{"id":"https://openalex.org/W4389026896","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.712.5","title":"Pharmacokinetic Analysis of Aerosol Propellant HFA\u2010134a Elimination in the Human Breath","display_name":"Pharmacokinetic Analysis of Aerosol Propellant HFA\u2010134a Elimination in the Human Breath","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389026896","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.712.5"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.712.5","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.712.5","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.712.5","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101775445","display_name":"Hye\u2010Won Shin","orcid":"https://orcid.org/0000-0002-0080-2586","observed_orcids":["https://orcid.org/0000-0002-0080-2586"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hye\u2010Won Shin","raw_affiliation_strings":["Pediatrics, UCI, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, UCI, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113560220","display_name":"Elliot M. Landaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliot M. Landaw","raw_affiliation_strings":["Biomathmatics, UCLA, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomathmatics, UCLA, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058569030","display_name":"Barbara Barletta","orcid":"https://orcid.org/0000-0003-3046-014X","observed_orcids":["https://orcid.org/0000-0003-3046-014X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Barletta","raw_affiliation_strings":["Chemistry, UCI, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry, UCI, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005451060","display_name":"Simone Meinardi","orcid":"https://orcid.org/0000-0003-4828-9889","observed_orcids":["https://orcid.org/0000-0003-4828-9889"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simone Meinardi","raw_affiliation_strings":["Chemistry, UCI, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry, UCI, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050725198","display_name":"Shlomit Radom Aizik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shlomit Aizik","raw_affiliation_strings":["Pediatrics, UCI, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, UCI, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052407087","display_name":"Szu\u2010Yun Leu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Szu\u2010Yun Leu","raw_affiliation_strings":["Pediatrics, UCI, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, UCI, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046694694","display_name":"Donald Ray Blake","orcid":"https://orcid.org/0000-0002-8283-5014","observed_orcids":["https://orcid.org/0000-0002-8283-5014"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Blake","raw_affiliation_strings":["Chemistry, UCI, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry, UCI, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024191718","display_name":"Dan Michael Cooper","orcid":"https://orcid.org/0000-0003-4022-0043","observed_orcids":["https://orcid.org/0000-0003-4022-0043"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan M. Cooper","raw_affiliation_strings":["Pediatrics, UCI, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, UCI, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34930168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.1525000035762787,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.031700000166893005,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/r-134a","display_name":"R134a","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hydrofluoroalkane-propellant","display_name":"hydrofluoroalkane propellant","score":0.8270000219345093},{"id":"https://openalex.org/keywords/exhaled-breath","display_name":"exhaled breath","score":0.6449999809265137},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7910000085830688},{"id":"https://openalex.org/keywords/elimination-kinetics","display_name":"elimination kinetics","score":0.8450000286102295},{"id":"https://openalex.org/keywords/asthma-inhalers","display_name":"asthma inhalers","score":0.7310000061988831},{"id":"https://openalex.org/keywords/metered-dose-inhaler","display_name":"MDI","score":0.7680000066757202},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mean-retention-time","display_name":"mean retention time","score":0.753000020980835},{"id":"https://openalex.org/keywords/alveolar-gas","display_name":"alveolar gas","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2780261241","wikidata":"https://www.wikidata.org/wiki/Q1394363","display_name":"Inhaler","level":3,"score":0.7560787200927734},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6911798715591431},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5210189819335938},{"id":"https://openalex.org/C43396882","wikidata":"https://www.wikidata.org/wiki/Q2197000","display_name":"Exhalation","level":2,"score":0.5155875086784363},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.44695955514907837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4409128427505493},{"id":"https://openalex.org/C93353639","wikidata":"https://www.wikidata.org/wiki/Q754258","display_name":"Breath gas analysis","level":2,"score":0.41450393199920654},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39566677808761597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3396286964416504},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.30029433965682983},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2831898033618927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19393226504325867}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.712.5","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.712.5","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.712.5","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1550720887","https://openalex.org/W2153626976","https://openalex.org/W1980966275","https://openalex.org/W4404098462","https://openalex.org/W2117420158","https://openalex.org/W2117401654","https://openalex.org/W2180796992","https://openalex.org/W1996741402","https://openalex.org/W2467873837","https://openalex.org/W2013860817"],"abstract_inverted_index":{"The":[0,127,155,186,218,264,358,369],"goal":[1],"of":[2,11,162,214,232,274,401,424],"the":[3,8,15,27,138,160,166,174,179,193,233,237,258,282,336,345,350,402],"study":[4,279],"is":[5,26,64],"to":[6,46,53,255,355,363,397],"model":[7],"elimination":[9,177,285,372],"kinetics":[10,307,343,359],"Hydrofluoroalkane":[12],"(HFA\u2010134a)":[13],"in":[14,33,84,137,178,286,383],"exhaled":[16],"breath":[17,48,62,80,139,180,253,276,283,386],"following":[18],"a":[19,65,150,182,251,294],"typical":[20],"single":[21],"asthma":[22,57,70,391],"inhaler":[23,58,71,392],"administration.":[24],"HFA\u2010134a":[25,49,63,130,135,284,361,371,387,406],"most":[28],"commonly":[29],"used":[30],"aerosol":[31],"propellant":[32],"metered":[34],"dose":[35],"inhalers.":[36],"We":[37,333],"previously":[38],"demonstrated":[39],"that":[40,257,281,335,404],"our":[41],"technical":[42],"capabilities":[43],"allow":[44],"us":[45],"measure":[47],"levels":[50,131,136,246,388],"at":[51,93,96,159],"24":[52],"48":[54],"hours":[55],"post":[56],"administration,":[59],"and":[60,75,95,116,140,168,203,220,228,308,317,347,395,427],"thus":[61],"promising":[66],"biomarker":[67],"for":[68,192,360,367,389],"identifying":[69],"compliance":[72,394],"(":[73],"Clinical":[74],"Translational":[76,419],"Science":[77],"2015).":[78],"Exhaled":[79],"gases":[81],"were":[82,132,144,196,247],"collected":[83],"evacuated":[85],"electro\u2010polished":[86],"stainless":[87],"steel":[88],"canisters":[89],"from":[90,173],"healthy":[91,287],"participants":[92],"baseline":[94],"5":[97],"min,":[98,100,102,104,106,314,316],"7":[99],"10":[101],"15":[103],"30":[105],"1hr,":[107],"2hr,":[108],"3hr,":[109],"4hr,":[110],"6hr,":[111],"8hr,":[112],"12hr.":[113],"24hr,":[114],"36hr,":[115],"48hr":[117],"\u2010post":[118],"inhaled":[119],"corticosteroids":[120],"administration":[121],"(Flovent":[122],"HFA,":[123],"Glaxo":[124],"Smith":[125],"Kline).":[126],"corresponding":[128,378],"ambient":[129,141],"also":[133,248],"measured.":[134],"air":[142],"samples":[143],"quantified":[145],"using":[146],"gas":[147,254,259],"chromatography":[148],"with":[149,207,344,385],"quadrupole":[151],"mass":[152],"spectrometer":[153],"detector.":[154],"Institutional":[156],"Review":[157],"Board":[158],"University":[161],"California,":[163],"Irvine":[164],"approved":[165],"study,":[167],"informed":[169],"consent":[170],"was":[171,261,270,414],"obtained":[172],"participants.":[175],"HFA":[176],"followed":[181],"three\u2010exponential":[183],"pharmacokinetic":[184],"model.":[185],"estimated":[187],"time":[188,212,311,339],"constants":[189,312,340,376],"(mean":[190],"(SD))":[191],"three":[194],"components":[195,223],"5.5":[197],"(0.5)":[198],"minutes,":[199,202,206],"62.4":[200],"(11.1)":[201],"664":[204],"(140)":[205],"an":[208],"overall":[209],"mean":[210,265],"retention":[211],"(MRT)":[213],"71.8":[215],"(40.4)":[216],"minutes.":[217],"shortest":[219],"longest":[221],"half\u2010life":[222],"comprised":[224],"66":[225],"(17)":[226],"%":[227,231,273],"9":[229],"(7)":[230],"total":[234],"area":[235],"under":[236],"curve,":[238],"respectively.":[239],"Breath":[240],"carbon":[241],"dioxide":[242],"(CO":[243],"2":[244,268],")":[245],"monitored":[249],"as":[250],"reference":[252],"ensure":[256],"sampled":[260],"alveolar":[262],"gas.":[263],"(SD)":[266],"CO":[267],"level":[269],"4.7":[271],"(0.6)":[272],"all":[275],"samples.":[277],"This":[278,412],"demonstrates":[280],"control":[288],"humans":[289],"can":[290],"be":[291,364,381],"described":[292],"by":[293,416],"3":[295],"rd":[296],"order":[297],"exponential":[298],"equation.":[299],"In":[300],"earlier":[301],"studies,":[302],"we":[303],"modeled":[304],"bicarbonate":[305],"distribution":[306,354],"found":[309],"similar":[310],"(2.2":[313],"11.9":[315],"83.3":[318],"min;":[319],"MRT":[320],"65":[321],"min.;":[322],"Barstow":[323],"et":[324],"al.":[325],"Am.":[326],"J.":[327],"Physiol.":[328],"259:":[329],"R163,":[330],"1990":[331],").":[332],"speculate":[334],"first":[337],"two":[338],"reflect":[341],"compartmental":[342],"lung":[346],"circulation":[348],"while":[349],"slowest":[351],"primarily":[352],"reflects":[353],"body":[356],"tissues.":[357],"appear":[362],"slower":[365],"than":[366],"bicarbonate.":[368],"calculated":[370],"parameters":[373],"(i.e.,":[374],"rate":[375],"or":[377,409],"half\u2010lives)":[379],"may":[380],"useful":[382],"conjunction":[384],"accessing":[390],"medication":[393],"further":[396],"understand":[398],"physiological":[399],"complexity":[400],"lungs":[403],"affect":[405],"elimination.":[407],"Support":[408],"Funding":[410],"Information":[411],"work":[413],"supported":[415],"NIH":[417],"grants:":[418],"Pilot":[420],"Research":[421],"Award":[422],"(subaward":[423],"UL1":[425],"TR000153)":[426],"Program":[428],"Project":[429],"Grant":[430],"P01HD048721":[431]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}