{"id":"https://openalex.org/W4389019336","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.753.1","title":"A Novel Reductase\u2010Independent Role of Nuclear Ribonucleotide Reductase","display_name":"A Novel Reductase\u2010Independent Role of Nuclear Ribonucleotide Reductase","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389019336","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.753.1"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.753.1","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.753.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.753.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012739930","display_name":"Yimon Aye","orcid":"https://orcid.org/0000-0002-1256-4159","observed_orcids":["https://orcid.org/0000-0002-1256-4159"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yimon Aye","raw_affiliation_strings":["Cornell University and Weill Cornell Medicine, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University and Weill Cornell Medicine, Ithaca, NY","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012739930"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2990051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribonucleotide-reductase","display_name":"ribonucleotide reductase","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dna-replication-inhibition","display_name":"DNA replication inhibition","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nucleotide-signaling","display_name":"nucleotide signaling","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nuclear-import","display_name":"nuclear import","score":0.9760000109672546},{"id":"https://openalex.org/keywords/focus-formation","display_name":"focus formation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"mutagenesis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/chemotherapy-targets","display_name":"chemotherapeutic target","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C4710235","wikidata":"https://www.wikidata.org/wiki/Q420089","display_name":"Ribonucleotide reductase","level":4,"score":0.973815381526947},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6391681432723999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5530722737312317},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.5415096879005432},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.45663338899612427},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.4536842107772827},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.41893208026885986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3607964515686035},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3345106840133667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3187652826309204},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.24722665548324585},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.18244117498397827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16831746697425842},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.11681964993476868},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.753.1","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.753.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.753.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309624","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2888439550","https://openalex.org/W4389024703","https://openalex.org/W1973109316","https://openalex.org/W101831931","https://openalex.org/W2054740290","https://openalex.org/W4404050882","https://openalex.org/W2167711536","https://openalex.org/W1991194699","https://openalex.org/W2211440948","https://openalex.org/W4252520025"],"abstract_inverted_index":{"Since":[0],"the":[1,6,39,116,148,185,208],"origins":[2],"of":[3,15,43,80,94,105,109,147],"DNA\u2010based":[4],"life,":[5],"enzyme":[7],"ribonucleotide":[8],"reductase":[9],"(RNR)":[10],"has":[11,55,68],"spurred":[12],"proliferation":[13],"because":[14],"its":[16],"rate\u2010limiting":[17],"role":[18],"in":[19,29,184,207],"de":[20],"novo":[21],"deoxynucleoside\u2010triphosphate":[22],"(dNTP)":[23],"biosynthesis.":[24],"Unsurprisingly":[25],"RNR":[26,33],"is":[27,91,111],"overexpressed":[28],"cancer":[30],"cells,":[31],"rendering":[32],"a":[34,49,95,103,135],"major":[35],"chemotherapeutic":[36],"target.":[37],"Paradoxically,":[38],"large":[40],"subunit,":[41],"RNR\u2010a,":[42],"this":[44,60],"obligatory":[45],"two\u2010component":[46],"complex":[47],"plays":[48],"stage\u2010/context\u2010specific":[50],"tumor\u2010suppressive":[51],"role.":[52],"Little":[53],"explanation":[54],"been":[56],"offered":[57],"to":[58,74],"resolve":[59],"dichotomy.":[61],"Here,":[62],"we":[63,100],"show":[64],"that":[65,88,123,141],"nuclear":[66,89,97,126,130],"RNR\u2010a":[67],"an":[69,92],"unappreciated":[70],"DNA\u2010replication\u2010inhibition":[71],"function,":[72],"leading":[73],"growth":[75],"retardation":[76],"and":[77,118,152,169,174,188,198],"ultimately":[78],"suppression":[79],"focus":[81],"formation.":[82],"A":[83],"large\u2010scale":[84],"protein\u2010interaction":[85],"study":[86],"uncovered":[87],"RNR\u2010\u03b1":[90,110],"inhibitor":[93],"novel":[96],"protein":[98],"which":[99],"identify":[101],"as":[102,134],"promoter":[104],"DNA\u2010synthesis.":[106],"This":[107],"non\u2010reductase\u2010role":[108],"regulated":[112],"by":[113,120],"exclusion":[114],"from":[115],"nucleus,":[117],"promoted":[119],"nucleotide\u2010induced":[121],"RNR\u2010a\u2010oligomerization":[122],"elicits":[124],"rapid":[125],"import.":[127],"The":[128],"newly\u2010discovered":[129],"signaling":[131],"axis":[132],"acts":[133],"primary":[136],"defense":[137],"against":[138],"elevated/imbalanced":[139],"dNTP\u2010pools":[140],"can":[142],"exert":[143],"mutagenic":[144],"effects":[145],"irrespective":[146],"cell":[149],"cycle.":[150],"(Fu":[151],"Long":[153],"et":[154],"al":[155],"\u2010":[156],"Under":[157],"Peer":[158],"Review\u20102016":[159],"Nat":[160],"Commun":[161],").":[162],"Support":[163],"or":[164],"Funding":[165],"Information":[166],"Cornell":[167,175],"University":[168,176],"Weill":[170],"Medicine":[171],"seed":[172],"grants":[173],"start\u2010up":[177],"funds":[178],"(for":[179,202],"Nucleotide":[180],"Signaling":[181,204],"research":[182,205],"program":[183,206],"Aye":[186,209],"lab),":[187],"NSF":[189],"CAREER,":[190],"NIH":[191],"Director's":[192],"New":[193],"Innovator,":[194],"Beckman":[195],"Young":[196],"Investigator,":[197],"Sloan":[199],"Fellowship":[200],"programs":[201],"Redox":[203],"lab).":[210]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}
