{"id":"https://openalex.org/W4389026599","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.853.13","title":"Progress Towards Addressing Gram Negative Bacterial Resistance","display_name":"Progress Towards Addressing Gram Negative Bacterial Resistance","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389026599","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.853.13"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.853.13","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.853.13","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.853.13","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027735219","display_name":"Bilyana N. Koleva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bilyana N. Koleva","raw_affiliation_strings":["Northeastern University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002257598","display_name":"Khuloud Takrouri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khuloud Takrouri","raw_affiliation_strings":["Northeastern University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024940698","display_name":"Harold D. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold D. Cooper","raw_affiliation_strings":["Northeastern University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024365073","display_name":"Andrew E. Spaulding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Spaulding","raw_affiliation_strings":["Northeastern University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079797306","display_name":"Paola Zucchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paola Zucchi","raw_affiliation_strings":["Northeastern University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091243257","display_name":"Dillon C. Cleary","orcid":"https://orcid.org/0000-0001-8179-7266","observed_orcids":["https://orcid.org/0000-0001-8179-7266"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dillon Cleary","raw_affiliation_strings":["Northeastern University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093341623","display_name":"Wesley Tear","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley Tear","raw_affiliation_strings":["Northeastern University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050141006","display_name":"Elizabeth B. Hirsch","orcid":"https://orcid.org/0000-0002-0462-0421","observed_orcids":["https://orcid.org/0000-0002-0462-0421"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth B. Hirsch","raw_affiliation_strings":["Northeastern University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062983432","display_name":"James B. Aggen","orcid":"https://orcid.org/0000-0001-7989-5131","observed_orcids":["https://orcid.org/0000-0001-7989-5131"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. Aggen","raw_affiliation_strings":["Northeastern University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015910317","display_name":"Penny J. Beuning","orcid":"https://orcid.org/0000-0002-7770-022X","observed_orcids":["https://orcid.org/0000-0002-7770-022X"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Penny J. Beuning","raw_affiliation_strings":["Northeastern University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12912129"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31448598,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.10109999775886536,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.9800000190734863},{"id":"https://openalex.org/keywords/oxazolidinones","display_name":"oxazolidinones","score":0.9919999837875366},{"id":"https://openalex.org/keywords/linezolid","display_name":"linezolid","score":0.984000027179718},{"id":"https://openalex.org/keywords/antibiotic-discovery","display_name":"antibiotic discovery","score":0.5789999961853027},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.8050000071525574},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9240000247955322},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7099999785423279},{"id":"https://openalex.org/keywords/protein-translation-inhibition","display_name":"protein translation inhibition","score":0.6000000238418579},{"id":"https://openalex.org/keywords/lead-optimization","display_name":"lead optimization","score":0.5860000252723694},{"id":"https://openalex.org/keywords/outer-membrane-permeability","display_name":"outer membrane permeability","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.8735713958740234},{"id":"https://openalex.org/C2781414143","wikidata":"https://www.wikidata.org/wiki/Q411377","display_name":"Linezolid","level":5,"score":0.7213484644889832},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.659015417098999},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6370768547058105},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.6177903413772583},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5783409476280212},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5325295925140381},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5051048398017883},{"id":"https://openalex.org/C2776051709","wikidata":"https://www.wikidata.org/wiki/Q632006","display_name":"Gram-negative bacteria","level":4,"score":0.46525293588638306},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.4471403658390045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38056355714797974},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33845648169517517},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.31641218066215515},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.15481996536254883},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09937235713005066},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0513346791267395},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.853.13","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.853.13","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.853.13","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392748039","https://openalex.org/W2942607619","https://openalex.org/W2339664776","https://openalex.org/W7066718308","https://openalex.org/W4211144518","https://openalex.org/W7064763879","https://openalex.org/W2339273814","https://openalex.org/W2168281308","https://openalex.org/W2028126965","https://openalex.org/W2400601374"],"abstract_inverted_index":{"Multidrug":[0],"antibiotic":[1,16,46,60],"resistance":[2,39],"poses":[3],"an":[4,248],"increasingly":[5],"urgent":[6],"threat":[7],"to":[8,31,122,130,168,175,178,227,259,262],"global":[9],"health":[10],"and":[11,90,162,174,192,201,204,210,225,231,252,255],"the":[12,23,50,64,100,105,110,124,132,150,172,180,234,245],"world":[13],"economies.":[14],"Among":[15],"resistant":[17,30],"species,":[18],"gram":[19,222],"negative":[20,223],"bacteria":[21,137,224],"present":[22],"utmost":[24],"urgency":[25],"as":[26],"they":[27],"have":[28],"become":[29],"nearly":[32],"all":[33],"available":[34],"treatment":[35,111],"options.":[36],"Combating":[37],"antibacterial":[38],"should":[40],"include":[41],"continuous":[42],"introduction":[43],"of":[44,66,68,71,81,112,118,126,135,187,199,233,239,247,266],"new":[45],"classes;":[47],"however":[48],"over":[49],"last":[51],"40":[52],"years":[53],"there":[54],"has":[55],"been":[56],"a":[57,79,155,197],"void":[58],"in":[59,128,196,244,249,264],"drug":[61],"discovery.":[62],"Extending":[63],"spectrum":[65],"activities":[67],"current":[69],"classes":[70],"antibiotics":[72,82],"is":[73,121],"another":[74],"approach.":[75],"The":[76,143],"oxazolidinones":[77,127],"are":[78,91],"class":[80],"that":[83],"work":[84,120],"by":[85],"interfering":[86],"with":[87],"protein":[88],"translation":[89,253],"mainly":[92],"active":[93],"against":[94,221],"gram\u2010positive":[95,114],"bacteria.":[96,115],"Linezolid,":[97],"marketed":[98],"under":[99],"trade":[101],"name":[102],"Zyvox\u00ae,":[103],"was":[104,190,242],"first":[106],"FDA\u2010approved":[107],"oxazolidinone":[108,188],"for":[109,194],"pathogenic":[113],"One":[116],"focus":[117],"this":[119],"optimize":[123],"properties":[125],"order":[129],"penetrate":[131],"lipopolysaccharide":[133],"layer":[134],"gram\u2010negative":[136],"while":[138],"maintaining":[139],"their":[140],"target":[141],"potency.":[142],"rational":[144],"lead":[145],"optimization":[146],"campaign":[147],"based":[148],"on":[149],"linezolid":[151,263],"scaffold":[152],"involves":[153],"keeping":[154],"low":[156],"molecular":[157],"weight":[158],"(MW":[159],"<400":[160],"Da),":[161],"high":[163],"polarity":[164],"(clog":[165],"D":[166],"<1)":[167],"allow":[169],"passage":[170],"through":[171],"porins":[173],"be":[176,260],"able":[177],"escape":[179],"bacterial":[181],"efflux":[182,206,235],"pumps.":[183,236],"A":[184,237],"focused":[185],"library":[186],"analogs":[189,217],"synthesized":[191],"evaluated":[193],"activity":[195,220],"panel":[198],"wild\u2010type":[200],"outer":[202],"membrane\u2010":[203],"or":[205],"pump\u2010compromised":[207],"Escherichia":[208],"coli":[209],"Staphylococcus":[211],"aureus":[212],".":[213],"Several":[214],"C\u2010ring":[215],"modification":[216],"offered":[218],"moderate":[219],"seem":[226],"improve":[228],"membrane":[229],"permeability":[230],"evasion":[232],"subset":[238],"these":[240],"compounds":[241],"tested":[243],"context":[246],"vitro":[250],"transcription":[251],"assay":[254],"most":[256],"were":[257],"found":[258],"comparable":[261],"terms":[265],"efficacy.":[267]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}