{"id":"https://openalex.org/W4389029559","doi":"https://doi.org/10.1093/ofid/ofad500.1790","title":"2167. Mutational Signature Analysis to Predict Drug-resistant Pseudomonas aeruginosa","display_name":"2167. Mutational Signature Analysis to Predict Drug-resistant Pseudomonas aeruginosa","publication_year":2023,"publication_date":"2023-11-27","ids":{"openalex":"https://openalex.org/W4389029559","doi":"https://doi.org/10.1093/ofid/ofad500.1790"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofad500.1790","doi":"https://doi.org/10.1093/ofid/ofad500.1790","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad500.1790","pdf_url":"https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1790/53768858/ofad500.1790.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1790/53768858/ofad500.1790.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090533564","display_name":"Kalen M. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalen M Hall","raw_affiliation_strings":["Tulane University School of Medicine , New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine , New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071450443","display_name":"Leonard G. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard G Williams","raw_affiliation_strings":["Tulane University School of Medicine , New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine , New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082139259","display_name":"Christine M. Bojanowski","orcid":"https://orcid.org/0000-0003-0451-6816","observed_orcids":["https://orcid.org/0000-0003-0451-6816"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine M Bojanowski","raw_affiliation_strings":["Tulane University School of Medicine , New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine , New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052237669","display_name":"Zachary F. Pursell","orcid":"https://orcid.org/0000-0001-5871-7192","observed_orcids":["https://orcid.org/0000-0001-5871-7192"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary F Pursell","raw_affiliation_strings":["Tulane University School of Medicine , New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine , New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066651904","display_name":"Lisa A. Morici","orcid":"https://orcid.org/0000-0002-4799-4941","observed_orcids":["https://orcid.org/0000-0002-4799-4941"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Morici","raw_affiliation_strings":["Tulane University School of Medicine , New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine , New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":{"value":3676,"currency":"USD","value_usd":3676},"apc_paid":{"value":3676,"currency":"USD","value_usd":3676},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1120193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"Supplement_2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.31470000743865967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.31470000743865967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.2750999927520752,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.08980000019073486,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.996999979019165},{"id":"https://openalex.org/keywords/mutational-signatures","display_name":"mutational signatures","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hypermutators","display_name":"hypermutators","score":0.8220000267028809},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/mutation-spectrum","display_name":"mutation spectrum","score":0.6869999766349792},{"id":"https://openalex.org/keywords/chronic-respiratory-tract-infections","display_name":"chronic respiratory infection","score":0.625},{"id":"https://openalex.org/keywords/antibiotic-resistance-prediction","display_name":"antibiotic resistance prediction","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.708913266658783},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.5771090388298035},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5617482662200928},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5301657319068909},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4930073916912079},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46888467669487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45586585998535156},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.42436423897743225},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3316222131252289},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1759648323059082},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1565069854259491},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.07631993293762207},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/ofid/ofad500.1790","doi":"https://doi.org/10.1093/ofid/ofad500.1790","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad500.1790","pdf_url":"https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1790/53768858/ofad500.1790.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10678401","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10678401","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10678401/pdf/ofad500.1790.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofad500.1790","doi":"https://doi.org/10.1093/ofid/ofad500.1790","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad500.1790","pdf_url":"https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1790/53768858/ofad500.1790.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389029559.pdf","grobid_xml":"https://content.openalex.org/works/W4389029559.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405986659","https://openalex.org/W2169053394","https://openalex.org/W4389030999","https://openalex.org/W1984876660","https://openalex.org/W2146761052","https://openalex.org/W2163856333","https://openalex.org/W1972847233","https://openalex.org/W2065070940","https://openalex.org/W3007780338","https://openalex.org/W2119803749"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Pseudomonas":[2],"aeruginosa":[3],"(Pa)":[4],"is":[5,82],"one":[6],"of":[7,29,188,203,256,285,295],"the":[8,39,75,130,151,186],"predominant":[9],"bacteria":[10],"that":[11,132,272],"contributes":[12],"to":[13,27,97,128,162,183,217,281],"chronic":[14,296],"respiratory":[15],"infection,":[16],"patient":[17],"morbidity,":[18],"and":[19,45,52,64,91,113,139,157,178,210,219,228,292],"mortality":[20],"in":[21,38,74,93,106,116,150,197,207,226,243,252],"cystic":[22],"fibrosis":[23],"(CF)":[24],"patients.":[25],"Up":[26],"60%":[28],"Pa":[30,115,201,297],"clinical":[31,76],"isolates":[32,173],"are":[33,46,69,234],"hypermutators,":[34],"caused":[35],"by":[36],"deficiency":[37],"DNA":[40],"mismatch":[41],"repair":[42],"(MMR)":[43],"system,":[44],"associated":[47],"with":[48,213,222,248],"increased":[49],"multidrug":[50,65],"resistance":[51],"treatment":[53,290],"failure.":[54],"In":[55],"vitro":[56,117],"studies":[57,270],"demonstrate":[58],"a":[59,194,208,278],"causative":[60],"relationship":[61],"between":[62],"hypermutation":[63],"resistance,":[66],"yet":[67],"hypermutators":[68],"not":[70,239],"currently":[71,83],"tested":[72],"for":[73,185],"setting":[77],"as":[78,262],"no":[79],"diagnostic":[80],"method":[81],"available.":[84],"Mutational":[85],"signatures":[86],"have":[87],"been":[88,104],"computationally":[89],"extracted":[90],"characterized":[92],"human":[94,164],"tumors,":[95],"but":[96],"our":[98],"knowledge":[99],"this":[100],"analysis":[101,135,275],"has":[102],"never":[103],"performed":[105,179],"prokaryotes.":[107],"Methods":[108],"Here,":[109],"we":[110,237],"evolved":[111,126,152,199],"MMR-deficient":[112,166,189,200],"-proficient":[114],"under":[118],"nine":[119],"different":[120],"antibiotic":[121],"treatments.":[122],"We":[123,142,169,192],"sequenced":[124,171],"these":[125,160],"lineages":[127,153],"test":[129],"hypothesis":[131],"mutational":[133,167,180,244,273],"signature":[134,181,196,274],"can":[136],"predict":[137],"MMR-status":[138],"drug":[140],"resistance.":[141],"identified":[143],"mutation":[144],"spectra":[145,161,246],"from":[146,174],"de":[147],"novo":[148],"mutations":[149],"after":[154],"ten":[155],"passages":[156],"then":[158,170],"compared":[159],"known":[163,235],"tumor":[165],"signatures.":[168,190],"14":[172],"seven":[175],"CF":[176],"patients":[177],"analyses":[182],"assess":[184],"presence":[187],"Results":[191],"observed":[193],"strong":[195],"all":[198],"strains":[202,284],"C":[204,218],">T":[205],"transitions":[206,225],"NCC":[209],"NCG":[211],"contexts":[212],"some":[214],"5\u2019":[215],"preference":[216],"G,":[220],"along":[221],"T":[223],">C":[224],"CTN":[227],"GTN":[229],"contexts.":[230],"Although":[231],"many":[232],"antibiotics":[233],"mutagens,":[236],"did":[238],"observe":[240],"treatment-dependent":[241],"changes":[242],"spectra.Mutation":[245],"consistent":[247],"MMR-deficiency":[249],"were":[250,258],"found":[251],"four":[253],"isolates,":[254],"each":[255],"which":[257,287],"also":[259],"functionally":[260],"validated":[261],"hypermutant":[263],"via":[264],"rifampicin":[265],"reversion":[266],"assay.":[267],"Conclusion":[268],"These":[269],"suggest":[271],"may":[276],"be":[277],"valuable":[279],"tool":[280],"identify":[282],"hypermutator":[283],"Pa,":[286],"could":[288],"inform":[289],"regimens":[291],"improve":[293],"management":[294],"infections.":[298],"Disclosures":[299],"Kalen":[300],"M.":[301],"Hall,":[302],"B.S.,":[303,313],"B.A.,":[304],"Informuta:":[305,314],"1|Informuta:":[306,315],"Ownership":[307,316],"Interest|Informuta:":[308,317],"Stocks/Bonds":[309,318],"Leonard":[310],"G.":[311],"Williams,":[312]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-11-27T00:00:00"}
