{"id":"https://openalex.org/W4389022366","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.612.10","title":"Using Transcriptomics for Biomarker Discovery Enabling High\u2010Throughput Drug Screening of iPSC\u2010Cardiomyocytes Modeling a Cardiomyopathy","display_name":"Using Transcriptomics for Biomarker Discovery Enabling High\u2010Throughput Drug Screening of iPSC\u2010Cardiomyocytes Modeling a Cardiomyopathy","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389022366","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.612.10"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.612.10","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.612.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.612.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086097843","display_name":"Teisha J. Rowland","orcid":"https://orcid.org/0000-0001-5038-6763","observed_orcids":["https://orcid.org/0000-0001-5038-6763"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teisha J Rowland","raw_affiliation_strings":["University of Colorado Denver Anschutz Medical Campus, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver Anschutz Medical Campus, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112438433","display_name":"Sherin I. Hashem","orcid":"https://orcid.org/0009-0009-1515-3679","observed_orcids":["https://orcid.org/0009-0009-1515-3679"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherin I. Hashem","raw_affiliation_strings":["University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075707322","display_name":"Kenneth L. Jones","orcid":"https://orcid.org/0000-0003-4572-3651","observed_orcids":["https://orcid.org/0000-0003-4572-3651"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Jones","raw_affiliation_strings":["University of Colorado Denver Anschutz Medical Campus, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver Anschutz Medical Campus, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058871241","display_name":"Andrew J. Bonham","orcid":"https://orcid.org/0000-0003-1591-8378","observed_orcids":["https://orcid.org/0000-0003-1591-8378"]},"institutions":[{"id":"https://openalex.org/I879689382","display_name":"Metropolitan State University of Denver","ror":"https://ror.org/03mnxwj46","country_code":"US","type":"education","lineage":["https://openalex.org/I879689382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Bonham","raw_affiliation_strings":["Department of Chemistry, Metropolitan State University of Denver, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Metropolitan State University of Denver, Denver, CO","institution_ids":["https://openalex.org/I879689382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108880646","display_name":"Susan Jett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Jett","raw_affiliation_strings":["University of Colorado Denver Anschutz Medical Campus, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver Anschutz Medical Campus, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081897240","display_name":"ERIC D. ADLER","orcid":"https://orcid.org/0000-0002-4765-0188","observed_orcids":["https://orcid.org/0000-0002-4765-0188"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Adler","raw_affiliation_strings":["University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062004692","display_name":"Daniel V. LaBarbera","orcid":"https://orcid.org/0000-0001-9460-3862","observed_orcids":["https://orcid.org/0000-0001-9460-3862"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel LaBarbera","raw_affiliation_strings":["University of Colorado Denver Anschutz Medical Campus, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver Anschutz Medical Campus, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067654253","display_name":"Luisa Mestroni","orcid":"https://orcid.org/0000-0003-1116-2286","observed_orcids":["https://orcid.org/0000-0003-1116-2286"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luisa Mestroni","raw_affiliation_strings":["University of Colorado Denver Anschutz Medical Campus, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver Anschutz Medical Campus, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066041440","display_name":"Matthew R.G. Taylor","orcid":"https://orcid.org/0000-0001-9043-0810","observed_orcids":["https://orcid.org/0000-0001-9043-0810"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Taylor","raw_affiliation_strings":["University of Colorado Denver Anschutz Medical Campus, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver Anschutz Medical Campus, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30254499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.10040000081062317,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/danon-disease","display_name":"Danon disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.906000018119812},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.9750000238418579},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.7799999713897705},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.8960000276565552},{"id":"https://openalex.org/keywords/high-throughput-drug-screening","display_name":"high-throughput drug screening","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cellular-respiration","display_name":"cellular respiration","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.7680000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/sarcomere-genes","display_name":"sarcomere genes","score":0.6159999966621399},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.7210000157356262},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.5569999814033508},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.781000018119812},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-seq","score":0.4090000092983246},{"id":"https://openalex.org/keywords/qrt-pcr","display_name":"qRT-PCR","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.6652882099151611},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.661820650100708},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5470911860466003},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5403274893760681},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5208802223205566},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.47283869981765747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46796661615371704},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.4299851357936859},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.370552122592926},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.328377366065979},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.2463614046573639},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23670002818107605},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.221967875957489},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15789109468460083},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.612.10","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.612.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.612.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1825981810","display_name":null,"funder_award_id":"R01HL109209","funder_id":"https://openalex.org/F4320337711","funder_display_name":"Colorado Clinical and Translational Sciences Institute"},{"id":"https://openalex.org/G4921130661","display_name":null,"funder_award_id":"R01 116906","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5853261428","display_name":"Colorado Clinical and Translational Sciences Institute","funder_award_id":"UL1TR001082","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6300707817","display_name":null,"funder_award_id":"K23 JL067915","funder_id":"https://openalex.org/F4320337711","funder_display_name":"Colorado Clinical and Translational Sciences Institute"},{"id":"https://openalex.org/G7204487764","display_name":"Sarcomere based Signals in Muscle Remodelling","funder_award_id":"291834","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G893732656","display_name":"Molecular Epidemiology of Dilated Cardiomyopath","funder_award_id":"R01HL069071","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G998814062","display_name":"Colorado Clinical and Translational Science Institute (UL1)","funder_award_id":"UL1RR025780","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337711","display_name":"Colorado Clinical and Translational Sciences Institute","ror":"https://ror.org/03xsh7c04"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2803950192","https://openalex.org/W4205086904","https://openalex.org/W2614974118","https://openalex.org/W6926684255","https://openalex.org/W3174396315","https://openalex.org/W2099169137","https://openalex.org/W2401409726","https://openalex.org/W4414937287","https://openalex.org/W3046457836","https://openalex.org/W16962052"],"abstract_inverted_index":{"Danon":[0,31,75,109,120,155,217],"disease":[1,32,110],"is":[2,33,48,64,178],"an":[3],"untreatable":[4,304],"and":[5,57,82,87,111,129,151,236,240,257,275,280,303,321,334,340,345],"severe":[6],"X\u2010linked":[7],"form":[8],"of":[9,40,74,95,131,145,164,186,210,242,253,269,325,360],"cardiomyopathy":[10],"that":[11],"leads":[12,70],"to":[13,35,71,158,223,233],"profound":[14],"cardiac":[15,23],"hypertrophy,":[16],"causing":[17],"death":[18],"or":[19,307],"a":[20,49,196,243,247,251,259,264,357],"need":[21],"for":[22,91,198,297],"transplantation":[24],"in":[25,54,148,154,168,180,215,285,354],"males":[26],"by":[27,38,228,314,356],"the":[28,41,72,80,119,216,364],"third":[29],"decade.":[30],"known":[34],"be":[36,221,273],"caused":[37],"loss":[39],"lysosome\u2010associated":[42],"membrane":[43,50],"protein\u20102":[44],"(LAMP\u20102)":[45],"protein,":[46],"which":[47],"glycoprotein":[51],"likely":[52],"involved":[53,86,147],"lysosome\u2010autophagosome":[55],"fusion":[56],"vesicle":[58],"trafficking":[59],"during":[60],"autophagy.":[61],"However,":[62],"it":[63],"unknown":[65],"how":[66],"LAMP\u20102":[67],"protein":[68],"deficiency":[69],"development":[73,239],"disease.":[76],"To":[77],"better":[78],"characterize":[79],"molecular":[81],"cellular":[83,149,165,213],"pathogenic":[84],"mechanisms":[85],"enable":[88,224],"biomarker":[89,191],"discovery":[90,192,203,227,262],"high\u2010throughput":[92],"screening":[93],"(HTS)":[94],"compound":[96],"libraries,":[97],"human":[98],"induced":[99],"pluripotent":[100],"stem":[101],"cells":[102],"(iPSCs)":[103],"were":[104,124],"generated":[105],"from":[106,118,363],"patients":[107],"with":[108,172,299],"differentiated":[112],"into":[113],"cardiomyocytes.":[114],"RNA":[115],"transcription":[116],"levels":[117,185],"iPSC\u2010derived":[121],"cardiomyocytes":[122],"(iPSC\u2010CMs)":[123],"analyzed":[125],"using":[126,204,250,263,278],"RNA\u2010Sequencing":[127],"(RNA\u2010Seq)":[128],"expression":[130,153],"key":[132],"genes":[133,146],"confirmed":[134,277,289],"via":[135],"quantitative":[136],"real\u2010time":[137],"PCR":[138],"(qRT\u2010PCR).":[139],"The":[140,162],"data":[141,170,174],"show":[142],"significant":[143],"upregulation":[144,163],"respiration":[150,166],"sarcomere":[152],"iPSC\u2010CMs":[156],"compared":[157],"unaffected":[159],"control":[160],"iPSC\u2010CMs.":[161],"transcripts":[167],"our":[169,207],"align":[171],"published":[173],"suggesting":[175],"mitochondrial":[176,187,234],"function":[177,235],"affected":[179],"these":[181,205,288],"cells,":[182,206],"including":[183],"increased":[184],"oxidative":[188],"stress.":[189],"While":[190],"has":[193],"previously":[194],"been":[195],"hurdle":[197],"successfully":[199],"undertaking":[200],"HTS":[201,225,245,249,260],"drug":[202,226,261],"RNA\u2010Seq":[208],"findings":[209],"potentially":[211],"impacted":[212],"functions":[214],"iPSC\u2010CM":[218],"model":[219],"can":[220],"used":[222],"identifying":[229],"novel":[230,293],"biomarkers":[231],"related":[232],"mitophagy.":[237],"Following":[238],"validation":[241],"primary":[244],"assay,":[246],"pilot":[248],"library":[252,268],"355":[254],"kinase":[255],"inhibitors":[256],"then":[258],"custom":[265],"designed":[266],"diversity":[267],"20,000":[270],"compounds":[271],"will":[272],"performed":[274],"hits":[276,290],"secondary":[279],"tertiary":[281],"assays.":[282],"After":[283],"additional":[284],"vivo":[286],"validation,":[287],"may":[291],"offer":[292],"potential":[294],"therapeutic":[295],"treatments":[296],"individuals":[298],"this":[300],"currently":[301],"devastating":[302],"cardiomyopathy.":[305],"Support":[306],"Funding":[308],"Information":[309],"This":[310,350],"work":[311,351],"was":[312,352],"supported":[313,353],"European":[315],"Union":[316],"grant":[317,362],"FP7\u2010PEOPLE\u20102011\u2010IRSES":[318],"291834":[319],"SarcoSI":[320],"U.S.":[322],"National":[323],"Institutes":[324],"Health":[326],"grants":[327,341],"UL1":[328,330],"RR025780,":[329],"TR001082,":[331],"R01":[332,335],"HL69071,":[333],"116906":[336],"(to":[337,347],"Dr.":[338,348],"Mestroni);":[339],"CCTSI":[342],"K23":[343],"JL067915":[344],"R01HL109209":[346],"Taylor).":[349],"part":[355],"Trans\u2010Atlantic":[358],"Network":[359],"Excellence":[361],"Leducq":[365],"Foundation":[366],"(14\u2010CVD":[367],"03).":[368]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}