{"id":"https://openalex.org/W4389024328","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1012.11","title":"Blood Pressure Responsiveness to Muscle Metaboreflex Activation in Older Adults Following Dietary Nitrate Supplementation","display_name":"Blood Pressure Responsiveness to Muscle Metaboreflex Activation in Older Adults Following Dietary Nitrate Supplementation","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389024328","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1012.11"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.1012.11","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1012.11","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.1012.11","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010477252","display_name":"Aaron C. Schneider","orcid":"https://orcid.org/0000-0002-5033-0724","observed_orcids":["https://orcid.org/0000-0002-5033-0724"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron C Schneider","raw_affiliation_strings":["University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101464255","display_name":"William Edward Hughes","orcid":"https://orcid.org/0000-0002-7580-9213","observed_orcids":["https://orcid.org/0000-0002-7580-9213","https://orcid.org/0000-0003-2064-4834"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E Hughes","raw_affiliation_strings":["University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077226662","display_name":"Nicholas T. Kruse","orcid":"https://orcid.org/0000-0001-9903-8743","observed_orcids":["https://orcid.org/0000-0001-9903-8743"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas T Kruse","raw_affiliation_strings":["University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054758021","display_name":"Kenichi Ueda","orcid":"https://orcid.org/0000-0002-4559-4581","observed_orcids":["https://orcid.org/0000-0002-4559-4581"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenichi Ueda","raw_affiliation_strings":["University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054111868","display_name":"Darren P. Casey","orcid":"https://orcid.org/0000-0003-4564-8604","observed_orcids":["https://orcid.org/0000-0003-4564-8604"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darren P Casey","raw_affiliation_strings":["University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.53773537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-nitrate-supplementation","display_name":"nitrate supplementation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/beetroot","display_name":"beetroot","score":0.7039999961853027},{"id":"https://openalex.org/keywords/muscle-metaboreflex","display_name":"muscle metaboreflex","score":0.9240000247955322},{"id":"https://openalex.org/keywords/blood-pressure-response","display_name":"blood pressure response","score":0.7950000166893005},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.718999981880188},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nitrate-nitrite-nitric-oxide-pathway","display_name":"nitrate-nitrite-nitric oxide pathway","score":0.9419999718666077},{"id":"https://openalex.org/keywords/isometric-handgrip-exercise","display_name":"isometric handgrip exercise","score":0.9559999704360962},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.46399998664855957},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4020000100135803},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.40799999237060547},{"id":"https://openalex.org/keywords/exercise-induced-hypertension","display_name":"exercise-induced hypertension","score":0.4020000100135803},{"id":"https://openalex.org/keywords/finger-plethysmography","display_name":"finger plethysmography","score":0.7480000257492065},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7586328983306885},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7236032485961914},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.6796979904174805},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6659820675849915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5907348990440369},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.579413890838623},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5560958981513977},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.5435961484909058},{"id":"https://openalex.org/C71316499","wikidata":"https://www.wikidata.org/wiki/Q7295547","display_name":"Rate pressure product","level":4,"score":0.43345049023628235},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4179142117500305},{"id":"https://openalex.org/C133165541","wikidata":"https://www.wikidata.org/wiki/Q472094","display_name":"Exercise physiology","level":2,"score":0.4162950813770294},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.1012.11","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.1012.11","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.1012.11","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2805597622","https://openalex.org/W2160255927","https://openalex.org/W2758690553","https://openalex.org/W7221107135","https://openalex.org/W4295078615","https://openalex.org/W2461363836","https://openalex.org/W3016896045","https://openalex.org/W3112693409","https://openalex.org/W7160939490","https://openalex.org/W2465320021"],"abstract_inverted_index":{"There":[0],"is":[1,66,444,465],"an":[2,481],"increased":[3,265],"risk":[4],"for":[5,156,282,292],"adverse":[6],"cardiac":[7],"events":[8],"in":[9,30,35,59,104,122,294,328,453,467,485],"older":[10,31,106,125,454,468],"individuals":[11,32],"that":[12,23,90,440,476],"exhibit":[13],"exaggerated":[14,25],"blood":[15,206],"pressure":[16,207,271],"(BP)":[17],"responses":[18,27,99,243],"to":[19,28,37,49,86,100,194,213,252,274],"exercise.":[20,223],"Evidence":[21],"suggests":[22,439],"the":[24,50,60,80,88,97,210,219,238,247,253,256,314,326,349,367,448,457,461],"BP":[26,53,98,226,242,436],"exercise":[29,190,452,462],"are":[33],"due":[34],"part":[36],"greater":[38,483],"muscle":[39,101,164,196,239,449],"metaboreflex":[40,102,165,197,240,450],"activation.":[41,198],"The":[42,163,434],"vasoactive":[43],"molecule":[44],"nitric":[45],"oxide":[46],"(NO)":[47],"contributes":[48],"regulation":[51],"of":[52,141,152,159,168,171,177,188,204,221,255,299,313,399,446,460],"and":[54,137,147,185,232,258,263,268,348,380],"may":[55,473],"play":[56],"a":[57,114,157,205],"role":[58],"metaboreflex.":[61],"With":[62],"aging,":[63],"NO":[64,92,142,153,300,337,400],"bioavailability":[65],"often":[67],"reduced":[68,394,435],"but":[69],"can":[70],"be":[71,474],"improved":[72],"through":[73],"nitrate":[74,442,477],"(NO":[75],"3":[76,93,143,154,216,301,309,323,338,371,401],")":[77,155],"supplementation":[78,94,144,302,339,443,478],"via":[79,229,235],"nitrate\u2010nitrite\u2010NO":[81],"pathway.":[82],"Therefore,":[83],"we":[84,112],"sought":[85],"test":[87,109,166],"hypothesis":[89,111],"dietary":[91,441],"would":[95],"reduce":[96],"activation":[103],"healthy":[105,124],"adults.":[107,455],"To":[108],"this":[110,486],"utilized":[113],"randomized,":[115],"double\u2010blind,":[116],"placebo":[117,148,315,350,404],"controlled":[118],"crossover":[119],"study":[120,161],"design":[121],"8":[123,344,356],"adults":[126,469],"(67":[127],"\u00b1":[128,304,308,318,322,341,345,353,357,370,374,383,387,411,415,423,427],"2":[129,169,183,342,346,358,384,388,412],"years;":[130],"5M/3F).":[131],"Each":[132],"subject":[133],"was":[134,200,227,290],"studied":[135],"before":[136,218],"after":[138,330],"4":[139,160,305,319,331,375],"weeks":[140,332],"(beetroot":[145,149],"powder)":[146],"powder":[150],"devoid":[151],"total":[158],"days.":[162],"consisted":[167],"min":[170],"isometric":[172],"handgrip":[173,222],"(IHG)":[174],"at":[175],"30%":[176],"maximal":[178],"voluntary":[179],"contraction":[180],"followed":[181],"by":[182,202,495],"minutes":[184],"15":[186,321,414],"seconds":[187,217],"post":[189],"forearm":[191],"ischemia":[192],"(PEI)":[193],"isolate":[195],"PEI":[199,259,264,396,438],"achieved":[201],"inflation":[203],"cuff":[208],"around":[209],"upper":[211],"arm":[212],"240":[214],"mmHg":[215],"end":[220,254],"Beat\u2010to\u2010beat":[224],"peripheral":[225],"measured":[228],"finger":[230],"plethysmography)":[231],"heart":[233],"rate":[234],"ECG":[236],"throughout":[237],"test.":[241],"were":[244,393],"analyzed":[245],"as":[246],"change":[248,327],"(\u0394)":[249],"from":[250],"baseline":[251],"IHG":[257,262,361],"periods.":[260],"Both":[261],"systolic":[266],"(SBP)":[267],"mean":[269],"arterial":[270],"(MAP)":[272],"relative":[273],"resting":[275],"(baseline)":[276],"measurements":[277],"(":[278],"P":[279,363,377,390,417,429],"<":[280],"0.05":[281],"both).":[283],"No":[284],"significant":[285],"interaction":[286],"(P":[287],"=":[288,364,378,391,418,430],"0.39)":[289],"found":[291],"changes":[293],"\u0394SBP":[295,368,409],"when":[296],"comparing":[297],"4\u2010weeks":[298,312,398],"(14":[303],"vs.":[306,311,320,343,355,372,385,413,425],"11":[307],"mmHg)":[310,347,359],"condition":[316,351],"(12":[317],"mmHg).":[324],"Likewise,":[325],"\u0394MAP":[329,381,421],"did":[333],"not":[334],"differ":[335],"between":[336],"(10":[340],"(8":[352],"1":[354,424],"during":[360,395,432,437,451],"(interaction,":[362],"0.29).":[365],"Conversely,":[366],"(19":[369],"13":[373],"mmHg,":[376,389],"0.03)":[379,392],"(11":[382],"7":[386],"following":[397],"supplementation,":[402],"whereas":[403],"had":[405],"no":[406],"effect":[407],"on":[408],"(13":[410],"2,":[416],"0.31)":[419],"or":[420,490],"(7":[422],"9":[426],"1,":[428],"0.22)":[431],"PEI.":[433],"capable":[445],"attenuating":[447],"Since":[456],"metabolic":[458],"component":[459],"pressor":[463],"reflex":[464],"augmented":[466],"with":[470],"hypertension,":[471],"it":[472],"possible":[475],"could":[479],"have":[480],"even":[482],"impact":[484],"patient":[487],"population.":[488],"Support":[489],"Funding":[491],"Information":[492],"Research":[493],"supported":[494],"Neogenis":[496],"Inc.":[497]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}