{"id":"https://openalex.org/W4389027442","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1212.6","title":"Regional Differences in Placental and Myoendometrial Vascularization and Placental and Fetal Development in Hypertensive\u2010Pregnancy","display_name":"Regional Differences in Placental and Myoendometrial Vascularization and Placental and Fetal Development in Hypertensive\u2010Pregnancy","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389027442","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1212.6"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.1212.6","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1212.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.1212.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072613067","display_name":"Carlos Alan Dias-Junior","orcid":"https://orcid.org/0000-0002-0348-6144","observed_orcids":["https://orcid.org/0000-0002-0348-6144"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Alan Dias\u2010Junior","raw_affiliation_strings":["Vascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077786796","display_name":"Zongli Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zongli Ren","raw_affiliation_strings":["Vascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048756235","display_name":"Minglin Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minglin Zhu","raw_affiliation_strings":["Vascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362092","display_name":"Jun Li","orcid":"https://orcid.org/0000-0003-3519-8638","observed_orcids":["https://orcid.org/0000-0003-3519-8638"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Vascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063840461","display_name":"Raouf A. Khalil","orcid":"https://orcid.org/0000-0002-7374-1956","observed_orcids":["https://orcid.org/0000-0002-7374-1956"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raouf A. Khalil","raw_affiliation_strings":["Vascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.53475737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hypertensive-disorders-of-pregnancy","display_name":"hypertensive disorders of pregnancy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/reduced-uterine-perfusion-pressure","display_name":"reduced uterine perfusion pressure","score":0.8420000076293945},{"id":"https://openalex.org/keywords/placental-arteries","display_name":"placental arteries","score":0.6759999990463257},{"id":"https://openalex.org/keywords/placental-development","display_name":"placental development","score":0.7590000033378601},{"id":"https://openalex.org/keywords/fetal-development","display_name":"fetal development","score":0.8330000042915344},{"id":"https://openalex.org/keywords/litter-size","display_name":"litter size","score":0.7929999828338623},{"id":"https://openalex.org/keywords/placental-weight","display_name":"placental weight","score":0.36899998784065247},{"id":"https://openalex.org/keywords/uteroplacental-ischemia","display_name":"uteroplacental ischemia","score":0.7329999804496765},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5049999952316284},{"id":"https://openalex.org/keywords/multiple-pregnancy","display_name":"multiple pregnancy","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.7237499356269836},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.709159791469574},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6938582062721252},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.6847177743911743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6514646410942078},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6331052780151367},{"id":"https://openalex.org/C45167389","wikidata":"https://www.wikidata.org/wiki/Q1114520","display_name":"Placentation","level":5,"score":0.5607535243034363},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5324336886405945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5215437412261963},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46093669533729553},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4580281376838684},{"id":"https://openalex.org/C2779429622","wikidata":"https://www.wikidata.org/wiki/Q1780867","display_name":"Litter","level":2,"score":0.42554882168769836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18566009402275085},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.1212.6","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1212.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.1212.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3554097583","display_name":"Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous Insufficiency","funder_award_id":"R21HL111775","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8229038284","display_name":"Vascular Mechanisms in Pregnancy-Induced Hypertension","funder_award_id":"R01HL065998","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2754382115","https://openalex.org/W2130986258","https://openalex.org/W2995116257","https://openalex.org/W4394958671","https://openalex.org/W1887683354","https://openalex.org/W4389027474","https://openalex.org/W2149321359","https://openalex.org/W2115780794","https://openalex.org/W2143396987","https://openalex.org/W2025866667"],"abstract_inverted_index":{"Preeclampsia":[0],"(PE)":[1],"is":[2,295],"a":[3,48,177,296,330],"form":[4],"of":[5,13,54,86,93,109,142,172,184,210,227,233,249,266,275,335],"hypertensive\u2010pregnancy":[6],"(HTN\u2010Preg)":[7],"with":[8,305],"unclear":[9],"mechanism.":[10],"General":[11],"reduction":[12,284],"uterine":[14,69,136,273],"perfusion":[15,70,321],"pressure":[16,129],"(RUPP)":[17],"could":[18,39,71,328],"be":[19,47,329],"an":[20],"initiating":[21],"event":[22],"leading":[23],"to":[24,114,281],"uteroplacental":[25,73,292],"ischemia,":[26,293],"abnormal":[27],"angiogenic/anti\u2010angiogenic":[28],"responses":[29,324],"and":[30,45,75,77,84,88,90,95,105,124,135,157,182,186,200,208,223,246,259,262,268,287,301,308,322,354],"HTN\u2010Preg.":[31],"Additional":[32],"regional":[33,66,315],"differences":[34,67,254,316],"in":[35,50,56,68,99,120,165,179,188,215,240,257,271,279,285,299,312,317,325,332,337],"placental":[36,76,94,211,267,286,300,307,320],"blood":[37,128,318],"flow":[38],"further":[40],"affect":[41,72],"the":[42,51,63,82,91,100,110,117,173,180,231,234,282,333],"pregnancy":[43],"outcome":[44],"may":[46],"factor":[49,331],"increased":[52],"risk":[53],"PE":[55,336],"twin":[57],"or":[58,264,341],"multiple":[59,338],"pregnancy.":[60,339],"To":[61],"test":[62],"hypothesis":[64],"that":[65,327],"vascularization":[74,303],"fetal":[78,288,309],"development,":[79],"we":[80],"compared":[81],"number":[83,92,141,181,207,232,261,265],"size":[85,153],"pups":[87,187,260],"placentae,":[89],"adjacent":[96,235],"myoendometrial":[97,236,269,302],"arteries":[98,212,237,270],"proximal":[101],"(prox\u2010U),":[102],"middle":[103],"(mid\u2010U)":[104],"distal":[106],"(distal\u2010U)":[107],"portions":[108],"uterus":[111,175],"(in":[112],"relation":[113],"distance":[115],"from":[116,350],"ovarian":[118],"arteries)":[119],"normal":[121],"pregnant":[122],"(NP)":[123],"RUPP":[125,166,174,228,250],"rats.":[126,229,251],"Maternal":[127],"was":[130,238,346],"higher":[131],"(127\u00b12":[132],"vs.":[133,139,145,150,155,161,194,219,243],"105\u00b14mmHg),":[134],"weight":[137,148,159,183,263],"(3.2\u00b10.1":[138],"4.6\u00b10.2g),":[140],"placentae":[143,185,258],"(9.5\u00b10.7":[144,154],"12.6\u00b10.5),":[146,156],"placenta":[147],"(401\u00b15":[149],"456\u00b14mg),":[151],"litter":[152],"pup":[158],"(1.18\u00b10.05":[160],"1.59\u00b10.04g)":[162],"were":[163,213,255],"less":[164,239],"than":[167],"NP":[168,276],"group.":[169,277],"Further":[170],"examination":[171],"showed":[176],"decrease":[178,298],"distal\u2010U":[189,216,241],"(0.4\u00b10.3,":[190],"210\u00b1120mg;":[191],"0.4\u00b10.3,":[192],"1.16\u00b10.51g)":[193],"prox\u2010U":[195,220,244],"(1\u00b10,":[196],"400\u00b1175mg;":[197],"1\u00b10,":[198],"1.67\u00b10.49g)":[199],"mid\u2010U":[201,224,247],"(0.6\u00b10.5,":[202],"337\u00b1184mg;":[203],"0.6\u00b10.5,":[204],"1.58\u00b10.46g).":[205],"The":[206],"diameter":[209],"smaller":[214],"(2.6\u00b10.5,":[217],"70\u00b18\u03bcm)":[218],"(5.0\u00b10.4,":[221],"105\u00b14\u03bcm)":[222],"(5.0\u00b10.5,":[225],"95\u00b17\u03bcm)":[226],"Also,":[230],"(1.3\u00b10.04)":[242],"(3.5\u00b10.06)":[245],"(2.5\u00b10.04)":[248],"No":[252],"significant":[253],"observed":[256,290],"different":[272],"regions":[274],"Thus,":[278],"addition":[280],"general":[283],"development":[289],"during":[291],"there":[294],"greater":[297,306],"associated":[304],"growth":[310],"restriction":[311],"distal\u2010U,":[313],"suggesting":[314],"flow,":[319],"angiogenic":[323],"HTN\u2010Preg":[326],"incidence":[334],"Support":[340],"Funding":[342],"Information":[343],"This":[344],"work":[345],"supported":[347],"by":[348],"grants":[349],"National":[351],"Heart,":[352],"Lung,":[353],"Blood":[355],"Institute":[356],"(HL\u201065998,HL\u2010111775).":[357]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-11-27T00:00:00"}