{"id":"https://openalex.org/W4389033833","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.979.6","title":"Tissue\u2010Specific Seasonal Changes in Mitochondrial Membrane Composition and Respiratory Function in the Golden\u2010Mantled Ground Squirrel","display_name":"Tissue\u2010Specific Seasonal Changes in Mitochondrial Membrane Composition and Respiratory Function in the Golden\u2010Mantled Ground Squirrel","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389033833","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.979.6"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.979.6","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.979.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.979.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072371598","display_name":"Ashley Barbara Heim","orcid":"https://orcid.org/0000-0001-8526-7342","observed_orcids":["https://orcid.org/0000-0001-8526-7342"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley B. Heim","raw_affiliation_strings":["Biology, Colorado State University, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040877808","display_name":"Susana A. Rosales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susana A. Rosales","raw_affiliation_strings":["Biology, Colorado State University, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024230075","display_name":"Adam J. Chicco","orcid":"https://orcid.org/0000-0003-0131-6851","observed_orcids":["https://orcid.org/0000-0003-0131-6851"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam J. Chicco","raw_affiliation_strings":["Biomedical Sciences, Colorado State University, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037327364","display_name":"Gregory L. Florant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory L. Florant","raw_affiliation_strings":["Biology, Colorado State University, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35107216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0697999969124794,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/golden-mantled-ground-squirrel","display_name":"golden-mantled ground squirrel","score":0.9950000047683716},{"id":"https://openalex.org/keywords/callospermophilus-lateralis","display_name":"Callospermophilus lateralis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hibernation","display_name":"hibernation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.765999972820282},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tissue-specific-differences","display_name":"tissue-specific differences","score":0.5709999799728394},{"id":"https://openalex.org/keywords/seasonal-variation","display_name":"seasonal variation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.8759999871253967},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.7919999957084656},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.906000018119812},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.8199999928474426},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.984000027179718},{"id":"https://openalex.org/keywords/cold-adaptation","display_name":"cold adaptation","score":0.47699999809265137},{"id":"https://openalex.org/keywords/hypometabolism","display_name":"hypometabolism","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.7705497741699219},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6818579435348511},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.6432461142539978},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.6125339865684509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5827876329421997},{"id":"https://openalex.org/C68394932","wikidata":"https://www.wikidata.org/wiki/Q12133470","display_name":"Respirometry","level":2,"score":0.5243796706199646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5218278765678406},{"id":"https://openalex.org/C2780588931","wikidata":"https://www.wikidata.org/wiki/Q389250","display_name":"Ground squirrel","level":3,"score":0.45185720920562744},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.43794557452201843},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.430530309677124},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4184146821498871},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.41175103187561035},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.32594597339630127},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23924952745437622},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.1477026343345642},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.14183500409126282},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1320262849330902},{"id":"https://openalex.org/C100564792","wikidata":"https://www.wikidata.org/wiki/Q190259","display_name":"Thermoregulation","level":2,"score":0.06778880953788757},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.979.6","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.979.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.979.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2563962785","https://openalex.org/W2618593986","https://openalex.org/W1964701960","https://openalex.org/W2023656275","https://openalex.org/W3170360755","https://openalex.org/W2622065631","https://openalex.org/W2081652303","https://openalex.org/W2071034567","https://openalex.org/W2277999290","https://openalex.org/W2577256403"],"abstract_inverted_index":{"Mammals":[0],"that":[1,70,128,140,349,355],"hibernate,":[2],"such":[3],"as":[4],"the":[5,25,32,42,102,115,138,151,198,277,312],"golden\u2010mantled":[6],"ground":[7],"squirrel":[8],"(":[9],"Callospermophilus":[10],"lateralis":[11],";":[12],"GMGS),":[13],"cease":[14],"to":[15,53,59,79,98,119,231,235,307,357],"feed,":[16],"reduce":[17],"metabolic":[18],"rate,":[19],"and":[20,55,104,121,157,169,177,195,205,240,242,249,289,335,346],"lower":[21],"body":[22],"temperature":[23,58,268],"during":[24],"winter":[26,122,178,236,308],"months,":[27,118],"surviving":[28],"almost":[29],"exclusively":[30],"on":[31,218],"oxidation":[33,258],"of":[34,45,88,109,160,200,203,315],"lipids":[35],"from":[36,111,114,164,174,222,233,273,305],"endogenous":[37],"fat":[38],"stores.":[39],"Whether":[40],"mitochondria,":[41],"cellular":[43],"sites":[44],"oxidative":[46,154,183],"metabolism,":[47],"undergo":[48],"adaptive":[49],"changes":[50,71,144,251,282,330],"in":[51,72,77,82,123,131,137,145,197,237,244,252,269,276,283,296,309,331,340],"response":[52,78],"hypometabolism":[54],"decreasing":[56,93,266],"ambient":[57],"facilitate":[60,86],"this":[61],"remarkable":[62],"phenotype":[63],"is":[64],"unclear.":[65],"It":[66],"has":[67],"been":[68],"postulated":[69],"mitochondrial":[73,132,146,182,284,297,332],"membrane":[74,105,147,158,209,285,298,333],"composition":[75,108,159,212,286,334],"reported":[76],"cold":[80],"exposure":[81],"some":[83],"species":[84],"may":[85,141,350],"maintenance":[87],"respiratory":[89,152,206,336],"enzyme":[90,155],"function":[91,103,337],"with":[92,247],"temperature.":[94],"However,":[95],"no":[96],"studies":[97],"date":[99],"have":[100,351],"investigated":[101],"fatty":[106,210,255],"acid":[107,211,256,300],"mitochondria":[110,162,272],"different":[112],"tissues":[113,288],"warm":[116],"summer":[117,234,306],"fall":[120],"a":[124,292,326],"hibernator.":[125],"We":[126,149],"hypothesize":[127],"tissue\u2010specific":[129],"differences":[130,348],"respiration":[133,186],"occur":[134],"across":[135,287,338],"seasons":[136,339],"GMGS":[139,161,275],"parallel":[142],"distinct":[143,344],"composition.":[148],"compared":[150],"capacity,":[153],"activity,":[156],"isolated":[163,223],"liver,":[165,238],"heart,":[166],"skeletal":[167,245],"muscle,":[168,246],"brown":[170],"adipose":[171],"tissue":[172,271],"(BAT)":[173],"summer,":[175],"fall,":[176],"(torpid)":[179],"seasons.":[180,290],"Maximal":[181,225],"phosphorylation":[184],"(OXPHOS)\u2010supported":[185],"was":[187,213,262,303],"determined":[188,214],"by":[189,215,265],"high\u2010resolution":[190],"respirometry":[191],"at":[192,228],"37\u00b0C,":[193],"25\u00b0C,":[194],"15\u00b0C":[196],"presence":[199],"saturating":[201],"concentrations":[202],"ADP":[204],"substrates.":[207],"Mitochondrial":[208],"gas":[216],"chromatography":[217],"phospholipid":[219],"fractions":[220],"obtained":[221],"mitochondria.":[224],"OXPHOS":[226,260],"assayed":[227],"37\u00b0C":[229],"tended":[230],"increase":[232],"heart":[239],"BAT,":[241],"decrease":[243,295],"tissue\u2010":[248,345],"season\u2010specific":[250,347],"pyruvate":[253],"versus":[254],"(palmitoylcarnitine)":[257],"capacity.":[259],"capacity":[261],"uniformly":[263],"suppressed":[264],"assay":[267],"all":[270,310],"torpid":[274],"winter,":[278],"despite":[279],"widely":[280],"variable":[281],"Interestingly,":[291],"consistent":[293,327],"relative":[294],"docosahexaenoic":[299],"(DHA;":[301],"22:6n3)":[302],"seen":[304],"tissues,":[311],"biological":[313,353],"relevance":[314],"which":[316],"merits":[317],"further":[318],"investigation.":[319],"Taken":[320],"together,":[321],"these":[322],"findings":[323],"argue":[324],"against":[325],"relationship":[328],"between":[329],"GMGS,":[341],"but":[342],"highlight":[343],"important":[352],"effects":[354],"remain":[356],"be":[358],"elucidated.":[359]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}