"Jon Jacobsen","orcid":"https://orcid.org/0000-0002-3582-1429","observed_orcids":["https://orcid.org/0000-0002-3582-1429"]},"institutions":[{"id":"https://openalex.org/I4210094165","display_name":"Aclaris Therapeutics (United States)","ror":"https://ror.org/00q1zbc26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Jacobsen","raw_affiliation_strings":["Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-3582-1429","affiliations":[{"raw_affiliation_string":"Aclaris Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094165"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5047461250"],"corresponding_institution_ids":["https://openalex.org/I4210094165"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":2.2284,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.86677903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"4","issue":"2","first_page":"100251","last_page":"100251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.7960000038146973},{"id":"https://openalex.org/keywords/systemic-exposure","display_name":"systemic exposure","score":0.8100000023841858},{"id":"https://openalex.org/keywords/eczema-area-and-severity-index","display_name":"Eczema Area and Severity Index","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7720000147819519},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.6819999814033508},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.8920504450798035},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7974011898040771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7328605651855469},{"id":"https://openalex.org/C2780699399","wikidata":"https://www.wikidata.org/wiki/Q20708049","display_name":"Eczema Area and Severity Index","level":3,"score":0.6344752311706543},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6097651720046997},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6056628227233887},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.44416871666908264},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4300031363964081},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42528703808784485},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41850078105926514},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.33357828855514526}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.xjidi.2023.100251","doi":"https://doi.org/10.1016/j.xjidi.2023.100251","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjidi.2023.100251","pdf_url":null,"source":{"id":"https://openalex.org/S4210189051","display_name":"JID Innovations","issn_l":"2667-0267","issn":["2667-0267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JID Innovations","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10825549","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10825549","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10825549/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JID Innov","raw_type":"Text"},{"id":"pmid:38299059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38299059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JID innovations : skin science from molecules to population health","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.xjidi.2023.100251","doi":"https://doi.org/10.1016/j.xjidi.2023.100251","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjidi.2023.100251","pdf_url":null,"source":{"id":"https://openalex.org/S4210189051","display_name":"JID Innovations","issn_l":"2667-0267","issn":["2667-0267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JID Innovations","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1114310655","display_name":null,"funder_award_id":"CA91842","funder_id":"https://openalex.org/F4320315130","funder_display_name":"Alvin J. Siteman Cancer Center"},{"id":"https://openalex.org/G1761549745","display_name":null,"funder_award_id":"ATI-1777","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G299873027","display_name":null,"funder_award_id":"#P30 CA91842","funder_id":"https://openalex.org/F4320315130","funder_display_name":"Alvin J. Siteman Cancer Center"},{"id":"https://openalex.org/G4950536974","display_name":null,"funder_award_id":"-0001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000907135","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA091842","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F1354449833","display_name":"Genome Technology Access Center","ror":"https://ror.org/038ndbh27"},{"id":"https://openalex.org/F4320315130","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389100739.pdf","grobid_xml":"https://content.openalex.org/works/W4389100739.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2060604544","https://openalex.org/W2060880575","https://openalex.org/W2111338617","https://openalex.org/W2114104545","https://openalex.org/W2133677036","https://openalex.org/W2143138262","https://openalex.org/W2465799764","https://openalex.org/W2787696154","https://openalex.org/W2913292104","https://openalex.org/W2914603675","https://openalex.org/W2920206917","https://openalex.org/W2978096514","https://openalex.org/W2979754363","https://openalex.org/W2980286352","https://openalex.org/W2981004305","https://openalex.org/W2991540591","https://openalex.org/W3004098925","https://openalex.org/W3007742275","https://openalex.org/W3010985734","https://openalex.org/W4255155429"],"related_works":["https://openalex.org/W3110269786","https://openalex.org/W4416073250","https://openalex.org/W4317868307","https://openalex.org/W4312967593","https://openalex.org/W7167495168","https://openalex.org/W4220672121","https://openalex.org/W2913292104","https://openalex.org/W3194970552","https://openalex.org/W4292474822","https://openalex.org/W3196069457"],"abstract_inverted_index":{"Introduction:":[0],"Atopic":[1],"dermatitis,":[2],"a":[3,22,91,126,129],"chronic,":[4],"pruritic":[5],"skin":[6,41],"disease,":[7],"affects":[8],"10-30%":[9],"of":[10,16,33,67,77,107,128,145,149,154,184],"children":[11],"and":[12,24,42,57,105,133,179],"up":[13],"to":[14,35,71,173],"14%":[15],"adults":[17,82],"in":[18,39,81,111],"developed":[19],"countries.":[20],"ATI-1777,":[21],"potent":[23],"selective":[25],"Jak1/3":[26,52],"inhibitor,":[27],"was":[28,70,125,191],"designed":[29],"with":[30,53,83,114,195],"multiple":[31],"sites":[32],"metabolism":[34],"deliver":[36],"local":[37],"efficacy":[38,76],"the":[40,73,101,150,196],"limit":[43],"systemic":[44,55,176],"exposure.":[45],"In":[46],"preclinical":[47],"studies,":[48],"ATI-1777":[49,78,108,146,155,169],"selectively":[50],"inhibited":[51],"limited":[54],"exposure":[56,178],"without":[58],"any":[59],"adverse":[60,163],"effects.":[61],"Primary":[62,120],"objective:":[63],"The":[64,122,189],"primary":[65,123],"goal":[66],"this":[68],"study":[69,190],"assess":[72],"preliminary":[74],"clinical":[75,182],"topical":[79,109],"solution":[80,110],"moderate":[84],"or":[85,161],"severe":[86],"atopic":[87,115,185],"dermatitis.":[88,186],"Design:":[89],"ATI-1777-AD-201,":[90],"phase":[92],"2a,":[93],"first-in-human,":[94],"randomized,":[95],"double-blind,":[96],"vehicle-controlled,":[97],"parallel-group":[98],"study,":[99],"evaluated":[100],"efficacy,":[102],"safety,":[103],"tolerability,":[104],"pharmacokinetics":[106],"48":[112],"participants":[113],"dermatitis":[116],"over":[117],"4":[118],"weeks.":[119],"endpoint:":[121],"endpoint":[124],"reduction":[127],"modified":[130],"Eczema":[131],"Area":[132],"Severity":[134],"Index":[135],"score":[136],"from":[137],"baseline.":[138],"Results:":[139],"<":[140],".001]).":[141],"Average":[142],"plasma":[143],"concentrations":[144],"were":[147,165],"<5%":[148],"half-maximal":[151],"inhibitory":[152],"concentration":[153],"for":[156],"inhibiting":[157],"Jak1/3.":[158],"No":[159],"deaths":[160],"serious":[162],"events":[164],"reported.":[166],"Conclusion:":[167],"Topical":[168],"does":[170],"not":[171],"lead":[172],"pharmacologically":[174],"relevant":[175],"drug":[177],"may":[180],"reduce":[181],"signs":[183],"Trial":[187],"Registration:":[188],"registered":[192],"at":[193],"ClinicalTrials.gov":[194],"number":[197],"NCT04598269.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-11-29T00:00:00"}