{"id":"https://openalex.org/W4389028653","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.919.1","title":"Overexpression and Characterization of the rquA Gene Product Involved in the Biosynthesis of Rhodoquinone","display_name":"Overexpression and Characterization of the rquA Gene Product Involved in the Biosynthesis of Rhodoquinone","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389028653","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.919.1"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.919.1","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.919.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.919.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Alison Zander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119888943","display_name":"Gonzaga University","ror":"https://ror.org/03ze70h02","country_code":"US","type":"education","lineage":["https://openalex.org/I119888943"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison Zander","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Gonzaga University, Spokane, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Gonzaga University, Spokane, WA","institution_ids":["https://openalex.org/I119888943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012033873","display_name":"Jennifer N. Shepherd","orcid":"https://orcid.org/0000-0002-6926-6777","observed_orcids":["https://orcid.org/0000-0002-6926-6777"]},"institutions":[{"id":"https://openalex.org/I119888943","display_name":"Gonzaga University","ror":"https://ror.org/03ze70h02","country_code":"US","type":"education","lineage":["https://openalex.org/I119888943"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Shepherd","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Gonzaga University, Spokane, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Gonzaga University, Spokane, WA","institution_ids":["https://openalex.org/I119888943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I119888943"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3152748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhodospirillum-rubrum","display_name":"Rhodospirillum rubrum","score":0.9079999923706055},{"id":"https://openalex.org/keywords/parasitic-helminths","display_name":"parasitic helminths","score":0.7829999923706055},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6470000147819519},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6209999918937683},{"id":"https://openalex.org/keywords/protein-complex-purification","display_name":"protein complex purification","score":0.5720000267028809},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.5680000185966492},{"id":"https://openalex.org/keywords/neglected-tropical-diseases","display_name":"neglected tropical diseases","score":0.7739999890327454},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.6836723685264587},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.643268883228302},{"id":"https://openalex.org/C2777082638","wikidata":"https://www.wikidata.org/wiki/Q24303","display_name":"Rhodospirillum rubrum","level":3,"score":0.5838374495506287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5402424335479736},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4913102686405182},{"id":"https://openalex.org/C195286587","wikidata":"https://www.wikidata.org/wiki/Q424689","display_name":"Gene product","level":4,"score":0.43352144956588745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4303989112377167},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4251474142074585},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2568126916885376},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24129310250282288}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.919.1","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.919.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.919.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.6000000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2530267051","display_name":"Elucidation and Regulation of Rhodoquinone Biosynthesis in Rhodospirillum rubrum","funder_award_id":"1r15gm096398-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7097210453","https://openalex.org/W2910992943","https://openalex.org/W7037120902","https://openalex.org/W3042528152","https://openalex.org/W4389020240","https://openalex.org/W3016716036","https://openalex.org/W3046143177","https://openalex.org/W2942993754","https://openalex.org/W2151420823","https://openalex.org/W2950191536"],"abstract_inverted_index":{"Infections":[0],"caused":[1],"by":[2],"parasitic":[3,23,69],"helminths":[4,24,44],"are":[5,25,45,66,181],"sometimes":[6],"referred":[7],"to":[8,16,63,68,74,79,87,91,217,250,284,304],"as":[9,51,139],"\u201cthe":[10],"great":[11],"neglected":[12],"tropical":[13],"diseases.\u201d":[14],"Endemic":[15],"many":[17],"countries,":[18],"including":[19],"the":[20,27,30,46,72,98,105,110,118,136,147,157,174,219,227,246],"United":[21],"States,":[22],"at":[26,278],"origin":[28],"of":[29,48,156,160,169,192,200,277,295],"diseases":[31],"most":[32],"commonly":[33],"diagnosed":[34],"in":[35,109,117,146,182,190,204,261],"developing":[36],"countries.":[37],"Affecting":[38],"both":[39],"humans":[40],"and":[41,120,154,177,198,269,298],"livestock,":[42],"these":[43,80,243],"target":[47,166],"extensive":[49],"research":[50],"their":[52],"genome":[53],"is":[54,82,104,127,141],"further":[55,188],"elucidated.":[56],"The":[57],"drug":[58],"products":[59],"that":[60,135,180,256,282],"currently":[61],"exist":[62],"combat":[64],"infections":[65],"subject":[67],"resistance;":[70],"therefore,":[71],"race":[73],"discover":[75],"different":[76],"drug\u2010targets":[77],"specific":[78],"parasites":[81],"essential.":[83],"In":[84],"an":[85,89],"effort":[86],"develop":[88],"answer":[90],"this":[92],"problem,":[93],"we":[94],"have":[95],"been":[96,133],"researching":[97],"rhodoquinone":[99],"(RQ)":[100],"biosynthetic":[101,125],"pathway.":[102],"RQ":[103,144,170],"final":[106],"electron":[107],"transporter":[108],"anaerobic":[111],"fumarate":[112],"reductase":[113],"pathway,":[114],"which":[115],"occurs":[116],"mitochondrial":[119],"plasma":[121],"membranes.":[122,241],"Although":[123],"its":[124,262],"pathway":[126],"still":[128],"largely":[129],"unknown,":[130],"it":[131,257],"has":[132],"discovered":[134],"gene":[137,158],"known":[138],"rquA":[140,161],"required":[142],"for":[143,167,245],"biosynthesis":[145],"model":[148],"organism,":[149],"Rhodospirillum":[150],"rubrum":[151,240],".":[152],"Expression":[153],"purification":[155,199],"product":[159],"(RquA)":[162],"could":[163,187],"provide":[164],"a":[165,183,193,208,222],"inhibition":[168],"biosynthesis.":[171],"Additionally,":[172],"determining":[173],"crystalline":[175],"structure":[176],"any":[178,253],"proteins":[179,255,281],"complex":[184,230,251],"with":[185,233,252,260,271,287],"RquA":[186,201,249],"information":[189],"development":[191],"novel":[194],"drug.":[195],"After":[196],"isolation":[197],"from":[202,236],"overexpression":[203],"E.":[205],"coli":[206],",":[207],"pull\u2010down":[209],"experiment":[210],"was":[211,231,275],"performed":[212],"using":[213],"nickel\u2010coated":[214],"magnetic":[215],"beads":[216],"bind":[218],"protein":[220,229,247],"(containing":[221],"hexahistidine":[223],"tag).":[224],"Following":[225],"this,":[226],"bead":[228],"combined":[232],"lysate":[234],"collected":[235],"solubilized":[237],"wild\u2010type":[238],"R.":[239],"Providing":[242],"conditions":[244],"allowed":[248],"other":[254],"may":[258],"interact":[259],"normal":[263],"state.":[264],"Upon":[265],"SDS\u2010PAGE":[266],"gel":[267],"electrophoresis,":[268],"staining":[270],"Coomassie":[272],"blue,":[273],"there":[274],"evidence":[276],"least":[279],"4":[280],"appear":[283],"be":[285],"associated":[286],"RquA.":[288],"Support":[289],"or":[290],"Funding":[291],"Information":[292],"National":[293],"Institutes":[294],"Health":[296],"(1R15GM096398\u201001)":[297],"Howard":[299],"Hughes":[300],"Medical":[301],"Institute":[302],"(award":[303],"Gonzaga":[305],"University)":[306]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}
