{"id":"https://openalex.org/W4389020779","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.527.2","title":"New insights into intravascular lipolysis and new causes of hypertriglyceridemia","display_name":"New insights into intravascular lipolysis and new causes of hypertriglyceridemia","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389020779","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.527.2"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.527.2","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.527.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.527.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085755071","display_name":"Stephen G. Young","orcid":"https://orcid.org/0000-0001-7270-3176","observed_orcids":["https://orcid.org/0000-0001-7270-3176"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen G. Young","raw_affiliation_strings":["Medicine, UCLA Los Angeles CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, UCLA Los Angeles CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090307190","display_name":"Anne P. Beigneux","orcid":"https://orcid.org/0000-0002-7892-150X","observed_orcids":["https://orcid.org/0000-0002-7892-150X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Beigneux","raw_affiliation_strings":["Medicine, UCLA Los Angeles CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, UCLA Los Angeles CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068606823","display_name":"Loren G. Fong","orcid":"https://orcid.org/0000-0002-4465-5290","observed_orcids":["https://orcid.org/0000-0002-4465-5290"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loren Fong","raw_affiliation_strings":["Medicine, UCLA Los Angeles CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, UCLA Los Angeles CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071117617","display_name":"Michael Ploug","orcid":"https://orcid.org/0000-0003-2215-4265","observed_orcids":["https://orcid.org/0000-0003-2215-4265"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michael Ploug","raw_affiliation_strings":["Finsen Laboratory Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Finsen Laboratory Copenhagen Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49591087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpihbp1","display_name":"GPIHBP1","score":0.8870000243186951},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.9670000076293945},{"id":"https://openalex.org/keywords/triglyceride-rich-lipoproteins","display_name":"triglyceride-rich lipoproteins","score":0.9959999918937683},{"id":"https://openalex.org/keywords/capillary-endothelium","display_name":"capillary endothelium","score":0.8410000205039978},{"id":"https://openalex.org/keywords/gpi-anchored-proteins","display_name":"GPI-anchored proteins","score":0.7310000061988831},{"id":"https://openalex.org/keywords/enzyme-stabilization","display_name":"enzyme stabilization","score":0.42899999022483826},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.8971437215805054},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.7425991296768188},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.602595865726471},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5005462169647217},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.4378887712955475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3900260627269745},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.339179664850235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.287450909614563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2653164863586426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2588118016719818},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.258392870426178},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.2457982301712036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.151628315448761},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.14802756905555725},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.12147408723831177},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.06617411971092224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.527.2","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.527.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.527.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2366056993","https://openalex.org/W1987372898","https://openalex.org/W4293485774","https://openalex.org/W2956054395","https://openalex.org/W2890401859","https://openalex.org/W2907500691","https://openalex.org/W2904247542","https://openalex.org/W1978801803","https://openalex.org/W2169920662","https://openalex.org/W3191528963"],"abstract_inverted_index":{"GPIHBP1,":[0],"a":[1],"GPI\u2010anchored":[2],"protein":[3],"of":[4,14,34,47,59,67,92,102,121,124],"capillary":[5,38],"endothelial":[6],"cells,":[7],"is":[8,41,115],"crucial":[9],"for":[10,44],"the":[11,24,29,37,45,57,64,81,89,100,119],"lipolytic":[12,52],"processing":[13,53],"triglyceride\u2010rich":[15],"lipoproteins":[16],"(TRLs).":[17],"GPIHBP1":[18,40,62,76,103,114],"binds":[19],"lipoprotein":[20],"lipase":[21],"(LPL)":[22],"in":[23,36],"interstitial":[25],"spaces":[26],"and":[27,97,106,135],"shuttles":[28],"enzyme":[30],"to":[31,61,104,118],"its":[32],"site":[33],"action":[35],"lumen.":[39],"also":[42,116],"required":[43],"margination":[46],"TRLs":[48],"along":[49],"capillaries\u2014so":[50],"that":[51,86,113],"can":[54],"proceed.":[55],"Finally,":[56],"binding":[58],"LPL":[60,73],"reduces":[63],"spontaneous":[65],"unfolding":[66],"LPL's":[68],"catalytic":[69,74],"domain,":[70],"thereby":[71,98],"stabilizing":[72],"activity.":[75],"mutations":[77,85],"cause":[78],"severe":[79],"hypertriglyceridemia;":[80],"majority":[82],"are":[83],"missense":[84],"interfere":[87],"with":[88],"proper":[90],"conformation":[91],"GPIHBP1's":[93],"LU":[94],"(Ly6\u2010uPAR)":[95],"domain":[96],"abolish":[99],"capacity":[101],"bind":[105],"transport":[107],"LPL.":[108],"Recent":[109],"studies":[110],"have":[111],"shown":[112],"highly":[117],"pathogenesis":[120],"acquired":[122],"forms":[123],"hypertriglyceridemia.":[125],"Support":[126],"or":[127],"Funding":[128],"Information":[129],"Leducq":[130],"Foundation;":[131],"National":[132],"Heart,":[133],"Lung,":[134],"Blood":[136],"Institute":[137]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2023-11-27T00:00:00"}