{"id":"https://openalex.org/W4389024316","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.811.1","title":"Mortalin Caught in Action: Structures of the Nucleotide Binding Domain in the Apo, ADP\u2010bound and AMP+PPi\u2010bound states","display_name":"Mortalin Caught in Action: Structures of the Nucleotide Binding Domain in the Apo, ADP\u2010bound and AMP+PPi\u2010bound states","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W4389024316","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.811.1"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.811.1","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.811.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.811.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008976235","display_name":"Mitchell A. Moseng","orcid":"https://orcid.org/0000-0003-4314-7283","observed_orcids":["https://orcid.org/0000-0003-4314-7283"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell Moseng","raw_affiliation_strings":["Chemistry and Biochemistry, Miami University, Oxford, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry, Miami University, Oxford, OH","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060164140","display_name":"Matthew Mignery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Mignery","raw_affiliation_strings":["Chemistry and Biochemistry, Miami University, Oxford, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry, Miami University, Oxford, OH","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093341373","display_name":"Paige Larney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige Larney","raw_affiliation_strings":["Chemistry and Biochemistry, Miami University, Oxford, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry, Miami University, Oxford, OH","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002601178","display_name":"Corey C. Emerson","orcid":"https://orcid.org/0000-0003-1311-2522","observed_orcids":["https://orcid.org/0000-0003-1311-2522"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corey Emerson","raw_affiliation_strings":["Chemistry and Biochemistry, Miami University, Oxford, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry, Miami University, Oxford, OH","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055041718","display_name":"Jay C. Nix","orcid":"https://orcid.org/0000-0002-4041-4975","observed_orcids":["https://orcid.org/0000-0002-4041-4975"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I4210156074","display_name":"Molecular Biology Consortium","ror":"https://ror.org/04mg7f574","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210156074"]},{"id":"https://openalex.org/I4387152530","display_name":"Advanced Light Source","ror":"https://ror.org/00319zh75","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521","https://openalex.org/I4387152530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay C Nix","raw_affiliation_strings":["Molecular Biology Consortium, Beamline 4.2.2, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Consortium, Beamline 4.2.2, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I4210156074","https://openalex.org/I4387152530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021853695","display_name":"Richard C. Page","orcid":"https://orcid.org/0000-0002-3006-3171","observed_orcids":["https://orcid.org/0000-0002-3006-3171"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard C Page","raw_affiliation_strings":["Chemistry and Biochemistry, Miami University, Oxford, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry, Miami University, Oxford, OH","institution_ids":["https://openalex.org/I83328450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27358194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mortalin","display_name":"mortalin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nucleotide-binding-domain","display_name":"nucleotide-binding domain","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hsp70-family","display_name":"HSP70 family","score":0.753000020980835},{"id":"https://openalex.org/keywords/adp-bound-state","display_name":"ADP-bound state","score":0.777999997138977},{"id":"https://openalex.org/keywords/apo-state","display_name":"apo state","score":0.6980000138282776},{"id":"https://openalex.org/keywords/nucleotide-binding-pocket","display_name":"nucleotide-binding pocket","score":0.7360000014305115},{"id":"https://openalex.org/keywords/mitochondrial-chaperone","display_name":"mitochondrial chaperone","score":0.656000018119812},{"id":"https://openalex.org/keywords/protein-refolding","display_name":"protein refolding","score":0.46299999952316284},{"id":"https://openalex.org/keywords/mitochondrial-protein-import","display_name":"mitochondrial protein import","score":0.5619999766349792},{"id":"https://openalex.org/keywords/iron-sulfur-cluster-assembly","display_name":"iron-sulfur cluster assembly","score":0.8370000123977661},{"id":"https://openalex.org/keywords/disease-associated-mutations","display_name":"disease-associated mutations","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.40299999713897705},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C113027372","wikidata":"https://www.wikidata.org/wiki/Q24768350","display_name":"Cyclic nucleotide-binding domain","level":4,"score":0.7238046526908875},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.6581111550331116},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.5881103873252869},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5195651054382324},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.49775221943855286},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.4811871647834778},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.47009846568107605},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.46578899025917053},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.45569223165512085},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44756239652633667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42238807678222656},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4063681960105896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3975585103034973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.387561559677124},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3183560371398926},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14981985092163086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.811.1","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.811.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.811.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1846067131","https://openalex.org/W2083175589","https://openalex.org/W6248325","https://openalex.org/W2072634039","https://openalex.org/W7097241504","https://openalex.org/W2903427149","https://openalex.org/W2035896591","https://openalex.org/W4364381022","https://openalex.org/W2391401501","https://openalex.org/W7026825311"],"abstract_inverted_index":{"The":[0,36,90,122,141],"heat":[1,38],"shock":[2,39],"protein":[3,40,55],"70,":[4],"Hsp70,":[5],"chaperone":[6],"family":[7],"plays":[8],"key":[9,153],"roles":[10],"in":[11,43,76,87,105,155,164,173],"cellular":[12,51],"homeostasis":[13],"and":[14,32,57,65,79,109,117,144,183,203,232],"stress":[15,52],"response.":[16],"Hsp70s":[17],"not":[18,171],"only":[19],"regulate":[20],"the":[21,98,106,128,165,197,209,213,228],"folding":[22],"of":[23,46,67,97,102,125,199,211,215,218,230],"nascent":[24],"proteins,":[25],"but":[26],"also":[27,135,194],"prevent":[28],"aggregation,":[29],"promote":[30],"disaggregation,":[31],"refold":[33],"misfolded":[34],"proteins.":[35],"mitochondrial":[37,54,63],"Mortalin":[41,73,104,201,219],"functions":[42],"a":[44,151,224],"variety":[45],"processes":[47],"such":[48],"as":[49,223],"apoptosis,":[50],"response,":[53],"import":[56],"quality":[58],"control,":[59],"Fe\u2010S":[60],"cluster":[61],"biogenesis,":[62],"homeostasis,":[64],"regulation":[66],"p53,":[68],"an":[69,84],"important":[70],"tumor":[71],"suppressor.":[72],"is":[74,80],"implicated":[75],"neurodegenerative":[77,233],"diseases,":[78],"known":[81],"to":[82,179,187,196,204],"play":[83],"anti\u2010apoptotic":[85],"role":[86],"cancer":[88,231],"cells.":[89],"Page":[91],"laboratory":[92],"has":[93,134,220],"elucidated":[94],"crystal":[95,123],"structures":[96,143],"nucleotide":[99,166,181],"binding":[100,167],"domain":[101],"human":[103],"apo,":[107],"ADP\u2010bound,":[108],"AMP\u2010bound":[110],"states":[111],"at":[112,138],"2.8":[113],"\u00c5,":[114,116],"2.78":[115],"1.75":[118],"\u00c5":[119],"resolutions,":[120],"respectively.":[121],"structure":[124],"Mortalin\u2010NBD":[126],"with":[127,150,208],"modified":[129],"ADP":[130],"homolog":[131],"N6P\u2010ADP":[132],"bound":[133],"been":[136,221],"determined":[137],"1.49":[139],"\u00c5.":[140],"overall":[142],"active":[145],"site":[146],"organizations":[147],"are":[148,170],"similar,":[149],"few":[152],"differences":[154],"side":[156],"chain":[157],"positions.":[158],"Our":[159,190],"data":[160,192],"identifies":[161],"specific":[162],"residues":[163],"pocket,":[168],"which":[169],"conserved":[172],"other":[174],"Hsp70\u2010family":[175],"members,":[176],"that":[177],"lead":[178],"lower":[180],"affinity":[182],"slower":[184],"turnover":[185],"relative":[186],"cytosolic":[188],"Hsp70.":[189],"structural":[191],"will":[193],"contribute":[195],"understanding":[198],"disease\u2010associated":[200],"mutations":[202],"improved":[205],"Mortalin\u2010targeted":[206],"compounds":[207],"aim":[210],"influencing":[212],"function":[214],"Mortalin.":[216],"Regulation":[217],"proposed":[222],"potential":[225],"avenue":[226],"for":[227],"treatment":[229],"diseases.":[234]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}