{"id":"https://openalex.org/W4389060468","doi":"https://doi.org/10.1016/j.jsps.2023.101888","title":"Novel ibuprofen prodrug: A possible promising agent for the management of complications of Alzheimer\u2019s disease","display_name":"Novel ibuprofen prodrug: A possible promising agent for the management of complications of Alzheimer\u2019s disease","publication_year":2023,"publication_date":"2023-11-27","ids":{"openalex":"https://openalex.org/W4389060468","doi":"https://doi.org/10.1016/j.jsps.2023.101888","pmid":"https://pubmed.ncbi.nlm.nih.gov/38090736","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10711515"},"language":"en","primary_location":{"id":"doi:10.1016/j.jsps.2023.101888","doi":"https://doi.org/10.1016/j.jsps.2023.101888","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jsps.2023.101888","pdf_url":null,"source":{"id":"https://openalex.org/S34003737","display_name":"Saudi Pharmaceutical Journal","issn_l":"1319-0164","issn":["1319-0164","2213-7475"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Pharmaceutical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jsps.2023.101888","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103249480","display_name":"Anjali Nayak","orcid":"https://orcid.org/0000-0002-3858-9012","observed_orcids":["https://orcid.org/0000-0002-3858-9012"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anjali Nayak","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bengaluru, Karnataka 560035, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bengaluru, Karnataka 560035, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016280622","display_name":"Rashu Raju","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rashu Raju","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bengaluru, Karnataka 560035, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bengaluru, Karnataka 560035, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paramita Das","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paramita Das","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bengaluru, Karnataka 560035, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bengaluru, Karnataka 560035, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081795204","display_name":"Kuntal Das","orcid":"https://orcid.org/0000-0001-6118-5270","observed_orcids":["https://orcid.org/0000-0001-6118-5270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuntal Das","raw_affiliation_strings":["Department of Pharmacognosy, Mallige College of Pharmacy, #71, Silvepura, Chikkabanavara Post, Bangalore 560090, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Mallige College of Pharmacy, #71, Silvepura, Chikkabanavara Post, Bangalore 560090, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093351942","display_name":"A. Suvitha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205133468","display_name":"Universitas Airlangga","ror":"https://ror.org/04ctejd88","country_code":"ID","type":"education","lineage":["https://openalex.org/I205133468"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"A. Suvitha","raw_affiliation_strings":["Department of Physics, Faculty of Science & Technology, Airlangga University, Surabaya 60115, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Faculty of Science & Technology, Airlangga University, Surabaya 60115, Indonesia","institution_ids":["https://openalex.org/I205133468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056745972","display_name":"Biswa Ranjan Meher","orcid":"https://orcid.org/0000-0003-0519-9074","observed_orcids":["https://orcid.org/0000-0003-0519-9074"]},"institutions":[{"id":"https://openalex.org/I90752740","display_name":"Berhampur University","ror":"https://ror.org/03m3xkg41","country_code":"IN","type":"education","lineage":["https://openalex.org/I90752740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Biswa Ranjan Meher","raw_affiliation_strings":["Computational Biology and Bioinformatics Laboratory, PG Department of Botany, Berhampur University, Berhampur, Odisha 760007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Bioinformatics Laboratory, PG Department of Botany, Berhampur University, Berhampur, Odisha 760007, India","institution_ids":["https://openalex.org/I90752740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081517305","display_name":"Saad Ebrahim Alobid","orcid":"https://orcid.org/0000-0002-0157-9240","observed_orcids":["https://orcid.org/0000-0002-0157-9240"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Saad Alobid","raw_affiliation_strings":["Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041201174","display_name":"Ali Ibrahim Almoteer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801066305","display_name":"King Saud Medical City","ror":"https://ror.org/03aj9rj02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2801066305"]},{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ali Ibrahim Almoteer","raw_affiliation_strings":["Department of Pharmacy, King Saud University Medical City, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, King Saud University Medical City, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2801066305","https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068576107","display_name":"Moneer E. Almadani","orcid":"https://orcid.org/0009-0000-8582-5455","observed_orcids":["https://orcid.org/0009-0000-8582-5455"]},"institutions":[{"id":"https://openalex.org/I4391767729","display_name":"Almaarefa University","ror":"https://ror.org/00s3s5518","country_code":"SA","type":"education","lineage":["https://openalex.org/I4391767729"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Moneer E. Almadani","raw_affiliation_strings":["Department of Clinical Medicine, College of Medicine, AlMaarefa University, Dariyah 13713, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, College of Medicine, AlMaarefa University, Dariyah 13713, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I4391767729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034443222","display_name":"Ahmed Alshehri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ahmed Alshehri","raw_affiliation_strings":["Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, King Faisal Road, Dammam 31441, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, King Faisal Road, Dammam 31441, Saudi Arabia","institution_ids":["https://openalex.org/I76571253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042355962","display_name":"Adel Alghamdi","orcid":"https://orcid.org/0000-0002-8063-0090","observed_orcids":["https://orcid.org/0000-0002-8063-0090"]},"institutions":[{"id":"https://openalex.org/I52207611","display_name":"Al Baha University","ror":"https://ror.org/0403jak37","country_code":"SA","type":"education","lineage":["https://openalex.org/I52207611"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Adel Alghamdi","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Clinical Pharmacy, Al Baha University, P.O. Box 1988 Al Baha, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-8063-0090","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Clinical Pharmacy, Al Baha University, P.O. Box 1988 Al Baha, Saudi Arabia","institution_ids":["https://openalex.org/I52207611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055389074","display_name":"Fuzail Ahmad","orcid":"https://orcid.org/0000-0002-1189-2206","observed_orcids":["https://orcid.org/0000-0002-1189-2206"]},"institutions":[{"id":"https://openalex.org/I4391767729","display_name":"Almaarefa University","ror":"https://ror.org/00s3s5518","country_code":"SA","type":"education","lineage":["https://openalex.org/I4391767729"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Fuzail Ahmad","raw_affiliation_strings":["College of Applied Sciences, AlMareefa University, Diriya, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Applied Sciences, AlMareefa University, Diriya, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I4391767729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062964233","display_name":"Syed Imam Rabbani","orcid":"https://orcid.org/0000-0001-6344-1071","observed_orcids":["https://orcid.org/0000-0001-6344-1071"]},"institutions":[{"id":"https://openalex.org/I156216236","display_name":"Qassim University","ror":"https://ror.org/01wsfe280","country_code":"SA","type":"education","lineage":["https://openalex.org/I156216236"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Syed Imam Rabbani","raw_affiliation_strings":["Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia","institution_ids":["https://openalex.org/I156216236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028700323","display_name":"Syed Mohammed Basheeruddin Asdaq","orcid":"https://orcid.org/0000-0003-1533-9667","observed_orcids":["https://orcid.org/0000-0003-1533-9667"]},"institutions":[{"id":"https://openalex.org/I4391767729","display_name":"Almaarefa University","ror":"https://ror.org/00s3s5518","country_code":"SA","type":"education","lineage":["https://openalex.org/I4391767729"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Syed Mohammed Basheeruddin Asdaq","raw_affiliation_strings":["Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah 13713, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah 13713, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I4391767729"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069098835","display_name":"Naira Nayeem","orcid":"https://orcid.org/0000-0001-6284-0724","observed_orcids":["https://orcid.org/0000-0001-6284-0724"]},"institutions":[{"id":"https://openalex.org/I118590987","display_name":"Northern Border University","ror":"https://ror.org/03j9tzj20","country_code":"SA","type":"education","lineage":["https://openalex.org/I118590987"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Naira Nayeem","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia","institution_ids":["https://openalex.org/I118590987"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5069098835","https://openalex.org/A5103249480"],"corresponding_institution_ids":["https://openalex.org/I118590987"],"apc_list":{"value":1450,"currency":"USD","value_usd":1450},"apc_paid":{"value":1450,"currency":"USD","value_usd":1450},"fwci":0.7465,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.63058919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"32","issue":"1","first_page":"101888","last_page":"101888"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.41040000319480896,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/beta-secretase-inhibition","display_name":"beta-secretase inhibition","score":0.9340000152587891},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":1.0},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7720000147819519},{"id":"https://openalex.org/keywords/molecular-descriptors","display_name":"molecular descriptors","score":0.3149999976158142},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.4749999940395355},{"id":"https://openalex.org/keywords/brain-histopathology","display_name":"brain histopathology","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.6158875226974487},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.5473010540008545},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.5366833209991455},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47532063722610474},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4700055718421936},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4503268003463745},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.4159623384475708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37005308270454407},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17595818638801575},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1536390483379364},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11845409870147705},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.0853516161441803}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jsps.2023.101888","doi":"https://doi.org/10.1016/j.jsps.2023.101888","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jsps.2023.101888","pdf_url":null,"source":{"id":"https://openalex.org/S34003737","display_name":"Saudi Pharmaceutical Journal","issn_l":"1319-0164","issn":["1319-0164","2213-7475"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Pharmaceutical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10711515","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10711515","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10711515/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Pharm J","raw_type":"Text"},{"id":"pmid:38090736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38090736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e812cf9114ed47ec81d2dc7f242bebf3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e812cf9114ed47ec81d2dc7f242bebf3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Saudi Pharmaceutical Journal, Vol 32, Iss 1, Pp 101888- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jsps.2023.101888","doi":"https://doi.org/10.1016/j.jsps.2023.101888","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jsps.2023.101888","pdf_url":null,"source":{"id":"https://openalex.org/S34003737","display_name":"Saudi Pharmaceutical Journal","issn_l":"1319-0164","issn":["1319-0164","2213-7475"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Pharmaceutical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G575175123","display_name":null,"funder_award_id":"RSPD2023R853","funder_id":"https://openalex.org/F4320321145","funder_display_name":"King Saud University"}],"funders":[{"id":"https://openalex.org/F4320318809","display_name":"AlMaarefa University","ror":"https://ror.org/00s3s5518"},{"id":"https://openalex.org/F4320321145","display_name":"King Saud University","ror":"https://ror.org/02f81g417"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389060468.pdf","grobid_xml":"https://content.openalex.org/works/W4389060468.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1528904262","https://openalex.org/W1968984443","https://openalex.org/W1976773921","https://openalex.org/W2128083863","https://openalex.org/W2134967712","https://openalex.org/W2298067136","https://openalex.org/W2305304932","https://openalex.org/W2539632116","https://openalex.org/W2621194814","https://openalex.org/W2913678295","https://openalex.org/W2964940927","https://openalex.org/W2996214974","https://openalex.org/W3039306930","https://openalex.org/W3047585658","https://openalex.org/W3092594107","https://openalex.org/W3097711534","https://openalex.org/W3114860884","https://openalex.org/W3118201984","https://openalex.org/W3123541559","https://openalex.org/W3129645128","https://openalex.org/W3131462776","https://openalex.org/W3138418840","https://openalex.org/W3155966446","https://openalex.org/W3179664255","https://openalex.org/W3190219068","https://openalex.org/W4205125680","https://openalex.org/W4205765478","https://openalex.org/W4210525741","https://openalex.org/W4213340239","https://openalex.org/W4220662185","https://openalex.org/W4221041873","https://openalex.org/W4223596392","https://openalex.org/W4224247151","https://openalex.org/W4280568763","https://openalex.org/W4281628485","https://openalex.org/W4287921523","https://openalex.org/W4291156601","https://openalex.org/W4295083386","https://openalex.org/W4318774486","https://openalex.org/W4380577391","https://openalex.org/W4387603944"],"related_works":["https://openalex.org/W2126470428","https://openalex.org/W1967583546","https://openalex.org/W7220767794","https://openalex.org/W2130655827","https://openalex.org/W2196160422","https://openalex.org/W3097794768","https://openalex.org/W2140131793","https://openalex.org/W4391405216","https://openalex.org/W2582928526","https://openalex.org/W7140129651"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1],"(AD)":[2],"is":[3,44,334],"a":[4,26,33,51,196,329],"severe,":[5],"varied,":[6],"and":[7,15,55,61,90,98,111,120,130,149,176,224,247,286,320],"complex":[8],"brain":[9,132,291],"condition":[10],"that":[11,22,185,228,274,296,333],"gradually":[12],"impairs":[13],"memory":[14],"cognitive":[16],"function.":[17],"Epidemiological":[18],"studies":[19,63,72,219,324],"have":[20,25,32],"shown":[21],"patients":[23],"who":[24],"history":[27],"of":[28,36,41,50,85,162,169,192,201,210,251,261,268,308,318,340],"long-term":[29],"NSAID":[30],"use":[31],"decreased":[34],"risk":[35],"developing":[37],"AD.":[38,309,341],"The":[39,70,108,138,159,181,204,216,256,270,293,310],"objective":[40],"this":[42],"study":[43],"to":[45,143,155,304,313],"conduct":[46],"the":[47,131,157,163,167,179,186,208,214,229,235,275,280,297,302,306,338],"structural":[48,160],"analysis":[49,145,183,206,272],"novel":[52,164],"ibuprofen":[53,99,187,298],"prodrug":[54,100],"test":[56,110],"its":[57],"anti-Alzheimer\u2019s":[58],"properties.":[59],"Computational":[60],"docking":[62,218],"were":[64,73,88,115,128,141],"conducted":[65,116],"using":[66,75],"AMBER":[67],"18":[68],"package.":[69],"in-vivo":[71,271],"performed":[74],"aluminum":[76,93,284],"chloride-induced":[77],"experimental":[78],"AD":[79],"in":[80,178,213,290,327,337],"rats.":[81],"Adult":[82],"Wistar":[83],"rats":[84],"either":[86],"sex":[87],"used":[89,135],"treated":[91],"with":[92,195,265],"chloride":[94,285],"(32.5":[95],"mg/kg,":[96,102],"p.o)":[97,103],"(50":[101],"daily":[104],"for":[105,136,234],"30":[106],"days.":[107],"hole-board":[109],"elevated":[112],"plus":[113],"maze":[114],"on":[117,124],"10th,":[118],"20th":[119],"30th":[121],"day.":[122],"Further,":[123],"31st":[125],"day,":[126],"animals":[127],"euthanized":[129],"tissue":[133],"was":[134,153],"histopathology.":[137],"results":[139],"obtained":[140],"subjected":[142],"statistical":[144],"by":[146,283],"one-way":[147],"ANOVA":[148],"Dunnet\u2019s":[150],"test,":[151],"p<0.05":[152],"considered":[154],"indicate":[156],"significance.":[158],"configuration":[161],"compound":[165,230],"indicated":[166,184,259],"presence":[168,209],"several":[170],"structures":[171],"such":[172],"as":[173],"aliphatic,":[174],"aromatic,":[175],"asymmetry":[177],"compound.":[180,215],"geometrical":[182],"conjugate":[188,299],"has":[189,231],"dreiding":[190],"energy":[191],"51.22":[193],"kcal/mol":[194],"van":[197],"der":[198],"waals":[199],"radius":[200],"62.56":[202],"A.":[203],"Huckel":[205],"confirmed":[207],"aromatic":[211],"rings":[212],"molecular":[217],"suggested":[220,295],"affinity":[221],"towards":[222],"beta-secretase":[223,319],"acetylcholinesterase,":[225],"besides":[226],"indicating":[227],"ideal":[232],"characteristics":[233],"oral":[236,248],"route":[237],"(Log":[238],"P":[239],"=":[240,245,254],"2.33),":[241],"cellular":[242],"absorption":[243],"(TPSA":[244],"95.50),":[246],"bioavailability":[249],"(number":[250],"rotatable":[252],"bonds":[253],"10).":[255],"toxicity":[257,264],"profile":[258],"devoid":[260],"major":[262],"systemic":[263],"mild":[266],"possibility":[267],"cytotoxicity.":[269],"showed":[273],"Ibu-prodrug":[276],"significantly":[277],"(P<0.001)":[278],"reversed":[279],"changes":[281],"induced":[282],"restored":[287],"histomorphological":[288],"features":[289],"tissue.":[292],"findings":[294],"might":[300,325],"possess":[301],"potential":[303],"manage":[305],"complications":[307],"action":[311],"appears":[312],"be":[314],"mediated":[315],"through":[316],"inhibition":[317],"acetylcholinesterase":[321],"activities.":[322],"More":[323],"aid":[326],"identifying":[328],"specific":[330],"therapeutic":[331],"intervention":[332],"still":[335],"lacking":[336],"treatment":[339]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-11-28T00:00:00"}
