{"id":"https://openalex.org/W4389027476","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.968.3","title":"Down\u2010regulation of Kir4.1 eliminates the basolateral K conductance in the distal convoluted tubule (DCT) and inhibits NCC activity","display_name":"Down\u2010regulation of Kir4.1 eliminates the basolateral K conductance in the distal convoluted tubule (DCT) and inhibits NCC activity","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389027476","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.968.3"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.968.3","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.968.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.968.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010068500","display_name":"Xiao\u2010Tong Su","orcid":"https://orcid.org/0000-0001-8121-8105","observed_orcids":["https://orcid.org/0000-0001-8121-8105"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao\u2010Tong Su","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115694760","display_name":"Mingxiao Wang","orcid":"https://orcid.org/0009-0008-1906-2371","observed_orcids":["https://orcid.org/0009-0008-1906-2371"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming\u2010Xiao Wang","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043472003","display_name":"Peng Wu","orcid":"https://orcid.org/0000-0002-9006-4977","observed_orcids":["https://orcid.org/0000-0002-9006-4977"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Wu","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003885631","display_name":"James A. McCormick","orcid":"https://orcid.org/0000-0003-4000-6653","observed_orcids":["https://orcid.org/0000-0003-4000-6653"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. McCormick","raw_affiliation_strings":["Department of Medicine Oregon Health &amp; Science University Portland OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Oregon Health &amp; Science University Portland OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David E. Ellison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Ellison","raw_affiliation_strings":["Department of Medicine Oregon Health &amp; Science University Portland OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Oregon Health &amp; Science University Portland OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100370077","display_name":"Wen\u2010Hui Wang","orcid":"https://orcid.org/0000-0002-7503-9554","observed_orcids":["https://orcid.org/0000-0002-7503-9554"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen\u2010Hui Wang","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27550198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.4936999976634979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kir4-1","display_name":"Kir4.1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/kcnj10","display_name":"KCNJ10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/basolateral-potassium-conductance","display_name":"basolateral potassium conductance","score":0.9169999957084656},{"id":"https://openalex.org/keywords/distal-convoluted-tubule","display_name":"distal convoluted tubule","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ncc","display_name":"NCC","score":0.6019999980926514},{"id":"https://openalex.org/keywords/nkcc1","display_name":"NKCC1","score":0.6499999761581421},{"id":"https://openalex.org/keywords/renal-tubular-dysfunction","display_name":"renal tubular dysfunction","score":0.6389999985694885},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2776777027","wikidata":"https://www.wikidata.org/wiki/Q2914731","display_name":"Distal convoluted tubule","level":4,"score":0.7335802912712097},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6475996971130371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6305171847343445},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5783346891403198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49817442893981934},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.473722368478775},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.47099703550338745},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.4630468189716339},{"id":"https://openalex.org/C39587587","wikidata":"https://www.wikidata.org/wiki/Q5383698","display_name":"Epithelial polarity","level":3,"score":0.4457731544971466},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.44101956486701965},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.42723873257637024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3729783594608307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22537347674369812},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.1896863877773285},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.14200866222381592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11718299984931946},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11381858587265015},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.968.3","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.968.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.968.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2015392008","https://openalex.org/W2344145029","https://openalex.org/W2886978341","https://openalex.org/W3173743852","https://openalex.org/W7154395305","https://openalex.org/W2805497571","https://openalex.org/W2282790046","https://openalex.org/W2343813338","https://openalex.org/W2164112784","https://openalex.org/W4389027363"],"abstract_inverted_index":{"Loss\u2010of\u2010function":[0],"mutations":[1,33],"of":[2,66,74,154,157,164,178,183,205,213,234,245,251,265,277],"the":[3,28,35,52,57,64,77,151,155,162,166,179,187,196,203,232,249,270,281],"inwardly":[4],"rectifying":[5],"potassium":[6],"channel":[7,146,170,267],"(Kir),":[8],"KCNJ10":[9,32,99],"(Kir4.1),":[10],"caused":[11],"EAST":[12],"or":[13,116,255],"SeSAME":[14],"syndrome.":[15],"The":[16,138,242],"renal":[17],"phenotype":[18],"includes":[19],"salt":[20],"wasting,":[21],"hypomagnesemia,":[22],"metabolic":[23],"alkalosis":[24],"and":[25,63,80,122,195,238,274,279],"hypokalemia.":[26],"However,":[27,71],"mechanism":[29],"by":[30,135],"which":[31],"cause":[34],"tubulopathy":[36],"is":[37,175,199,261],"not":[38,84],"completely":[39],"understood.":[40],"Our":[41],"previous":[42],"studies":[43],"demonstrated":[44],"that":[45,126,182,212,259],"Kir4.1":[46,130,246,260],"was":[47,132],"a":[48,105,142,262],"main":[49],"contributor":[50],"to":[51,211,230],"basolateral":[53,152,271],"K":[54,145,169,190,266,272],"conductance":[55,273],"in":[56,150,171,202,209,236,268],"early":[58],"distal":[59],"convoluted":[60],"tubule":[61],"(DCT1)":[62],"disruption":[65],"Kir.4.1":[67,75],"inhibited":[68,248],"NCC":[69,235,253,283],"expression.":[70,284],"global":[72],"deletion":[73],"impaired":[76],"animal":[78],"growth":[79],"those":[81],"mice":[82,101,113,173,208],"could":[83],"survive":[85],"more":[86,127],"than":[87,128,181],"two":[88],"weeks":[89],"after":[90],"birth.":[91],"Thus":[92],"we":[93,217,225],"have":[94,218],"developed":[95],"inducible":[96],"kidney":[97],"specific":[98],"knockout":[100],"(Ks\u2010Kcnj10":[102],"KO)":[103],"using":[104],"Pax8+/Cre+/Kcnj10f/f":[106],"system.":[107],"We":[108,257],"fed":[109],"8":[110],"week":[111],"old":[112],"with":[114],"doxycycline":[115],"vehicle":[117],"for":[118],"10":[119],"days.":[120],"Immunofluorescence":[121],"western":[123,227],"analysis":[124,229],"confirmed":[125],"90%":[129],"protein":[131,254],"knocked":[133],"down":[134,243],"this":[136],"method.":[137],"patch\u2010clamp":[139],"study":[140],"detected":[141],"40":[143,167],"pS":[144,168],"(a":[147],"Kir4.1/5.1":[148],"heterotetramer)":[149],"membrane":[153,197,275],"DCT1":[156,204],"wildtype":[158],"(WT)":[159],"mice,":[160],"but":[161],"probability":[163],"finding":[165],"doxycycline\u2010treated":[172],"(KO)":[174],"lower":[176],"(10%":[177],"control)":[180],"WT":[184,214,237],"mice.":[185,215,223,241],"Moreover,":[186],"whole\u2010cell":[188],"Ba2+\u2010sensitive":[189],"currents":[191],"are":[192],"largely":[193],"abolished":[194],"potential":[198,276],"less":[200],"negative":[201],"KS\u2010Kcnj10":[206,221,239],"KO":[207,222,240],"comparison":[210],"Thus,":[216],"successfully":[219],"generated":[220],"Finally,":[224],"used":[226],"blot":[228],"examine":[231],"expression":[233,250],"regulation":[244],"significantly":[247],"total":[252],"phosphor\u2010NCC.":[256],"conclude":[258],"major":[263],"type":[264],"determining":[269],"DCT":[278],"determines":[280],"apical":[282]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}
