{"id":"https://openalex.org/W4389064809","doi":"https://doi.org/10.1615/critrevimmunol.2023050792","title":"Molecular Mechanism of SOX18 in Lipopolysaccharide-Induced Injury of Human Umbilical Vein Endothelial Cells","display_name":"Molecular Mechanism of SOX18 in Lipopolysaccharide-Induced Injury of Human Umbilical Vein Endothelial Cells","publication_year":2023,"publication_date":"2023-11-27","ids":{"openalex":"https://openalex.org/W4389064809","doi":"https://doi.org/10.1615/critrevimmunol.2023050792","pmid":"https://pubmed.ncbi.nlm.nih.gov/38421701"},"language":"en","primary_location":{"id":"doi:10.1615/critrevimmunol.2023050792","doi":"https://doi.org/10.1615/critrevimmunol.2023050792","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critrevimmunol.2023050792","pdf_url":null,"source":{"id":"https://openalex.org/S73794665","display_name":"Critical Reviews in Immunology","issn_l":"0197-3355","issn":["0197-3355","1040-8401","2162-6472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111009801","display_name":"Jian Luo","orcid":"https://orcid.org/0000-0002-3569-719X","observed_orcids":["https://orcid.org/0000-0002-3569-719X"]},"institutions":[{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Luo","raw_affiliation_strings":["Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, China","institution_ids":["https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029331616","display_name":"Honglong Fang","orcid":"https://orcid.org/0009-0000-9697-5213","observed_orcids":["https://orcid.org/0009-0000-9697-5213"]},"institutions":[{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Honglong Fang","raw_affiliation_strings":["Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, China","institution_ids":["https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066903723","display_name":"Danqiong Wang","orcid":"https://orcid.org/0000-0003-2667-3134","observed_orcids":["https://orcid.org/0000-0003-2667-3134"]},"institutions":[{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danqiong Wang","raw_affiliation_strings":["Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, China","institution_ids":["https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781687","display_name":"Jianhua Hu","orcid":"https://orcid.org/0000-0002-1749-3636","observed_orcids":["https://orcid.org/0000-0002-1749-3636"]},"institutions":[{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhua Hu","raw_affiliation_strings":["Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, China","institution_ids":["https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035916673","display_name":"Weiwen Zhang","orcid":"https://orcid.org/0000-0001-8305-5653","observed_orcids":["https://orcid.org/0000-0001-8305-5653"]},"institutions":[{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiwen Zhang","raw_affiliation_strings":["Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, China","institution_ids":["https://openalex.org/I4210088331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101614955","display_name":"Ronglin Jiang","orcid":"https://orcid.org/0000-0002-3821-0228","observed_orcids":["https://orcid.org/0000-0002-3821-0228"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ronglin Jiang","raw_affiliation_strings":["the First Clinical Medical College of Zhejiang Chinese Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the First Clinical Medical College of Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101614955"],"corresponding_institution_ids":["https://openalex.org/I114539943"],"apc_list":null,"apc_paid":null,"fwci":0.0405,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.08731466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"44","issue":"3","first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.20309999585151672,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.08370000123977661,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sox18","display_name":"SOX18","score":1.0},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7730000019073486},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9380000233650208},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mir-204-5p","display_name":"miR-204-5p","score":0.9760000109672546},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.925000011920929},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9049999713897705},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.6808390617370605},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6429812908172607},{"id":"https://openalex.org/C2777834122","wikidata":"https://www.wikidata.org/wiki/Q5939177","display_name":"Human umbilical vein endothelial cell","level":4,"score":0.6368007659912109},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5603839755058289},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.552182674407959},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5210703611373901},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.46912574768066406},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.46373501420021057},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4531472325325012},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.44110679626464844},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.43849706649780273},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.43224501609802246},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41006743907928467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40112364292144775},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3196328282356262},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29825499653816223},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.21435829997062683},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17905974388122559},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14357763528823853},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.14341378211975098},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05717188119888306},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055760","descriptor_name":"SOXF Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1615/critrevimmunol.2023050792","doi":"https://doi.org/10.1615/critrevimmunol.2023050792","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critrevimmunol.2023050792","pdf_url":null,"source":{"id":"https://openalex.org/S73794665","display_name":"Critical Reviews in Immunology","issn_l":"0197-3355","issn":["0197-3355","1040-8401","2162-6472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Immunology","raw_type":"journal-article"},{"id":"pmid:38421701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38421701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1964220568","https://openalex.org/W1979251800","https://openalex.org/W1980640097","https://openalex.org/W2022692486","https://openalex.org/W2032827308","https://openalex.org/W2107277218","https://openalex.org/W2134629862","https://openalex.org/W2153653063","https://openalex.org/W2175358519","https://openalex.org/W2404234615","https://openalex.org/W2478946756","https://openalex.org/W2767809858","https://openalex.org/W2792128273","https://openalex.org/W2897825874","https://openalex.org/W2903059149","https://openalex.org/W2937307384","https://openalex.org/W2944750154","https://openalex.org/W2970358232","https://openalex.org/W2971786659","https://openalex.org/W2973431785","https://openalex.org/W3008170328","https://openalex.org/W3020639193","https://openalex.org/W3029653066","https://openalex.org/W3030473668","https://openalex.org/W3037574082","https://openalex.org/W3048439331","https://openalex.org/W3083148784","https://openalex.org/W3120316183","https://openalex.org/W3177175288","https://openalex.org/W3200158711","https://openalex.org/W3204050032","https://openalex.org/W3214025722","https://openalex.org/W3215596355","https://openalex.org/W3216053553","https://openalex.org/W3216832069","https://openalex.org/W4205154570","https://openalex.org/W4213326281","https://openalex.org/W4214671856","https://openalex.org/W4214856135","https://openalex.org/W4226284529","https://openalex.org/W4247544731","https://openalex.org/W4255156463","https://openalex.org/W4283831937","https://openalex.org/W4289731095","https://openalex.org/W4292363594","https://openalex.org/W4312187460","https://openalex.org/W4315620773","https://openalex.org/W4361287168"],"related_works":["https://openalex.org/W4401369240","https://openalex.org/W4385876549","https://openalex.org/W4386390251","https://openalex.org/W3098900452","https://openalex.org/W4410360105","https://openalex.org/W3103514173","https://openalex.org/W3045556046","https://openalex.org/W3029653066","https://openalex.org/W4411329518","https://openalex.org/W3197430233"],"abstract_inverted_index":{"Endothelial":[0],"dysfunction":[1],"is":[2],"associated":[3],"with":[4,40],"the":[5,14,21,45,140,158],"progression":[6],"of":[7,17,80,103,122,161,171],"sepsis.":[8],"This":[9],"study":[10],"sought":[11],"to":[12,43,139,143],"probe":[13],"molecular":[15],"route":[16],"sex-determining":[18],"region":[19],"on":[20],"Y":[22],"chromosome-box":[23],"transcription":[24],"factor":[25],"18":[26],"(SOX18)":[27],"in":[28,87,163],"sepsis-associated":[29],"endothelial":[30,35],"injury.":[31,165],"Human":[32],"umbilical":[33],"vein":[34],"cells":[36,88],"(HUVECs)":[37],"were":[38,66,89],"treated":[39],"lipopolysaccharide":[41],"(LPS)":[42],"establish":[44],"sepsis":[46,186],"cell":[47,69,127],"model.":[48],"Cell":[49],"viability,":[50,128],"lactate":[51],"dehydrogenase":[52],"(LDH)":[53],"release,":[54],"oxidative":[55,133],"stress":[56],"(reactive":[57],"oxygen":[58],"species/malondialdehyde/superoxide":[59],"dismutase),":[60],"and":[61,73,84,97,106,113,120,135,147,154,176],"inflammation":[62],"(interleukin-1\u03b2/tumor":[63],"necrosis":[64],"factor-\u03b1/interleukin-6)":[65],"evaluated":[67],"by":[68,91,110,173],"counting":[70],"kit-8":[71],"assay":[72,75],"relevant":[74],"kits.":[76],"The":[77,101],"expression":[78],"levels":[79],"SOX18,":[81,104],"microRNA":[82],"(miR)-204-5p,":[83],"cadherin-2":[85],"(CDH2)":[86],"determined":[90],"real-time":[92],"quantitative":[93],"polymerase":[94],"chain":[95],"reaction":[96],"Western":[98],"blot":[99],"assay.":[100,115],"interaction":[102],"miR-204-5p,":[105],"CDH2":[107,150,155],"was":[108],"analyzed":[109],"chromatin":[111],"immunoprecipitation":[112],"dual-luciferase":[114],"LPS":[116],"induced":[117],"HUVECs":[118,164,172],"injury":[119,170],"downregulation":[121],"SOX18.":[123],"SOX18":[124,137,162,167],"overexpression":[125,156],"increased":[126],"while":[129],"decreased":[130],"LDH":[131],"activity,":[132],"stress,":[134],"inflammation.":[136],"bound":[138],"miR-204-5p":[141,145,152,175],"promoter":[142],"promote":[144],"expression,":[146],"further":[148],"repressed":[149],"expression.":[151],"knockdown":[153],"abrogated":[157],"protective":[159],"role":[160],"Overall,":[166],"alleviated":[168],"LPS-induced":[169],"promoting":[174],"repressing":[177],"CDH2,":[178],"suggesting":[179],"it":[180],"as":[181],"a":[182],"potential":[183],"target":[184],"for":[185],"treatment.":[187]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-28T00:00:00"}
