{"id":"https://openalex.org/W4389028226","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.lb50","title":"Investigating Env9's Mechanism of Membrane Insertion in Saccharomyces cerevisiae","display_name":"Investigating Env9's Mechanism of Membrane Insertion in Saccharomyces cerevisiae","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389028226","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.lb50"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.lb50","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.lb50","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.lb50","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076532994","display_name":"Vanessa Cervantes","orcid":"https://orcid.org/0000-0002-5512-7493","observed_orcids":["https://orcid.org/0000-0002-5512-7493"]},"institutions":[{"id":"https://openalex.org/I59897056","display_name":"California State University, Long Beach","ror":"https://ror.org/0080fxk18","country_code":"US","type":"education","lineage":["https://openalex.org/I59897056"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa Cervantes","raw_affiliation_strings":["Biology, CSULB, Long Beach, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology, CSULB, Long Beach, CA","institution_ids":["https://openalex.org/I59897056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065461330","display_name":"Editte Gharakhanian","orcid":"https://orcid.org/0000-0003-0111-0829","observed_orcids":["https://orcid.org/0000-0003-0111-0829"]},"institutions":[{"id":"https://openalex.org/I59897056","display_name":"California State University, Long Beach","ror":"https://ror.org/0080fxk18","country_code":"US","type":"education","lineage":["https://openalex.org/I59897056"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Editte Gharakhanian","raw_affiliation_strings":["Biology, CSULB, Long Beach, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology, CSULB, Long Beach, CA","institution_ids":["https://openalex.org/I59897056"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I59897056"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31291565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tail-anchored-proteins","display_name":"tail-anchored proteins","score":0.9750000238418579},{"id":"https://openalex.org/keywords/membrane-insertion","display_name":"membrane insertion","score":0.8420000076293945},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8460000157356262},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7260000109672546},{"id":"https://openalex.org/keywords/negative-genetic-interactions","display_name":"negative genetic interactions","score":0.6060000061988831},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7162879705429077},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5502243638038635},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.53788822889328},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.5370944738388062},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.5313865542411804},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5093742609024048},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.48088815808296204},{"id":"https://openalex.org/C559089031","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein targeting","level":4,"score":0.4804639220237732},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.4604746401309967},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4594164490699768},{"id":"https://openalex.org/C14053116","wikidata":"https://www.wikidata.org/wiki/Q284398","display_name":"N-terminus","level":4,"score":0.4474395513534546},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.41324982047080994},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.3810018301010132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37869468331336975},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3633900582790375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34479135274887085},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30160731077194214},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.19395416975021362},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.17247667908668518},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.lb50","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.lb50","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.lb50","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6458799643","display_name":"CSULB Research Initiative for Scientific Enhancement 2020-2025","funder_award_id":"R25GM071638","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1502589273","https://openalex.org/W1986206637","https://openalex.org/W2040191491","https://openalex.org/W2119840692","https://openalex.org/W2106728955","https://openalex.org/W2062941789","https://openalex.org/W1966236299","https://openalex.org/W2048161143","https://openalex.org/W3084328881","https://openalex.org/W2078968207"],"abstract_inverted_index":{"Tail\u2010anchored":[0],"proteins":[1,27,47],"have":[2,28,174,181,252],"vital":[3,338],"roles":[4],"within":[5],"the":[6,49,74,273,297,303,307,314,328,331,343,351,363,420,436,445],"cell":[7],"such":[8,393],"as":[9,383,385,394],"vesicular":[10],"transport":[11],"and":[12,14,64,107,151,168,180,197,227,233,266,283,300,380,416,447],"apoptosis,":[13],"often":[15],"times":[16],"their":[17,24,32],"specific":[18],"membrane":[19],"localization":[20,224,255,376],"is":[21,48,91,129,134],"crucial":[22],"to":[23,37,98,121,136,189,222,251,269,272,294,335,430],"function.":[25],"These":[26,287,317],"hydrophobic":[29,114,149],"regions":[30],"near":[31,116],"C\u2010terminus,":[33],"making":[34],"them":[35],"identifiable":[36],"protein":[38,87,285],"insertion":[39,127,310,364],"machinery.":[40],"One":[41],"pathway":[42,80],"which":[43,81],"targets":[44,83],"C\u2010tail":[45,339],"anchored":[46,340],"well\u2010characterized":[50],"G":[51],"uided":[52],"E":[53],"ntry":[54],"of":[55,62,88,93,145,156,309,311,330,365,439,444],"T":[56],"ail\u2010Anchored":[57],"Protein":[58],"(GET)":[59],"complex,":[60],"consisting":[61],"Get1\u20105":[63],"Sgt2.":[65],"Interestingly,":[66],"a":[67,113,218],"second":[68],"mechanism":[69,128],"has":[70],"been":[71,175,182],"proposed":[72],"named":[73],"S":[75],"RP\u2010i":[76],"nd":[77],"ependent":[78],"(SND)":[79],"similarly":[82],"tail\u2010anchored":[84],"proteins.":[85,341],"Our":[86],"interest,":[89],"Env9,":[90],"one":[92,325],"four":[94],"novel":[95],"en":[96],"dosome":[97],"v":[99],"acuole":[100],"interface":[101],"(":[102,165,171],"ENV":[103],")":[104,167,173],"gene":[105],"products":[106],"our":[108,185],"data":[109],"suggests":[110],"it":[111],"possesses":[112],"region":[115],"its":[117,126,147,152],"C\u2010terminus.":[118],"Env9":[119,133,200,254,290,312,366,375],"localizes":[120],"lipid":[122,278],"droplet":[123],"membranes":[124,137,295],"however,":[125],"unknown.":[130],"We":[131,359],"hypothesize":[132],"targeted":[135,293],"by":[138,324,350,405],"either":[139,204],"GET":[140,226,245,298,304,378,446],"or":[141,214,397],"SND":[142,228,248,448],"pathways":[143],"because":[144],"both":[146,157,163,195],"c\u2010terminal":[148],"domain":[150],"interactions":[153,161,388],"with":[154,162,169,203],"components":[155],"complexes.":[158,286],"Negative":[159],"genetic":[160],"ENV8":[164],"GET4":[166],"ENV10":[170],"SND2":[172],"reported":[176],"in":[177,184,225,244,306,327,333,356,377],"systematic":[178],"studies":[179],"observed":[183],"laboratory.":[186],"In":[187,257],"order":[188,334],"investigate":[190],"these":[191,357],"interactions,":[192],"we":[193,372],"used":[194,355],"microscopic":[196],"biochemical":[198,391],"approaches.":[199],"was":[201,403],"tagged":[202,262],"GFP":[205],"(green":[206],"fluorescent":[207],"protein)":[208],"under":[209,217],"an":[210],"inducible":[211],"galactose":[212],"promoter":[213,221],"HA":[215],"(hemagglutinin)":[216],"constitutive":[219],"PGK":[220],"analyze":[223],"mutants":[229,246,249,264],"via":[230,296,389],"confocal":[231,414],"microscopy":[232,239],"western":[234,259],"blot":[235,260],"analysis,":[236,261],"respectively.":[237],"Preliminary":[238],"results":[240,288],"show":[241],"slight":[242],"disruption":[243],"whereas":[247],"appear":[250],"wild\u2010type":[253],"patterns.":[256],"preliminary":[258],"double":[263,379],"\u0394get4/env9":[265],"\u0394snd2/env9":[267],"continue":[268],"localize":[270],"Env9\u2010HA":[271],"P13":[274],"pellet":[275],"that":[276],"includes":[277],"droplets,":[279],"but":[280],"also":[281,321],"vacuoles":[282],"aggregated":[284],"suggest":[289,322],"may":[291,320,346],"be":[292,347],"complex":[299,305,326],"specifically":[301],"implicate":[302],"process":[308],"into":[313],"ER":[315],"membrane.":[316],"moderate":[318],"phenotypes":[319],"compensation":[323],"absence":[329],"other":[332,390],"accurately":[336],"target":[337],"Additionally,":[342,371],"compensatory":[344],"effect":[345],"further":[348],"stimulated":[349],"highly":[352],"overexpressed":[353],"constructs":[354],"studies.":[358],"are":[360,373],"currently":[361],"exploring":[362],"expressed":[367],"at":[368,435],"native":[369],"levels.":[370],"examining":[374],"triple":[381],"mutants,":[382],"well":[384],"determining":[386],"protein\u2010protein":[387],"approaches":[392],"co\u2010immunoprecipitation.":[395],"Support":[396],"Funding":[398],"Information":[399],"Acknowledgements:":[400],"This":[401],"project":[402],"supported":[404],"NIH":[406,417],"AREA":[407],"#R\u201015":[408],"GM85794\u201002,":[409],"NSF\u2010MRI":[410],"grant":[411],"#DBI0722757":[412],"for":[413,419,423,441],"microscopy,":[415],"2R25GM071638\u201009A1":[418],"Research":[421],"Initiative":[422],"Scientific":[424],"Advancement":[425],"Fellowship":[426],"funding.":[427],"We'd":[428],"like":[429],"thank":[431],"Dr.":[432],"Maya":[433],"Schuldiner":[434],"Weizmann":[437],"Institute":[438],"Science":[440],"her":[442],"donations":[443],"mutants.":[449]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}
