{"id":"https://openalex.org/W4389020330","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.773.5","title":"Lipid\u2010derived electrophiles regulate isoform\u2010specific redox\u2010dependent kinase signaling","display_name":"Lipid\u2010derived electrophiles regulate isoform\u2010specific redox\u2010dependent kinase signaling","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389020330","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.773.5"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.773.5","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.773.5","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.773.5","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005077107","display_name":"Sanjna L. Surya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjna Surya","raw_affiliation_strings":["Chemistry and Chemical Biology, Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Chemical Biology, Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080199288","display_name":"Saba Parvez","orcid":"https://orcid.org/0000-0001-8608-1494","observed_orcids":["https://orcid.org/0000-0001-8608-1494"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saba Parvez","raw_affiliation_strings":["Chemistry and Chemical Biology, Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Chemical Biology, Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060276866","display_name":"Marcus J. C. Long","orcid":"https://orcid.org/0000-0002-0343-9671","observed_orcids":["https://orcid.org/0000-0002-0343-9671"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus John Curtis Long","raw_affiliation_strings":["Chemistry and Chemical Biology, Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Chemical Biology, Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012937873","display_name":"Yi Zhao","orcid":"https://orcid.org/0000-0002-6049-1943","observed_orcids":["https://orcid.org/0000-0002-6049-1943"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Zhao","raw_affiliation_strings":["Chemistry and Chemical Biology, Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Chemical Biology, Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088715619","display_name":"Joseph A. Haegele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Haegele","raw_affiliation_strings":["Chemistry and Chemical Biology, Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Chemical Biology, Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Huang","raw_affiliation_strings":["Chemistry and Chemical Biology, Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Chemical Biology, Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012739930","display_name":"Yimon Aye","orcid":"https://orcid.org/0000-0002-1256-4159","observed_orcids":["https://orcid.org/0000-0002-1256-4159"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yimon Aye","raw_affiliation_strings":["Chemistry and Chemical Biology, Cornell University, Ithaca, NY","Department of Biochemistry, Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Chemical Biology, Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Biochemistry, Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30013042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.7333999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.7333999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.16279999911785126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akt3","display_name":"AKT3","score":0.9399999976158142},{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cysteine-modification","display_name":"cysteine modification","score":0.7590000033378601},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.7099999785423279},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5979999899864197},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C154137905","wikidata":"https://www.wikidata.org/wiki/Q17816452","display_name":"AKT1","level":4,"score":0.7557756900787354},{"id":"https://openalex.org/C154779307","wikidata":"https://www.wikidata.org/wiki/Q18034943","display_name":"AKT3","level":5,"score":0.719407856464386},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.712705135345459},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.639417290687561},{"id":"https://openalex.org/C88216763","wikidata":"https://www.wikidata.org/wiki/Q4652205","display_name":"AKT2","level":5,"score":0.6182221174240112},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49913930892944336},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.4858238697052002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4719483256340027},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4623483419418335},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.45030462741851807},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41515377163887024},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37377023696899414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3661622405052185},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19140633940696716},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18756917119026184}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.773.5","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.773.5","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.773.5","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2582758165","https://openalex.org/W3026797206","https://openalex.org/W2126593560","https://openalex.org/W2562051643","https://openalex.org/W2032556863","https://openalex.org/W6887951230","https://openalex.org/W2018786910","https://openalex.org/W3172716528","https://openalex.org/W2072367583","https://openalex.org/W2047073581"],"abstract_inverted_index":{"Akt":[0,17,46,76],"is":[1,106,189,196],"a":[2,6,19,84,107,113,122,181,206],"serine/threonine\u2010specific":[3],"kinase":[4,217,269],"and":[5,12,48,70,80,91,155,242,248,305,320],"master":[7],"regulator":[8],"of":[9,16,44,121,132,177,180,209,215,228,237,268,280],"metabolism,":[10],"proliferation":[11],"apoptosis.":[13],"Isoform\u2010specific":[14],"deregulation":[15],"plays":[18],"key":[20],"role":[21],"in":[22,33,83,130,135,141,213,245,254,259,277],"distinct":[23],"tumor":[24],"phenotypes.":[25],"Pan\u2010Akt":[26],"inhibitors":[27],"such":[28],"as":[29,138,140],"MK\u20102206":[30],"are":[31,220,251],"currently":[32],"clinical":[34,42],"trials":[35],"for":[36,292,327],"cancer":[37],"therapy,":[38],"further":[39],"highlighting":[40],"the":[41,74,174,226,278,289],"significance":[43],"understanding":[45],"regulation":[47],"innovating":[49],"novel":[50],"tools":[51],"to":[52,58,66,110,127,148,172,199,263,296,302,324],"inhibit":[53],"its":[54],"activity.":[55,218],"However,":[56],"methods":[57],"develop":[59],"isozyme\u2010specific":[60,281],"therapeutics":[61],"have":[62],"remained":[63],"elusive,":[64],"due":[65],"large":[67],"sequence":[68],"homology":[69],"functional":[71,175,207],"similarity":[72],"among":[73],"three":[75],"isozymes,":[77],"Akt1,":[78],"2":[79],"3.":[81],"Recently,":[82],"collaborative":[85],"study":[86],"with":[87],"my":[88],"graduate":[89],"student":[90],"postdoc":[92],"mentors":[93],"(Long":[94],"et":[95],"al.":[96],"Nature":[97],"Chemical":[98],"Biology":[99],"2016":[100],"accepted),":[101],"we":[102,185],"discovered":[103,188],"that":[104,205,250],"Akt3":[105,128,133,216,238],"privileged":[108],"responder":[109],"4\u2010hydroxynonenal":[111],"(HNE),":[112],"bioactive":[114],"lipid\u2010derived":[115,273],"electrophilic":[116,119,232],"signal.":[117],"Target\u2010specific":[118],"modification":[120,144,179,233],"cysteine":[123],"residue":[124,195,211],"(C119)":[125],"unique":[126,198],"resulted":[129],"downregulation":[131],"activity":[134],"mammalian":[136],"cells":[137,247],"well":[139,252],"zebrafish.":[142],"This":[143,194],"alone":[145],"was":[146],"sufficient":[147],"upregulate":[149],"endogenous":[150,272],"downstream":[151,235],"pro\u2010apoptotic":[152],"genes.":[153],"Akt1":[154],"Akt2":[156],"were":[157],"both":[158],"unresponsive":[159],"under":[160],"otherwise":[161],"identical":[162],"conditions.":[163],"My":[164,201],"independent":[165],"research":[166,328],"will":[167],"build":[168],"on":[169,234],"this":[170,210,229,260],"discovery":[171],"investigate":[173],"impacts":[176],"HNE":[178],"non\u2010cysteine":[182,230],"residue,":[183],"which":[184],"had":[186],"recently":[187],"also":[190,197],"modified":[191],"by":[192,271],"HNE.":[193],"Akt3.":[200],"preliminary":[202],"data":[203],"suggests":[204],"mutation":[208],"results":[212],"upregulation":[214],"We":[219,287],"now":[221],"making":[222],"headway":[223],"towards":[224],"examining":[225],"effects":[227],"site\u2010specific":[231],"targets":[236],"using":[239],"chemical":[240],"biology":[241],"genetic":[243],"approaches":[244],"cultured":[246],"zebrafish":[249],"established":[253],"our":[255],"laboratory.":[256],"Further":[257],"investigations":[258],"area":[261],"promises":[262],"reveal":[264],"intricate":[265],"regulatory":[266],"mechanisms":[267],"isozymes":[270],"electrophiles,":[274],"ultimately":[275],"aiding":[276],"development":[279],"drugs.":[282],"Support":[283],"or":[284],"Funding":[285],"Information":[286],"acknowledge":[288],"Hill":[290],"Fellowship":[291,322],"Undergraduate":[293],"Summer":[294],"Research":[295],"Sanjna":[297],"Surya,":[298],"HHMI":[299],"pre\u2010doctoral":[300],"fellowship":[301],"Saba":[303],"Parvez,":[304],"NIH":[306],"New":[307],"Innovator":[308],"Award":[309],"(1DP2GM114850),":[310],"Beckman":[311],"Young":[312],"Investigator,":[313],"NSF":[314],"CAREER":[315],"(CHE\u20101351400),":[316],"Burroughs":[317],"Wellcome":[318],"CRTG,":[319],"Sloan":[321],"programs":[323],"Yimon":[325],"Aye":[326],"support.":[329]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}
