{"id":"https://openalex.org/W4389019244","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.867.1","title":"The Impact of Nitrate Supplementation on the Peripheral Chemoreceptor Reflex to Hypoxia in Older Adults","display_name":"The Impact of Nitrate Supplementation on the Peripheral Chemoreceptor Reflex to Hypoxia in Older Adults","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W4389019244","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.867.1"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.867.1","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.867.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.867.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023677104","display_name":"Josh Bock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josh Bock","raw_affiliation_strings":["Physical Therapy &amp; Rehabilitation Science University of Iowa Iowa City IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Therapy &amp; Rehabilitation Science University of Iowa Iowa City IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003362911","display_name":"Jacqueline K. Limberg","orcid":"https://orcid.org/0000-0001-9982-5851","observed_orcids":["https://orcid.org/0000-0001-9982-5851"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Limberg","raw_affiliation_strings":["Department of Anesthesiology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101464255","display_name":"William Edward Hughes","orcid":"https://orcid.org/0000-0002-7580-9213","observed_orcids":["https://orcid.org/0000-0002-7580-9213","https://orcid.org/0000-0003-2064-4834"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Hughes","raw_affiliation_strings":["Physical Therapy &amp; Rehabilitation Science University of Iowa Iowa City IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Therapy &amp; Rehabilitation Science University of Iowa Iowa City IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077226662","display_name":"Nicholas T. Kruse","orcid":"https://orcid.org/0000-0001-9903-8743","observed_orcids":["https://orcid.org/0000-0001-9903-8743"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Kruse","raw_affiliation_strings":["Physical Therapy &amp; Rehabilitation Science University of Iowa Iowa City IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Therapy &amp; Rehabilitation Science University of Iowa Iowa City IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054758021","display_name":"Kenichi Ueda","orcid":"https://orcid.org/0000-0002-4559-4581","observed_orcids":["https://orcid.org/0000-0002-4559-4581"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken\u2010ichi Ueda","raw_affiliation_strings":["Anesthesia, University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesia, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054111868","display_name":"Darren P. Casey","orcid":"https://orcid.org/0000-0003-4564-8604","observed_orcids":["https://orcid.org/0000-0003-4564-8604"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darren Casey","raw_affiliation_strings":["Physical Therapy &amp; Rehabilitation Science University of Iowa Iowa City IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Therapy &amp; Rehabilitation Science University of Iowa Iowa City IA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.30363467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-nitrate-supplementation","display_name":"nitrate supplementation","score":0.796999990940094},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9559999704360962},{"id":"https://openalex.org/keywords/carotid-body-chemoreceptors","display_name":"carotid chemoreceptors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hypoxic-ventilatory-response","display_name":"hypoxic ventilatory response","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7319999933242798},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9039999842643738},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5080000162124634},{"id":"https://openalex.org/keywords/heart-rate-response","display_name":"heart rate response","score":0.6420000195503235},{"id":"https://openalex.org/keywords/beetroot-powder","display_name":"beetroot powder","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cardiorespiratory-reflexes","display_name":"cardiorespiratory reflexes","score":0.7620000243186951},{"id":"https://openalex.org/keywords/oxygen-saturation","display_name":"oxygen saturation","score":0.527999997138977},{"id":"https://openalex.org/keywords/isocapnic-hypoxia","display_name":"isocapnic hypoxia","score":0.6190000176429749},{"id":"https://openalex.org/keywords/minute-ventilation","display_name":"minute ventilation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7629046440124512},{"id":"https://openalex.org/C117437137","wikidata":"https://www.wikidata.org/wiki/Q5038720","display_name":"Cardiorespiratory fitness","level":2,"score":0.7569719552993774},{"id":"https://openalex.org/C2778113364","wikidata":"https://www.wikidata.org/wiki/Q1532008","display_name":"Carotid body","level":3,"score":0.6941478252410889},{"id":"https://openalex.org/C103247709","wikidata":"https://www.wikidata.org/wiki/Q1069641","display_name":"Chemoreceptor","level":3,"score":0.6677981615066528},{"id":"https://openalex.org/C136511781","wikidata":"https://www.wikidata.org/wiki/Q7168702","display_name":"Peripheral chemoreceptors","level":4,"score":0.660480797290802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6460845470428467},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.643785834312439},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5874444246292114},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.48445940017700195},{"id":"https://openalex.org/C2780157289","wikidata":"https://www.wikidata.org/wiki/Q16918363","display_name":"Hypoxic ventilatory response","level":3,"score":0.4773592948913574},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4719654321670532},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.4625081419944763},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.45378798246383667},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43766552209854126},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.4342237114906311},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.42698389291763306},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.42493370175361633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4135701358318329},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2566106915473938},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20211109519004822},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.17380589246749878},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15919813513755798},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.14279630780220032},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.12919968366622925},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.867.1","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.867.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.867.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4254789224","https://openalex.org/W2760154572","https://openalex.org/W2113255705","https://openalex.org/W2075313859","https://openalex.org/W1999033302","https://openalex.org/W1983881147","https://openalex.org/W1987334860","https://openalex.org/W3174520413","https://openalex.org/W2054116195","https://openalex.org/W2053195761"],"abstract_inverted_index":{"Peripheral":[0],"chemoreceptors":[1],"located":[2],"within":[3],"the":[4,67,72,187,215,218,243,284,306,310,324,382,391],"carotid":[5,46],"bodies":[6],"activate":[7],"cardiorespiratory":[8,87,383],"reflexes":[9],"in":[10,24,49,91,118,378,397],"response":[11,50,287],"to":[12,21,51,89,103,115,328,374,385],"hypoxia.":[13,52,386],"Carotid":[14],"body":[15,47],"chemoreceptor":[16],"activity":[17],"has":[18,38],"been":[19,39],"shown":[20],"be":[22],"enhanced":[23],"conditions":[25],"such":[26,63],"as":[27,41,64,234],"congestive":[28],"heart":[29,111,325],"failure,":[30],"hypertension,":[31],"and":[32,110,126,136,196,228,253,270],"possibly":[33],"aging.":[34,65],"Nitric":[35],"oxide":[36],"(NO)":[37],"proposed":[40],"an":[42],"inhibitory":[43],"modulator":[44],"of":[45,130,141,217,237,279,309,371,394],"chemosensitivity":[48],"Additionally,":[53,323],"NO":[54,76,131,142,280,335,372,376,395],"bioavailability":[55,77,377],"is":[56],"often":[57],"reduced":[58,283,333],"with":[59,160,186,214,352],"cardiovascular":[60],"risk":[61],"factors":[62],"In":[66],"present":[68],"study,":[69],"we":[70],"tested":[71],"hypothesis":[73],"that":[74,369],"increasing":[75],"via":[78],"dietary":[79],"nitrate":[80],"(NO":[81],"3":[82,132,143,281,336,373,396],")":[83,109],"supplementation":[84,133,282,337,370],"would":[85],"reduce":[86],"responses":[88,114,327,384],"hypoxia":[90,117,245,265,330],"older":[92,120,379],"adults.":[93],"A":[94],"double\u2010blind,":[95],"randomized,":[96],"placebo\u2010controlled,":[97],"cross\u2010over":[98],"study":[99,147,249,259,311],"design":[100],"was":[101,303],"used":[102,254],"evaluate":[104],"minute":[105],"ventilation":[106],"(V":[107,226],"E":[108,193,227,269],"rate":[112,326],"(HR)":[113],"acute":[116,264,329],"7":[119],"adults":[121,380],"(66\u00b12":[122],"years;":[123],"5M/2F)":[124],"before":[125],"after":[127],"4":[128],"weeks":[129,278],"(beetroot":[134,138],"powder)":[135],"placebo":[137,307,353],"powder":[139],"devoid":[140],").":[144,164],"On":[145,258],"each":[146,203,223,248],"visit,":[148],"subjects":[149,188],"underwent":[150],"two":[151,244],"separate":[152],"isocapnic":[153],"hypoxic":[154,177,204,285],"tests":[155,246],"(self\u2010regulating,":[156],"partial":[157],"rebreathing":[158],"system":[159],"10%":[161,168],"O":[162,169],"2":[163,170,173,198,232,296,320,346,362],"Subjects":[165],"remained":[166],"on":[167,247],"until":[171],"SpO":[172,197,231],"reached":[174],"\u226480%.":[175],"The":[176,240],"exposures":[178],"were":[179,199,207,251,331],"separated":[180],"by":[181,410],"a":[182,211,235],"15\u2010minute":[183],"washout":[184],"period":[185],"breathing":[189],"room":[190],"air.":[191],"V":[192,268],",":[194,297,321,347,363],"HR,":[195],"continuously":[200],"monitored":[201],"throughout":[202],"exposure.":[205],"Data":[206],"grouped":[208],"together":[209],"using":[210],"7\u2010breath":[212],"average":[213],"slope":[216],"linear":[219],"regression":[220],"line":[221],"for":[222,242,255,275],"dependent":[224],"variable":[225],"HR)":[229],"versus":[230],"serving":[233],"measure":[236],"peripheral":[238,402],"chemosensitivity.":[239,403],"slopes":[241],"visit":[250],"averaged":[252],"statistical":[256],"comparisons.":[257],"day":[260],"one":[261],"(true":[262],"baseline)":[263],"increased":[266],"both":[267],"HR":[271],"(":[272],"P":[273,298,348],"<0.05":[274],"both).":[276],"Four":[277],"ventilatory":[286],"(\u22120.16":[288],"\u00b1":[289,293,313,317,339,343,355,359],"\u22120.05":[290,344],"vs.":[291,315,341,357],"\u22120.06":[292],"\u22120.03":[294],"L/minute/%SpO":[295,319],"<0.05),":[299,349],"whereas":[300],"no":[301],"change":[302],"observed":[304],"following":[305,334],"phase":[308],"(\u22120.14":[312],"\u22120.07":[314],"\u22120.14":[316],"\u22120.08":[318,340,360],"P=0.67).":[322],"also":[332],"(\u22120.49":[338],"\u22120.30":[342],"beats/minute/%SpO":[345,361],"but":[350],"not":[351],"(\u22120.54":[354],"\u22120.11":[356],"\u22120.45":[358],"P=0.21).":[364],"Our":[365],"preliminary":[366],"findings":[367],"suggest":[368],"boost":[375],"blunts":[381],"Future":[387],"studies":[388],"should":[389],"examine":[390],"therapeutic":[392],"potential":[393],"patient":[398],"populations":[399],"exhibiting":[400],"exaggerated":[401],"Support":[404],"or":[405],"Funding":[406],"Information":[407],"Research":[408],"supported":[409],"Neogenis":[411],"Inc.":[412]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-27T00:00:00"}
