{"id":"https://openalex.org/W4389029313","doi":"https://doi.org/10.1093/ofid/ofad500.968","title":"923. EDP-938, A Respiratory Syncytial Virus (RSV) antiviral, demonstrates a high barrier to resistance in a human challenge study","display_name":"923. EDP-938, A Respiratory Syncytial Virus (RSV) antiviral, demonstrates a high barrier to resistance in a human challenge study","publication_year":2023,"publication_date":"2023-11-27","ids":{"openalex":"https://openalex.org/W4389029313","doi":"https://doi.org/10.1093/ofid/ofad500.968"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofad500.968","doi":"https://doi.org/10.1093/ofid/ofad500.968","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad500.968","pdf_url":"https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.968/53778538/ofad500.968.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.968/53778538/ofad500.968.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015916301","display_name":"Rachel Emily Levene","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157808","display_name":"Enanta Pharmaceuticals (United States)","ror":"https://ror.org/04fpkm116","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel E Levene","raw_affiliation_strings":["Enanta Pharmaceuticals , Watertown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enanta Pharmaceuticals , Watertown, Massachusetts","institution_ids":["https://openalex.org/I4210157808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036771694","display_name":"John P. DeVincenzo","orcid":"https://orcid.org/0000-0003-2655-344X","observed_orcids":["https://orcid.org/0000-0003-2655-344X"]},"institutions":[{"id":"https://openalex.org/I4210157808","display_name":"Enanta Pharmaceuticals (United States)","ror":"https://ror.org/04fpkm116","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John DeVincenzo","raw_affiliation_strings":["Enanta Pharmaceuticals , Watertown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enanta Pharmaceuticals , Watertown, Massachusetts","institution_ids":["https://openalex.org/I4210157808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055799155","display_name":"Annie L. Conery","orcid":"https://orcid.org/0009-0009-1400-3468","observed_orcids":["https://orcid.org/0009-0009-1400-3468"]},"institutions":[{"id":"https://openalex.org/I4210157808","display_name":"Enanta Pharmaceuticals (United States)","ror":"https://ror.org/04fpkm116","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annie Conery","raw_affiliation_strings":["Enanta Pharmaceuticals , Watertown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enanta Pharmaceuticals , Watertown, Massachusetts","institution_ids":["https://openalex.org/I4210157808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055204938","display_name":"Alaa Mohammad Ahmad","orcid":"https://orcid.org/0000-0002-6935-6748","observed_orcids":["https://orcid.org/0000-0002-6935-6748"]},"institutions":[{"id":"https://openalex.org/I4210157808","display_name":"Enanta Pharmaceuticals (United States)","ror":"https://ror.org/04fpkm116","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alaa Ahmad","raw_affiliation_strings":["Enanta Pharmaceuticals , Watertown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enanta Pharmaceuticals , Watertown, Massachusetts","institution_ids":["https://openalex.org/I4210157808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043120561","display_name":"Bryan J. Goodwin","orcid":"https://orcid.org/0000-0002-5908-8380","observed_orcids":["https://orcid.org/0000-0002-5908-8380"]},"institutions":[{"id":"https://openalex.org/I4210157808","display_name":"Enanta Pharmaceuticals (United States)","ror":"https://ror.org/04fpkm116","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Goodwin","raw_affiliation_strings":["Enanta Pharmaceuticals , Watertown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enanta Pharmaceuticals , Watertown, Massachusetts","institution_ids":["https://openalex.org/I4210157808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111556658","display_name":"Yat Sun Or","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157808","display_name":"Enanta Pharmaceuticals (United States)","ror":"https://ror.org/04fpkm116","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yat Sun Or","raw_affiliation_strings":["Enanta Pharmaceuticals, Inc. , Watertown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enanta Pharmaceuticals, Inc. , Watertown, MA","institution_ids":["https://openalex.org/I4210157808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090471054","display_name":"Michael H. J. Rhodin","orcid":"https://orcid.org/0000-0003-4032-7545","observed_orcids":["https://orcid.org/0000-0003-4032-7545"]},"institutions":[{"id":"https://openalex.org/I4210157808","display_name":"Enanta Pharmaceuticals (United States)","ror":"https://ror.org/04fpkm116","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Rhodin","raw_affiliation_strings":["Enanta Pharmaceuticals, Inc. , Watertown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enanta Pharmaceuticals, Inc. , Watertown, MA","institution_ids":["https://openalex.org/I4210157808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210157808"],"apc_list":{"value":3676,"currency":"USD","value_usd":3676},"apc_paid":{"value":3676,"currency":"USD","value_usd":3676},"fwci":0.1989,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55022777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"10","issue":"Supplement_2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.9419999718666077},{"id":"https://openalex.org/keywords/resistance-barrier","display_name":"resistance barrier","score":0.6840000152587891},{"id":"https://openalex.org/keywords/human-challenge-studies","display_name":"human challenge studies","score":0.7329999804496765},{"id":"https://openalex.org/keywords/viral-fitness","display_name":"viral fitness","score":0.878000020980835},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.5360000133514404},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.7670000195503235},{"id":"https://openalex.org/keywords/rsv-prophylaxis","display_name":"RSV prophylaxis","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7755603194236755},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.6394568681716919},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6353163719177246},{"id":"https://openalex.org/C2779278377","wikidata":"https://www.wikidata.org/wiki/Q1351647","display_name":"Rhinovirus","level":3,"score":0.5635578632354736},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5540176033973694},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.43205636739730835},{"id":"https://openalex.org/C182707283","wikidata":"https://www.wikidata.org/wiki/Q7315622","display_name":"Resistance mutation","level":5,"score":0.42724502086639404},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.23257339000701904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17346695065498352},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1678113043308258},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.10331109166145325},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.07645592093467712},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07198810577392578}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/ofid/ofad500.968","doi":"https://doi.org/10.1093/ofid/ofad500.968","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad500.968","pdf_url":"https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.968/53778538/ofad500.968.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10677260","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10677260","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10677260/pdf/ofad500.968.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofad500.968","doi":"https://doi.org/10.1093/ofid/ofad500.968","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad500.968","pdf_url":"https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.968/53778538/ofad500.968.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389029313.pdf","grobid_xml":"https://content.openalex.org/works/W4389029313.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403707843","https://openalex.org/W3136399202","https://openalex.org/W2982243736","https://openalex.org/W4309294121","https://openalex.org/W4214649569","https://openalex.org/W4212941773","https://openalex.org/W4213132087","https://openalex.org/W3043617955","https://openalex.org/W4283159956","https://openalex.org/W7122468588"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"RSV":[2,25,99,115],"can":[3],"cause":[4],"substantial":[5],"morbidity":[6],"and":[7,14,41,107,120,160,218,236,240,249,258,262,295],"mortality":[8],"to":[9,55,69,139,155,274,308,327],"populations":[10],"at":[11,102,233],"high":[12,67,325],"risk":[13],"there":[15],"are":[16],"no":[17,175,304],"approved":[18],"direct":[19],"acting":[20],"antiviral":[21,293],"treatments.":[22],"EDP-938,":[23],"an":[24,202,229],"nucleoprotein":[26],"(N)":[27],"inhibitor":[28],"in":[29,38,48,58,71,178,180,191,265,279,291,299,312],"Phase":[30,314],"2":[31,192,315],"clinical":[32,77,306,331],"development,":[33,59],"has":[34,65,323],"demonstrated":[35],"significant":[36,305],"reductions":[37],"viral":[39,136,219,241,251,263,280],"load":[40,137,220,242],"symptoms":[42],"after":[43,108],"5":[44,237],"days":[45,234],"of":[46,98,112,143,149,195,209,238,330,349,386,399],"dosing":[47],"a":[49,66,296,324],"human":[50],"challenge":[51,83,316],"study.":[52,84,151,317],"In":[53,302],"contrast":[54],"other":[56,226],"mechanisms":[57],"such":[60],"as":[61],"fusion":[62],"inhibitors,":[63],"EDP-938":[64,82,119,275,292,309,322,387],"barrier":[68,326],"resistance":[70,78,182,261,273,288,307],"vitro.":[72,266],"Here,":[73],"we":[74],"characterize":[75],"the":[76,81,90,113,141,147,150,171,245,328],"profile":[79],"from":[80,95],"Methods":[85],"To":[86],"assess":[87],"emerging":[88],"resistance,":[89],"N":[91],"gene":[92],"was":[93,167,215,243,310],"sequenced":[94],"nasal":[96,126],"washes":[97],"infected":[100,116],"subjects":[101,117],"multiple":[103],"timepoints":[104],"before,":[105],"during":[106],"dosing.":[109],"A":[110],"subset":[111],"124":[114],"(37":[118],"11":[121],"placebo":[122],"subjects,":[123,193],"159":[124],"total":[125],"wash":[127],"samples)":[128],"were":[129,153,184,189,253],"chosen":[130],"for":[131,260],"sequence":[132],"analysis":[133],"based":[134],"on":[135,206],"curves":[138],"encompass":[140],"range":[142],"patterns":[144],"observed":[145,311],"over":[146],"course":[148],"Sequences":[152],"compared":[154],"baseline":[156],"(RSV-A":[157],"Memphis":[158],"37)":[159],"low":[161],"frequency":[162],"variant":[163],"detection":[164],"(<":[165],"1%)":[166],"performed.":[168],"Results":[169],"Of":[170],"158":[172],"sequences":[173],"obtained,":[174],"mutations":[176,188],"identified":[177],"preclinical":[179],"vitro":[181],"studies":[183],"observed.":[185],"Single":[186],"N-protein":[187],"detected":[190,205,232],"both":[194],"whom":[196],"received":[197],"EDP-938.":[198],"One":[199],"subject":[200,227],"had":[201,228],"E112G":[203,248,268],"mutation":[204,231,269,284],"day":[207],"3":[208],"treatment,":[210],"however":[211],"only":[212],"wildtype":[213],"virus":[214],"subsequently":[216],"detected,":[217],"became":[221],"undetectable":[222,244],"shortly":[223],"thereafter.":[224],"The":[225,267,282],"L139I":[230,250,283],"4":[235],"treatment":[239],"next":[246],"day.":[247],"variants":[252],"created":[254],"by":[255],"reverse":[256],"genetics":[257],"tested":[259],"fitness":[264],"did":[270],"not":[271],"confer":[272],"nor":[276],"any":[277],"changes":[278],"fitness.":[281,300],"conferred":[285],"very":[286],"low-level":[287],"(10-fold":[289],"decrease":[290],"activity)":[294],"modest":[297],"reduction":[298],"Conclusion":[301],"conclusion,":[303],"this":[313],"These":[318],"data":[319],"demonstrate":[320],"that":[321],"development":[329],"resistance.":[332],"Disclosures":[333],"Rachel":[334],"E.":[335],"Levene,":[336],"PhD,":[337,361],"Enanta":[338,346,350,355,362,372,383,395],"Pharmaceuticals:":[339,341,347,373,376,384,389],"Salary|Enanta":[340],"Stocks/Bonds":[342,358,368,377,390,403],"John":[343],"DeVincenzo,":[344],"MD,":[345],"employee":[348],"Pharmaceuticals":[351,363,366,396,401],"Annie":[352],"Conery,":[353],"Ph.D.,":[354,371],"Pharmaceuticals,":[356],"Inc.:":[357,364,367,397,402],"Alaa":[359],"Ahmad,":[360],"Employee|Enanta":[365,375],"Bryan":[369],"Goodwin,":[370],"Former":[374],"Yat":[378],"Sun":[379],"Or,":[380],"Ph.":[381,393],"D,":[382,394],"Co-inventor":[385],"patents|Enanta":[388],"Michael":[391],"Rhodin,":[392],"Employee":[398],"Enanta|Enanta":[400]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-11-27T00:00:00"}