{"id":"https://openalex.org/W4389025517","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.lb754","title":"Stromal Support of Pancreatic Tumor Metabolism","display_name":"Stromal Support of Pancreatic Tumor Metabolism","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389025517","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.lb754"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.lb754","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.lb754","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.lb754","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085494535","display_name":"Costas Andreas Lyssiotis","orcid":"https://orcid.org/0000-0001-9309-6141","observed_orcids":["https://orcid.org/0000-0001-9309-6141"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Costas A Lyssiotis","raw_affiliation_strings":["Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI","Molecular and Integrative Physiology, Division of Gastroenterology, University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Molecular and Integrative Physiology, Division of Gastroenterology, University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085494535"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42078246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7760000228881836},{"id":"https://openalex.org/keywords/pancreatic-stellate-cells","display_name":"pancreatic stellate cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6919999718666077},{"id":"https://openalex.org/keywords/non-essential-amino-acids","display_name":"non-essential amino acids","score":0.8519999980926514},{"id":"https://openalex.org/keywords/alanine","display_name":"alanine","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.7950000166893005},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.699999988079071},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.656000018119812},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7350000143051147},{"id":"https://openalex.org/keywords/metabolic-crosstalk","display_name":"metabolic crosstalk","score":0.7620000243186951},{"id":"https://openalex.org/keywords/mitochondrial-health","display_name":"mitochondrial health","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8239262104034424},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7272354364395142},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6975821256637573},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5767226219177246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49571168422698975},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4516460597515106},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41178014874458313},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39252328872680664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37619107961654663},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2681400775909424},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.09057790040969849}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.lb754","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.lb754","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.lb754","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306271","display_name":"Damon Runyon Cancer Research Foundation","ror":"https://ror.org/01gd7b947"},{"id":"https://openalex.org/F4320306791","display_name":"Pancreatic Cancer Action Network","ror":"https://ror.org/03t5n9b81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2739920567","https://openalex.org/W2516006356","https://openalex.org/W3019567338","https://openalex.org/W2076065432","https://openalex.org/W2744692848","https://openalex.org/W2518067410","https://openalex.org/W3090968312","https://openalex.org/W4247496663","https://openalex.org/W4323067046","https://openalex.org/W2115240134"],"abstract_inverted_index":{"Pancreatic":[0,224],"Ductal":[1],"Adenocarcinoma":[2],"(PDAC)":[3],"is":[4,25,158,220,269],"an":[5,104,187,211],"aggressive":[6],"disease":[7],"characterized":[8],"by":[9,166,222,272],"a":[10,53,163,174,193],"prominent":[11],"desmoplastic":[12],"stromal":[13,45],"reaction":[14,46],"and":[15,27,56,70,86,112,124,127,140,180,191,242,252,282],"deregulated":[16],"metabolism.":[17],"The":[18,43,267],"role":[19,106],"of":[20,96,255,285],"stroma":[21],"in":[22,115,132,146,210,263,278],"PDAC":[23,91,116],"biology":[24],"complex":[26],"has":[28],"been":[29],"shown":[30],"to":[31,52,72,117,207],"play":[32],"critical":[33,89],"roles":[34],"that":[35,80,154],"may":[36],"differ":[37],"depending":[38],"on":[39,138,160],"the":[40,49,94,119,136,147,167,223,253,273],"biological":[41],"context.":[42],"intense":[44],"also":[47],"impacts":[48],"vasculature,":[50],"leading":[51],"highly":[54],"hypoxic":[55],"nutrient":[57,289],"poor":[58],"environment.":[59],"As":[60],"such,":[61],"these":[62],"tumors":[63,200],"must":[64],"adapt":[65],"how":[66],"nutrients":[67],"are":[68,88,144,205],"captured":[69],"utilized":[71,206],"support":[73],"their":[74],"metabolic":[75,176,196],"needs.":[76],"Recently,":[77],"we":[78,102,152],"found":[79],"stromal-associated":[81],"pancreatic":[82,148,199,247,264],"stellate":[83,265],"cells":[84,249,286],"(PSCs)":[85],"macrophages":[87],"for":[90,107],"metabolism":[92],"through":[93],"secretion":[95,157],"non-essential":[97],"amino":[98,256],"acids":[99,257],"(NEAA).":[100],"Specifically,":[101],"uncovered":[103],"undescribed":[105],"alanine,":[108],"which":[109,143,276],"outcompetes":[110],"glucose":[111,139],"glutamine-derived":[113],"carbon":[114,189],"fuel":[118,133,203],"tricarboxylic":[120],"acid":[121],"(TCA)":[122],"cycle,":[123],"thus":[125],"NEAA":[126],"lipid":[128],"biosynthesis.":[129],"This":[130],"shift":[131],"sources":[134,204],"decreases":[135],"dependence":[137],"serum-derived":[141],"nutrients,":[142],"limiting":[145],"tumor":[149,213],"microenvironment.":[150,214],"Moreover,":[151],"demonstrated":[153],"PSC":[155,161],"alanine":[156,185,261],"dependent":[159],"autophagy,":[162],"process":[164],"stimulated":[165],"cancer":[168,181,248],"cells.":[169,266],"Thus,":[170],"our":[171],"results":[172,277],"demonstrate":[173],"novel":[175],"crosstalk":[177],"between":[178],"PSCs":[179],"cells,":[182,275],"with":[183],"PSC-derived":[184],"as":[186],"alternative":[188],"source,":[190],"highlight":[192],"previously":[194],"unappreciated":[195],"network":[197],"within":[198],"where":[201],"diverse":[202],"promote":[208],"growth":[209],"austere":[212],"Support":[215],"or":[216],"Funding":[217],"Information":[218],"C.A.L.":[219],"supported":[221],"Cancer":[225,230,235],"Action":[226],"Network,":[227],"Damon":[228],"Runyon":[229],"Research":[231],"Foundation,":[232,236,238],"Sidney":[233],"Kimmel":[234],"V":[237],"National":[239],"Pancreas":[240],"Foundation":[241],"American":[243],"Gastroenterological":[244],"Association.":[245],"Epithelial":[246],"induce":[250],"autophagy":[251],"release":[254],"(AA),":[258],"notably":[259],"free":[260],"(Ala),":[262],"Ala":[268],"then":[270],"consumed":[271],"neoplastic":[274],"increased":[279],"mitochondrial":[280],"health":[281],"proliferative":[283],"capacity":[284],"grown":[287],"under":[288],"limited":[290],"conditions.":[291]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}