{"id":"https://openalex.org/W4389024944","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1004.3","title":"Structural Heteropolysaccharide Binding to the Visceral Mesothelial Glycocalyx","display_name":"Structural Heteropolysaccharide Binding to the Visceral Mesothelial Glycocalyx","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389024944","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1004.3"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.1004.3","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1004.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.1004.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064180481","display_name":"Andrew B. Servais","orcid":"https://orcid.org/0000-0001-8656-9166","observed_orcids":["https://orcid.org/0000-0001-8656-9166"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Servais","raw_affiliation_strings":["Laboratory of Adaptive and Regenerative Biology Brigham &amp; Women's Hospital Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Adaptive and Regenerative Biology Brigham &amp; Women's Hospital Boston MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025508774","display_name":"Arne Kienzle","orcid":"https://orcid.org/0000-0002-4556-2993","observed_orcids":["https://orcid.org/0000-0002-4556-2993"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arne Kienzle","raw_affiliation_strings":["Laboratory of Adaptive and Regenerative Biology Brigham &amp; Women's Hospital Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Adaptive and Regenerative Biology Brigham &amp; Women's Hospital Boston MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074225322","display_name":"Cristian D. Valenzuela","orcid":"https://orcid.org/0000-0002-8694-9174","observed_orcids":["https://orcid.org/0000-0002-8694-9174"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristian Valenzuela","raw_affiliation_strings":["Laboratory of Adaptive and Regenerative Biology Brigham &amp; Women's Hospital Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Adaptive and Regenerative Biology Brigham &amp; Women's Hospital Boston MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038105546","display_name":"Alexandra B. Ysasi","orcid":"https://orcid.org/0000-0002-2932-870X","observed_orcids":["https://orcid.org/0000-0002-2932-870X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Ysasi","raw_affiliation_strings":["Laboratory of Adaptive and Regenerative Biology Brigham &amp; Women's Hospital Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Adaptive and Regenerative Biology Brigham &amp; Women's Hospital Boston MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036089918","display_name":"Willi Linus Wagner","orcid":"https://orcid.org/0000-0002-2748-5429","observed_orcids":["https://orcid.org/0000-0002-2748-5429"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Willi Wagner","raw_affiliation_strings":["Institute of Functional and Clinical Anatomy, University Medical Center of Johannes Gutenberg-University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional and Clinical Anatomy, University Medical Center of Johannes Gutenberg-University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086646925","display_name":"Maximilian Ackermann","orcid":"https://orcid.org/0000-0001-9996-2477","observed_orcids":["https://orcid.org/0000-0001-9996-2477"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Ackermann","raw_affiliation_strings":["Institute of Functional and Clinical Anatomy, University Medical Center of Johannes Gutenberg-University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional and Clinical Anatomy, University Medical Center of Johannes Gutenberg-University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019584033","display_name":"Akira Tsuda","orcid":"https://orcid.org/0000-0003-4542-1573","observed_orcids":["https://orcid.org/0000-0003-4542-1573"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akira Tsuda","raw_affiliation_strings":["Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013315084","display_name":"Steven J. Mentzer","orcid":"https://orcid.org/0000-0003-1496-6044","observed_orcids":["https://orcid.org/0000-0003-1496-6044"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Mentzer","raw_affiliation_strings":["Laboratory of Adaptive and Regenerative Biology Brigham &amp; Women's Hospital Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Adaptive and Regenerative Biology Brigham &amp; Women's Hospital Boston MA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48168645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.08940000087022781,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pectin","display_name":"pectin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/high-methoxyl-pectin","display_name":"high methoxyl pectin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/low-methoxyl-pectin","display_name":"low methoxyl pectin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/carboxymethyl-cellulose","display_name":"carboxymethyl cellulose","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mucoadhesion","display_name":"mucoadhesion","score":0.8130000233650208},{"id":"https://openalex.org/keywords/peel-strength","display_name":"peel strength","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tensile-strength","display_name":"tensile strength","score":0.9829999804496765},{"id":"https://openalex.org/keywords/amidated-pectin","display_name":"amidated pectin","score":0.871999979019165},{"id":"https://openalex.org/keywords/heteropolysaccharide","display_name":"heteropolysaccharide","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2779747549","wikidata":"https://www.wikidata.org/wiki/Q35970","display_name":"Mesothelium","level":3,"score":0.9027667045593262},{"id":"https://openalex.org/C2776634624","wikidata":"https://www.wikidata.org/wiki/Q4914690","display_name":"Bioadhesive","level":3,"score":0.8275185823440552},{"id":"https://openalex.org/C2780020223","wikidata":"https://www.wikidata.org/wiki/Q25323681","display_name":"Mucoadhesion","level":4,"score":0.7647605538368225},{"id":"https://openalex.org/C2780756937","wikidata":"https://www.wikidata.org/wiki/Q188154","display_name":"Pectin","level":2,"score":0.7633959054946899},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.749040424823761},{"id":"https://openalex.org/C2780098789","wikidata":"https://www.wikidata.org/wiki/Q898356","display_name":"Glycocalyx","level":2,"score":0.6511081457138062},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5992048382759094},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.5681754946708679},{"id":"https://openalex.org/C2909640154","wikidata":"https://www.wikidata.org/wiki/Q35970","display_name":"Mesothelial Cell","level":2,"score":0.5644971132278442},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.4612639546394348},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4358213245868683},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39240050315856934},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.23058763146400452},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1459285020828247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10247904062271118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08699202537536621},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08338576555252075}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.1004.3","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1004.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.1004.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000210217","display_name":null,"funder_award_id":"T32-HL007734","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2611803514","https://openalex.org/W3016991413","https://openalex.org/W4414292588","https://openalex.org/W7213979065","https://openalex.org/W3196833097","https://openalex.org/W2762036613","https://openalex.org/W2021791734","https://openalex.org/W2162142815","https://openalex.org/W1979667251","https://openalex.org/W4313891107"],"abstract_inverted_index":{"Bioadhesives":[0],"are":[1,210],"biopolymers":[2],"with":[3,40,77,108,113,172,188,208],"potential":[4,21,61,227],"applications":[5],"in":[6,25,153,203,221],"wound":[7],"healing,":[8],"drug":[9],"delivery":[10],"and":[11,83,87,101,124,156,190,234],"tissue":[12,184,219],"engineering.":[13],"Pectin,":[14],"a":[15,23,31,66,173,211],"plant\u2010based":[16],"heteropolysaccharide,":[17],"has":[18],"recently":[19],"demonstrated":[20],"as":[22,65],"mucoadhesive":[24],"the":[26,35,38,53,60,71,78,91,118,121,128,178,222,226],"bowel.":[27,84],"Since":[28],"mucoadhesion":[29],"is":[30],"process":[32],"likely":[33],"involving":[34],"interpenetration":[36],"of":[37,55,63,73,80,90,117,127,139,175,217,231],"polymer":[39],"mucin":[41],"chains,":[42],"we":[43,69],"hypothesized":[44],"that":[45,199],"pectin":[46,64,75,131,146,162,181],"may":[47],"also":[48],"be":[49],"effective":[50],"at":[51],"targeting":[52,230],"glycocalyx":[54,224],"visceral":[56],"mesothelium.":[57,236],"To":[58],"explore":[59],"role":[62],"mesothelial":[67,158,213,223],"bioadhesive,":[68],"studied":[70],"interaction":[72,93],"various":[74],"formulations":[76],"mesothelium":[79,185],"lung,":[81,154,232],"liver":[82,155,233],"Peel":[85],"strength":[86,89,123,126],"tensile":[88,125],"bioadhesive\u2010mesothelial":[92],"was":[94,106,132,164,186],"measured":[95],"by":[96,192],"tensilometry.":[97],"In":[98],"both":[99],"high":[100,129,160,179,200],"low":[102,140,144,168],"methoxyl":[103,130,141,145,161,169,180,201],"pectins,":[104,202],"bioadhesion":[105],"greatest":[107],"an":[109,204],"equal":[110,205],"weight/%":[111,206],"formulation":[112,207],"carboxymethylcellulose.":[114],"Largely":[115],"independent":[116],"carboxymethylcellulose":[119],"concentration,":[120],"peel":[122],"nearly":[133],"3\u2010fold":[134],"greater":[135,166],"than":[136,167],"comparable":[137],"adhesion":[138,163,182],"or":[142,238],"amidated":[143],"(p<0.05).":[147],"Although":[148],"tissue\u2010specific":[149],"variations":[150],"were":[151],"observed":[152],"bowel":[157,235],"adhesion,":[159],"consistently":[165],"formulations.":[170],"Consistent":[171],"mechanism":[174],"polymer\u2010glycocalyx":[176],"interpenetration,":[177],"to":[183],"reversed":[187],"hydration":[189],"limited":[191],"enzyme":[193],"treatment":[194],"(pronase).":[195],"These":[196],"data":[197],"indicate":[198],"carboxymethylcellulose,":[209],"promising":[212],"bioadhesive.":[214],"Further":[215],"characterization":[216],"apparent":[218],"differences":[220],"offers":[225],"for":[228],"selective":[229],"Support":[237],"Funding":[239],"Information":[240],"NIH":[241,244],"T32":[242],"HL007734":[243],"R01":[245],"HL94567":[246]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}
