{"id":"https://openalex.org/W4389019772","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.740.23","title":"Stereocilin Paralogs Have Distinct Roles in Zebrafish Inner Ear Development","display_name":"Stereocilin Paralogs Have Distinct Roles in Zebrafish Inner Ear Development","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389019772","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.740.23"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.740.23","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.740.23","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.740.23","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088403731","display_name":"Kenneth L. Kramer","orcid":"https://orcid.org/0009-0003-0668-7595","observed_orcids":["https://orcid.org/0009-0003-0668-7595","https://orcid.org/0000-0002-5930-1612"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth L Kramer","raw_affiliation_strings":["Creighton University, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creighton University, Omaha, NE","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015658066","display_name":"Christopher J. Inserra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J Inserra","raw_affiliation_strings":["Creighton University, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creighton University, Omaha, NE","institution_ids":["https://openalex.org/I114493937"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114493937"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35373777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.20980000495910645,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13738","display_name":"Congenital Ear and Nasal Anomalies","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinocilium","display_name":"kinocilium","score":0.9559999704360962},{"id":"https://openalex.org/keywords/stereocilia","display_name":"stereocilia","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tectorial-membrane","display_name":"tectorial membrane","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gpi-anchored-proteins","display_name":"GPI-anchored proteins","score":0.49000000953674316},{"id":"https://openalex.org/keywords/vestibular-hair-cells","display_name":"vestibular hair cells","score":0.5740000009536743},{"id":"https://openalex.org/keywords/auditory-hair-cells","display_name":"auditory hair cells","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C11658465","wikidata":"https://www.wikidata.org/wiki/Q6414172","display_name":"Kinocilium","level":4,"score":0.9835211038589478},{"id":"https://openalex.org/C2776557274","wikidata":"https://www.wikidata.org/wiki/Q7611233","display_name":"Stereocilia (inner ear)","level":4,"score":0.8928993344306946},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.7754990458488464},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.723191499710083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6794518828392029},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6562627553939819},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6496919393539429},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.48946917057037354},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.46020573377609253},{"id":"https://openalex.org/C131151476","wikidata":"https://www.wikidata.org/wiki/Q809753","display_name":"Basal body","level":4,"score":0.4567606747150421},{"id":"https://openalex.org/C2778079943","wikidata":"https://www.wikidata.org/wiki/Q974231","display_name":"Utricle","level":3,"score":0.4464263617992401},{"id":"https://openalex.org/C2776927070","wikidata":"https://www.wikidata.org/wiki/Q26864","display_name":"Aurelia aurita","level":3,"score":0.4330172538757324},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.41538119316101074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1339840292930603},{"id":"https://openalex.org/C115811362","wikidata":"https://www.wikidata.org/wiki/Q189998","display_name":"Flagellum","level":3,"score":0.08606085181236267},{"id":"https://openalex.org/C2779735984","wikidata":"https://www.wikidata.org/wiki/Q30178","display_name":"Jellyfish","level":2,"score":0.06745636463165283},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.740.23","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.740.23","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.740.23","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4089763268","display_name":"The Molecular Biology of Neurosurgery Systems","funder_award_id":"P20GM103471","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2283995102","https://openalex.org/W2997283256","https://openalex.org/W2001452730","https://openalex.org/W1971047575","https://openalex.org/W1510589793","https://openalex.org/W2125224427","https://openalex.org/W2745799369","https://openalex.org/W7204896428","https://openalex.org/W2061968382","https://openalex.org/W2017068376"],"abstract_inverted_index":{"In":[0,217],"the":[1,19,92,104,128,156,162,169,186,190,207,245,283,290],"vertebrate":[2],"inner":[3,119],"ear,":[4],"sound":[5],"and":[6,49,73,78,103,133,137,228,235,255,270,289],"movement":[7],"are":[8,44,139],"transduced":[9],"into":[10],"electrical":[11],"signals":[12],"by":[13,54,195,280],"specialized":[14],"bundles":[15],"of":[16,22,31,40,57,84,159,189,193,209,286],"cilia":[17,97,102],"on":[18,155],"apical":[20],"surface":[21],"sensory":[23],"hair":[24,27,80,143,163,215],"cells.":[25,81,216],"Each":[26],"bundle":[28],"is":[29,68,114,153,174,263],"composed":[30],"a":[32,55,63,176,181],"single":[33],"Tubulin\u2010filled":[34],"kinocilium":[35],"attached":[36],"to":[37,46,50,110,168,211,214,222,251],"multiple":[38],"rows":[39],"Actin\u2010packed":[41],"stereocilia.":[42],"Cilia":[43],"linked":[45],"each":[47],"other":[48],"an":[51],"overlying":[52,105],"membrane":[53],"complex":[56],"proteins":[58,243],"that":[59,67,125,135,261],"includes":[60],"Stereocilin":[61],"(STRC),":[62],"putative":[64],"GPI\u2010linked":[65],"protein":[66],"expressed":[69,141],"in":[70,75,86,89,91,117,180,202,225,232,240,244,253],"both":[71,94,140],"stereocilia":[72],"kinocilia":[74,160,210],"mouse":[76,87],"auditory":[77],"vestibular":[79],"Since":[82],"loss":[83],"STRC":[85,113,131],"results":[88],"defects":[90],"attachments":[93],"between":[95,101],"neighboring":[96],"as":[98,100],"well":[99],"tectorial":[106],"membrane,":[107],"we":[108],"sought":[109],"determine":[111],"if":[112],"similarly":[115],"required":[116,265],"zebrafish":[118,130,267],"ear":[120],"development.":[121],"We":[122,259],"generated":[123],"antibodies":[124],"specifically":[126],"distinguish":[127],"two":[129],"paralogs":[132],"found":[134,154,175],"STRCa":[136,173],"STRCb":[138,152,262],"during":[142],"cell":[144],"formation":[145],"but":[146],"with":[147],"slightly":[148],"different":[149],"expression":[150],"patterns.":[151],"distal":[157,187],"tip":[158],"when":[161],"cells":[164],"first":[165],"start":[166],"tethering":[167],"seeding":[170],"otoliths,":[171],"while":[172],"few":[177,182],"hours":[178],"later":[179],"punctate":[183],"locations":[184],"along":[185],"half":[188],"kinocilium.":[191],"Knockdown":[192],"strcb":[194,201,233],"injecting":[196],"antisense":[197],"morpholinos":[198],"or":[199,273],"eliminating":[200],"CRISPR/Cas9\u2010generated":[203],"mutant":[204,229,236],"embryos":[205,237],"blocked":[206],"ability":[208],"tether":[212],"otoliths":[213,252],"contrast,":[218],"otolith":[219,247,268],"attachment":[220,269],"appeared":[221],"be":[223],"normal":[224,239,254],"strca":[226,256],"morphants":[227],"embryos.":[230],"Kinocilia":[231],"morphant":[234],"were":[238,248],"length,":[241],"yet":[242],"unattached":[246],"disorganized":[249],"compared":[250],"\u2010deficient":[257],"zebrafish.":[258],"conclude":[260],"uniquely":[264],"for":[266],"organization.":[271],"Support":[272],"Funding":[274],"Information":[275],"The":[276],"work":[277],"was":[278],"supported":[279],"grants":[281],"from":[282],"National":[284],"Institutes":[285],"Health":[287,292],"(8P20GM103471)":[288],"Creighton":[291],"Science":[293],"Strategic":[294],"Investment":[295],"Fund.":[296]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}
