{"id":"https://openalex.org/W4389022508","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.606.2","title":"Metal drives chemistry: dual\u2010function of acireductone dioxygenase enzymes","display_name":"Metal drives chemistry: dual\u2010function of acireductone dioxygenase enzymes","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389022508","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.606.2"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.606.2","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.606.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.606.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101660971","display_name":"A.R. Deshpande","orcid":"https://orcid.org/0000-0003-1481-2635","observed_orcids":["https://orcid.org/0000-0003-1481-2635"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditi Rajiva Deshpande","raw_affiliation_strings":["Allena Pharmaceuticals, Newton, MA","Brandeis University, Waltham, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allena Pharmaceuticals, Newton, MA","institution_ids":[]},{"raw_affiliation_string":"Brandeis University, Waltham, MA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074212942","display_name":"K. Wagenpfeil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karina Wagenpfeil","raw_affiliation_strings":["Biology, Brandeis University, Waltham, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology, Brandeis University, Waltham, MA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052965284","display_name":"Thomas C. Pochapsky","orcid":"https://orcid.org/0000-0001-8995-1088","observed_orcids":["https://orcid.org/0000-0001-8995-1088"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Charles Pochapsky","raw_affiliation_strings":["Biochemistry & Chemistry Brandeis University Waltham MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry & Chemistry Brandeis University Waltham MA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007934367","display_name":"Gregory A. Petsko","orcid":"https://orcid.org/0000-0003-3668-3694","observed_orcids":["https://orcid.org/0000-0003-3668-3694"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Petsko","raw_affiliation_strings":["Neuroscience, Weil Cornell Medical School, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience, Weil Cornell Medical School, New York, NY","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014900252","display_name":"Dagmar Ringe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dagmar Ringe","raw_affiliation_strings":["Biochemistry, Brandeis University, Waltham, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry, Brandeis University, Waltham, MA","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.1046,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45376794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metalloenzymes","display_name":"metalloenzymes","score":0.7580000162124634},{"id":"https://openalex.org/keywords/bifunctional-enzyme","display_name":"bifunctional enzyme","score":0.5630000233650208},{"id":"https://openalex.org/keywords/metal-dependent-catalysis","display_name":"metal-dependent catalysis","score":0.5929999947547913},{"id":"https://openalex.org/keywords/iron","display_name":"iron","score":0.31200000643730164},{"id":"https://openalex.org/keywords/nickel","display_name":"nickel","score":0.996999979019165},{"id":"https://openalex.org/keywords/cobalt","display_name":"cobalt","score":0.8259999752044678},{"id":"https://openalex.org/keywords/manganese","display_name":"manganese","score":0.9980000257492065},{"id":"https://openalex.org/keywords/methionine-salvage-pathway","display_name":"methionine salvage pathway","score":0.9789999723434448},{"id":"https://openalex.org/keywords/klebsiella-oxytoca","display_name":"Klebsiella oxytoca","score":0.9670000076293945},{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.8820000290870667},{"id":"https://openalex.org/keywords/protein-thermostability","display_name":"protein thermal stability","score":0.7039999961853027},{"id":"https://openalex.org/keywords/metal-coordination","display_name":"metal coordination","score":0.6809999942779541},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7200000286102295},{"id":"https://openalex.org/keywords/solution-nmr","display_name":"solution NMR","score":0.7829999923706055},{"id":"https://openalex.org/keywords/isoenzymes","display_name":"isozymes","score":0.5849999785423279},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7827466726303101},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5445336699485779},{"id":"https://openalex.org/C2780178953","wikidata":"https://www.wikidata.org/wiki/Q2001841","display_name":"Formate","level":3,"score":0.5249119997024536},{"id":"https://openalex.org/C512735826","wikidata":"https://www.wikidata.org/wiki/Q2025","display_name":"Carbon monoxide","level":3,"score":0.509650707244873},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.4911362826824188},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.46734315156936646},{"id":"https://openalex.org/C106773901","wikidata":"https://www.wikidata.org/wiki/Q19588","display_name":"Transition metal","level":3,"score":0.45011600852012634},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.43922463059425354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3079058527946472},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16680991649627686}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.606.2","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.606.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.606.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6997404690","display_name":"Structural Basis for Bridged Bimetallic Enzyme Catalysis","funder_award_id":"R01GM026788","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2737650880","https://openalex.org/W2569054210","https://openalex.org/W2281668735","https://openalex.org/W2006523627","https://openalex.org/W2546547385","https://openalex.org/W2802566642","https://openalex.org/W2112345842","https://openalex.org/W1973067651","https://openalex.org/W3096916280","https://openalex.org/W2087221183"],"abstract_inverted_index":{"Acireductone":[0],"dioxygenase":[1],"(ARD)":[2],"from":[3,196,337],"the":[4,12,26,29,41,50,62,68,74,125,175,187,215,224,228,242,250,264,312,320,338],"methionine":[5,229],"salvage":[6,230],"pathway":[7],"of":[8,28,65,95,103,112,124,127,146,174,191,227,241,269,297,341],"Klebsiella":[9,197],"oxytoca":[10],"is":[11,118,130],"only":[13],"known":[14],"naturally":[15],"occurring":[16],"metalloenzyme":[17],"which":[18],"exhibits":[19],"dual\u2010chemistry":[20,106],"in":[21,40,107,116,149,238,332],"vivo":[22],"determined":[23],"solely":[24],"by":[25,254,334],"identity":[27],"divalent":[30],"transition":[31,166],"metal":[32,167,284,313],"ion":[33],"(Fe":[34],"2+":[35,38,46,70,179,207,210,213,220,246,256,259,262,271,299,302,305],"or":[36,211,325],"Ni":[37,69,206,245,270,301],")":[39],"active":[42],"site.":[43],"The":[44,110,177],"Fe":[45,178,219,258,298],"containing":[47,71],"isozyme":[48,72],"catalyzes":[49],"on\u2010pathway":[51,225],"reaction":[52,217,226],"using":[53],"substrates":[54,76],"acireductone":[55],"and":[56,61,86,98,138,153,159,201,257,260,278,287,291,303,346],"dioxygen":[57],"to":[58,77,82,161,186,194,205,319,344],"generate":[59],"formate":[60],"ketoacid":[63],"precursor":[64],"methionine,":[66],"whereas":[67,218],"uses":[73],"same":[75],"catalyze":[78],"an":[79,131,143],"off\u2010pathway":[80,128,216],"shunt":[81],"methylthiopropionate,":[83],"carbon":[84,121],"monoxide":[85],"formate.":[87],"We":[88],"recently":[89],"have":[90,141],"shown":[91],"that":[92,311],"mammalian":[93],"homologs":[94],"ARD":[96,148,155,181,195,203,222,248,274,308],"(mouse":[97],"human)":[99],"are":[100],"also":[101],"capable":[102],"this":[104,113],"metal\u2010dependent":[105],"vitro":[108],".":[109],"possibility":[111],"dual":[114],"chemistry":[115],"mammals":[117],"interesting":[119],"since":[120],"monoxide,":[122],"one":[123],"products":[126],"reaction,":[129],"anti\u2010apoptotic":[132],"molecule.":[133],"In":[134],"addition,":[135],"several":[136],"biochemical":[137],"genetic":[139],"studies":[140],"indicated":[142,234],"inhibitory":[144],"role":[145],"human":[147,154,200,307],"cancer.":[150],"Recombinant":[151],"mouse":[152,202,273],"isozymes":[156,309],"were":[157],"expressed":[158],"purified":[160],"obtain":[162],"a":[163,235,335],"homogeneous":[164],"single":[165],"(Mn,":[168],"Fe,":[169],"Co,":[170],"Ni)":[171],"bound":[172,204],"form":[173],"enzymes.":[176],"\u2010bound":[180,221,247,272,306],"showed":[182],"highest":[183],"activity":[184],"compared":[185],"other":[188],"metal\u2010bound":[189],"forms":[190],"ARD.":[192],"Similar":[193],",":[198,208,300],"both":[199],"Co":[209,255,304],"Mn":[212,261],"catalyzed":[214,223],"pathway.":[231],"Thermal":[232],"stability":[233],"large":[236],"difference":[237],"melting":[239],"temperatures":[240],"proteins;":[243],"with":[244,276],"being":[249,263],"most":[251],"stable":[252],"followed":[253],"least":[265],"stable.":[266],"Crystal":[267],"structures":[268],"co\u2010crystallized":[275],"product":[277,288],"substrate":[279,286],"analogs":[280],"provided":[281],"insight":[282],"into":[283],"coordination,":[285],"binding":[289],"coordination":[290],"catalytic":[292],"mechanism.":[293],"Solution":[294],"NMR":[295],"data":[296],"indicate":[310],"center":[314],"imparts":[315],"significant":[316],"structural":[317],"differences":[318],"overall":[321],"protein":[322],"structure.":[323],"Support":[324],"Funding":[326],"Information":[327],"This":[328],"work":[329],"was":[330],"supported":[331],"part":[333],"grant":[336],"National":[339],"Institutes":[340],"Health":[342],"(GM26788":[343],"G.A.P.":[345],"D.R.)":[347]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-11-27T00:00:00"}