{"id":"https://openalex.org/W4389028289","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.510.1","title":"Reversing The Paradigm: Protein Kinase C As A Tumor Suppressor","display_name":"Reversing The Paradigm: Protein Kinase C As A Tumor Suppressor","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389028289","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.510.1"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.510.1","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.510.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.510.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081055838","display_name":"Alexandra C. Newton","orcid":"https://orcid.org/0000-0002-2906-3705","observed_orcids":["https://orcid.org/0000-0002-2906-3705"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexandra Newton","raw_affiliation_strings":["Univ. of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081055838"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.31410368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/loss-of-function-variants","display_name":"loss-of-function mutations","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gain-of-function-mutations","display_name":"gain-of-function mutations","score":0.953000009059906},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.8960000276565552},{"id":"https://openalex.org/keywords/protein-kinase-c-inhibitors","display_name":"PKC inhibitors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6819999814033508},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9679999947547913},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/phospholipid-hydrolysis","display_name":"phospholipid hydrolysis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/pkc-isoforms","display_name":"PKC isoforms","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.8592445850372314},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6474271416664124},{"id":"https://openalex.org/C105951970","wikidata":"https://www.wikidata.org/wiki/Q1036748","display_name":"Loss function","level":4,"score":0.5442587733268738},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5433753728866577},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.5324042439460754},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5278641581535339},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.48808467388153076},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4763510525226593},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4739251732826233},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.47390496730804443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4543614983558655},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.44729408621788025},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44694870710372925},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4327920377254486},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.417951762676239},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41155263781547546},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4016014337539673},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31003281474113464},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2853686213493347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23562002182006836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1803264617919922}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.510.1","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.510.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.510.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000008283","display_name":null,"funder_award_id":"GM-43154","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2610191231","https://openalex.org/W1539815659","https://openalex.org/W2087517352","https://openalex.org/W605236969","https://openalex.org/W1594465089","https://openalex.org/W4232950154","https://openalex.org/W2082878002","https://openalex.org/W2792970702","https://openalex.org/W2617081687","https://openalex.org/W3122252422"],"abstract_inverted_index":{"Protein":[0],"kinase":[1],"C":[2],"(PKC)":[3],"isozymes":[4],"transduce":[5],"the":[6,46,53,61,97],"myriad":[7],"of":[8,15,65,93,96,146],"signals":[9],"resulting":[10],"from":[11],"receptor":[12],"mediated":[13],"hydrolysis":[14],"phospholipids,":[16],"playing":[17],"critical":[18],"roles":[19],"in":[20,41,45,85,89,101,117,177,183],"diverse":[21,125],"cellular":[22,31],"functions.":[23],"Its":[24],"activity":[25,39,176,182],"must":[26],"be":[27],"precisely":[28],"tuned":[29],"for":[30,52],"homeostasis":[32],"and":[33,110,121,143,179],"too":[34],"much,":[35],"or":[36,133,187],"not":[37,79,81],"enough,":[38],"results":[40,166],"pathophysiologies.":[42],"The":[43],"discovery":[44],"1980s":[47],"that":[48,63,105,155,168],"PKCs":[49],"are":[50,108,112],"receptors":[51],"potent":[54],"tumor":[55,141],"promoting":[56],"phorbol":[57,68],"esters":[58,69],"led":[59],"to":[60],"dogma":[62],"activation":[64],"PKC":[66,76,119,137,175],"by":[67,123],"promotes":[70],"tumorigenesis.":[71],"However,":[72],"clinical":[73],"trials":[74],"with":[75],"inhibitors":[77],"have":[78,80],"only":[82],"failed":[83],"but,":[84],"some":[86],"cases,":[87],"resulted":[88],"worsened":[90],"outcome.":[91],"Analysis":[92],"approximately":[94],"10%":[95],">500":[98],"mutations":[99,107,115,157],"identified":[100],"human":[102],"cancers":[103],"reveals":[104],"most":[106],"loss\u2010of\u2010function":[109],"none":[111],"activating.":[113],"Loss\u2010of\u2010function":[114],"occur":[116,122],"all":[118],"subgroups":[120],"disrupting":[124],"mechanisms:":[126],"they":[127],"impede":[128],"second\u2010messenger":[129],"binding,":[130],"prevent":[131],"phosphorylation,":[132],"inhibit":[134],"catalysis.":[135],"Thus,":[136],"functions":[138],"as":[139,162],"a":[140,148],"suppressor":[142],"its":[144,181],"loss":[145],"confers":[147],"survival":[149],"advantage.":[150],"In":[151],"contrast,":[152],"we":[153],"show":[154],"gain\u2010of\u2010function":[156],"accompany":[158],"degenerative":[159],"diseases":[160],"such":[161],"Alzheimer's":[163],"disease.":[164],"Our":[165],"reveal":[167],"therapeutic":[169],"strategies":[170],"should":[171],"focus":[172],"on":[173],"restoring":[174],"cancer":[178],"inhibiting":[180],"neurodegenerative":[184],"diseases.":[185],"Support":[186],"Funding":[188],"Information":[189],"NIH":[190],"GM43154":[191]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-11-27T00:00:00"}